TDMS Study 93005-03 Pathology Tables
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
Facility: National Center for Toxicological Research
Chemical CAS #: 569-64-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X X X X X|
Developmental Malformation | X X X |
Eosinophilic Focus | |
Eosinophilic Focus, Multiple | |
Hematopoietic Cell Proliferation | 1 2 |
Hepatodiaphragmatic Nodule | X X |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Focal, Granulomatous | 2 2 1 1 2|
Inflammation, Focal, Suppurative | |
Vacuolization Cytoplasmic | 2 3 1 |
Bile Duct, Hyperplasia | 2 2 1|
|__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 3 2 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 2 1 2 1 1|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 1 1 2 |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | 2 1 1 |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic | 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + M M M + + + + + M + +|
Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Pars Distalis, Cyst | 1 2 1 1 |
Pars Distalis, Hyperplasia | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Thyroid Gland | + + + + + + + + + + + + + + + M M + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation | 2 1 2 2 2 2 3 2 |
Duct, Dilatation | 3 3 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 2 2 3 2 2 3 |
Cyst | 2 2 3 2 |
Infiltration Cellular, Lymphocyte | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Cervix, Hypertrophy | 3 |
Cervix, Serosa, Cyst | |
Endometrium, Hyperplasia, Cystic | 2 1 2 3 2 2 |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Myelostromal Proliferation | |
Myeloid Cell, Hyperplasia | 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Deep Cervical, Hemorrhage | |
Deep Cervical, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Lymphoid | 2 |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lumbar, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Ectasia | |
Renal, Hemorrhage | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 4 3 2 |
Hyperplasia, Focal | |
Pigmentation | 3 |
|__________________________________________________________________________|
Thymus | M M M + M + + + + + M + + + + + + + + + M + + M +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 3 2|
Hyperplasia | 3 3 1 3 2 3 2 1 2 3 2 2 2 2 1 2 2 2 1|
Duct, Dilatation | 1 3 2 2 2 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 3 |
Femur, Osteopetrosis | 3 3 2 |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Sternum, Osteopetrosis | 3 3 2 |
Turbinate, Osteopetrosis | 3 3 |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hypothalamus, Compression | 2 1 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Nasolacrimal Duct, Inflammation | 3 2 2 2 2 1 2 2 1 2 3|
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 |
Olfactory Epithelium, Respiratory | |
Epithelium, Cytoplasmic | |
Alteration | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 4| 3| 3| 2| 2| 5| 8| 0| 2| 2| 4| 3| 4| 4| 6| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 3| 5| 6| 9| 2| 9| 6| 6| 6| 1| 1| 1| 7| 7| 4| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 6| 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 2| 4| 5| 6| 7| 8| 9| 0| 6| 1| 4| 4| 6| 0| 2| 5| 2| 1| 2| 3| 4| 5| 6| 7| 1|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Eye | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cataract | 1 2 1 |
Bilateral, Cataract | |
Bilateral, Retina, Degeneration | 2 3 3 3 4 3 3 2 2|
Retina, Autolysis | |
Retina, Degeneration | 2 1 3 |
Sclera, Metaplasia, Osseous | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 1 1 1 1 2 2 1 2 1 1 1 1|
Inflammation | |
|__________________________________________________________________________|
Lacrimal Gland | + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Metaplasia | 2 2 2 2 2 2 2 2 2 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 2 2 2 2 3 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 |
Nephropathy | 1 2 1 2 3 1 1 1 1 2 1 1 1 1 1 3 1 1|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | | 2 |
Basophilic Focus, Multiple | X X X X X X X X X X X X X | 19 |
Developmental Malformation | X | 4 |
Eosinophilic Focus | X X X | 3 |
Eosinophilic Focus, Multiple | X X | 2 |
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | X | 3 |
Infiltration Cellular, Lymphocyte | 1 | 2 1.0|
Inflammation, Focal, Granulomatous | 2 1 1 2 2 1 2 2 1 1 2 2 1 | 18 1.6|
Inflammation, Focal, Suppurative | 1 | 1 1.0|
Vacuolization Cytoplasmic | 3 | 4 2.3|
Bile Duct, Hyperplasia | 1 1 2 1 2 1 1 | 10 1.4|
|__________________________________________________________________________|____________|
Mesentery | + + + | 9 |
Fat, Necrosis | 3 2 3 | 7 2.6|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Acinus, Atrophy | 1 1 1 1 1 | 13 1.2|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | 2 1 1 2 1 1 | 13 1.5|
Atrium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Accessory Adrenal Cortical Nodule | 2 | 1 2.0|
Angiectasis | 1 2 1 1 1 1 2 | 10 1.3|
Hypertrophy, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 1 2 | 6 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + | 47 |
Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 43 |
Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 3 2 2 | 5 2.4|
Pars Distalis, Cyst | 1 1 2 3 | 8 1.5|
Pars Distalis, Hyperplasia | 3 2 2 1 | 5 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
C-Cell, Hyperplasia | 1 1 1 2 1 | 8 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 3 2 2 2 | 5 2.2|
Inflammation | 2 3 2 4 2 2 2 2 2 2 2 2 2 | 21 2.1|
Duct, Dilatation | 3 3 2 | 6 2.8|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 2 2 2 3 2 3 2 3 2 | 18 2.4|
Cyst | 3 | 5 2.4|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | | 1 2.0|
Cervix, Hypertrophy | | 1 3.0|
Cervix, Serosa, Cyst | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | | 6 2.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | | 3 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | | 1 2.0|
Myelostromal Proliferation | 2 | 1 2.0|
Myeloid Cell, Hyperplasia | 2 | 5 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 10 |
Deep Cervical, Hemorrhage | 2 | 1 2.0|
Deep Cervical, Hyperplasia, Lymphoid | 2 | 1 2.0|
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
Lumbar, Hyperplasia, Lymphoid | 2 | 2 2.0|
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 2 2.0|
Pancreatic, Hemorrhage | 2 | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Ectasia | 3 | 1 3.0|
Renal, Hemorrhage | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + | 47 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Plasma Cell | 3 2 | 5 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + I + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hematopoietic Cell Proliferation | | 6 2.8|
Hyperplasia, Focal | 4 | 1 4.0|
Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M | 40 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + M + + + | 46 |
Galactocele | 2 | 4 2.5|
Hyperplasia | 3 2 2 2 3 2 3 2 1 | 28 2.1|
Duct, Dilatation | 1 3 2 2 2 | 12 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperkeratosis | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Femur, Fibrous Osteodystrophy | | 1 3.0|
Femur, Osteopetrosis | 2 2 4 3 2 | 8 2.6|
Sternum, Osteopetrosis | 2 2 4 3 2 | 8 2.6|
Turbinate, Osteopetrosis | 2 2 4 3 2 | 7 2.7|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | | 1 1.0|
Hypothalamus, Compression | 2 2 2 | 5 1.8|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation | 1 1 1 2 2 1 1 1 | 19 1.7|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 3 | 2 2.5|
Olfactory Epithelium, Respiratory | | |
Epithelium, Cytoplasmic | | |
Alteration | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cataract | 2 2 1 1 | 7 1.4|
Bilateral, Cataract | 1 | 1 1.0|
Bilateral, Retina, Degeneration | 3 3 3 2 | 13 2.8|
Retina, Autolysis | X | 1 |
Retina, Degeneration | 1 3 3 2 2 | 8 2.1|
Sclera, Metaplasia, Osseous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Atrophy | 1 | 1 1.0|
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 1 1 1 1 2 1 2 1 2 1 1 | 34 1.4|
Inflammation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | + + + + + + + + + | 18 |
Infiltration Cellular, Lymphocyte | 2 1 | 2 1.5|
Metaplasia | 3 2 1 2 2 2 2 2 2 | 18 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 2| 1| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mineralization | 2 2 2 2 2 2 2 2 2 | 33 2.0|
Nephropathy | 1 1 1 1 2 2 1 2 1 1 1 2 1 1 2 1 1 1 1 2 3 | 39 1.4|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|
| 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 PPM | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|
| 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + A + + + + +|
Dilatation | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X|
Clear Cell Focus | |
Cyst | 2 |
Developmental Malformation | X |
Eosinophilic Focus | X X X X |
Eosinophilic Focus, Multiple | |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X X |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Focal, Granulomatous | 2 2 1 |
Inflammation, Focal, Suppurative | 2|
Mixed Cell Focus | |
Necrosis | |
Vacuolization Cytoplasmic | 4 3 |
Bile Duct, Hyperplasia | 2 3 1 1|
|__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|
| 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 PPM | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|
| 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Acinus, Atrophy | 1 3 1 2 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + M + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation | 3 1 |
Necrosis | 2 |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic | 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + M + + + M + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|
| 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 PPM | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|
| 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Angiectasis | 1 2 |
Pars Distalis, Cyst | 1 1 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Inflammation | 1 2 2 2 3 3 2 2 2 2 3 2|
Duct, Dilatation | 3 3 3 3 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 3 2 2 2 2 2 2 |
Cyst | 2 |
Interstitial Cell, Hyperplasia | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Hypertrophy | 3 |
Endometrium, Hyperplasia, Cystic | 2 |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
|__________________________________________________________________________|
Lymph Node | + + + + |
Pigmentation | |
Lumbar, Hematopoietic Cell | |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|
| 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 PPM | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|
| 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Proliferation | 2 |
Lumbar, Hemorrhage | 2 |
Mediastinal, Hemorrhage | 2 |
Renal, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + M + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Plasma Cell | 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Plasma Cell | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Pigmentation | 3 3 |
Capsule, Hemorrhage | 3 |
|__________________________________________________________________________|
Thymus | + + + + M + M + + + + + + M + + + + + + M + + + +|
Ectopic Parathyroid Gland | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 3 3 |
Hyperplasia | 3 2 2 1 2 4 2 1 1 2 2 1 2 2 2 2 1|
Inflammation | |
Duct, Dilatation | 2 2 2 3 2 2 2 2 2 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Epidermis, Hyperplasia | |
Epidermis, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|
| 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 PPM | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|
| 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Femur, Fibrous Osteodystrophy | 2 |
Femur, Osteopetrosis | 3 2 |
Sternum, Fibrous Osteodystrophy | 2 |
Sternum, Osteopetrosis | 3 2 |
Turbinate, Osteopetrosis | 3 2 |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hypothalamus, Compression | 3 2 3 2 2 1 1 2 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | |
Inflammation, Chronic, Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | 1 1 2 2 2|
Olfactory Epithelium, Cytoplasmic | |
Alteration | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 8| 9| 1| 3| 4| 5| 7| 7| 9| 1| 9| 1| 9| 0| 4| 4| 2| 8| 0| 8| 1| 2| 2| 2|
| 3| 5| 4| 2| 9| 0| 6| 7| 4| 6| 0| 8| 3| 1| 0| 1| 8| 4| 7| 7| 6| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
100 PPM | 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 8| 8| 8| 8| 9| 9| 0|
| 3| 8| 1| 2| 3| 4| 5| 8| 1| 2| 3| 5| 7| 8| 9| 2| 5| 7| 1| 5| 6| 9| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Cataract | 2 |
Bilateral, Cataract | 2 |
Bilateral, Retina, Degeneration | 1 2 3 3 2 2 2 2 2|
Retina, Autolysis | X X X |
Retina, Degeneration | 2 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 3 1|
|__________________________________________________________________________|
Lacrimal Gland | + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 |
Metaplasia | 2 2 1 2 2 2 2 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
Nephropathy | 2 2 2 1 1 2 2 1 2 2 2 1 1 1 1 1 1|
Pelvis, Inflammation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 20
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Dilatation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basophilic Focus | X | 3 |
Basophilic Focus, Multiple | X X X X X X X X X X X X | 14 |
Clear Cell Focus | X X | 2 |
Cyst | | 1 2.0|
Developmental Malformation | X X X X X X | 7 |
Eosinophilic Focus | X X X X X | 9 |
Eosinophilic Focus, Multiple | X | 1 |
Hematopoietic Cell Proliferation | 1 1 | 3 1.0|
Hepatodiaphragmatic Nodule | X X | 6 |
Infiltration Cellular, Lymphocyte | 1 1 | 3 1.3|
Inflammation, Focal, Granulomatous | 2 1 2 2 2 1 1 1 2 1 2 1 | 15 1.5|
Inflammation, Focal, Suppurative | 3 | 2 2.5|
Mixed Cell Focus | X X | 2 |
Necrosis | 1 2 | 2 1.5|
Vacuolization Cytoplasmic | 2 2 | 4 2.8|
Bile Duct, Hyperplasia | 2 1 2 2 1 2 | 10 1.7|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + | 5 |
Fat, Necrosis | 3 | 4 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Acinus, Atrophy | 3 2 2 2 1 1 1 2 1 | 14 1.6|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Atrophy | | 2 1.5|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Edema | | 1 2.0|
Inflammation | | 2 2.0|
Necrosis | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 2 | 22 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 1 1 1 1 2 2 1 2 2 | 11 1.5|
Hyperplasia, Focal | 2 | 1 2.0|
Hypertrophy, Focal | 2 1 1 | 4 1.5|
Vacuolization Cytoplasmic | 2 2 | 5 1.8|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 2 3 | 3 2.3|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + | 43 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Angiectasis | | 2 1.5|
Pars Distalis, Cyst | 1 2 | 5 1.4|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
C-Cell, Hyperplasia | 1 1 2 2 | 5 1.4|
Follicle, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 2 2 | 4 2.0|
Inflammation | 3 2 2 3 2 3 2 2 2 2 2 2 2 3 3 3 2 1 | 30 2.2|
Duct, Dilatation | | 5 2.8|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 2 2 2 2 | 14 2.1|
Cyst | 3 2 2 | 4 2.3|
Interstitial Cell, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cervix, Hypertrophy | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 1 | 3 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 1 | 3 1.7|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Pigmentation | 2 | 1 2.0|
Lumbar, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Lumbar, Hemorrhage | | 1 2.0|
Mediastinal, Hemorrhage | | 1 2.0|
Renal, Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Ectasia | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
Infiltration Cellular, Plasma Cell | 2 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Plasma Cell | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hematopoietic Cell Proliferation | 2 2 | 2 2.0|
Pigmentation | | 2 3.0|
Capsule, Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + M + + + + + + + + + + + | 42 |
Ectopic Parathyroid Gland | | 1 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Galactocele | 3 3 3 3 3 | 8 3.0|
Hyperplasia | 2 2 2 3 2 1 1 1 2 3 2 3 1 1 2 1 | 33 1.8|
Inflammation | 3 | 1 3.0|
Duct, Dilatation | 2 1 2 2 2 2 2 2 1 2 1 | 22 1.9|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation | | 1 3.0|
Epidermis, Hyperplasia | 2 | 1 2.0|
Epidermis, Necrosis | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Femur, Fibrous Osteodystrophy | | 1 2.0|
Femur, Osteopetrosis | 1 | 3 2.0|
Sternum, Fibrous Osteodystrophy | | 1 2.0|
Sternum, Osteopetrosis | 1 | 3 2.0|
Turbinate, Osteopetrosis | | 2 2.5|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | | 1 2.0|
Hypothalamus, Compression | 2 3 2 2 2 1 | 14 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + M + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic, Diffuse | 2 | 1 2.0|
Inflammation, Chronic, Focal | 1 2 | 3 1.7|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Nasolacrimal Duct, Inflammation | 2 1 2 2 1 | 10 1.6|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 2 3 2 | 3 2.3|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cataract | 1 | 2 1.5|
Bilateral, Cataract | | 1 2.0|
Bilateral, Retina, Degeneration | 2 2 2 2 2 | 14 2.1|
Retina, Autolysis | X | 4 |
Retina, Degeneration | 2 2 1 2 2 2 | 8 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 2 2 2 1 1 1 1 1 1 1 2 1 2 1 1 1 2 1 | 37 1.2|
|__________________________________________________________________________|____________|
Lacrimal Gland | + + + + + + + | 14 |
Infiltration Cellular, Lymphocyte | 1 | 2 1.0|
Metaplasia | 2 3 2 2 2 1 2 | 14 1.9|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 0| 0| 1| 1| 1| 3| 3| 4| 4| 4| 4| 5| 6| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| | L |
| 1| 9| 0| 8| 9| 1| 9| 0| 1| 2| 3| 9| 1| 7| 8| 9| 0| 1| 4| 3| 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Metaplasia, Squamous | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mineralization | 2 2 2 2 2 2 2 | 31 2.0|
Nephropathy | 3 2 1 1 3 3 2 1 1 3 1 2 1 1 2 1 2 1 2 1 1 | 38 1.6|
Pelvis, Inflammation | 1 | 1 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X X X X X X X |
Clear Cell Focus, Multiple | X |
Degeneration, Cystic | 2 |
Developmental Malformation | X |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | X X X X X X X X|
Hematopoietic Cell Proliferation | 1 1 1 |
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Lymphocyte | 1 1|
Inflammation, Focal, Granulomatous | 1 2 2 2 2 2 2 1 1 |
Necrosis | 2 1 |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 1 2 1 |
|__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Acinus, Atrophy | 1 2 2 1 2 |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Angiectasis | 2 2 1 1 2 1 1 2 |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + I + + + + + + + + + + + + + +|
Angiectasis | 3 1 |
Pars Distalis, Cyst | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Hyperplasia | 2 2 3 2 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 2 1 2 1 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 2 2 |
Inflammation | 2 2 2 2 1 2 3 1 2 2 3 3 2 3 3 2 |
Duct, Dilatation | 2 2 2 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Atrophy | 2 2 4 2 4 |
Cyst | 2 2 2 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Cervix, Hypertrophy | 2 |
Endometrium, Hyperplasia, Cystic | 2 2 1 |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | 3 2 |
|__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Hemorrhage | 3 2 |
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pancreatic, Hematopoietic Cell | |
Proliferation | |
Renal, Hemorrhage | 1 |
Renal, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Plasma Cell | 2 3 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 |
Pigmentation | 3 3 |
Thrombosis | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + M + + + + M + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 3 |
Hyperplasia | 3 2 2 2 2 2 2 2 2 3 3 1 2 2 1 1 2 2|
Duct, Dilatation | 2 2 2 3 2 2 2 2 1 1 2 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | 2 |
Sternum, Osteopetrosis | 2 |
Turbinate, Osteopetrosis | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | 2 2 2 3 3 2 1 2 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic, Focal | 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Suppurative | 3 |
Nasolacrimal Duct, Inflammation | 1 2 3 1 2|
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 2 |
Olfactory Epithelium, Respiratory | |
Epithelium, Cytoplasmic | |
Alteration | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Phthisis Bulbi | X X |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 0| 2| 2| 1| 5| 5| 6| 5| 9| 7| 1| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 4| 8| 3| 6| 7| 9| 2| 9| 6| 9| 7| 3| 9| 2| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
300 PPM | 1| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2|
| 7| 9| 0| 3| 6| 0| 8| 9| 1| 3| 8| 0| 7| 8| 0| 2| 3| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Bilateral, Cataract | 2 |
Bilateral, Retina, Degeneration | 2 2 3 2 2 2 2 3 2 2 2 3 2|
Retina, Degeneration | 2 2 2 2 2 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 2 1 1 1 2 1 1 2 1 2 1 1 1 1|
|__________________________________________________________________________|
Lacrimal Gland | + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 |
Metaplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Nephropathy | 2 1 2 2 1 1 1 2 2 2 1 1 2 1 1 1 1 1 2 2 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________|__________________________________________________________________________
Page 33
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
300 PPM | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0| | L |
| 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basophilic Focus | | 2 |
Basophilic Focus, Multiple | X X X X X X 1 X X X | 18 1.0|
Clear Cell Focus, Multiple | | 1 |
Degeneration, Cystic | | 1 2.0|
Developmental Malformation | X | 2 |
Eosinophilic Focus | X X | 3 |
Eosinophilic Focus, Multiple | X X | 10 |
Hematopoietic Cell Proliferation | 1 | 4 1.0|
Hepatodiaphragmatic Nodule | X | 2 |
Infiltration Cellular, Lymphocyte | 1 | 3 1.0|
Inflammation, Focal, Granulomatous | 1 2 1 1 1 2 2 2 1 2 1 1 1 1 | 23 1.5|
Necrosis | | 2 1.5|
Vacuolization Cytoplasmic | | 1 3.0|
Bile Duct, Cyst | 2 | 1 2.0|
Bile Duct, Hyperplasia | 3 1 1 1 1 | 9 1.4|
|__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
300 PPM | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0| | L |
| 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Acinus, Atrophy | 1 1 1 1 1 2 1 | 12 1.3|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Erosion | | 1 2.0|
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 | 19 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Angiectasis | 2 1 1 1 1 2 2 2 2 | 17 1.5|
Hyperplasia, Focal | | 1 2.0|
Hypertrophy, Focal | | 1 2.0|
Vacuolization Cytoplasmic | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
300 PPM | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0| | L |
| 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + | 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Angiectasis | | 2 2.0|
Pars Distalis, Cyst | 1 3 2 1 2 2 2 | 9 1.9|
Pars Distalis, Hyperplasia | 2 2 2 2 2 3 | 11 2.2|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + | 47 |
C-Cell, Hyperplasia | 1 1 1 | 11 1.4|
Follicle, Cyst | 3 | 1 3.0|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | | 2 2.0|
Inflammation | 2 2 2 2 2 3 2 | 23 2.2|
Duct, Dilatation | 3 3 3 | 7 2.6|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Atrophy | 2 2 2 2 3 2 | 11 2.5|
Cyst | 2 2 2 | 7 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Thrombosis | 3 | 1 3.0|
Cervix, Hypertrophy | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 1 3 2 2 2 1 | 11 1.8|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
300 PPM | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0| | L |
| 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | | 5 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 1 3 | 2 2.0|
Myelofibrosis | 2 | 2 2.0|
Myeloid Cell, Hyperplasia | 2 1 2 | 5 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Mediastinal, Hemorrhage | 2 | 3 2.3|
Pancreatic, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Renal, Hemorrhage | | 1 1.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hemorrhage | 2 | 2 2.5|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Infiltration Cellular, Plasma Cell | | 5 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ectasia | | 1 2.0|
Hemorrhage | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hematopoietic Cell Proliferation | 3 2 2 2 2 | 7 2.3|
Pigmentation | | 2 3.0|
Thrombosis | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + M + + + + + M + + + + + + + + + + + + + + + | 43 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
300 PPM | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0| | L |
| 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Galactocele | | 2 2.5|
Hyperplasia | 2 1 1 2 2 3 2 2 1 2 2 | 29 1.9|
Duct, Dilatation | 2 2 2 2 2 2 | 18 1.9|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Femur, Osteopetrosis | 3 3 | 3 2.7|
Sternum, Osteopetrosis | 3 3 | 3 2.7|
Turbinate, Osteopetrosis | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hypothalamus, Compression | 3 3 | 10 2.3|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Foreign Body | | 1 2.0|
Inflammation, Chronic, Focal | 1 2 | 4 1.8|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 4 2 | 2 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
300 PPM | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0| | L |
| 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Foreign Body | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Nasolacrimal Duct, Inflammation | 1 2 2 2 1 2 | 11 1.7|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 2 2 1 2 | 6 1.8|
Olfactory Epithelium, Respiratory | | |
Epithelium, Cytoplasmic | | |
Alteration | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation | 2 | 3 1.7|
Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | | 1 2.0|
Phthisis Bulbi | | 2 |
Bilateral, Cataract | 2 | 2 2.0|
Bilateral, Retina, Degeneration | 2 2 2 3 2 2 2 | 20 2.2|
Retina, Degeneration | 2 1 2 | 9 1.9|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 2 1 1 1 1 1 2 2 1 1 2 1 2 1 | 36 1.3|
|__________________________________________________________________________|____________|
Lacrimal Gland | | 15 |
Infiltration Cellular, Lymphocyte | | 2 1.5|
Metaplasia | | 15 2.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
300 PPM | 4| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 0| | L |
| 4| 5| 6| 7| 8| 9| 0| 0| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hydronephrosis | 2 | 1 2.0|
Mineralization | 2 2 2 2 2 1 1 | 30 1.9|
Nephropathy | 2 1 1 1 1 1 1 1 1 2 2 2 3 1 2 3 1 1 1 1 | 41 1.4|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
DAY ON TEST | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|
| 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
600 PPM | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|
| 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Foreign Body | X |
|__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Basophilic Focus, Multiple | X X|
Developmental Malformation | X X X X |
Eosinophilic Focus | X X X X |
Eosinophilic Focus, Multiple | |
Fatty Change | |
Hematopoietic Cell Proliferation | 2 3 1 |
Hepatodiaphragmatic Nodule | |
Infiltration Cellular, Lymphocyte | 1 1 1 |
Inflammation, Focal, Granulomatous | 2 1 2 2 1 1 1|
Mixed Cell Focus, Multiple | X |
Necrosis | 1 |
Vacuolization Cytoplasmic | 2 3 2|
Bile Duct, Hyperplasia | 1 1 2|
Centrilobular, Necrosis | 3 2 2 3 |
|__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
DAY ON TEST | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|
| 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
600 PPM | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|
| 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | 2 |
Acinus, Atrophy | 2 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Infiltration Cellular, Lymphocyte | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 3 2 1 2 |
Atrophy | 2 2|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 1 |
Infiltration Cellular, Lymphocyte | |
Vacuolization Cytoplasmic | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
DAY ON TEST | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|
| 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
600 PPM | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|
| 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Parathyroid Gland | + + + + + + M + + + M + M M + + + M + + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + M + + + M + + + + + + + + + + I + + + + + +|
Angiectasis | |
Pars Distalis, Cyst | 2 1 2 1 2 2 3|
Pars Distalis, Hyperplasia | 2 1 2 1 |
Pars Intermedia, Cyst | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
C-Cell, Hyperplasia | 1 2 |
Follicle, Cyst | 3 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation | 2 2 3 3 3 2 2 3 2 3|
Metaplasia, Squamous | 2 |
Duct, Dilatation | 2 2 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 3|
Congestion | 3 |
Cyst | 2 2 2 2 |
Cyst, Multiple | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | |
Hemorrhage | 4 |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 1 2 2|
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
DAY ON TEST | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|
| 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
600 PPM | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|
| 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Prolapse | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Myeloid Cell, Hyperplasia | 3 2 |
|__________________________________________________________________________|
Lymph Node | + + + |
Deep Cervical, Hyperplasia, Lymphoid | 2 |
Lumbar, Ectasia | 2 |
Lumbar, Hemorrhage | 1 |
Lumbar, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 2 3 |
Infiltration Cellular, Plasma Cell | 1 3 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 3 2 2 2 2 1 3 2 2 3 |
Pigmentation | 3 3 3 |
|__________________________________________________________________________|
Thymus | + + M + + + M M M + + + + + + + + + + M + M + + +|
Hyperplasia, Reticulum Cell | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
Hyperplasia | 3 2 1 1 2 2 2 1 1 2 4 2 3 3 2 2 2|
Duct, Dilatation | 2 2 3 2 2 2 3|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
DAY ON TEST | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|
| 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
600 PPM | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|
| 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 1 1 |
Femur, Osteopetrosis | 2 |
Sternum, Osteopetrosis | 2 |
Turbinate, Osteopetrosis | 2 |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | 3 3 1|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 3 |
Hemorrhage | 2 |
Inflammation, Chronic, Focal | 3 3 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 3 |
Inflammation, Suppurative | 3 3 |
Nasolacrimal Duct, Inflammation | 2 1 2 1 2 2 2 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | |
Respiratory Epithelium, Cytoplasmic | |
Alteration | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
_____________________________________________________________________________________________________________________
| 1| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
DAY ON TEST | 1| 2| 7| 5| 4| 0| 7| 4| 6| 8| 8| 0| 2| 3| 1| 3| 3| 5| 7| 9| 9| 8| 9| 2| 2|
| 1| 3| 8| 4| 3| 8| 0| 6| 2| 1| 9| 5| 0| 3| 9| 0| 4| 4| 0| 4| 7| 5| 9| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
600 PPM | 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 8| 8| 0| 0|
| 1| 6| 1| 5| 6| 0| 4| 6| 7| 9| 4| 2| 5| 8| 9| 1| 3| 4| 6| 7| 9| 3| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Inflammation | 3 |
Epithelium, Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 1 2 2 1 |
Bilateral, Cataract | 2 2|
Bilateral, Retina, Degeneration | 3 2 2 2 2 2|
Cornea, Inflammation | 3 |
Retina, Autolysis | X X |
Retina, Degeneration | 3 2 2 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 1 2 1 1 1 2 1 1 2 2 2|
Pigmentation | 3 |
|__________________________________________________________________________|
Lacrimal Gland | + + +|
Infiltration Cellular, Lymphocyte | |
Metaplasia | 2 2 2|
|__________________________________________________________________________|
Zymbal's Gland | M + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2|
Nephropathy | 1 1 1 2 1 2 2 1 1 1 2 3 1 1 1 1 3|
Renal Tubule, Necrosis | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________|__________________________________________________________________________
Page 46
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Dilatation | | 1 3.0|
Foreign Body | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basophilic Focus | X X X | 7 |
Basophilic Focus, Multiple | X X X X X X | 8 |
Developmental Malformation | 1 | 5 1.0|
Eosinophilic Focus | X X X X X X X | 11 |
Eosinophilic Focus, Multiple | X X X | 3 |
Fatty Change | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 1 | 5 1.8|
Hepatodiaphragmatic Nodule | X X X | 3 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 | 8 1.0|
Inflammation, Focal, Granulomatous | 1 2 1 1 1 1 2 1 1 2 1 1 | 19 1.3|
Mixed Cell Focus, Multiple | | 1 |
Necrosis | | 1 1.0|
Vacuolization Cytoplasmic | 2 1 1 | 6 1.8|
Bile Duct, Hyperplasia | 1 1 | 5 1.2|
Centrilobular, Necrosis | | 4 2.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + | 4 |
Fat, Necrosis | 3 2 | 3 2.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 | 2 1.0|
Inflammation | | 1 2.0|
Acinus, Atrophy | 1 1 1 1 | 7 1.1|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | 2 1 1 1 1 1 1 1 | 14 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 2 1 2 1 1 1 1 2 2 2 | 16 1.6|
Atrophy | | 2 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia, Focal | | 1 2.0|
Hypertrophy, Focal | 2 2 2 | 4 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 1 | 3 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + M + + + M + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Angiectasis | 2 2 | 2 2.0|
Pars Distalis, Cyst | 1 3 | 9 1.9|
Pars Distalis, Hyperplasia | 3 2 | 6 1.8|
Pars Intermedia, Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + | 46 |
C-Cell, Hyperplasia | 1 2 1 3 | 6 1.7|
Follicle, Cyst | 1 2 | 3 2.0|
Follicular Cell, Hyperplasia | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 2 2 2 2 2 | 6 2.2|
Inflammation | 3 3 1 1 3 2 3 2 1 2 2 3 1 2 1 2 | 26 2.2|
Metaplasia, Squamous | | 1 2.0|
Duct, Dilatation | 3 3 3 | 6 2.7|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 1 2 2 3 2 1 | 10 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Congestion | | 1 3.0|
Cyst | 2 2 2 3 2 2 | 10 2.1|
Cyst, Multiple | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Decidual Reaction | 2 | 1 2.0|
Hemorrhage | | 1 4.0|
Thrombosis | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 | 8 1.8|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | | 1 2.0|
Prolapse | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | | 2 2.0|
Myeloid Cell, Hyperplasia | 2 2 | 4 2.3|
|__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Deep Cervical, Hyperplasia, Lymphoid | | 1 2.0|
Lumbar, Ectasia | 4 | 2 3.0|
Lumbar, Hemorrhage | | 1 1.0|
Lumbar, Hyperplasia, Lymphoid | 4 | 1 4.0|
Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Lymphoid | 2 | 5 2.6|
Infiltration Cellular, Plasma Cell | 2 2 2 | 7 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Plasma Cell | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | | 1 3.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 12 2.2|
Pigmentation | | 3 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + M + + + + + + + + + + + | 40 |
Hyperplasia, Reticulum Cell | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Galactocele | 2 | 2 2.5|
Hyperplasia | 2 2 2 1 2 2 2 2 1 3 1 3 2 3 1 2 2 1 | 35 2.0|
Duct, Dilatation | 2 2 2 1 | 11 2.1|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Femur, Fibrous Osteodystrophy | 1 | 3 1.0|
Femur, Osteopetrosis | 3 2 | 3 2.3|
Sternum, Osteopetrosis | 3 2 | 3 2.3|
Turbinate, Osteopetrosis | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hypothalamus, Compression | 2 2 2 3 | 7 2.3|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Foreign Body | 2 3 | 4 2.8|
Hemorrhage | 1 | 2 1.5|
Inflammation, Chronic, Focal | 1 1 2 3 1 | 8 1.9|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Foreign Body | | 2 3.0|
Inflammation, Suppurative | | 2 3.0|
Nasolacrimal Duct, Inflammation | 1 2 3 2 1 1 | 13 1.7|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 | 1 1.0|
Respiratory Epithelium, Cytoplasmic | | |
Alteration | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation | | 1 3.0|
Epithelium, Hyperplasia | | 2 2.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cataract | 2 3 2 | 7 1.9|
Bilateral, Cataract | | 2 2.0|
Bilateral, Retina, Degeneration | 2 2 2 3 3 3 2 3 3 2 2 2 | 18 2.3|
Cornea, Inflammation | | 1 3.0|
Retina, Autolysis | | 2 |
Retina, Degeneration | 2 3 1 2 2 | 9 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 93005-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 14:26:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | A |
600 PPM | 0| 0| 0| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 0| 0| 0| 0| 0| | L |
| 6| 7| 8| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 2 3 1 1 1 1 2 1 1 1 2 1 | 32 1.4|
Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | + + + + + + | 9 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 3 1.0|
Metaplasia | 2 3 2 2 2 2 | 9 2.1|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mineralization | 1 2 2 2 1 2 2 | 30 1.8|
Nephropathy | 2 1 2 1 2 3 1 3 1 2 1 1 1 2 1 1 2 1 1 1 1 1 1 | 40 1.5|
Renal Tubule, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + | 47 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------