TDMS Study 93023-06 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Southern Research Inst 2,4-HEXADIENAL DATE: 03/14/01
EXPERIMENT: 93023 TEST: 06 TIME: 15:01:58
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP: C93023B
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: SOUTHERN RESEARCH INSTITUTE 2,4-HEXADIENAL DATE: 03/14/01
EXPERIMENT: 93023 TEST: 06 TIME: 15:11:37
SPECIES: RATS, FISCHER 344
TEST TYPE: TWO YEAR ROUTE: ORAL GAVAGE NTP: 93023B
CONT: N01-ES-55393 CAS: 142-83-6
MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
TWO YEAR ORAL GAVAGE STUDY OF 2,4-HEXADIENAL
==========================================================================================================
WEEK 0 MG/KG/DY 22.5 MG/KG/DY 45 MG/KG/DY 90 MG/KG/DY
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 80.0 50 78.4 98.0 50 78.9 98.6 50 80.1 100.1 50
1 80.0 50 78.4 98.0 50 78.9 98.6 50 80.1 100.1 50
3 163.2 50 163.7 100.3 50 165.3 101.3 50 161.5 99.0 50
7 254.8 50 256.5 100.7 50 258.3 101.4 50 249.7 98.0 50
11 310.3 50 310.9 100.2 50 310.5 100.1 50 298.0 96.0 50
15 349.1 50 349.3 100.1 50 349.0 100.0 50 334.1 95.7 50
19 377.4 50 376.7 99.8 50 378.5 100.3 50 360.5 95.5 50
23 400.2 50 399.4 99.8 50 400.4 100.0 50 380.8 95.2 49
27 417.3 50 413.5 99.1 50 416.5 99.8 50 395.9 94.9 49
31 432.6 50 427.7 98.9 49 431.3 99.7 50 408.2 94.4 49
35 448.3 50 443.4 98.9 49 444.8 99.2 50 420.5 93.8 49
39 462.4 49 455.8 98.6 49 459.4 99.4 50 434.1 93.9 49
43 473.7 49 465.8 98.3 49 470.3 99.3 50 442.4 93.4 49
47 481.6 49 472.9 98.2 49 480.7 99.8 50 451.9 93.8 49
51 492.1 49 485.1 98.6 48 489.4 99.5 50 457.6 93.0 48
55 492.7 49 486.9 98.8 47 489.9 99.4 49 459.1 93.2 46
59 502.2 49 493.6 98.3 47 500.2 99.6 49 466.7 92.9 46
63 503.4 49 497.6 98.8 47 503.8 100.1 49 470.3 93.4 46
67 505.9 49 499.2 98.7 47 504.4 99.7 49 467.8 92.5 46
71 510.6 48 496.5 97.2 47 502.8 98.5 48 468.7 91.8 45
75 510.4 48 500.7 98.1 46 502.8 98.5 47 467.5 91.6 45
79 509.0 47 499.7 98.2 45 492.5 96.8 46 464.2 91.2 45
83 505.9 46 497.5 98.3 45 495.8 98.0 44 460.5 91.0 42
87 505.6 45 502.2 99.3 44 500.5 99.0 43 464.2 91.8 42
91 506.6 41 499.7 98.6 43 502.8 99.2 39 458.1 90.4 39
95 502.4 40 497.8 99.1 39 500.8 99.7 37 456.6 90.9 35
99 494.5 40 487.7 98.6 38 491.8 99.5 34 447.0 90.4 34
103 481.5 37 488.1 101.4 35 489.9 101.7 33 445.0 92.4 30
TERM. SAC. 37 35 33 30
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
TWO YEAR ORAL GAVAGE STUDY OF 2,4-HEXADIENAL
==========================================================================================================
WEEK 0 MG/KG/DY 22.5 MG/KG/DY 45 MG/KG/DY 90 MG/KG/DY
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 78.7 50 79.3 100.8 50 80.2 101.9 50 80.5 102.3 50
1 78.7 50 79.3 100.8 50 80.2 101.9 50 80.5 102.3 50
4 131.6 50 130.6 99.2 50 130.1 98.9 50 131.8 100.2 50
8 165.0 50 164.1 99.5 50 163.4 99.0 50 166.3 100.8 50
12 182.4 50 180.6 99.0 50 179.0 98.1 50 180.3 98.8 50
16 192.1 50 190.3 99.1 50 189.8 98.8 50 190.9 99.4 50
20 199.7 50 197.7 99.0 50 197.1 98.7 50 199.7 100.0 50
24 207.5 50 207.5 100.0 50 207.6 100.0 50 208.4 100.4 50
28 214.2 50 211.8 98.9 50 211.8 98.9 50 212.5 99.2 50
32 219.1 50 217.8 99.4 50 215.9 98.5 50 216.5 98.8 50
36 226.3 50 223.6 98.8 50 221.4 97.8 50 223.6 98.8 50
40 231.4 50 228.7 98.8 50 228.8 98.9 50 228.1 98.6 50
44 238.8 49 236.7 99.1 50 235.8 98.7 50 235.3 98.5 50
48 243.9 49 241.4 99.0 50 240.8 98.7 50 236.3 96.9 50
52 251.2 49 248.6 99.0 48 245.1 97.6 50 240.9 95.9 49
56 258.0 49 254.8 98.8 48 253.4 98.2 50 246.8 95.7 45
60 267.5 49 265.2 99.1 48 264.0 98.7 50 256.4 95.9 44
64 276.1 49 275.7 99.9 48 274.3 99.3 50 265.1 96.0 44
68 282.9 48 282.3 99.8 48 279.4 98.8 50 269.7 95.3 43
72 288.1 48 287.0 99.6 48 283.2 98.3 48 274.5 95.3 43
76 293.1 47 291.8 99.6 48 288.4 98.4 48 280.6 95.7 43
80 293.5 47 294.5 100.3 47 291.8 99.4 45 280.9 95.7 42
84 299.1 45 297.4 99.4 47 293.8 98.2 45 285.1 95.3 41
88 306.2 45 303.1 99.0 47 299.4 97.8 44 294.0 96.0 40
92 309.6 44 308.9 99.8 44 302.9 97.8 43 294.9 95.3 37
96 311.4 42 308.9 99.2 43 303.9 97.6 42 297.1 95.4 35
100 308.9 42 306.5 99.2 42 305.5 98.9 41 297.6 96.3 32
104 314.6 38 306.3 97.4 40 308.8 98.2 41 297.0 94.4 31
TERM. SAC. 37 39 41 31
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.