TDMS Study 93023-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst 2,4-HEXADIENAL DATE: 02/15/01
EXPERIMENT: 93023 TEST: 07 TIME: 11:14:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55393 ROUTE: GAVAGE NTP C#: 93023B
PATHOLOGIST: FARNELL, DANIEL R. CAS: 142-83-6
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1/MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst 2,4-HEXADIENAL DATE: 02/15/01
EXPERIMENT: 93023 TEST: 07 TIME: 11:14:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: GAVAGE NTP C#: 93023B
PATHOLOGIST: FARNELL, DANIEL R. CAS: 142-83-6
Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
---------------
Adrenal Cortex
Adrenal Medulla
Clitoral/Preputial Gland
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Ovary
Pituitary Gland
Spleen
Testes
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst 2,4-HEXADIENAL DATE: 02/15/01
EXPERIMENT: 93023 TEST: 07 TIME: 11:14:45
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: GAVAGE NTP C#: 93023B
PATHOLOGIST: FARNELL, DANIEL R. CAS: 142-83-6
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF 2,4-HEXADIENAL
===============================================================
Male Mice
------------
Organ Morphology
----- ----------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)
Squamous Cell Carcinoma
Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Stomach, Forestomach Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
Tongue Squamous Cell Carcinoma
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Harderian Gland Adenoma
Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Carcinoma or Adenoma
Skeletal Muscle Sarcoma
Skin Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma
Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma
Stomach, Forestomach Squamous Cell Carcinoma
Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
Uterus Hemangiosarcoma
All Organs Benign Tumors
Malignant and Benign Tumors
===============================================================
Date: 02/15/01 EXPERIMENT: 93023 TEST: 07 Page 1
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - 2,4-HEXADIENAL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 30 60 120 |0 30 60 120 |
| | MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 6/50 (12%) 6/50 (12%) 4/50 (8%) |0/50 (0%) 0/48 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 4/48.54 6/44.73 6/47.82 4/45.44 |0/47.56 0/44.73 0/46.55 0/46.05 |
|POLY-3 PERCENT (g) | 8.2% 13.4% 12.6% 8.8% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 4/44 (9%) 6/39 (15%) 5/44 (11%) 4/39 (10%) |0/42 (0%) 0/37 (0%) 0/37 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 704 729 (T) |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.556N P=0.295 P=0.371 P=0.576 |(e) (e) (e) (e) |
|POLY 3 | P=0.538N P=0.320 P=0.361 P=0.606 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.525N P=0.338 P=0.363 P=0.619 |(e) (e) (e) (e) |
|POLY 6 | P=0.553N P=0.302 P=0.360 P=0.592 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.553N P=0.295 P=0.356 P=0.576 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.500N P=0.370 P=0.370 P=0.643N |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 30 60 120 |0 30 60 120 |
| | MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |1/50 (2%) 0/48 (0%) 0/49 (0%) 0/49 (0%) |
|POLY-3 RATE (b) | 0/47.97 0/44.73 0/47.72 2/45.44 |1/47.56 0/44.73 0/45.55 0/45.05 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 4.4% |2.1% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/44 (0%) 0/39 (0%) 0/44 (0%) 2/39 (5%) |1/42 (2%) 0/37 (0%) 0/36 (0%) 0/38 (0%) |
|FIRST INCIDENCE | --- --- --- 729 (T) |729 (T) --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.041 * (e) (e) P=0.212 |P=0.317N P=0.525N P=0.531N P=0.520N |
|POLY 3 | P=0.045 * (e) (e) P=0.225 |P=0.302N P=0.512N P=0.509N P=0.511N |
|POLY 1.5 | P=0.045 * (e) (e) P=0.231 |P=0.303N P=0.511N P=0.506N P=0.509N |
|POLY 6 | P=0.044 * (e) (e) P=0.219 |P=0.301N P=0.515N P=0.513N P=0.514N |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.212 |P=0.317N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.047 * (e) (e) P=0.253 |P=0.305N P=0.510N P=0.505N P=0.505N |
|=================================================================================================================================|
Date: 02/15/01 EXPERIMENT: 93023 TEST: 07 Page 2
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - 2,4-HEXADIENAL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 30 60 120 |0 30 60 120 |
| | MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |1/50 (2%) 0/48 (0%) 1/49 (2%) 0/49 (0%) |
|POLY-3 RATE (b) | 0/47.97 0/44.73 0/47.72 2/45.44 |1/47.56 0/44.73 1/45.55 0/45.05 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 4.4% |2.1% 0.0% 2.2% 0.0% |
|TERMINAL (d) | 0/44 (0%) 0/39 (0%) 0/44 (0%) 2/39 (5%) |1/42 (2%) 0/37 (0%) 1/36 (3%) 0/38 (0%) |
|FIRST INCIDENCE | --- --- --- 729 (T) |729 (T) --- 729 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.041 * (e) (e) P=0.212 |P=0.424N P=0.525N P=0.727 P=0.520N |
|POLY 3 | P=0.045 * (e) (e) P=0.225 |P=0.411N P=0.512N P=0.751 P=0.511N |
|POLY 1.5 | P=0.045 * (e) (e) P=0.231 |P=0.411N P=0.511N P=0.753 P=0.509N |
|POLY 6 | P=0.044 * (e) (e) P=0.219 |P=0.413N P=0.515N P=0.746 P=0.514N |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.212 |P=0.424N (e) P=0.727 (e) |
|COCH-ARM / FISHERS | P=0.047 * (e) (e) P=0.253 |P=0.408N P=0.510N P=0.747 P=0.505N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 30 60 120 |0 30 60 120 |
| | MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 6/50 (12%) 3/50 (6%) 4/50 (8%) |7/50 (14%) 6/50 (12%) 2/50 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 7/48.58 6/44.73 3/47.72 4/45.44 |7/47.56 6/46.57 2/46.55 1/46.05 |
|POLY-3 PERCENT (g) | 14.4% 13.4% 6.3% 8.8% |14.7% 12.9% 4.3% 2.2% |
|TERMINAL (d) | 6/44 (14%) 6/39 (15%) 3/44 (7%) 4/39 (10%) |7/42 (17%) 6/37 (16%) 2/37 (5%) 1/39 (3%) |
|FIRST INCIDENCE | 718 729 (T) 729 (T) 729 (T) |729 (T) 729 (T) 729 (T) 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.204N P=0.593N P=0.162N P=0.336N |P=0.014N* P=0.598N P=0.113N P=0.041N* |
|POLY 3 | P=0.183N P=0.563N P=0.166N P=0.301N |P=0.011N* P=0.516N P=0.084N P=0.034N* |
|POLY 1.5 | P=0.178N P=0.540N P=0.164N P=0.287N |P=0.011N* P=0.510N P=0.082N P=0.033N* |
|POLY 6 | P=0.188N P=0.587N P=0.167N P=0.317N |P=0.011N* P=0.526N P=0.089N P=0.035N* |
|LOGISTIC REGRESSION| P=0.200N P=0.611N P=0.166N P=0.332N |P=0.014N* P=0.598N P=0.113N P=0.041N* |
|COCH-ARM / FISHERS | P=0.168N P=0.500N P=0.159N P=0.262N |P=0.011N* P=0.500N P=0.080N P=0.030N* |
|=================================================================================================================================|
Date: 02/15/01 EXPERIMENT: 93023 TEST: 07 Page 3
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - 2,4-HEXADIENAL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 30 60 120 |0 30 60 120 |
| | MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 1/50 (2%) 1/50 (2%) |0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/48.76 4/45.05 1/47.72 1/45.44 |0/47.56 0/46.57 2/46.86 0/46.05 |
|POLY-3 PERCENT (g) | 4.1% 8.9% 2.1% 2.2% |0.0% 0.0% 4.3% 0.0% |
|TERMINAL (d) | 1/44 (2%) 3/39 (8%) 1/44 (2%) 1/39 (3%) |0/42 (0%) 0/37 (0%) 0/37 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 670 643 729 (T) 729 (T) |--- --- 649 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.258N P=0.286 P=0.505N P=0.543N |P=0.576 (e) P=0.224 (e) |
|POLY 3 | P=0.251N P=0.302 P=0.508N P=0.524N |P=0.574 (e) P=0.234 (e) |
|POLY 1.5 | P=0.243N P=0.314 P=0.505N P=0.516N |P=0.578 (e) P=0.236 (e) |
|POLY 6 | P=0.259N P=0.289 P=0.510N P=0.534N |P=0.570 (e) P=0.231 (e) |
|LOGISTIC REGRESSION| P=0.234N P=0.340 P=0.490N P=0.500N |P=0.606 (e) P=0.244 (e) |
|COCH-ARM / FISHERS | P=0.230N P=0.339 P=0.500N P=0.500N |P=0.589 (e) P=0.247 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 30 60 120 |0 30 60 120 |
| | MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 10/50 (20%) 4/50 (8%) 5/50 (10%) |7/50 (14%) 6/50 (12%) 4/50 (8%) 1/50 (2%) |
|POLY-3 RATE (b) | 9/48.81 10/45.05 4/47.72 5/45.44 |7/47.56 6/46.57 4/46.86 1/46.05 |
|POLY-3 PERCENT (g) | 18.4% 22.2% 8.4% 11.0% |14.7% 12.9% 8.5% 2.2% |
|TERMINAL (d) | 7/44 (16%) 9/39 (23%) 4/44 (9%) 5/39 (13%) |7/42 (17%) 6/37 (16%) 2/37 (5%) 1/39 (3%) |
|FIRST INCIDENCE | 670 643 729 (T) 729 (T) |729 (T) 729 (T) 649 729 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.112N P=0.386 P=0.123N P=0.271N |P=0.024N* P=0.598N P=0.334N P=0.041N* |
|POLY 3 | P=0.097N P=0.423 P=0.125N P=0.235N |P=0.020N* P=0.516N P=0.270N P=0.034N* |
|POLY 1.5 | P=0.092N P=0.451 P=0.122N P=0.220N |P=0.019N* P=0.510N P=0.266N P=0.033N* |
|POLY 6 | P=0.104N P=0.395 P=0.127N P=0.254N |P=0.020N* P=0.526N P=0.277N P=0.035N* |
|LOGISTIC REGRESSION| P=0.101N P=0.410 P=0.123N P=0.247N |P=0.022N* P=0.598N P=0.282N P=0.041N* |
|COCH-ARM / FISHERS | P=0.083N P=0.500 P=0.117N P=0.194N |P=0.018N* P=0.500N P=0.262N P=0.030N* |
|=================================================================================================================================|
Date: 02/15/01 EXPERIMENT: 93023 TEST: 07 Page 4
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - 2,4-HEXADIENAL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 30 60 120 |0 30 60 120 |
| | MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |#