TDMS Study 93005-03 Pathology Tables
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
Facility: National Center for Toxicological Research
Chemical CAS #: 569-64-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma, Multiple | |
Leukemia Mononuclear | X X X X X X X X X X X X |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Leukemia Mononuclear | X |
Sarcoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + M M M + + + + + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M M + + + + + + + +|
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X|
Carcinoma | X X X X X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X X X |
Sarcoma Stromal | X |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Deep Cervical, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
|__________________________________________________________________________|
Thymus | M M M + M + + + + + M + + + + + + + + + M + + M +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Carcinoma | X |
Fibroadenoma | X X X X X X X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Cerebellum, Leukemia Mononuclear | X |
Cerebrum, Leukemia Mononuclear | X |
|__________________________________________________________________________|
Peripheral Nerve | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Sarcoma, Metastatic, Mesentery | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
|__________________________________________________________________________|
Harderian Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + + + + + + + + + |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hepatocellular Adenoma, Multiple | X | 1 |
Leukemia Mononuclear | X X X X X X X | 19 |
|__________________________________________________________________________|____________|
Mesentery | + + + | 9 |
Leukemia Mononuclear | | 1 |
Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | | 2 |
Leukemia Mononuclear | | 3 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Medulla | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + | 47 |
Leukemia Mononuclear | | 3 |
Pheochromocytoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 43 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Pars Distalis, Adenoma | X X X X X X X X X X X X | 26 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
C-Cell, Adenoma | X X X X | 4 |
C-Cell, Carcinoma | X X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | X X X | 7 |
Carcinoma | | 5 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X | 4 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Polyp Stromal | X X X X X X X X | 14 |
Sarcoma Stromal | X | 2 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 10 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 2 |
Mediastinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 2 |
Renal, Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + I + + + + + + + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | | 5 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X X X X X | 19 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M | 40 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + M + + + | 46 |
Carcinoma | X | 2 |
Fibroadenoma | X X X X X X | 15 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basal Cell Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
Cerebellum, Leukemia Mononuclear | | 1 |
Cerebrum, Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X | 12 |
Sarcoma, Metastatic, Mesentery | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lacrimal Gland | + + + + + + + + + | 18 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 2 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X X X X X | 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|
| 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 PPM | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|
| 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uterus | X |
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X |
|__________________________________________________________________________|
Mesentery | + + + + |
Carcinoma, Metastatic, Uterus | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uterus | X |
Leukemia Mononuclear | X X X X |
|__________________________________________________________________________|
Salivary Glands | + + + + + M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________|__________________________________________________________________________|
Page 12
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|
| 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 PPM | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|
| 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + M + + + M + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
Abdominal, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|
| 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 PPM | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|
| 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Leukemia Mononuclear | X |
Bilateral, Carcinoma | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
Leukemia Mononuclear | X X X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X X X X |
Sarcoma Stromal | |
Endometrium, Carcinoma | X |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Leukemia Mononuclear | |
Axillary, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
Thoracic, Leukemia Mononuclear | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | A + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|
| 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 PPM | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|
| 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uterus | X |
Leukemia Mononuclear | X X X X X X X X X X X X X |
|__________________________________________________________________________|
Thymus | + + + + M + M + + + + + + M + + + + + + M + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X X X X |
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Leukemia Mononuclear | X |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|
| 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 PPM | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|
| 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X X X X X X X |
Sarcoma Stromal, Metastatic, Uterus | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + + + + + + + |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Transitional Epithelium, Papilloma | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Uterus | | 1 |
Hepatocellular Adenoma | X | 1 |
Leukemia Mononuclear | X X X | 16 |
|__________________________________________________________________________|____________|
Mesentery | + | 5 |
Carcinoma, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Uterus | | 1 |
Leukemia Mononuclear | X | 5 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X | 5 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | | 4 |
Pheochromocytoma Benign | X | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | X X | 2 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + | 43 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X | 36 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | X X X | 5 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Abdominal, Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | X X X X | 5 |
Carcinoma | X | 1 |
Leukemia Mononuclear | | 1 |
Bilateral, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Granulosa Cell Tumor Malignant | X | 1 |
Leukemia Mononuclear | | 4 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
Polyp Stromal | X X X | 7 |
Sarcoma Stromal | X | 1 |
Endometrium, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Leukemia Mononuclear | X | 1 |
Axillary, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | X | 2 |
Mediastinal, Leukemia Mononuclear | | 3 |
Pancreatic, Leukemia Mononuclear | X | 2 |
Renal, Leukemia Mononuclear | X | 1 |
Thoracic, Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Leukemia Mononuclear | X | 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | X | 5 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Uterus | | 1 |
Leukemia Mononuclear | X X X X | 17 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + M + + + + + + + + + + + | 42 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma | X | 2 |
Fibroadenoma | X X X X X X X | 13 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Subcutaneous Tissue, Fibroma | X | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cerebrum, Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + M + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X | 12 |
Sarcoma Stromal, Metastatic, Uterus | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Lacrimal Gland | + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 2 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
Transitional Epithelium, Papilloma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X X | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Adenomatous | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X |
|__________________________________________________________________________|
Mesentery | + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + I + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X|
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Adenoma | X X |
Carcinoma | X X X |
Bilateral, Carcinoma | |
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Clitoral Gland| X |
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X X |
Sarcoma Stromal | X |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Deep Cervical, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + M + + + + M + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Carcinoma | |
Fibroadenoma | X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
|__________________________________________________________________________|
Lacrimal Gland | + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
300 PPM | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0| | L |
| 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Polyp Adenomatous | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Adenoma | X X | 3 |
Leukemia Mononuclear | X X X | 10 |
|__________________________________________________________________________|____________|
Mesentery | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 2 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
300 PPM | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0| | L |
| 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 2 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 2 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | X | 1 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + | 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X | 32 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + | 47 |
C-Cell, Adenoma | | 3 |
C-Cell, Carcinoma | | 2 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
300 PPM | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0| | L |
| 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenoma | X X X X X X | 8 |
Carcinoma | X X | 5 |
Bilateral, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Carcinoma, Metastatic, Clitoral Gland| | 1 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
Polyp Stromal | X X X | 5 |
Sarcoma Stromal | | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | X | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | X | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X | 2 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
300 PPM | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0| | L |
| 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X | 10 |
|__________________________________________________________________________|____________|
Thymus | + M + + + + + M + + + + + + + + + + + + + + + | 43 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma | X | 1 |
Fibroadenoma | X X X X X X X | 12 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Keratoacanthoma | X | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
300 PPM | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0| | L |
| 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Leukemia Mononuclear | X X | 5 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 15 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
DAY ON TEST | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|
| 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
600 PPM | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|
| 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Adenomatous | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | X|
Leukemia Mononuclear | X |
Sarcoma, Metastatic, Ovary | X |
|__________________________________________________________________________|
Mesentery | + + |
Sarcoma, Metastatic, Ovary | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Ovary | X |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
DAY ON TEST | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|
| 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
600 PPM | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|
| 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Ovary | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Ovary | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
Sarcoma, Metastatic, Ovary | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M + M M + + + M + + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + M + + + M + + + + + + + + + + I + + + + + +|
Carcinoma, Metastatic, Zymbal's Gland| X |
Pars Distalis, Adenoma | X X X X X X X X X|
Pars Distalis, Carcinoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Sarcoma, Metastatic, Ovary | X |
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
DAY ON TEST | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|
| 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
600 PPM | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|
| 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Adenoma | X X X X |
Carcinoma | X X X X |
Bilateral, Carcinoma | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X X |
Sarcoma, Metastatic, Ovary | X |
Schwannoma Malignant | X |
Endometrium, Adenoma | |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Leukemia Mononuclear | X |
Thoracic, Leukemia Mononuclear | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Leukemia Mononuclear | X |
Sarcoma, Metastatic, Ovary | X |
|__________________________________________________________________________|
Thymus | + + M + + + M M M + + + + + + + + + + M + M + + +|
Sarcoma, Metastatic, Ovary | X |
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
DAY ON TEST | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|
| 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
600 PPM | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|
| 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X X |
Fibroadenoma | X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Sarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Oligodendroglioma Malignant | |
Ventricle, Carcinoma, Metastatic, | |
Pituitary Gland | X |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Zymbal's Gland| X |
Leukemia Mononuclear | X |
Sarcoma, Metastatic, Uncertain | |
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
_____________________________________________________________________________________________________________________
| 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
DAY ON TEST | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|
| 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
600 PPM | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|
| 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Primary Site | |
Mediastinum, Sarcoma, Metastatic, | |
Ovary | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
Pinna, Neural Crest Tumor | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Lacrimal Gland | + + +|
|__________________________________________________________________________|
Zymbal's Gland | M + + + + + + + + + + + + + + + + + + M + + + + +|
Carcinoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | X |
Transitional Epithelium, Carcinoma | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Polyp Adenomatous | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hepatocellular Adenoma | X X X | 3 |
Hepatocellular Adenoma, Multiple | | 1 |
Leukemia Mononuclear | | 1 |
Sarcoma, Metastatic, Ovary | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Sarcoma, Metastatic, Ovary | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Sarcoma, Metastatic, Ovary | | 1 |
Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Sarcoma, Metastatic, Ovary | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Sarcoma, Metastatic, Ovary | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Pheochromocytoma Benign | X | 1 |
Sarcoma, Metastatic, Ovary | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + M + + + M + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X | 29 |
Pars Distalis, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + | 46 |
Sarcoma, Metastatic, Ovary | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Adenoma | X X X | 3 |
C-Cell, Carcinoma | X | 1 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenoma | X X X X | 8 |
Carcinoma | | 4 |
Bilateral, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Polyp Stromal | X X X X X X X X X X X | 16 |
Sarcoma, Metastatic, Ovary | | 1 |
Schwannoma Malignant | | 1 |
Endometrium, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inguinal, Leukemia Mononuclear | | 1 |
Thoracic, Leukemia Mononuclear | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemangiosarcoma | X | 1 |
Leukemia Mononuclear | | 1 |
Sarcoma, Metastatic, Ovary | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + M + + + + + + + + + + + | 40 |
Sarcoma, Metastatic, Ovary | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma | X X | 5 |
Fibroadenoma | X X X X X | 9 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Subcutaneous Tissue, Sarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Oligodendroglioma Malignant | X | 1 |
Ventricle, Carcinoma, Metastatic, | | |
Pituitary Gland | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
Leukemia Mononuclear | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Mediastinum, Sarcoma, Metastatic, | | |
Ovary | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
Pinna, Neural Crest Tumor | X | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 93005-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lacrimal Gland | + + + + + + | 9 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + | 47 |
Sarcoma, Metastatic, Skin | | 1 |
Transitional Epithelium, Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
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---------- END OF REPORT ----------
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