TDMS Study 93023-07 Pathology Tables
NTP Experiment-Test: 93023-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 02/15/01
Route: GAVAGE Time: 11:14:18
FINAL #1/MICE
Facility: Southern Research Institute
Chemical CAS #: 142-83-6
Lock Date: 02/24/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93023-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 02/15/01
Route: GAVAGE Time: 11:14:18
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B6C3F1 MICE FEMALE 0 30 60 120
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
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DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 6 4 5 6
Moribund Sacrifice 2 8 8 4
Dosing Accident 1
Survivors
Terminal Sacrifice 42 37 37 37
Natural Death 2
Missing 1
Animals Examined Microscopically 50 49 50 50
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ALIMENTARY SYSTEM
Esophagus (49) (49) (50) (50)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (2%)
Gallbladder (44) (45) (47) (41)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Intestine Large, Colon (46) (46) (49) (49)
Histiocytic Sarcoma 1 (2%)
Intestine Large, Cecum (45) (45) (47) (44)
Intestine Small, Duodenum (45) (44) (47) (43)
Polyp Adenomatous 1 (2%)
Intestine Small, Ileum (43) (46) (48) (44)
Histiocytic Sarcoma 1 (2%)
Liver (50) (49) (50) (50)
Cholangiocarcinoma 1 (2%)
Hepatocellular Carcinoma 3 (6%) 3 (6%) 3 (6%) 4 (8%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 10 (20%) 3 (6%) 10 (20%) 5 (10%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Ito Cell Tumor Benign 1 (2%) 1 (2%)
Ito Cell Tumor Malignant 1 (2%)
Serosa, Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Mesentery (31) (30) (37) (25)
Histiocytic Sarcoma 1 (3%) 1 (3%) 1 (4%)
Ito Cell Tumor Malignant, Metastatic, Liver 1 (3%)
Sarcoma, Metastatic, Skeletal Muscle 1 (3%)
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NTP Experiment-Test: 93023-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 02/15/01
Route: GAVAGE Time: 11:14:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 30 60 120
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 3 (12%)
Pancreas (47) (46) (50) (47)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 2 (4%)
Salivary Glands (49) (48) (48) (50)
Stomach, Forestomach (48) (48) (50) (48)
Squamous Cell Carcinoma 7 (15%)
Squamous Cell Papilloma 2 (4%) 2 (4%) 9 (18%) 11 (23%)
Squamous Cell Papilloma, Multiple 2 (4%) 2 (4%)
Stomach, Glandular (45) (45) (48) (46)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 3 (7%)
Serosa, Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Tooth (1) (2)
Peridontal Tissue, Sarcoma 1 (100%)
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CARDIOVASCULAR SYSTEM
Heart (49) (49) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (48) (50) (50)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Adrenal Medulla (50) (48) (49) (49)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (47) (46) (49) (49)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (46) (48) (47) (50)
Pars Distalis, Adenoma 2 (4%) 5 (10%) 7 (15%) 3 (6%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 2 (4%) 1 (2%) 1 (2%)
Thyroid Gland (49) (46) (49) (50)
Bilateral, Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 2 (4%)
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NTP Experiment-Test: 93023-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 02/15/01
Route: GAVAGE Time: 11:14:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 30 60 120
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
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GENERAL BODY SYSTEM
Peritoneum (1)
Sarcoma, Metastatic, Skeletal Muscle 1 (100%)
Tissue NOS (1) (1) (2) (1)
Fibrosarcoma 1 (50%)
Abdominal, Sarcoma 1 (100%)
Thoracic, Sarcoma, Multiple 1 (100%)
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GENITAL SYSTEM
Ovary (49) (47) (48) (48)
Cystadenoma 1 (2%) 1 (2%) 3 (6%) 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 2 (4%)
Histiocytic Sarcoma 1 (2%)
Luteoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (2%)
Uterus (50) (49) (50) (50)
Hemangiosarcoma 2 (4%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leiomyoma 1 (2%)
Polyp Stromal 1 (2%)
Sarcoma 1 (2%)
Endometrium, Adenoma 1 (2%)
Endometrium, Polyp Stromal 1 (2%) 2 (4%) 1 (2%)
Vagina (1) (1) (1)
Hemangioma 1 (100%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (47) (50) (48)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Lymph Node (8) (9) (9) (7)
Bronchial, Histiocytic Sarcoma 1 (11%)
Iliac, Histiocytic Sarcoma 1 (11%)
Inguinal, Histiocytic Sarcoma 1 (11%)
Mediastinal, Histiocytic Sarcoma 1 (13%) 1 (14%)
Mediastinal, Squamous Cell Carcinoma,
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NTP Experiment-Test: 93023-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 02/15/01
Route: GAVAGE Time: 11:14:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 30 60 120
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Metastatic, Stomach, Forestomach 2 (29%)
Renal, Histiocytic Sarcoma 1 (11%)
Lymph Node, Mandibular (47) (47) (48) (49)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Lymph Node, Mesenteric (47) (46) (49) (49)
Histiocytic Sarcoma 1 (2%) 2 (4%) 1 (2%)
Sarcoma 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (2%)
Spleen (48) (47) (50) (49)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Thymus (44) (46) (48) (46)
Histiocytic Sarcoma 1 (2%)
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INTEGUMENTARY SYSTEM
Mammary Gland (48) (49) (50) (50)
Adenoacanthoma 1 (2%)
Carcinoma 1 (2%) 3 (6%) 1 (2%)
Skin (50) (49) (50) (50)
Pinna, Fibrous Histiocytoma 1 (2%)
Sebaceous Gland, Pinna, Adenoma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 2 (4%) 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
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MUSCULOSKELETAL SYSTEM
Bone (43) (49) (49) (39)
Osteoma 1 (2%)
Skeletal Muscle (6) (4) (5) (2)
Histiocytic Sarcoma 1 (25%)
Sarcoma 5 (83%) 1 (25%) 2 (40%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 2 (100%)
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NTP Experiment-Test: 93023-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 2,4-HEXADIENAL Date: 02/15/01
Route: GAVAGE Time: 11:14:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 30 60 120
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (48) (50) (50)
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RESPIRATORY SYSTEM
Lung (49) (49) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 3 (6%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Sarcoma 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Mediastinum, Histiocytic Sarcoma 1 (2%)
Mediastinum, Sarcoma, Metastatic, Skeletal
Muscle 1 (2%)
Nose (50) (48) (50) (50)
Trachea (49) (49) (50) (50)
Peritracheal Tissue, Histiocytic Sarcoma 1 (2%)
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SPECIAL SENSES SYSTEM
Eye (2) (3) (2) (2)
Retrobulbar, Carcinoma, Metastatic,
Harderian Gland 1 (50%)
Harderian Gland (8) (6) (4) (1)
Adenoma 7 (88%) 6 (100%) 2 (50%) 1 (100%)
Carcinoma 2 (50%)
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