TDMS Study 93005-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: NCTR MALACHITE GREEN DATE: 06/18/03
EXPERIMENT: 93005 TEST: 03 TIME: 14:28:35
TEST TYPE: CHRONIC PAGE: 1
CONT: 224-93-00001 ROUTE: DOSED FEED NTP C#: C93005
PATHOLOGIST: MELLICK, PAUL CAS: 569-64-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: NCTR MALACHITE GREEN DATE: 06/18/03
EXPERIMENT: 93005 TEST: 03 TIME: 14:28:35
TEST TYPE: CHRONIC
CONT: 224-93-00001 ROUTE: DOSED FEED NTP C#: C93005
PATHOLOGIST: MELLICK, PAUL CAS: 569-64-2
MALACHITE GREEN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 401 443 526 529 533 535 552 589 606 626 |
| 626 631 641 641 647 667 704 711 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 443 485 494 512 539 540 556 574 577 591 |
| 596 598 600 610 613 624 641 648 686 687 |
| 707 708 718 718 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 484 508 603 619 626 627 652 659 659 666 |
| 673 692 697 697 715 719 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MALACHITE GREEN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 111 323 378 443 454 508 546 562 570 581 |
| 589 605 619 620 630 633 634 654 670 685 |
| 694 697 699 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MALACHITE GREEN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 97.9 95.8 87.5 83.3 68.8 60.4 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 100.0 95.8 87.5 72.9 62.5 47.9 |
| | |
| | |
|300 PPM | 100.0 100.0 100.0 100.0 100.0 97.9 95.8 93.7 81.2 66.7 |
| | |
| | |
|600 PPM | 100.0 97.9 97.9 95.8 93.8 89.6 87.5 75.0 62.5 52.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 100 PPM 300 PPM 600 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.4% 47.9% 66.7% 52.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.804 P=0.312 P=0.500N P=0.452 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 596.3 607.5 643.5 561.1 |
|NATURAL DEATHS (C) | (19.9) (15.9) (16.8) (29.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 675.9 665.2 699.8 648.0 |
|(STANDARD ERROR) | (12.2) (12.0) ( 8.0) (18.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MALACHITE GREEN
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
100 PPM = 2
300 PPM = 3
600 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.00 +1 4 1 2 3
| 4 4 1 1 2 3
| 4 4 1 22 3 1 3
| 4 4 2 2 3 3
91.67 + 4 4 2 11 33
| 4 4 22
P | 4 1212 3 3
E | 41242 1 3 3
R 83.33 + 422 1 1
C | 42 2 1 1 33
E | 4 22 33
N | 4 4 11 3 3
T 75.00 + 4 4 11 33
| 2 2
S | 44 11 3 3
U | 2 24 1 1
R 66.67 + 2 2 1 1 33
V | 4224 11
I | 24 4 2 1 1
V | 4 22 1
A 58.33 + 4242
L | 22
| 22
| 4 4
50.00 + 22
| 2
|
|
41.67 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.