TDMS Study 93023-06 Pathology Tables
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:12:24
FINAL#1/RATS
Facility: Southern Research Institute
Chemical CAS #: 142-83-6
Lock Date: 02/28/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 12 9 6 9
Natural Death 1 1 2 4
Dosing Accident 1 1 6
Survivors
Terminal Sacrifice 37 38 41 31
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (49) (50)
Intestine Large, Rectum (49) (50) (50) (49)
Intestine Large, Cecum (50) (50) (50) (50)
Intestine Small, Duodenum (50) (49) (50) (50)
Leiomyoma 1 (2%)
Liver (50) (50) (50) (50)
Mesentery (13) (16) (19) (15)
Oral Mucosa (1)
Squamous Cell Papilloma 1 (100%)
Pancreas (50) (50) (50) (50)
Acinus, Adenoma 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (49) (50) (50)
Squamous Cell Papilloma 1 (2%) 4 (8%) 16 (32%)
Squamous Cell Papilloma, Multiple 1 (2%) 1 (2%)
Stomach, Glandular (50) (49) (50) (50)
Tongue (1) (2) (1)
Squamous Cell Carcinoma 1 (50%)
Squamous Cell Papilloma 1 (50%) 1 (100%)
Tooth (1)
Odontogenic Tumor 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Adrenal Medulla (50) (49) (50) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 1 (2%) 5 (10%) 5 (10%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 19 (38%) 26 (52%) 22 (44%) 20 (40%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 11 (22%) 6 (12%) 7 (14%) 6 (12%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (50)
Adenoma 5 (10%) 8 (16%) 11 (22%) 7 (14%)
Carcinoma 2 (4%) 1 (2%) 3 (6%) 3 (6%)
Ovary (50) (50) (50) (50)
Thecoma Malignant 1 (2%)
Uterus (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Deciduoma Benign 1 (2%)
Polyp Stromal 14 (28%) 11 (22%) 9 (18%) 13 (26%)
Sarcoma Stromal 1 (2%)
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NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Vagina (1) (3) (1) (1)
Sarcoma 1 (33%)
Sarcoma Stromal, Metastatic, Uterus 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Lymph Node (29) (30) (30) (38)
Fibrosarcoma, Metastatic, Skin 1 (3%)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (3%)
Lymph Node, Mandibular (6) (2) (5) (1)
Lymph Node, Mesenteric (50) (50) (50) (50)
Spleen (50) (50) (50) (50)
Thymus (48) (47) (50) (50)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 2 (4%)
Carcinoma 2 (4%) 3 (6%) 1 (2%)
Fibroadenoma 22 (44%) 28 (56%) 22 (44%) 18 (36%)
Schwannoma Benign 1 (2%)
Skin (49) (49) (50) (50)
Basal Cell Adenoma 1 (2%)
Fibrous Histiocytoma 1 (2%)
Keratoacanthoma 1 (2%)
Neural Crest Tumor 1 (2%)
Pinna, Neural Crest Tumor 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 2 (4%)
Glioma Malignant 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Spinal Cord (3) (1)
Astrocytoma Malignant, Metastatic, Brain 1 (33%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 10 (20%) 11 (22%) 5 (10%) 16 (32%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 48 48 44
Total Primary Neoplasms 109 112 106 113
Total Animals with Benign Neoplasms 45 45 43 44
Total Benign Neoplasms 86 89 88 89
Total Animals with Malignant Neoplasms 18 19 14 21
Total Malignant Neoplasms 22 23 16 24
Total Animals with Metastatic Neoplasms 1 1 1 1
Total Metastatic Neoplasm 1 1 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 2
Total Uncertain Neoplasms 1 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 10 11 13 10
Dosing Accident 1 2 1 5
Natural Death 2 2 3 5
Survivors
Terminal Sacrifice 37 35 33 30
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (49) (50) (50)
Carcinoma 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50)
Intestine Small, Duodenum (50) (50) (50) (50)
Intestine Small, Jejunum (49) (50) (50) (47)
Intestine Small, Ileum (49) (49) (50) (50)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Mesentery (13) (8) (19) (17)
Hemangiosarcoma 1 (6%)
Oral Mucosa (1) (1) (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%) 1 (100%)
Pancreas (50) (50) (50) (50)
Acinus, Adenoma 10 (20%) 5 (10%) 9 (18%) 6 (12%)
Salivary Glands (50) (50) (50) (50)
Schwannoma Malignant 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Lipoma 1 (2%)
Squamous Cell Carcinoma 1 (2%) 2 (4%)
Squamous Cell Papilloma 3 (6%) 10 (20%) 18 (36%)
Squamous Cell Papilloma, Multiple 11 (22%)
Stomach, Glandular (50) (50) (50) (50)
Tongue (2) (1) (2) (1)
Squamous Cell Carcinoma 1 (50%)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Adrenal Medulla (50) (49) (50) (49)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 4 (8%)
Pheochromocytoma Complex 1 (2%) 1 (2%)
Pheochromocytoma Benign 7 (14%) 6 (12%) 7 (14%) 7 (14%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 4 (8%) 6 (12%) 5 (10%) 1 (2%)
Carcinoma 2 (4%) 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 12 (24%) 16 (32%) 15 (30%) 19 (38%)
Thyroid Gland (50) (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%) 1 (2%)
C-Cell, Adenoma 4 (8%) 4 (8%) 5 (10%) 6 (12%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 4 (8%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (4) (1) (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (49) (50) (50) (50)
Adenoma 1 (2%) 4 (8%) 1 (2%)
Carcinoma 3 (6%) 3 (6%) 5 (10%) 1 (2%)
Prostate (49) (47) (50) (50)
Ventral, Adenoma 2 (4%) 2 (4%) 3 (6%) 3 (6%)
Seminal Vesicle (50) (50) (50) (50)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 35 (70%) 36 (72%) 32 (64%) 40 (80%)
Interstitial Cell, Adenoma 6 (12%) 9 (18%) 13 (26%) 6 (12%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Lymph Node (21) (27) (29) (28)
Deep Cervical, Carcinoma, Metastatic,
Zymbal's Gland 1 (4%)
Mediastinal, Carcinoma, Metastatic, Thyroid
Gland 1 (4%)
Pancreatic, Histiocytic Sarcoma 1 (3%)
Lymph Node, Mandibular (8) (1) (3) (2)
Lymph Node, Mesenteric (50) (50) (50) (50)
Spleen (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Thymus (50) (49) (50) (49)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (45) (46) (44)
Carcinoma 2 (4%)
Fibroadenoma 3 (6%) 1 (2%) 1 (2%) 2 (5%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Keratoacanthoma 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Neural Crest Tumor 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Trichoepithelioma 1 (2%)
Pinna, Neural Crest Tumor 1 (2%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 3 (6%) 6 (12%) 5 (10%)
Subcutaneous Tissue, Fibrosarcoma 3 (6%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemangiopericytoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%) 1 (2%) 1 (2%)
Skeletal Muscle (1) (6) (1) (3)
Sarcoma 1 (17%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Spinal Cord (2) (4) (1) (2)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 4 (8%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 1 (2%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2) (1) (2)
Adenoma 1 (50%)
Carcinoma 1 (50%) 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Page 10
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Leukemia Mononuclear 11 (22%) 14 (28%) 9 (18%) 17 (34%)
Mesothelioma Malignant 4 (8%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 93023-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 03/14/01
Route: GAVAGE Time: 15:12:24
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 22.5 45 90
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 48 50 47
Total Primary Neoplasms 128 132 147 170
Total Animals with Benign Neoplasms 48 47 49 46
Total Benign Neoplasms 99 100 117 128
Total Animals with Malignant Neoplasms 21 23 24 30
Total Malignant Neoplasms 28 31 30 40
Total Animals with Metastatic Neoplasms 1 3 1 2
Total Metastatic Neoplasm 1 3 3 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1 2
Total Uncertain Neoplasms 1 1 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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