TDMS Study 93005-04 Pathology Tables
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:15:44
Facility: National Center for Toxicological Research
Chemical CAS #: 569-64-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:15:44
____________________________________________________________________________________________________________________________________
C57BL/6N XC3H/HEN MTN-NCTR FEMALE 0 PPM 100 PPM 225 PPM 450 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 48 48 48 48
Early Deaths
Natural Death 4 1 4 3
Accidently Killed 1
Moribund Sacrifice 4 3 3 4
Survivors
Terminal Sacrifice 40 44 40 41
Animals Examined Microscopically 48 48 48 48
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (46) (47) (45) (46)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Jejunum (46) (47) (44) (47)
Hyperplasia, Lymphoid 1 (2%)
Liver (48) (48) (46) (48)
Basophilic Focus 1 (2%) 1 (2%) 3 (7%)
Fatty Change, Focal 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 2 (4%)
Infiltration Cellular, Lymphocyte 4 (8%) 6 (13%) 8 (17%) 12 (25%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic Active, Focal 5 (10%) 9 (19%) 8 (17%) 4 (8%)
Necrosis 2 (4%)
Tension Lipidosis 10 (21%) 7 (15%) 8 (17%) 6 (13%)
Bile Duct, Cyst 1 (2%)
Mesentery (2) (5) (1)
Infiltration Cellular, Lymphocyte 1 (20%)
Fat, Necrosis, Focal 2 (100%) 3 (60%) 1 (100%)
Pancreas (47) (47) (44) (47)
Cyst 1 (2%)
Cytoplasmic Alteration 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 6 (13%) 4 (9%) 2 (5%) 3 (6%)
Necrosis, Focal 1 (2%)
Acinus, Atrophy 2 (4%)
Salivary Glands (48) (48) (48) (48)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Parotid Gland, Infiltration Cellular,
Lymphocyte 5 (10%) 12 (25%) 4 (8%) 5 (10%)
Sublingual Gland, Infiltration Cellular,
Lymphocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:15:44
____________________________________________________________________________________________________________________________________
C57BL/6N XC3H/HEN MTN-NCTR FEMALE 0 PPM 100 PPM 225 PPM 450 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Submandibular Gland, Infiltration Cellular,
Lymphocyte 35 (73%) 28 (58%) 28 (58%) 28 (58%)
Stomach, Forestomach (47) (47) (46) (48)
Hyperkeratosis, Focal 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Chronic Active 2 (4%) 3 (6%) 2 (4%) 1 (2%)
Ulcer 1 (2%)
Epithelium, Hyperplasia, Diffuse 2 (4%) 2 (4%) 1 (2%)
Epithelium, Hyperplasia, Focal 11 (23%) 8 (17%) 4 (9%) 7 (15%)
Stomach, Glandular (47) (47) (46) (48)
Erosion 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Tongue (48) (48) (48) (48)
Artery, Inflammation, Chronic 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (48) (48) (48) (48)
Infiltration Cellular, Lymphocyte 2 (4%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (47) (47) (45) (47)
Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Hypertrophy, Focal 1 (2%) 2 (4%)
Mineralization, Focal 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Bilateral, Hypertrophy, Focal 1 (2%)
Subcapsular, Hyperplasia 46 (98%) 46 (98%) 44 (98%) 45 (96%)
Adrenal Medulla (47) (46) (44) (46)
Hyperplasia, Focal 1 (2%) 1 (2%)
Pituitary Gland (48) (47) (46) (45)
Pars Distalis, Hyperplasia, Focal 1 (2%) 2 (4%) 5 (11%)
Pars Intermedia, Hyperplasia, Focal 1 (2%)
Thyroid Gland (47) (46) (46) (48)
Hyperplasia, Focal 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Ultimobranchial Cyst 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:15:44
____________________________________________________________________________________________________________________________________
C57BL/6N XC3H/HEN MTN-NCTR FEMALE 0 PPM 100 PPM 225 PPM 450 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicular Cell, Cyst 2 (4%) 2 (4%) 3 (7%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (47) (46) (44)
Inflammation, Chronic 1 (2%)
Duct, Cyst 44 (92%) 47 (100%) 45 (98%) 44 (100%)
Ovary (48) (46) (46) (45)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Atrophy 28 (58%) 33 (72%) 36 (78%) 36 (80%)
Cyst 15 (31%) 18 (39%) 11 (24%) 11 (24%)
Hemorrhage 3 (6%) 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
Bilateral, Cyst 4 (8%) 3 (7%) 3 (7%) 2 (4%)
Germinal Epithelium, Hyperplasia 2 (4%)
Uterus (48) (48) (47) (48)
Angiectasis 1 (2%) 1 (2%)
Hyperplasia, Cystic 42 (88%) 46 (96%) 44 (94%) 42 (88%)
Inflammation, Acute 1 (2%)
Thrombosis 1 (2%)
Vagina (48) (48) (46) (48)
Inflammation, Chronic 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (47) (47) (47) (48)
Fibrosis 1 (2%)
Lymph Node (13) (13) (6) (9)
Inguinal, Hyperplasia, Lymphoid 1 (17%)
Lumbar, Hyperplasia, Lymphoid 4 (31%) 4 (31%) 2 (33%) 1 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:15:44
____________________________________________________________________________________________________________________________________
C57BL/6N XC3H/HEN MTN-NCTR FEMALE 0 PPM 100 PPM 225 PPM 450 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Hemorrhage 2 (15%)
Mediastinal, Infiltration Cellular,
Mononuclear Cell 1 (8%)
Pancreatic, Infiltration Cellular,
Mononuclear Cell 1 (8%)
Renal, Hemorrhage 1 (8%)
Renal, Hyperplasia, Lymphoid 2 (15%) 1 (8%) 2 (33%) 1 (11%)
Lymph Node, Mandibular (48) (48) (47) (48)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Lymph Node, Mesenteric (45) (46) (44) (46)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 8 (18%) 8 (17%) 5 (11%) 5 (11%)
Spleen (47) (47) (45) (47)
Angiectasis 1 (2%) 1 (2%)
Depletion Cellular 1 (2%)
Hematopoietic Cell Proliferation 9 (19%) 8 (17%) 3 (7%) 5 (11%)
Hyperplasia, Lymphoid 6 (13%) 6 (13%) 7 (16%) 2 (4%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Necrosis, Focal 1 (2%)
Thymus (43) (44) (43) (47)
Angiectasis 1 (2%)
Cyst 4 (9%) 2 (5%) 3 (7%) 3 (6%)
Ectopic Parathyroid Gland 3 (7%) 1 (2%) 2 (5%) 3 (6%)
Hyperplasia, Lymphoid 3 (7%) 5 (11%) 6 (14%) 2 (4%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (48) (45) (46)
Infiltration Cellular, Lymphocyte 1 (2%)
Skin (48) (48) (46) (48)
Fibrosis 1 (2%)
Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (48) (48) (48) (48)
Hyperostosis 1 (2%)
Cranium, Fibrous Osteodystrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:15:44
____________________________________________________________________________________________________________________________________
C57BL/6N XC3H/HEN MTN-NCTR FEMALE 0 PPM 100 PPM 225 PPM 450 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Femur, Fibrous Osteodystrophy 4 (8%) 5 (10%) 2 (4%) 2 (4%)
Sternum, Degeneration, Cystic 2 (4%) 4 (8%) 3 (6%)
Sternum, Fibrous Osteodystrophy 12 (25%) 14 (29%) 5 (10%) 5 (10%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (48) (48) (48) (48)
Infiltration Cellular, Lymphocyte 1 (2%)
Cerebrum, Mineralization 25 (52%) 18 (38%) 17 (35%) 17 (35%)
Spinal Cord (48) (48) (48) (48)
Thoracic, Axon, Degeneration 13 (27%) 14 (29%) 19 (40%) 19 (40%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (48) (48) (48) (48)
Hemorrhage, Focal 1 (2%)
Infiltration Cellular, Lymphocyte 6 (13%) 6 (13%) 6 (13%) 2 (4%)
Infiltration Cellular, Histiocyte 2 (4%) 3 (6%) 2 (4%)
Inflammation, Chronic, Focal 1 (2%)
Pigmentation 1 (2%)
Proteinosis 3 (6%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (48) (48) (47) (48)
Bilateral, Lens, Cataract 4 (8%) 2 (4%) 5 (11%) 2 (4%)
Cornea, Mineralization 1 (2%)
Lens, Cataract 1 (2%) 2 (4%) 1 (2%) 6 (13%)
Harderian Gland (48) (48) (48) (48)
Atrophy 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 4 (8%) 5 (10%) 5 (10%) 4 (8%)
Zymbal's Gland (48) (48) (47) (47)
Atrophy 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:15:44
____________________________________________________________________________________________________________________________________
C57BL/6N XC3H/HEN MTN-NCTR FEMALE 0 PPM 100 PPM 225 PPM 450 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (48) (47) (48) (47)
Infiltration Cellular, Lymphocyte 2 (4%) 7 (15%) 3 (6%) 2 (4%)
Metaplasia, Focal 1 (2%)
Nephropathy 1 (2%) 1 (2%)
Glomerulus, Amyloid Deposition 2 (4%)
Glomerulus, Casts Protein 1 (2%) 1 (2%)
Glomerulus, Hypertrophy 1 (2%)
Glomerulus, Inflammation, Acute 1 (2%)
Pelvis, Dilatation 2 (4%)
Renal Tubule, Accumulation, Hyaline Droplet 4 (8%) 1 (2%) 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (47) (46) (45) (48)
Inclusion Body Intracytoplasmic 7 (15%) 15 (33%) 34 (76%) 39 (81%)
Infiltration Cellular, Lymphocyte 36 (77%) 34 (74%) 33 (73%) 25 (52%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------