TDMS Study 93005-04 Pathology Tables
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:21:07
Facility: National Center for Toxicological Research
Chemical CAS #: 569-64-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:21:07
____________________________________________________________________________________________________________________________________
C57BL/6N XC3H/HEN MTN-NCTR FEMALE 0 PPM 100 PPM 225 PPM 450 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 48 48 48 48
Early Deaths
Natural Death 4 1 4 3
Accidently Killed 1
Moribund Sacrifice 4 3 3 4
Survivors
Terminal Sacrifice 40 44 40 41
Animals Examined Microscopically 48 48 48 48
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (43) (46) (44) (43)
Intestine Large, Colon (48) (46) (44) (46)
Intestine Large, Rectum (46) (46) (46) (48)
Intestine Large, Cecum (46) (47) (45) (46)
Intestine Small, Duodenum (46) (47) (43) (47)
Polyp Adenomatous 1 (2%)
Intestine Small, Jejunum (46) (47) (44) (47)
Intestine Small, Ileum (46) (47) (44) (46)
Liver (48) (48) (46) (48)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 1 (2%) 2 (4%) 1 (2%)
Hepatocellular Adenoma 3 (6%) 2 (4%) 2 (4%) 2 (4%)
Histiocytic Sarcoma 3 (6%) 1 (2%) 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Sarcoma, Metastatic, Uterus 1 (2%)
Mesentery (2) (5) (1)
Sarcoma, Metastatic, Skin 1 (20%)
Sarcoma, Metastatic, Uterus 1 (50%)
Pancreas (47) (47) (44) (47)
Histiocytic Sarcoma 2 (4%)
Sarcoma, Metastatic, Ovary 1 (2%)
Salivary Glands (48) (48) (48) (48)
Stomach, Forestomach (47) (47) (46) (48)
Squamous Cell Papilloma 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Stomach, Glandular (47) (47) (46) (48)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:21:07
____________________________________________________________________________________________________________________________________
C57BL/6N XC3H/HEN MTN-NCTR FEMALE 0 PPM 100 PPM 225 PPM 450 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (48) (48) (48) (48)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (47) (47) (45) (47)
Sarcoma, Metastatic, Skin 1 (2%)
Subcapsular, Adenoma 1 (2%)
Adrenal Medulla (47) (46) (44) (46)
Pheochromocytoma Benign 2 (4%) 1 (2%) 1 (2%)
Islets, Pancreatic (46) (46) (43) (47)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (48) (47) (46) (45)
Pars Distalis, Adenoma 2 (4%) 2 (4%)
Thyroid Gland (47) (46) (46) (48)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Hemangiosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (46) (46) (45)
Granulosa Cell Tumor Benign 2 (4%)
Histiocytic Sarcoma 2 (4%)
Luteoma 1 (2%)
Sarcoma 1 (2%)
Sarcoma, Metastatic, Uterus 1 (2%)
Yolk Sac Carcinoma 1 (2%)
Uterus (48) (48) (47) (48)
Adenoma 1 (2%)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Polyp Stromal 1 (2%)
Sarcoma 1 (2%)
Vagina (48) (48) (46) (48)
Leiomyoma 1 (2%)
Sarcoma 1 (2%)
Page 3
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:21:07
____________________________________________________________________________________________________________________________________
C57BL/6N XC3H/HEN MTN-NCTR FEMALE 0 PPM 100 PPM 225 PPM 450 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Squamous Cell Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (47) (47) (47) (48)
Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%)
Lymph Node (13) (13) (6) (9)
Lumbar, Histiocytic Sarcoma 1 (8%) 1 (17%)
Pancreatic, Sarcoma, Metastatic, Skin 1 (8%)
Renal, Histiocytic Sarcoma 1 (8%) 1 (17%)
Renal, Sarcoma, Metastatic, Skin 1 (8%)
Lymph Node, Mandibular (48) (48) (47) (48)
Lymph Node, Mesenteric (45) (46) (44) (46)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Sarcoma, Metastatic, Ovary 1 (2%)
Sarcoma, Metastatic, Uterus 1 (2%)
Spleen (47) (47) (45) (47)
Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Sarcoma, Metastatic, Ovary 1 (2%)
Thymus (43) (44) (43) (47)
Histiocytic Sarcoma 2 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (48) (45) (46)
Carcinoma 2 (4%) 1 (2%) 1 (2%) 4 (9%)
Skin (48) (48) (46) (48)
Hemangiosarcoma 1 (2%)
Sarcoma 2 (4%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (48) (48) (48) (48)
Sarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:21:07
____________________________________________________________________________________________________________________________________
C57BL/6N XC3H/HEN MTN-NCTR FEMALE 0 PPM 100 PPM 225 PPM 450 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (48) (48) (48) (48)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (48) (48) (48) (48)
Alveolar/Bronchiolar Adenoma 2 (4%) 4 (8%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Histiocytic Sarcoma 3 (6%) 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%) 1 (2%)
Nose (48) (48) (48) (48)
Trachea (48) (47) (46) (48)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (48) (48) (48) (48)
Adenoma 3 (6%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (48) (47) (48) (47)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Ovary 1 (2%)
Urinary Bladder (47) (46) (45) (48)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(48) *(48) *(48) *(48)
Histiocytic Sarcoma 3 (6%) 1 (2%) 1 (2%)
Leukemia Granulocytic 1 (2%)
Lymphoma Malignant 7 (15%) 10 (21%) 6 (13%) 13 (27%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 93005-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:21:07
____________________________________________________________________________________________________________________________________
C57BL/6N XC3H/HEN MTN-NCTR FEMALE 0 PPM 100 PPM 225 PPM 450 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 25 23 20 25
Total Primary Neoplasms 35 32 29 31
Total Animals with Benign Neoplasms 12 11 11 8
Total Benign Neoplasms 13 13 15 9
Total Animals with Malignant Neoplasms 18 15 12 20
Total Malignant Neoplasms 22 19 14 22
Total Animals with Metastatic Neoplasms 2 1 1 2
Total Metastatic Neoplasm 8 5 2 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------