TDMS Study 93023-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst 2,4-HEXADIENAL DATE: 03/14/01
EXPERIMENT: 93023 TEST: 06 TIME: 15:20:00
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55393 ROUTE: GAVAGE NTP C#: 93023B
PATHOLOGIST: HEATH, JAMES E. CAS: 142-83-6
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1/RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst 2,4-HEXADIENAL DATE: 03/14/01
EXPERIMENT: 93023 TEST: 06 TIME: 15:20:00
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: GAVAGE NTP C#: 93023B
PATHOLOGIST: HEATH, JAMES E. CAS: 142-83-6
2,4-HEXADIENAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 1 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 479 542 554 587 609 629 634 634 655 699 |
| 699 704 |
| CENSORED DEATHS |
| 259 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 22.5 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 2 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 371 509 537 582 634 643 659 662 664 671 |
| 704 704 715 |
| CENSORED DEATHS |
| 190 345 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 45 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 1 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 483 503 536 553 560 606 620 620 624 629 |
| 663 664 671 686 691 713 |
| CENSORED DEATHS |
| 364 |
| |
==================================================================================
2,4-HEXADIENAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 90 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 5 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 350 496 566 574 609 620 636 643 651 655 |
| 659 691 697 705 715 |
| CENSORED DEATHS |
| 148 364 364 575 709 |
| |
==================================================================================
2,4-HEXADIENAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 98.0 95.9 91.8 81.6 75.5 |
|MG/KG/DY | |
| | |
|22.5 | 100.0 100.0 100.0 100.0 97.9 97.9 93.7 91.7 81.2 72.9 |
|MG/KG/DY | |
| | |
|45 | 100.0 100.0 100.0 100.0 100.0 98.0 93.9 89.8 75.5 67.3 |
|MG/KG/DY | |
| | |
|90 | 100.0 100.0 100.0 98.0 98.0 98.0 95.8 91.6 76.3 67.5 |
|MG/KG/DY | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 22.5 45 90 |
| MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 75.5% 72.9% 67.3% 67.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.411 P=0.979 P=0.465 P=0.537 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 618.8 619.6 613.9 617.8 |
|NATURAL DEATHS (C) | (20.0) (27.1) (17.3) (24.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 693.1 682.1 684.9 665.9 |
|(STANDARD ERROR) | (12.0) (15.6) (11.4) (17.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2,4-HEXADIENAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 285 445 511 554 560 629 659 664 704 705 |
| 712 722 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 22.5 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 1 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 347 544 610 629 634 664 671 719 719 722 |
| CENSORED DEATHS |
| 346 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 45 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 1 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 476 536 544 546 602 610 659 671 |
| CENSORED DEATHS |
| 483 |
| |
==================================================================================
2,4-HEXADIENAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 90 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 6 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 445 536 560 601 631 636 638 651 666 690 |
| 691 691 721 |
| CENSORED DEATHS |
| 346 363 364 364 364 405 |
| |
==================================================================================
2,4-HEXADIENAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 100.0 98.0 98.0 96.0 94.0 90.0 84.0 74.0 |
|MG/KG/DY | |
| | |
|22.5 | 100.0 100.0 100.0 98.0 98.0 98.0 95.9 95.9 87.8 79.6 |
|MG/KG/DY | |
| | |
|45 | 100.0 100.0 100.0 100.0 100.0 98.0 93.9 89.8 85.7 83.7 |
|MG/KG/DY | |
| | |
|90 | 100.0 100.0 100.0 100.0 100.0 97.7 95.5 90.9 81.8 70.5 |
|MG/KG/DY | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 22.5 45 90 |
| MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.0% 79.6% 83.7% 70.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.704 P=0.638N P=0.383N P=0.847 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 605.9 625.9 580.5 627.5 |
|NATURAL DEATHS (C) | (36.5) (35.7) (23.6) (21.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 697.0 700.7 700.3 659.2 |
|(STANDARD ERROR) | (12.0) (11.6) ( 9.6) (17.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2,4-HEXADIENAL
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG/DY = 1
22.5 MG/KG/DY = 2
45 MG/KG/DY = 3
90 MG/KG/DY = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1
|
| 4 2 1 432 1
| 432 21 14
95 +
| 2 3144 1
P |
E | 33 4 1 1 2
R 90 + 3 1 4122
C |
E | 3 3112 2
N |
T 85 + 44
| 331 1
S | 44
U | 41 22 1
R 80 + 3 3
V | 4 42 2
I | 11
V | 4 4
A 75 + 33 1 2 1
L | 3 344
| 44 2 2
| 33
70 + 3 434
|
| 34 3
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 17 obs hidden.
2,4-HEXADIENAL
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG/DY = 1
22.5 MG/KG/DY = 2
45 MG/KG/DY = 3
90 MG/KG/DY = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 4 3
|
| 1 2 1 3 32
| 1 1 32 2
P 95 + 4 4
E | 1 1 4 2 2
R | 3 3
C | 4 22
E 90 + 1 3 3 12 2
N |
T | 3 1 12
| 44 32 2
S 85 +
U | 44 13 1 3
R |
V | 4 4 22
I 80 + 4 4 11 2 2
V |
A | 1 1
L |
75 +
| 1 1
| 4 4
|
70 + 4 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.