TDMS Study 93023-06 Pathology Tables
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:11:34
FINAL#1/RATS
Facility: Southern Research Institute
Chemical CAS #: 142-83-6
Lock Date: 02/28/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:11:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 12 9 6 9
Natural Death 1 1 2 4
Dosing Accident 1 1 6
Survivors
Terminal Sacrifice 37 38 41 31
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (48) (47) (50) (48)
Inflammation, Chronic 1 (2%)
Perforation 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50)
Edema 1 (2%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Basophilic Focus 47 (94%) 49 (98%) 48 (96%) 45 (90%)
Clear Cell Focus 7 (14%) 8 (16%) 11 (22%) 4 (8%)
Eosinophilic Focus 9 (18%) 10 (20%) 6 (12%) 4 (8%)
Hepatodiaphragmatic Nodule 9 (18%) 6 (12%) 6 (12%) 4 (8%)
Infiltration Cellular, Mixed Cell 15 (30%) 10 (20%) 10 (20%) 17 (34%)
Mixed Cell Focus 6 (12%) 12 (24%) 6 (12%) 9 (18%)
Bile Duct, Hyperplasia 5 (10%) 1 (2%)
Hepatocyte, Cytomegaly 2 (4%) 1 (2%)
Hepatocyte, Necrosis 2 (4%) 1 (2%) 3 (6%)
Hepatocyte, Vacuolization Cytoplasmic 1 (2%) 3 (6%) 1 (2%)
Kupffer Cell, Pigmentation 2 (4%) 3 (6%) 1 (2%)
Mesentery (13) (16) (19) (15)
Fat, Necrosis 13 (100%) 16 (100%) 18 (95%) 15 (100%)
Pancreas (50) (50) (50) (50)
Atrophy 7 (14%) 12 (24%) 8 (16%) 8 (16%)
Cyst 2 (4%) 4 (8%) 1 (2%) 3 (6%)
Acinus, Cytoplasmic Alteration 1 (2%) 2 (4%) 2 (4%)
Acinus, Hyperplasia, Focal 3 (6%) 2 (4%) 2 (4%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 2 (4%) 5 (10%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:11:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis 1 (2%)
Stomach, Forestomach (50) (49) (50) (50)
Edema 1 (2%) 1 (2%) 2 (4%)
Erosion 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
Ulcer 1 (2%) 1 (2%)
Epithelium, Cyst 1 (2%)
Epithelium, Hyperplasia 2 (4%) 16 (33%) 37 (74%) 41 (82%)
Stomach, Glandular (50) (49) (50) (50)
Edema 1 (2%)
Erosion 1 (2%)
Ulcer 1 (2%) 1 (2%)
Tongue (1) (2) (1)
Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 20 (40%) 20 (40%) 17 (34%) 13 (26%)
Myocardium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 13 (26%) 13 (26%) 13 (26%) 13 (26%)
Angiectasis 3 (6%) 2 (4%) 1 (2%) 2 (4%)
Degeneration, Fatty 12 (24%) 11 (22%) 11 (22%) 11 (22%)
Hyperplasia, Diffuse 2 (4%) 1 (2%) 1 (2%)
Hyperplasia, Focal 3 (6%) 6 (12%) 5 (10%) 4 (8%)
Hypertrophy, Focal 9 (18%) 9 (18%) 8 (16%) 5 (10%)
Necrosis 2 (4%)
Adrenal Medulla (50) (49) (50) (50)
Hyperplasia 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Angiectasis 9 (18%) 3 (6%) 5 (10%) 2 (4%)
Pars Distalis, Cyst 22 (44%) 14 (28%) 12 (24%) 15 (30%)
Pars Distalis, Hyperplasia 3 (6%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 13 (26%) 8 (16%) 7 (14%) 9 (18%)
Pars Intermedia, Angiectasis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:11:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Ultimobranchial Cyst 2 (4%) 2 (4%)
C-Cell, Hyperplasia 24 (48%) 22 (44%) 26 (52%) 14 (28%)
Follicle, Cyst 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (50)
Cyst 8 (16%) 6 (12%) 2 (4%) 2 (4%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 6 (12%) 3 (6%) 5 (10%)
Ovary (50) (50) (50) (50)
Cyst 12 (24%) 7 (14%) 8 (16%) 9 (18%)
Uterus (50) (50) (50) (50)
Hydrometra 2 (4%) 7 (14%) 6 (12%) 2 (4%)
Hyperplasia, Cystic 3 (6%) 4 (8%) 4 (8%) 5 (10%)
Inflammation, Chronic 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 2 (4%) 5 (10%) 5 (10%) 2 (4%)
Infiltration Cellular, Histiocyte 1 (2%)
Lymph Node (29) (30) (30) (38)
Deep Cervical, Hemorrhage 1 (3%) 1 (3%) 1 (3%) 1 (3%)
Deep Cervical, Hyperplasia, Lymphoid 1 (3%)
Deep Cervical, Pigmentation 1 (3%) 1 (3%) 1 (3%) 1 (3%)
Mediastinal, Hemorrhage 3 (10%) 4 (13%) 2 (5%)
Mediastinal, Hyperplasia, Lymphoid 5 (17%) 8 (27%) 10 (33%) 3 (8%)
Mediastinal, Pigmentation 4 (14%) 8 (27%) 7 (23%) 3 (8%)
Pancreatic, Hemorrhage 8 (28%) 8 (27%) 13 (43%) 17 (45%)
Pancreatic, Hyperplasia 1 (3%)
Pancreatic, Hyperplasia, Lymphoid 17 (59%) 24 (80%) 18 (60%) 28 (74%)
Pancreatic, Pigmentation 24 (83%) 25 (83%) 24 (80%) 32 (84%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:11:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mandibular (6) (2) (5) (1)
Ectasia 2 (33%) 1 (50%) 2 (40%)
Hyperplasia, Lymphoid 1 (17%)
Pigmentation 3 (50%) 1 (50%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Hemorrhage 10 (20%) 6 (12%) 3 (6%) 4 (8%)
Hyperplasia, Lymphoid 9 (18%) 17 (34%) 15 (30%) 13 (26%)
Pigmentation 42 (84%) 42 (84%) 33 (66%) 34 (68%)
Spleen (50) (50) (50) (50)
Fibrosis 2 (4%)
Hematopoietic Cell Proliferation 34 (68%) 26 (52%) 29 (58%) 21 (42%)
Infiltration Cellular, Mixed Cell 1 (2%)
Pigmentation 29 (58%) 34 (68%) 35 (70%) 36 (72%)
Lymphoid Follicle, Atrophy 4 (8%)
Lymphoid Follicle, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Hyperplasia 43 (86%) 47 (94%) 48 (96%) 40 (80%)
Hyperplasia, Lobular 2 (4%)
Skin (49) (49) (50) (50)
Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Femur, Osteopetrosis 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 7 (14%) 12 (24%) 6 (12%) 8 (16%)
Hydrocephalus 3 (6%) 8 (16%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:11:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Congestion 1 (2%) 2 (4%) 2 (4%) 7 (14%)
Edema 2 (4%) 3 (6%) 7 (14%)
Foreign Body 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 4 (8%)
Infiltration Cellular, Histiocyte 41 (82%) 41 (82%) 41 (82%) 43 (86%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%) 2 (4%)
Alveolar Epithelium, Hyperplasia 2 (4%) 6 (12%) 7 (14%) 5 (10%)
Alveolar Epithelium, Hyperplasia, Multifocal 1 (2%)
Nose (50) (50) (50) (50)
Foreign Body 2 (4%) 3 (6%) 2 (4%)
Inflammation, Chronic 4 (8%) 3 (6%) 4 (8%) 4 (8%)
Respiratory Epithelium, Hyperplasia 3 (6%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (1)
Cataract 1 (100%) 3 (100%) 1 (100%)
Retina, Degeneration 1 (100%) 3 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Hydronephrosis 2 (4%)
Inflammation, Chronic 2 (4%)
Nephropathy 2 (4%) 6 (12%) 6 (12%) 6 (12%)
Renal Tubule, Cytoplasmic Alteration 3 (6%) 4 (8%) 5 (10%) 4 (8%)
Renal Tubule, Dilatation 1 (2%)
Renal Tubule, Infarct 1 (2%)
Renal Tubule, Necrosis 1 (2%) 2 (4%)
Renal Tubule, Pigmentation 4 (8%) 2 (4%) 3 (6%) 8 (16%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Inflammation, Chronic 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:11:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 10 11 13 10
Dosing Accident 1 2 1 5
Natural Death 2 2 3 5
Survivors
Terminal Sacrifice 37 35 33 30
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (49) (48) (50)
Hemorrhage 1 (2%)
Perforation 1 (2%) 1 (2%) 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50)
Edema 1 (2%)
Liver (50) (50) (50) (50)
Basophilic Focus 33 (66%) 32 (64%) 31 (62%) 23 (46%)
Clear Cell Focus 7 (14%) 6 (12%) 8 (16%) 7 (14%)
Degeneration, Cystic 1 (2%) 1 (2%)
Eosinophilic Focus 4 (8%) 9 (18%) 10 (20%) 5 (10%)
Hemorrhage 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 2 (4%) 7 (14%) 3 (6%) 6 (12%)
Infiltration Cellular, Mixed Cell 5 (10%) 2 (4%) 1 (2%) 3 (6%)
Mixed Cell Focus 7 (14%) 7 (14%) 10 (20%) 2 (4%)
Bile Duct, Hyperplasia 25 (50%) 34 (68%) 39 (78%) 15 (30%)
Centrilobular, Necrosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 1 (2%) 9 (18%) 6 (12%) 1 (2%)
Kupffer Cell, Pigmentation 1 (2%) 1 (2%)
Mesentery (13) (8) (19) (17)
Accessory Spleen 2 (15%) 1 (13%) 1 (5%) 2 (12%)
Hemorrhage 1 (8%) 1 (6%)
Fat, Necrosis 11 (85%) 7 (88%) 17 (89%) 14 (82%)
Oral Mucosa (1) (1) (1) (1)
Hyperplasia 1 (100%)
Pancreas (50) (50) (50) (50)
Atrophy 16 (32%) 14 (28%) 7 (14%) 13 (26%)
Cyst 2 (4%) 3 (6%) 2 (4%) 2 (4%)
Acinus, Cytoplasmic Alteration 3 (6%) 2 (4%) 3 (6%) 2 (4%)
Acinus, Hyperplasia, Focal 17 (34%) 13 (26%) 18 (36%) 12 (24%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:11:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Salivary Glands (50) (50) (50) (50)
Atrophy 3 (6%) 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Edema 2 (4%) 2 (4%)
Erosion 1 (2%)
Inflammation, Chronic Active 1 (2%) 6 (12%)
Ulcer 1 (2%)
Epithelium, Cyst 1 (2%) 5 (10%)
Epithelium, Hyperplasia 3 (6%) 19 (38%) 42 (84%) 50 (100%)
Stomach, Glandular (50) (50) (50) (50)
Edema 1 (2%)
Erosion 1 (2%) 1 (2%) 2 (4%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Tongue (2) (1) (2) (1)
Hyperplasia 1 (100%)
Epithelium, Hyperplasia 2 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 36 (72%) 40 (80%) 42 (84%) 40 (80%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 18 (36%) 21 (42%) 17 (34%) 17 (34%)
Angiectasis 1 (2%) 1 (2%) 2 (4%)
Degeneration, Fatty 12 (24%) 8 (16%) 10 (20%) 11 (22%)
Hyperplasia, Diffuse 1 (2%) 2 (4%) 1 (2%)
Hyperplasia, Focal 1 (2%) 2 (4%) 6 (12%) 6 (12%)
Hypertrophy, Focal 5 (10%) 3 (6%) 5 (10%) 8 (16%)
Metaplasia, Osseous 1 (2%)
Adrenal Medulla (50) (49) (50) (49)
Hyperplasia 7 (14%) 10 (20%) 6 (12%) 5 (10%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 2 (4%)
Pituitary Gland (50) (50) (50) (50)
Cyst 1 (2%)
Pars Distalis, Angiectasis 3 (6%) 4 (8%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:11:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cyst 4 (8%) 1 (2%) 6 (12%) 8 (16%)
Pars Distalis, Hyperplasia 2 (4%)
Pars Distalis, Hyperplasia, Focal 8 (16%) 8 (16%) 9 (18%) 9 (18%)
Pars Intermedia, Angiectasis 2 (4%) 2 (4%)
Pars Intermedia, Cyst 1 (2%) 4 (8%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 26 (52%) 16 (32%) 18 (36%) 10 (20%)
Follicle, Cyst 1 (2%) 2 (4%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Atypia Cellular 35 (70%) 36 (72%) 28 (56%) 37 (74%)
Preputial Gland (49) (50) (50) (50)
Cyst 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic 21 (43%) 21 (42%) 31 (62%) 24 (48%)
Prostate (49) (47) (50) (50)
Inflammation, Chronic 15 (31%) 17 (36%) 17 (34%) 13 (26%)
Epithelium, Hyperplasia 3 (6%)
Epithelium, Ventral, Degeneration 3 (6%) 1 (2%)
Epithelium, Ventral, Hyperplasia 12 (24%) 9 (19%) 11 (22%) 10 (20%)
Ventral, Inflammation 3 (6%) 1 (2%)
Testes (50) (50) (50) (50)
Germinal Epithelium, Atrophy 8 (16%) 9 (18%) 11 (22%) 5 (10%)
Interstitial Cell, Hyperplasia 8 (16%) 7 (14%) 7 (14%) 5 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 4 (8%) 3 (6%) 6 (12%) 4 (8%)
Lymph Node (21) (27) (29) (28)
Deep Cervical, Hyperplasia, Lymphoid 1 (4%)
Iliac, Pigmentation 1 (4%)
Mediastinal, Ectasia 1 (5%) 1 (4%)
Mediastinal, Hemorrhage 3 (14%) 1 (4%) 4 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:11:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Hyperplasia, Lymphoid 5 (24%) 4 (15%) 4 (14%) 4 (14%)
Mediastinal, Pigmentation 3 (14%) 5 (17%)
Pancreatic, Ectasia 1 (3%) 2 (7%)
Pancreatic, Hemorrhage 8 (38%) 9 (33%) 11 (38%) 11 (39%)
Pancreatic, Hyperplasia, Lymphoid 8 (38%) 14 (52%) 15 (52%) 16 (57%)
Pancreatic, Pigmentation 12 (57%) 18 (67%) 22 (76%) 23 (82%)
Lymph Node, Mandibular (8) (1) (3) (2)
Ectasia 1 (13%) 1 (33%)
Hyperplasia, Lymphoid 1 (13%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Ectasia 2 (4%) 1 (2%)
Hemorrhage 14 (28%) 8 (16%) 5 (10%) 4 (8%)
Hyperplasia, Lymphoid 16 (32%) 9 (18%) 22 (44%) 22 (44%)
Pigmentation 43 (86%) 32 (64%) 31 (62%) 21 (42%)
Spleen (50) (50) (50) (50)
Fibrosis 2 (4%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 20 (40%) 20 (40%) 22 (44%) 14 (28%)
Pigmentation 7 (14%) 9 (18%) 18 (36%) 20 (40%)
Lymphoid Follicle, Atrophy 3 (6%)
Lymphoid Follicle, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Thymus (50) (49) (50) (49)
Hemorrhage 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (45) (46) (44)
Cyst 1 (2%)
Hyperplasia 13 (27%) 12 (27%) 14 (30%) 10 (23%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 2 (4%) 2 (4%)
Foreign Body 1 (2%)
Granuloma 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Ulcer 2 (4%)
Epidermis, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:11:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Cranium, Osteopetrosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 7 (14%) 3 (6%) 6 (12%) 3 (6%)
Hemorrhage 1 (2%) 1 (2%)
Hydrocephalus 3 (6%) 2 (4%) 1 (2%) 3 (6%)
Necrosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 1 (2%) 1 (2%) 2 (4%) 3 (6%)
Edema 3 (6%) 1 (2%) 1 (2%) 5 (10%)
Foreign Body 1 (2%)
Hemorrhage 4 (8%) 3 (6%) 1 (2%) 4 (8%)
Infiltration Cellular, Histiocyte 33 (66%) 25 (50%) 19 (38%) 27 (54%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%) 2 (4%) 1 (2%)
Alveolar Epithelium, Hyperplasia 7 (14%) 4 (8%) 5 (10%) 6 (12%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Nose (50) (50) (50) (50)
Foreign Body 5 (10%) 6 (12%) 5 (10%) 2 (4%)
Inflammation, Chronic 9 (18%) 10 (20%) 12 (24%) 8 (16%)
Olfactory Epithelium, Atrophy 2 (4%)
Respiratory Epithelium, Hyperplasia 2 (4%) 7 (14%) 7 (14%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 3 (6%) 2 (4%)
Trachea (50) (50) (50) (50)
Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2) (3)
Cataract 1 (100%) 2 (100%) 2 (67%)
Hemorrhage 1 (33%)
Inflammation, Chronic 1 (33%)
Retina, Degeneration 1 (100%) 2 (100%) 1 (33%)
Harderian Gland (1) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:11:34
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Pigmentation 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Glomerulosclerosis 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic 3 (6%) 3 (6%) 2 (4%) 2 (4%)
Nephropathy 28 (56%) 22 (44%) 19 (38%) 19 (38%)
Renal Tubule, Cytoplasmic Alteration 2 (4%)
Renal Tubule, Dilatation 1 (2%) 1 (2%) 2 (4%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 1 (2%) 3 (6%)
Transitional Epithelium, Hyperplasia 2 (4%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Edema 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
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