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TDMS Study 93023-07 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  2,4-HEXADIENAL                                    DATE: 02/15/01       
EXPERIMENT: 93023 TEST: 07                                                                                     TIME: 11:21:33       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55393                              ROUTE: GAVAGE                                                  NTP C#: 93023B       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 142-83-6        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  2,4-HEXADIENAL                                    DATE: 02/15/01       
EXPERIMENT: 93023 TEST: 07                                                                                     TIME: 11:21:33       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: GAVAGE                                                  NTP C#: 93023B       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 142-83-6        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  2,4-HEXADIENAL                                                                                  
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
Heart                                  Infiltration Cellular Mixed Cell                                                             
Liver: Hepatocyte                      Mixed Cell Focus                                                                             
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lymph Node, Mediastinal                Hyperplasia                                                                                  
Spleen                                 Hematopoietic Cell Proliferation                                                             
Stomach, Forestomach                   Ulcer                                                                                        
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Stomach, Glandular: Glands             Degeneration Cystic Focal                                                                    
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Liver                                  Infiltration Cellular Mixed Cell                                                             
Liver: Hepatocyte, Midzonal            Vacuolization Cytoplasmic                                                                    
Nose: Mucosa, Glands                   Dilatation Focal                                                                             
Nose: Olfactory Epithelium             Cytoplasmic Alteration                                                                       
Spleen                                 Hematopoietic Cell Proliferation                                                             
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Thymus                                 Cyst                                                                                         
Thyroid Gland                          Degeneration Cystic Focal                                                                    
Uterus                                 Hydrometra                                                                                   
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  02/15/01                           EXPERIMENT: 93023 TEST: 07                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                   2,4-HEXADIENAL      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            30           60           120         |0            30           60           120          | 
|                   |     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY    |MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessor