TDMS Study 93023-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst 2,4-HEXADIENAL DATE: 02/15/01
EXPERIMENT: 93023 TEST: 07 TIME: 11:24:04
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55393 ROUTE: GAVAGE NTP C#: 93023B
PATHOLOGIST: FARNELL, DANIEL R. CAS: 142-83-6
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1/MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst 2,4-HEXADIENAL DATE: 02/15/01
EXPERIMENT: 93023 TEST: 07 TIME: 11:24:04
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: GAVAGE NTP C#: 93023B
PATHOLOGIST: FARNELL, DANIEL R. CAS: 142-83-6
2,4-HEXADIENAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 568 603 670 698 701 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 353 400 504 533 544 631 643 646 650 672 |
| 675 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 60 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 352 587 637 649 680 704 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2,4-HEXADIENAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 120 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 239 504 558 573 595 606 627 643 690 709 |
| 713 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2,4-HEXADIENAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 96.0 88.0 |
|MG/KG/DY | |
| | |
|30 | 100.0 100.0 100.0 98.0 96.0 96.0 90.0 90.0 82.0 78.0 |
|MG/KG/DY | |
| | |
|60 | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 96.0 92.0 88.0 |
|MG/KG/DY | |
| | |
|120 | 100.0 100.0 98.0 98.0 98.0 98.0 96.0 90.0 84.0 78.0 |
|MG/KG/DY | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 30 60 120 |
| MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 88.0% 78.0% 88.0% 78.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.387 P=0.237 P=1.000 P=0.253 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 659.7 568.3 601.5 587.0 |
|NATURAL DEATHS (C) | (24.7) (33.7) (52.5) (39.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 720.7 693.6 713.7 697.8 |
|(STANDARD ERROR) | ( 4.2) (11.9) ( 8.3) (11.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2,4-HEXADIENAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 538 538 609 635 653 698 712 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 1 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 349 587 616 643 649 664 683 684 685 710 |
| 713 713 |
| CENSORED DEATHS |
| 708 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 60 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 533 587 627 635 637 643 649 661 672 687 |
| 716 725 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
2,4-HEXADIENAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 120 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 1 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 543 594 614 637 638 643 657 669 716 725 |
| CENSORED DEATHS |
| 239 |
| |
==================================================================================
2,4-HEXADIENAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 96.0 90.0 84.0 |
|MG/KG/DY | |
| | |
|30 | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 96.0 88.0 75.9 |
|MG/KG/DY | |
| | |
|60 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 96.0 84.0 74.0 |
|MG/KG/DY | |
| | |
|120 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 95.9 85.7 79.6 |
|MG/KG/DY | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 30 60 120 |
| MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 84.0% 75.9% 74.0% 79.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.776 P=0.447 P=0.327 P=0.751 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 638.6 641.3 653.7 643.6 |
|NATURAL DEATHS (C) | (26.0) (28.9) (15.2) (17.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 714.5 707.5 709.4 702.1 |
|(STANDARD ERROR) | ( 6.2) ( 8.6) ( 6.1) (11.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
2,4-HEXADIENAL
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG/DY = 1
30 MG/KG/DY = 2
60 MG/KG/DY = 3
120 MG/KG/DY = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1
|
| 4 2 2 4 1 3 1
|
P 96 + 2 2 4 3 1 3 1
E |
R | 2 2 4 4 3 3 1 1
C |
E 92 + 22 4 4 3 3 11
N |
T | 2 4 4 2 3 1 1
|
S 88 + 4 422 3 1 1
U |
R | 4 22
V |
I 84 + 4 4
V |
A | 2 2 4 4
L |
80 + 22
|
| 2 4 2
|
76 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.
2,4-HEXADIENAL
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG/DY = 1
30 MG/KG/DY = 2
60 MG/KG/DY = 3
120 MG/KG/DY = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 14
|
| 2 34 2 4
| 1 2 4 12 3
P 95 +
E | 12 312
R | 1221
C | 44
E 90 + 3321 2 1
N |
T | 334 2 2 1 1
| 34 34 1 1
S 85 +
U | 33 41 1
R | 3 23 2
V | 44
I 80 + 3 34 4
V |
A | 33
L | 2 2
75 +
| 3 3
|
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.