TDMS Study 93005-03 Pathology Tables
NTP Experiment-Test: 93005-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
Facility: National Center for Toxicological Research
Chemical CAS #: 569-64-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93005-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
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FISCHER 344 RATS FEMALE 0 PPM 100 PPM 300 PPM 600 PPM
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DISPOSITION SUMMARY
Animals Initially in Study 48 48 48 48
Early Deaths
Natural Death 1 3 1 6
Moribund Sacrifice 18 22 15 17
Survivors
Terminal Sacrifice 29 23 32 25
Animals Examined Microscopically 48 48 48 48
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ALIMENTARY SYSTEM
Intestine Large, Colon (47) (47) (48) (47)
Polyp Adenomatous 1 (2%)
Intestine Large, Rectum (48) (46) (48) (48)
Polyp Adenomatous 1 (2%)
Intestine Small, Ileum (47) (46) (48) (47)
Liver (48) (48) (48) (48)
Carcinoma, Metastatic, Uterus 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 3 (6%) 3 (6%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (2%)
Sarcoma, Metastatic, Ovary 1 (2%)
Mesentery (9) (5) (2) (4)
Carcinoma, Metastatic, Uterus 1 (20%)
Sarcoma 1 (11%)
Sarcoma, Metastatic, Ovary 1 (25%)
Pancreas (48) (48) (48) (48)
Carcinoma, Metastatic, Uterus 1 (2%)
Salivary Glands (48) (47) (48) (48)
Tongue (48) (48) (48) (48)
Sarcoma, Metastatic, Ovary 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
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NTP Experiment-Test: 93005-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 100 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (48) (48) (48) (48)
Sarcoma, Metastatic, Ovary 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (48) (48) (48) (48)
Adenoma 2 (4%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Sarcoma, Metastatic, Ovary 1 (2%)
Adrenal Medulla (47) (47) (48) (48)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Sarcoma, Metastatic, Ovary 1 (2%)
Islets, Pancreatic (48) (48) (48) (48)
Adenoma 2 (4%) 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (48) (47) (46) (45)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Pars Distalis, Adenoma 26 (54%) 36 (77%) 32 (70%) 29 (64%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (46) (48) (47) (46)
Sarcoma, Metastatic, Ovary 1 (2%)
C-Cell, Adenoma 4 (9%) 5 (10%) 3 (6%) 3 (7%)
C-Cell, Carcinoma 3 (7%) 1 (2%) 2 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 2 (4%) 1 (2%)
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GENERAL BODY SYSTEM
Tissue NOS (1)
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GENITAL SYSTEM
Clitoral Gland (48) (48) (47) (47)
Adenoma 7 (15%) 5 (10%) 8 (17%) 8 (17%)
Carcinoma 5 (10%) 1 (2%) 5 (11%) 4 (9%)
Bilateral, Carcinoma 1 (2%) 1 (2%) 1 (2%)
Ovary (48) (48) (47) (48)
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NTP Experiment-Test: 93005-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 100 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Carcinoma, Metastatic, Clitoral Gland 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%)
Sarcoma 1 (2%)
Uterus (48) (48) (48) (48)
Polyp Stromal 14 (29%) 7 (15%) 5 (10%) 16 (33%)
Sarcoma, Metastatic, Ovary 1 (2%)
Sarcoma Stromal 2 (4%) 1 (2%) 1 (2%)
Schwannoma Malignant 1 (2%)
Endometrium, Adenoma 1 (2%)
Endometrium, Carcinoma 1 (2%)
Vagina (48) (48) (48) (48)
Sarcoma 1 (2%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (48) (48) (48) (48)
Lymph Node (10) (7) (7) (5)
Lymph Node, Mandibular (47) (46) (47) (48)
Lymph Node, Mesenteric (47) (47) (48) (48)
Spleen (48) (48) (48) (48)
Carcinoma, Metastatic, Uterus 1 (2%)
Hemangiosarcoma 1 (2%)
Sarcoma, Metastatic, Ovary 1 (2%)
Thymus (40) (42) (43) (40)
Sarcoma, Metastatic, Ovary 1 (3%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
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INTEGUMENTARY SYSTEM
Mammary Gland (46) (48) (48) (48)
Carcinoma 2 (4%) 2 (4%) 1 (2%) 5 (10%)
Fibroadenoma 15 (33%) 13 (27%) 12 (25%) 9 (19%)
Skin (48) (48) (48) (48)
Basal Cell Adenoma 1 (2%)
Keratoacanthoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Sarcoma 2 (4%)
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NTP Experiment-Test: 93005-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 100 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (48) (48) (48) (48)
Sarcoma 1 (2%)
Skeletal Muscle (48) (48) (48) (48)
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NERVOUS SYSTEM
Brain (48) (48) (48) (48)
Oligodendroglioma Malignant 1 (2%)
Ventricle, Carcinoma, Metastatic, Pituitary
Gland 1 (2%)
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RESPIRATORY SYSTEM
Lung (48) (48) (48) (48)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Mediastinum, Sarcoma, Metastatic, Ovary 1 (2%)
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SPECIAL SENSES SYSTEM
Ear (1)
Pinna, Neural Crest Tumor 1 (100%)
Eye (47) (48) (48) (48)
Harderian Gland (47) (48) (48) (48)
Adenoma 1 (2%)
Zymbal's Gland (47) (48) (48) (46)
Carcinoma 1 (2%) 1 (2%) 2 (4%)
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URINARY SYSTEM
Kidney (48) (48) (48) (48)
Urinary Bladder (47) (48) (47) (47)
Sarcoma, Metastatic, Skin 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
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NTP Experiment-Test: 93005-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 100 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Transitional Epithelium, Papilloma 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(48) *(48) *(48) *(48)
Leukemia Mononuclear 19 (40%) 17 (35%) 10 (21%) 1 (2%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 93005-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:23:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 100 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 48 46 42
Total Primary Neoplasms 104 99 94 102
Total Animals with Benign Neoplasms 41 42 40 35
Total Benign Neoplasms 70 74 69 75
Total Animals with Malignant Neoplasms 29 24 21 23
Total Malignant Neoplasms 34 25 25 26
Total Animals with Metastatic Neoplasms 2 3 1 5
Total Metastatic Neoplasm 2 6 1 17
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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