TDMS Study 93005-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: NCTR MALACHITE GREEN DATE: 06/19/03
EXPERIMENT: 93005 TEST: 04 TIME: 07:27:20
TEST TYPE: CHRONIC PAGE: 1
CONT: 224-93-00001 ROUTE: DOSED FEED NTP C#: C93005
PATHOLOGIST: TROTTER, RONALD CAS: 569-64-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: NCTR MALACHITE GREEN DATE: 06/19/03
EXPERIMENT: 93005 TEST: 04 TIME: 07:27:20
TEST TYPE: CHRONIC
CONT: 224-93-00001 ROUTE: DOSED FEED NTP C#: C93005
PATHOLOGIST: TROTTER, RONALD CAS: 569-64-2
MALACHITE GREEN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 378 562 599 647 673 676 676 694 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 4 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 596 644 659 711 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 225 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 7 CENSORED DEATHS 1 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 252 442 444 568 673 694 707 |
| CENSORED DEATHS |
| 226 |
| |
==================================================================================
MALACHITE GREEN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 450 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 161 318 626 633 673 704 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
MALACHITE GREEN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 727 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 97.9 97.9 97.9 93.7 91.7 83.3 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 97.9 93.7 91.7 |
| | |
| | |
|225 PPM | 100.0 100.0 97.9 97.9 97.9 93.6 93.6 91.5 91.5 85.1 |
| | |
| | |
|450 PPM | 100.0 97.9 97.9 95.8 95.8 95.8 95.8 95.8 91.7 85.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 100 PPM 225 PPM 450 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 83.3% 91.7% 85.1% 85.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.346N P=1.000N P=0.991N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 613.1 652.5 540.0 548.3 |
|NATURAL DEATHS (C) | (37.1) (23.7) (64.0) (82.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 708.0 720.8 689.3 700.9 |
|(STANDARD ERROR) | ( 8.5) ( 3.5) (16.3) (14.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MALACHITE GREEN
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
100 PPM = 2
225 PPM = 3
450 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 1 2
|
|
|
98 + 4 3 4 1 3 1 2 2
|
|
|
96 + 4 1 1 4 2 2
|
P |
E |
R 94 + 1 44 1 2 2
C | 3 3
E |
N |
T 92 +
| 3 4 1 1 2 2
S |
U |
R 90 +
V | 3 34
I |
V |
A 88 +
L | 4 4
| 33
|
86 +
| 1 1 4
| 3 3
|
84 +
| 1 1
|
|
82 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 6 obs hidden.