TDMS Study 93005-04 Pathology Tables
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
Facility: National Center for Toxicological Research
Chemical CAS #: 569-64-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 3| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 6| 9| 4| 7| 9| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 2| 9| 7| 6| 4| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 1| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7|
| 9| 7| 4| 7| 1| 2| 4| 5| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | M A + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hematopoietic Cell Proliferation | 1 1 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic Active, Focal | 1 2 |
Tension Lipidosis | 1 1 1 |
|__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
|__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 2|
Acinus, Atrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Infiltration Cellular,| |
Lymphocyte | 2 2 1 2|
Submandibular Gland, Infiltration | |
Cellular, Lymphocyte | 1 1 2 1 3 2 1 2 2 1 2 2 2 1 2 2|
|__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 3| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 6| 9| 4| 7| 9| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 2| 9| 7| 6| 4| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 1| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7|
| 9| 7| 4| 7| 1| 2| 4| 5| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hyperkeratosis, Focal | |
Inflammation, Chronic Active | 1|
Epithelium, Hyperplasia, Diffuse | 2 2 |
Epithelium, Hyperplasia, Focal | 1 1 1 2|
|__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Focal | 1 |
Vacuolization Cytoplasmic | 4 |
Subcapsular, Hyperplasia | 1 2 2 1 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | A A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Follicular Cell, Cyst | 1 |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 3| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 6| 9| 4| 7| 9| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 2| 9| 7| 6| 4| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 1| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7|
| 9| 7| 4| 7| 1| 2| 4| 5| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 2 2 1 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 2 3 2 1 2 2 2 2 2 2 1 2 2|
Cyst | 1 1 1 1 1 |
Hemorrhage | 1 1 |
Mineralization | |
Bilateral, Cyst | 1 1 1 1 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Cystic | 1 2 2 4 2 4 3 2 3 3 2 2 3 1 2 3 2 3 2|
Thrombosis | |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Lumbar, Hyperplasia, Lymphoid | 2 2 2|
Renal, Hemorrhage | |
Renal, Hyperplasia, Lymphoid | 2 2|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | A A + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 3| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 6| 9| 4| 7| 9| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 2| 9| 7| 6| 4| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 1| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7|
| 9| 7| 4| 7| 1| 2| 4| 5| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 3 3 |
Hyperplasia, Lymphoid | 3 3 2|
|__________________________________________________________________________|
Thymus | M + + M + + + + + + + + + + + + + + M + + + + + +|
Cyst | 1 1 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 1 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | 2|
Sternum, Fibrous Osteodystrophy | 2 1 1 3 1 1 |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Cerebrum, Mineralization | 1 1 1 2 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thoracic, Axon, Degeneration | 1 1 1 2 1 |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 3| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 6| 9| 4| 7| 9| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 2| 9| 7| 6| 4| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 1| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7|
| 9| 7| 4| 7| 1| 2| 4| 5| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 1|
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic, Focal | |
Proteinosis | 4 1 |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Lens, Cataract | 3 1 2 |
Cornea, Mineralization | 3 |
Lens, Cataract | 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2|
Glomerulus, Casts Protein | |
Pelvis, Dilatation | 3 2 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 1 2 2 |
Renal Tubule, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
Inclusion Body Intracytoplasmic | |
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 2 2 1 1 1 2 1 1 1 1 2 1|
__________________________________________|__________________________________________________________________________
Page 6
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 8| 0| 0| 0| 0| 0| 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| | L |
| 0| 5| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + M + + + + M + + + + + | 43 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basophilic Focus | | 1 |
Hematopoietic Cell Proliferation | | 2 1.0|
Infiltration Cellular, Lymphocyte | 1 1 1 | 4 1.0|
Inflammation, Chronic Active, Focal | 1 1 2 | 5 1.4|
Tension Lipidosis | 1 2 2 1 1 1 1 | 10 1.2|
|__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Necrosis, Focal | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | 2 1 2 | 6 1.7|
Acinus, Atrophy | 4 1 | 2 2.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Parotid Gland, Infiltration Cellular,| | |
Lymphocyte | 1 | 5 1.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 8| 0| 0| 0| 0| 0| 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| | L |
| 0| 5| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Submandibular Gland, Infiltration | | |
Cellular, Lymphocyte | 1 1 2 2 1 1 1 2 1 1 1 1 2 1 1 2 1 1 3 | 35 1.5|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperkeratosis, Focal | 1 | 1 1.0|
Inflammation, Chronic Active | 1 | 2 1.0|
Epithelium, Hyperplasia, Diffuse | | 2 2.0|
Epithelium, Hyperplasia, Focal | 1 2 1 2 1 3 2 | 11 1.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Artery, Inflammation, Chronic | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + M + + + + + | 47 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Artery, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + M + + + + + + + + + + | 47 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia, Focal | | 1 1.0|
Vacuolization Cytoplasmic | | 1 4.0|
Subcapsular, Hyperplasia | 2 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 46 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 8| 0| 0| 0| 0| 0| 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| | L |
| 0| 5| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Parathyroid Gland | + M + + + + + + + + + + + + + + + + M + + + + | 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Pars Distalis, Hyperplasia, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + | 47 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Follicular Cell, Cyst | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Duct, Cyst | 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 | 44 1.9|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | | 1 2.0|
Atrophy | 4 2 2 2 3 2 3 3 2 1 2 2 3 1 3 | 28 2.1|
Cyst | 1 1 1 1 1 1 1 1 1 1 | 15 1.0|
Hemorrhage | 1 | 3 1.0|
Mineralization | 2 | 1 2.0|
Bilateral, Cyst | | 4 1.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 2 | 1 2.0|
Hyperplasia, Cystic | 3 2 2 2 2 3 1 3 1 1 4 3 2 3 2 3 3 1 2 1 1 3 3 | 42 2.3|
Thrombosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 8| 0| 0| 0| 0| 0| 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| | L |
| 0| 5| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 13 |
Lumbar, Hyperplasia, Lymphoid | 2 | 4 2.0|
Renal, Hemorrhage | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Lymphoid | | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Hyperplasia, Lymphoid | 1 2 3 1 3 2 2 | 8 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Angiectasis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 3 2 3 1 3 1 | 9 2.4|
Hyperplasia, Lymphoid | 2 2 1 | 6 2.2|
|__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + M + + + + + + + + + | 43 |
Cyst | 1 1 | 4 1.0|
Ectopic Parathyroid Gland | 1 1 1 | 3 1.0|
Hyperplasia, Lymphoid | 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperostosis | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 8| 0| 0| 0| 0| 0| 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| | L |
| 0| 5| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Cranium, Fibrous Osteodystrophy | 2 | 1 2.0|
Femur, Fibrous Osteodystrophy | 4 1 1 | 4 2.0|
Sternum, Fibrous Osteodystrophy | 2 4 2 2 2 1 | 12 1.8|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Thoracic, Axon, Degeneration | 1 2 1 1 1 1 1 2 | 13 1.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | | 6 1.7|
Infiltration Cellular, Histiocyte | 2 | 2 2.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
Proteinosis | 1 | 3 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Bilateral, Lens, Cataract | 2 | 4 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 8| 0| 0| 0| 0| 0| 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| | L |
| 0| 5| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Cornea, Mineralization | | 1 3.0|
Lens, Cataract | | 1 1.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 | 4 1.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 | 2 1.5|
Glomerulus, Casts Protein | 3 | 1 3.0|
Pelvis, Dilatation | | 2 2.5|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 4 1.8|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Inclusion Body Intracytoplasmic | 1 1 1 1 1 2 1 | 7 1.1|
Infiltration Cellular, Lymphocyte | 1 2 2 1 1 1 2 1 1 1 1 1 2 1 1 3 2 1 2 | 36 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 5| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 4| 9| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
100 PPM | 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 1| 1|
| 3| 8| 0| 8| 0| 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | A + M + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Lymphocyte | 1 1 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic Active, Focal | 1 1 1 1 1 1 2 |
Tension Lipidosis | 1 1 2 1 |
|__________________________________________________________________________|
Mesentery | + + |
Infiltration Cellular, Lymphocyte | |
Fat, Necrosis, Focal | 2 |
|__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 |
Infiltration Cellular, Lymphocyte | 1 |
Necrosis, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Parotid Gland, Infiltration Cellular,| |
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 5| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 4| 9| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
100 PPM | 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 1| 1|
| 3| 8| 0| 8| 0| 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Lymphocyte | 1 2 2 1 2 |
Sublingual Gland, Infiltration | |
Cellular, Lymphocyte | |
Submandibular Gland, Infiltration | |
Cellular, Lymphocyte | 2 1 2 1 1 1 1 2 2 2 1 1 1 1 1|
|__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Hyperplasia, Diffuse | 1 1 |
Epithelium, Hyperplasia, Focal | 2 1 |
|__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | M + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Subcapsular, Hyperplasia | 2 2 2 3 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Adrenal Medulla | M + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
|__________________________________________________________________________|
Islets, Pancreatic | M + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + M M + M + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 1 1 |
Pars Intermedia, Hyperplasia, Focal | 2 |
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 5| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 4| 9| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
100 PPM | 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 1| 1|
| 3| 8| 0| 8| 0| 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + M +|
Follicular Cell, Cyst | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 2 2 2 1 2 2 2 2 2 2 2 1 2 2 1 2 1 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Ovary | M + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 2 3 1 3 2 2 3 3 2 3 3 2 1 2 2 3 2|
Cyst | 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Acute | 3 |
Thrombosis | 4 |
Bilateral, Cyst | 1 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 2 2 4 2 2 2 4 3 2 2 4 2 3 3 2 2 3 2 3 2 2 3|
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Lumbar, Hyperplasia, Lymphoid | 2 3 2|
Mediastinal, Hemorrhage | 3 1 |
Mediastinal, Infiltration Cellular, | |
Mononuclear Cell | 2 |
Pancreatic, Infiltration Cellular, | |
Mononuclear Cell | 3 |
Renal, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 5| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 4| 9| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
100 PPM | 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 1| 1|
| 3| 8| 0| 8| 0| 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + M + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 1 2 2 |
|__________________________________________________________________________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 2 3 |
Hyperplasia, Lymphoid | 2 2 2 |
Infiltration Cellular, Mononuclear | |
Cell | 3 |
Necrosis, Focal | 3 |
|__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + M + + + + + M + +|
Cyst | 1 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Mononuclear | |
Cell | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 1 1 |
Sternum, Degeneration, Cystic | |
Sternum, Fibrous Osteodystrophy | 1 1 2 2 2 1 1 1 |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 5| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 4| 9| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
100 PPM | 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 1| 1|
| 3| 8| 0| 8| 0| 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thoracic, Axon, Degeneration | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 1 1 2 |
Infiltration Cellular, Histiocyte | 1 1 1 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Lens, Cataract | 3 |
Lens, Cataract | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 1 1 1 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 5| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 4| 9| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
100 PPM | 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 1| 1|
| 3| 8| 0| 8| 0| 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Metaplasia, Focal | 1 |
Glomerulus, Casts Protein | |
|__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + M + +|
Inclusion Body Intracytoplasmic | 1 1 1 1 1 2 1|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 1 1 1 1 1 1 2 2|
__________________________________________|__________________________________________________________________________
Page 18
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + M + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basophilic Focus | | 1 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 3 1 | 6 1.3|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Chronic Active, Focal | 1 1 | 9 1.1|
Tension Lipidosis | 1 1 2 | 7 1.3|
|__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Fat, Necrosis, Focal | 2 1 | 3 1.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cytoplasmic Alteration | | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 2 2 | 4 1.5|
Necrosis, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Parotid Gland, Infiltration Cellular,| | |
Lymphocyte | 2 2 1 2 1 2 1 | 12 1.6|
Sublingual Gland, Infiltration | | |
Cellular, Lymphocyte | 1 | 1 1.0|
Submandibular Gland, Infiltration | | |
Cellular, Lymphocyte | 1 1 3 3 2 1 2 2 3 1 2 2 1 | 28 1.6|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Inflammation, Chronic Active | 1 1 1 | 3 1.0|
Epithelium, Hyperplasia, Diffuse | | 2 1.0|
Epithelium, Hyperplasia, Focal | 2 1 1 2 3 2 | 8 1.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Erosion | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + M + + + + + + | 46 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 46 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Hyperplasia, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M + + M + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Pars Distalis, Hyperplasia, Focal | | 2 1.0|
Pars Intermedia, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Follicular Cell, Cyst | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Duct, Cyst | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 47 1.9|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + | 46 |
Angiectasis | 3 | 1 3.0|
Atrophy | 2 2 3 2 3 2 3 2 3 2 1 2 3 2 2 3 | 33 2.3|
Cyst | 1 1 1 1 1 1 | 18 1.0|
Inflammation, Acute | | 1 3.0|
Thrombosis | | 1 4.0|
Bilateral, Cyst | 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Cystic | 3 3 1 3 2 3 2 3 3 3 1 3 4 2 1 4 2 4 3 3 3 2 | 46 2.5|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 13 |
Lumbar, Hyperplasia, Lymphoid | 1 | 4 2.0|
Mediastinal, Hemorrhage | | 2 2.0|
Mediastinal, Infiltration Cellular, | | |
Mononuclear Cell | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Mononuclear Cell | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | 3 3 2 2 1 | 8 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hematopoietic Cell Proliferation | 3 2 3 | 8 2.5|
Hyperplasia, Lymphoid | 2 3 3 | 6 2.3|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 3.0|
Necrosis, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + | 44 |
Cyst | 1 | 2 1.0|
Ectopic Parathyroid Gland | 1 | 1 1.0|
Hyperplasia, Lymphoid | 2 2 3 | 5 2.2|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Femur, Fibrous Osteodystrophy | 1 1 2 | 5 1.2|
Sternum, Degeneration, Cystic | 1 1 | 2 1.0|
Sternum, Fibrous Osteodystrophy | 2 1 1 2 2 2 | 14 1.5|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1 1 | 18 1.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + M + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Thoracic, Axon, Degeneration | 1 1 1 1 1 1 2 1 1 | 14 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 2 2 | 6 1.8|
Infiltration Cellular, Histiocyte | | 3 1.0|
Pigmentation | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 | 3 1.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 1| 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Bilateral, Lens, Cataract | 1 | 2 2.0|
Lens, Cataract | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | 1 3 1 1 | 7 1.4|
Metaplasia, Focal | | 1 1.0|
Glomerulus, Casts Protein | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Inclusion Body Intracytoplasmic | 1 2 1 1 1 1 1 1 | 15 1.1|
Infiltration Cellular, Lymphocyte | 1 2 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 | 34 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 2| 2| 4| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 4| 4| 6| 7| 0| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 4| 2| 8| 3| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
225 PPM | 0| 0| 1| 1| 2| 2| 3| 3| 5| 5| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2|
| 6| 7| 5| 6| 2| 9| 6| 7| 8| 9| 0| 1| 2| 3| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A A + + + A A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + M A + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + M A + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A A + + + A A + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + M A + + + A A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + M A + + + A A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + A A + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Fatty Change, Focal | 2 |
Infiltration Cellular, Lymphocyte | 2 1 1 2 1 3 1 |
Inflammation, Chronic Active, Focal | 1 1 1|
Tension Lipidosis | 1 1 2 2 2|
|__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 2 |
|__________________________________________________________________________|
Pancreas | + A A + + + A A + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 |
Infiltration Cellular, Lymphocyte | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Infiltration Cellular,| |
Lymphocyte | 1 1 2 |
Submandibular Gland, Infiltration | |
Cellular, Lymphocyte | 1 2 1 1 1 2 2 2 2 1 2 2 2 3 1 1|
|__________________________________________________________________________|
Stomach, Forestomach | + M A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 2| 2| 4| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 4| 4| 6| 7| 0| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 4| 2| 8| 3| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
225 PPM | 0| 0| 1| 1| 2| 2| 3| 3| 5| 5| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2|
| 6| 7| 5| 6| 2| 9| 6| 7| 8| 9| 0| 1| 2| 3| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation, Chronic Active | 2 |
Epithelium, Hyperplasia, Diffuse | |
Epithelium, Hyperplasia, Focal | 2 2 2 1 |
|__________________________________________________________________________|
Stomach, Glandular | + M A + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + M A + + + M + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia, Focal | |
Hypertrophy, Focal | |
Mineralization, Focal | |
Subcapsular, Hyperplasia | 2 1 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Adrenal Medulla | + M A + + + M + M + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
|__________________________________________________________________________|
Islets, Pancreatic | + A A + + + A A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M A + + + M + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 1 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + A A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 2| 2| 4| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 4| 4| 6| 7| 0| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 4| 2| 8| 3| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
225 PPM | 0| 0| 1| 1| 2| 2| 3| 3| 5| 5| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2|
| 6| 7| 5| 6| 2| 9| 6| 7| 8| 9| 0| 1| 2| 3| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Ultimobranchial Cyst | 1 1 |
Follicular Cell, Cyst | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | A + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + M + + + + + M + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Duct, Cyst | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Ovary | + M A + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 3 2 3 3 3 2 2 2 3 2 2 1 2 3 2 3 3 3|
Cyst | 1 1 1 1|
Hemorrhage | |
Inflammation, Chronic Active | |
Bilateral, Cyst | 1 |
Germinal Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Uterus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 4 2 2 2 2 2 2 3 2 4 1 3 3 3 2 2 4 2 2 1|
Inflammation, Acute | 3 |
|__________________________________________________________________________|
Vagina | + M + + + + + M + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 2 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + A + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1|
|__________________________________________________________________________|
Lymph Node | + + + + + |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 2| 2| 4| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 4| 4| 6| 7| 0| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 4| 2| 8| 3| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
225 PPM | 0| 0| 1| 1| 2| 2| 3| 3| 5| 5| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2|
| 6| 7| 5| 6| 2| 9| 6| 7| 8| 9| 0| 1| 2| 3| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lumbar, Hyperplasia, Lymphoid | 1 |
Renal, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + A A + + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 2 |
|__________________________________________________________________________|
Spleen | + A A + + + + A + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 3 2 3 |
|__________________________________________________________________________|
Thymus | + + A + + + M + M + + + + + + + + + + + + + + + +|
Cyst | 1 |
Ectopic Parathyroid Gland | 1 |
Hyperplasia, Lymphoid | 3 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + A A + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + A A + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 1 |
Sternum, Degeneration, Cystic | 1 1 |
Sternum, Fibrous Osteodystrophy | 2 1 1 2 |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 2| 2| 4| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 4| 4| 6| 7| 0| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 4| 2| 8| 3| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
225 PPM | 0| 0| 1| 1| 2| 2| 3| 3| 5| 5| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2|
| 6| 7| 5| 6| 2| 9| 6| 7| 8| 9| 0| 1| 2| 3| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thoracic, Axon, Degeneration | 1 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1|
Infiltration Cellular, Histiocyte | 1 |
Thrombosis | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + A A + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + A + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Lens, Cataract | 3 1 3 3 1 |
Lens, Cataract | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular, Lymphocyte | 1 2 |
|__________________________________________________________________________|
Zymbal's Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 |
Nephropathy | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 2| 2| 4| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 4| 4| 6| 7| 0| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 6| 2| 4| 2| 8| 3| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
225 PPM | 0| 0| 1| 1| 2| 2| 3| 3| 5| 5| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2|
| 6| 7| 5| 6| 2| 9| 6| 7| 8| 9| 0| 1| 2| 3| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Urinary Bladder | + M A + + + + + + + + + + + + + + + + + + + + + +|
Inclusion Body Intracytoplasmic | 1 2 1 1 1 2 1 2 1 1 1 1 2 1 1 2 1|
Infiltration Cellular, Lymphocyte | 2 2 1 1 1 2 2 2 1 1 1 2 2 2 1 1 |
__________________________________________|__________________________________________________________________________
Page 30
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
225 PPM | 2| 2| 2| 2| 2| 5| 5| 5| 6| 6| 6| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 4| 5| 6| 7| 8| 7| 8| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 43 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Basophilic Focus | X X | 3 |
Fatty Change, Focal | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 | 8 1.6|
Inflammation, Chronic Active, Focal | 1 1 1 1 1 | 8 1.0|
Tension Lipidosis | 1 1 2 | 8 1.5|
|__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
Cytoplasmic Alteration | | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Parotid Gland, Infiltration Cellular,| | |
Lymphocyte | 1 | 4 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
225 PPM | 2| 2| 2| 2| 2| 5| 5| 5| 6| 6| 6| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 4| 5| 6| 7| 8| 7| 8| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Submandibular Gland, Infiltration | | |
Cellular, Lymphocyte | 1 3 1 3 1 1 2 2 2 3 1 3 | 28 1.8|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Inflammation, Chronic Active | 1 | 2 1.5|
Epithelium, Hyperplasia, Diffuse | 1 | 1 1.0|
Epithelium, Hyperplasia, Focal | | 4 1.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
Hyperplasia, Focal | 1 | 1 1.0|
Hypertrophy, Focal | 2 | 1 2.0|
Mineralization, Focal | 4 | 1 4.0|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 2 | 44 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
Hyperplasia, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + I + + + + + + + + + + + + + + | 43 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
225 PPM | 2| 2| 2| 2| 2| 5| 5| 5| 6| 6| 6| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 4| 5| 6| 7| 8| 7| 8| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Parathyroid Gland | + M + + + + + + + + + + + M + + + M + + + + + | 41 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + | 46 |
Pars Distalis, Hyperplasia, Focal | 2 2 | 5 1.6|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Hyperplasia, Focal | 1 | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Ultimobranchial Cyst | | 2 1.0|
Follicular Cell, Cyst | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Inflammation, Chronic | 2 | 1 2.0|
Duct, Cyst | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 45 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Angiectasis | 2 | 1 2.0|
Atrophy | 3 3 2 2 3 2 3 3 2 2 3 3 3 2 2 2 3 2 | 36 2.5|
Cyst | 1 1 1 1 1 1 1 | 11 1.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Bilateral, Cyst | 1 1 | 3 1.0|
Germinal Epithelium, Hyperplasia | 1 | 2 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia, Cystic | 1 2 2 4 3 2 3 2 3 2 2 2 4 4 4 3 1 4 4 2 1 1 | 44 2.4|
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
225 PPM | 2| 2| 2| 2| 2| 5| 5| 5| 6| 6| 6| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 4| 5| 6| 7| 8| 7| 8| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Artery, Inflammation, Chronic | | 1 2.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Fibrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node | + | 6 |
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Lumbar, Hyperplasia, Lymphoid | 3 | 2 2.0|
Renal, Hyperplasia, Lymphoid | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + | 44 |
Hyperplasia, Lymphoid | 2 2 | 5 2.2|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Depletion Cellular | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Hyperplasia, Lymphoid | 1 1 3 2 | 7 2.1|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + M | 43 |
Cyst | 1 1 | 3 1.0|
Ectopic Parathyroid Gland | 1 | 2 1.0|
Hyperplasia, Lymphoid | 2 2 3 | 6 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
225 PPM | 2| 2| 2| 2| 2| 5| 5| 5| 6| 6| 6| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 4| 5| 6| 7| 8| 7| 8| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Femur, Fibrous Osteodystrophy | 3 | 2 2.0|
Sternum, Degeneration, Cystic | 2 1 | 4 1.3|
Sternum, Fibrous Osteodystrophy | 1 | 5 1.4|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cerebrum, Mineralization | 1 1 1 1 1 1 | 17 1.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + M + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Thoracic, Axon, Degeneration | 1 1 2 1 1 1 1 2 2 1 | 19 1.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 2 2 2 1 | 6 1.7|
Infiltration Cellular, Histiocyte | 1 | 2 1.0|
Thrombosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
225 PPM | 2| 2| 2| 2| 2| 5| 5| 5| 6| 6| 6| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 4| 5| 6| 7| 8| 7| 8| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Bilateral, Lens, Cataract | | 5 2.2|
Lens, Cataract | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 1 | 5 1.2|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Inflammation, Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 | 3 1.0|
Nephropathy | 1 | 1 1.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + | 45 |
Inclusion Body Intracytoplasmic | 2 2 1 1 2 2 1 1 1 1 1 1 2 1 2 1 2 | 34 1.4|
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 1 1 2 1 1 1 2 1 1 1 | 33 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 1| 3| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 3| 2| 7| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 8| 3| 6| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
450 PPM | 0| 0| 2| 2| 3| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 2| 3| 3| 3|
| 1| 8| 5| 6| 3| 9| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Gallbladder | A A + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
|__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 2 2 |
Inflammation, Chronic Active, Focal | 1 1 1 1|
Necrosis | 3 |
Tension Lipidosis | 2 1 1 |
Bile Duct, Cyst | 3 |
|__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cytoplasmic Alteration | |
Infiltration Cellular, Lymphocyte | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Infiltration Cellular,| |
Lymphocyte | 1 1 2 |
Submandibular Gland, Infiltration | |
Cellular, Lymphocyte | 1 1 1 2 2 3 1 2 2 3 2 2 2 3 1 2 1 2|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 1| 3| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 3| 2| 7| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 8| 3| 6| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
450 PPM | 0| 0| 2| 2| 3| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 2| 3| 3| 3|
| 1| 8| 5| 6| 3| 9| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | |
Inflammation, Chronic Active | |
Ulcer | 2 |
Epithelium, Hyperplasia, Focal | 1 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Ulcer | 1 |
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + M + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hypertrophy, Focal | |
Bilateral, Hypertrophy, Focal | 3 |
Subcapsular, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 1 |
Follicular Cell, Cyst | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 1| 3| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 3| 2| 7| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 8| 3| 6| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
450 PPM | 0| 0| 2| 2| 3| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 2| 3| 3| 3|
| 1| 8| 5| 6| 3| 9| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | A M + + + + + + + + + + + + + + + M + M + + + + +|
Duct, Cyst | 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Ovary | A + + + + + + + + + + + + + + + + + + + + + + M +|
Atrophy | 2 2 3 2 3 3 3 2 3 3 3 3 2 3 3 3 3 3|
Cyst | 1 1 1 1 1 1 1 1|
Hemorrhage | 1 |
Bilateral, Cyst | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Cystic | 1 1 4 4 2 1 1 4 2 2 3 4 2 1 3 1 1 1 4 2|
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mast Cell | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 1 |
|__________________________________________________________________________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 3 2 3 3 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 1| 3| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 3| 2| 7| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 8| 3| 6| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
450 PPM | 0| 0| 2| 2| 3| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 2| 3| 3| 3|
| 1| 8| 5| 6| 3| 9| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Cyst | 1 1 |
Ectopic Parathyroid Gland | 1 1|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | |
Sternum, Degeneration, Cystic | |
Sternum, Fibrous Osteodystrophy | 1 |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thoracic, Axon, Degeneration | 1 1 2 1 1 1 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Infiltration Cellular, Lymphocyte | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
_____________________________________________________________________________________________________________________
| 1| 3| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 3| 2| 7| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 8| 3| 6| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
450 PPM | 0| 0| 2| 2| 3| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 2| 3| 3| 3|
| 1| 8| 5| 6| 3| 9| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Lens, Cataract | |
Lens, Cataract | 3 1 2 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Infiltration Cellular, Lymphocyte | 1 1 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Nephropathy | 1|
Glomerulus, Amyloid Deposition | 4 4|
Glomerulus, Hypertrophy | 2 |
Glomerulus, Inflammation, Acute | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inclusion Body Intracytoplasmic | 1 2 1 2 2 1 1 2 1 2 2 2 2 2 1 2 1|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 2 1 1|
__________________________________________|__________________________________________________________________________
Page 41
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | A |
450 PPM | 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| | L |
| 3| 4| 5| 6| 7| 8| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + + + + + + + + M + + + + + | 43 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia, Lymphoid | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hematopoietic Cell Proliferation | | 2 1.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 | 12 1.2|
Inflammation, Chronic Active, Focal | | 4 1.0|
Necrosis | 2 | 2 2.5|
Tension Lipidosis | 2 2 1 | 6 1.5|
Bile Duct, Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cyst | 2 | 1 2.0|
Cytoplasmic Alteration | 1 | 1 1.0|
Infiltration Cellular, Lymphocyte | 2 1 | 3 1.7|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Parotid Gland, Infiltration Cellular,| | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | A |
450 PPM | 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| | L |
| 3| 4| 5| 6| 7| 8| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Lymphocyte | 2 1 | 5 1.4|
Submandibular Gland, Infiltration | | |
Cellular, Lymphocyte | 2 1 1 1 2 2 3 2 1 2 | 28 1.8|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Mast Cell | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | | 1 2.0|
Epithelium, Hyperplasia, Focal | 2 2 1 2 2 | 7 1.7|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Erosion | 2 | 1 2.0|
Ulcer | | 1 1.0|
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Artery, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
Hypertrophy, Focal | 2 3 | 2 2.5|
Bilateral, Hypertrophy, Focal | | 1 3.0|
Subcapsular, Hyperplasia | 2 2 1 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 45 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | A |
450 PPM | 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| | L |
| 3| 4| 5| 6| 7| 8| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + M M + + + + M + M + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + + I + + + + + + | 45 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ultimobranchial Cyst | | 2 1.0|
Follicular Cell, Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
Duct, Cyst | 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 1 1 2 2 2 2 | 44 1.9|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + M + + + + | 45 |
Atrophy | 3 2 2 2 3 3 4 2 2 3 2 3 3 2 1 3 3 2 | 36 2.6|
Cyst | 1 1 1 | 11 1.0|
Hemorrhage | | 1 1.0|
Bilateral, Cyst | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 2 | 1 2.0|
Hyperplasia, Cystic | 1 2 4 1 1 1 3 1 1 1 4 3 3 4 4 4 2 1 1 3 2 1 | 42 2.2|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 9 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | A |
450 PPM | 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| | L |
| 3| 4| 5| 6| 7| 8| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lumbar, Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal, Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Mast Cell | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + | 46 |
Hyperplasia, Lymphoid | 3 2 | 5 2.2|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 4 | 5 3.0|
Hyperplasia, Lymphoid | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + | 47 |
Angiectasis | 2 | 1 2.0|
Cyst | 1 | 3 1.0|
Ectopic Parathyroid Gland | 1 | 3 1.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Femur, Fibrous Osteodystrophy | 3 1 | 2 2.0|
Sternum, Degeneration, Cystic | 1 1 1 | 3 1.0|
Sternum, Fibrous Osteodystrophy | 1 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | A |
450 PPM | 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| | L |
| 3| 4| 5| 6| 7| 8| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1 1 | 17 1.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Thoracic, Axon, Degeneration | 1 1 1 1 1 1 1 | 19 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage, Focal | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Bilateral, Lens, Cataract | 1 1 | 2 1.0|
Lens, Cataract | 1 3 | 6 1.8|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 | 4 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 93005-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:24:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | A |
450 PPM | 3| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| | L |
| 3| 4| 5| 6| 7| 8| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Zymbal's Gland | + + + + + + M + + + + + + + + + + + + + + + + | 47 |
Atrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | 1 2 | 2 1.5|
Nephropathy | | 1 1.0|
Glomerulus, Amyloid Deposition | | 2 4.0|
Glomerulus, Hypertrophy | | 1 2.0|
Glomerulus, Inflammation, Acute | 2 | 1 2.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inclusion Body Intracytoplasmic | 1 1 1 2 1 1 2 1 1 1 2 1 2 1 1 1 2 2 2 1 1 1 | 39 1.4|
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 2 1 1 2 1 1 | 25 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
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---------- END OF REPORT ----------
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