TDMS Study 93026-07 Pathology Tables
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DECALIN Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28
FINAL#1
Facility: Battelle Northwest
Chemical CAS #: 91-17-8
Lock Date: 05/31/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DECALIN Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 16 10 10 17
Natural Death 2 5 5
Accidently Killed 1
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 32 35 38 28
Animals Examined Microscopically 50 50 50 50
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ALIMENTARY SYSTEM
Liver (50) (48) (49) (50)
Histiocytic Sarcoma 1 (2%)
Mesentery (26) (20) (20) (17)
Oral Mucosa (1) (2)
Gingival, Squamous Cell Carcinoma 1 (100%)
Stomach, Glandular (50) (47) (49) (49)
Adenoma 1 (2%)
Tongue (2) (1)
Squamous Cell Carcinoma 1 (50%)
Squamous Cell Papilloma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Medulla (50) (48) (49) (49)
Pheochromocytoma Malignant 2 (4%) 1 (2%)
Pheochromocytoma Benign 1 (2%) 1 (2%) 3 (6%) 1 (2%)
Islets, Pancreatic (50) (47) (49) (49)
Adenoma 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (50) (49) (49) (50)
Pars Distalis, Adenoma 34 (68%) 27 (55%) 29 (59%) 30 (60%)
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NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DECALIN Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Distalis, Carcinoma 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (50) (49) (49) (50)
C-Cell, Adenoma 5 (10%) 3 (6%) 2 (4%) 3 (6%)
C-Cell, Carcinoma 3 (6%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (49) (49) (50)
Adenoma 8 (17%) 2 (4%) 1 (2%)
Carcinoma 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Ovary (50) (50) (49) (50)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 2 (4%)
Thecoma Malignant 1 (2%)
Uterus (50) (49) (49) (50)
Polyp Stromal 6 (12%) 8 (16%) 14 (29%) 12 (24%)
Sarcoma Stromal 1 (2%)
Bilateral, Polyp Stromal 1 (2%)
Endometrium, Carcinoma 2 (4%) 1 (2%)
Vagina (1) (2)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (49) (50)
Lymph Node (6) (4) (2)
Lymph Node, Bronchial (2) (10) (7) (5)
Carcinoma, Metastatic, Uterus 1 (14%)
Lymph Node, Mesenteric (50) (50) (49) (49)
Lymph Node, Mediastinal (45) (46) (49) (44)
Spleen (50) (49) (49) (50)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DECALIN Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50)
Carcinoma 5 (10%) 3 (6%) 6 (12%) 3 (6%)
Fibroadenoma 17 (34%) 14 (28%) 17 (35%) 18 (36%)
Fibroadenoma, Multiple 8 (16%) 8 (16%) 3 (6%) 5 (10%)
Skin (50) (50) (49) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%) 1 (2%)
Sarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Neural Crest Tumor 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Humerus, Osteosarcoma 1 (2%) 1 (2%)
Skeletal Muscle (1) (2) (1)
Carcinoma, Metastatic, Uterus 1 (100%)
Carcinoma, Metastatic, Zymbal's Gland 1 (50%)
Osteosarcoma, Metastatic, Bone 1 (50%)
Rhabdomyosarcoma 1 (100%)
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NERVOUS SYSTEM
Brain (50) (49) (49) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Uterus 1 (2%) 1 (2%)
Granulosa Cell Tumor Malignant, Metastatic,
Ovary 1 (2%)
Page 4
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DECALIN Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Pleura (20) (25) (25) (28)
Carcinoma, Metastatic, Uterus 1 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (46) (49) (50)
Granulosa Cell Tumor Malignant, Metastatic,
Ovary 1 (2%)
Pelvis, Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (50) (47) (49) (50)
Sarcoma, Metastatic, Vagina 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 11 (22%) 15 (30%) 12 (24%) 14 (28%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DECALIN Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 44 46 48
Total Primary Neoplasms 114 96 103 95
Total Animals with Benign Neoplasms 46 41 44 44
Total Benign Neoplasms 83 66 72 72
Total Animals with Malignant Neoplasms 25 22 25 18
Total Malignant Neoplasms 30 30 31 22
Total Animals with Metastatic Neoplasms 1 4 2 2
Total Metastatic Neoplasm 1 6 5 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DECALIN Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 20
Early Deaths
Moribund Sacrifice 17 21 23 23 6
Natural Death 5 6 3 7
Survivors
Terminal Sacrifice 28 23 23 20 14
Other 1
Animals Examined Microscopically 50 50 49 50 20
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ALIMENTARY SYSTEM
Intestine Large, Colon (48) (47) (48) (49) (20)
Polyp Adenomatous 1 (2%)
Intestine Small, Jejunum (47) (45) (46) (47) (20)
Intestine Small, Ileum (46) (45) (46) (48) (20)
Leiomyoma 1 (2%)
Liver (50) (50) (49) (50) (20)
Histiocytic Sarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic, Skeletal
Muscle 1 (2%)
Mesentery (16) (19) (20) (13) (10)
Carcinoma, Metastatic, Urinary Bladder 1 (5%)
Schwannoma Malignant 1 (8%)
Oral Mucosa (2) (2) (1)
Pharyngeal, Squamous Cell Carcinoma 1 (100%)
Pharyngeal, Squamous Cell Papilloma 1 (50%) 2 (100%)
Pancreas (50) (50) (49) (50) (20)
Carcinoma 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Salivary Glands (50) (50) (49) (50) (20)
Sarcoma 1 (2%)
Schwannoma Malignant 1 (2%)
Stomach, Glandular (50) (50) (49) (50) (20)
Tongue (1) (2) (1)
Squamous Cell Papilloma 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DECALIN Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49) (50) (20)
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ENDOCRINE SYSTEM
Adrenal Medulla (49) (49) (49) (49) (20)
Pheochromocytoma Malignant 2 (4%) 2 (4%) 7 (14%) 3 (15%)
Pheochromocytoma Benign 7 (14%) 8 (16%) 10 (20%) 9 (18%) 4 (20%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%) 1 (2%) 2 (10%)
Islets, Pancreatic (50) (50) (49) (50) (20)
Adenoma 3 (6%) 3 (6%) 3 (6%) 2 (4%) 1 (5%)
Carcinoma 4 (8%) 1 (2%) 4 (8%)
Pituitary Gland (50) (50) (49) (49) (20)
Craniopharyngeal Duct, Craniopharyngioma 1 (2%)
Pars Distalis, Adenoma 27 (54%) 33 (66%) 25 (51%) 25 (51%) 9 (45%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (49) (49) (20)
C-Cell, Adenoma 7 (14%) 4 (8%) 4 (8%) 3 (6%) 2 (10%)
C-Cell, Carcinoma 2 (4%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2) (2) (2)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (49) (50) (20)
Preputial Gland (50) (49) (49) (50) (20)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (2%) 3 (6%) 2 (10%)
Prostate, NOS (50) (50) (49) (50) (20)
Carcinoma, Metastatic, Urinary Bladder 1 (2%)
Ventral, Adenoma 1 (2%)
Seminal Vesicle (50) (50) (49) (50) (20)
Carcinoma, Metastatic, Kidney 1 (2%)
Testes (50) (50) (49) (50) (20)
Bilateral, Interstitial Cell, Adenoma 34 (68%) 31 (62%) 39 (80%) 29 (58%) 16 (80%)
Interstitial Cell, Adenoma 6 (12%) 10 (20%) 8 (16%) 15 (30%) 4 (20%)
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Page 8
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DECALIN Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50) (20)
Histiocytic Sarcoma 1 (2%)
Lymph Node (8) (10) (14) (11) (1)
Deep Cervical, Carcinoma, Metastatic, Kidney 1 (10%)
Pancreatic, Histiocytic Sarcoma 1 (10%)
Lymph Node, Bronchial (7) (8) (18) (17) (7)
Lymph Node, Mandibular (3) (2) (3) (1)
Lymph Node, Mesenteric (50) (50) (49) (49) (20)
Carcinoma, Metastatic, Urinary Bladder 1 (2%)
Histiocytic Sarcoma, Metastatic, Skeletal
Muscle 1 (2%)
Lymph Node, Mediastinal (48) (45) (44) (48) (16)
Carcinoma, Metastatic, Kidney 1 (2%)
Spleen (50) (50) (49) (50) (20)
Capsule, Carcinoma, Metastatic, Kidney 1 (2%)
Thymus (50) (48) (47) (50) (20)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50) (20)
Adenoma 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Fibroadenoma 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Skin (50) (50) (49) (50) (20)
Basal Cell Adenoma 1 (2%) 2 (4%) 1 (5%)
Keratoacanthoma 1 (2%) 2 (4%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Trichoepithelioma 1 (2%)
Pinna, Neural Crest Tumor 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 5 (10%) 3 (6%) 2 (4%) 1 (5%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DECALIN Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49) (50) (20)
Osteosarcoma 1 (2%)
Cranium, Osteoma 1 (2%)
Cranium, Squamous Cell Carcinoma, Metastatic,
Oral Mucosa 1 (2%)
Skeletal Muscle (1) (5)
Histiocytic Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50) (20)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50) (20)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (5%)
Carcinoma, Metastatic, Kidney 1 (2%) 1 (2%)
Carcinoma, Metastatic, Urinary Bladder 1 (2%)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma, Metastatic, Skeletal
Muscle 1 (2%)
Neural Crest Tumor, Metastatic, Skin 1 (2%)
Pleura (9) (8) (8) (5) (6)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (2) (1)
Carcinoma, Metastatic, Pituitary Gland 1 (50%)
Harderian Gland (1) (2)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (50%)
Zymbal's Gland (2) (2)
Carcinoma 2 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DECALIN Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50) (20)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma, Metastatic, Skeletal
Muscle 1 (2%)
Bilateral, Renal Tubule, Carcinoma 1 (2%)
Cortex, Renal Tubule, Adenoma 1 (2%) 2 (4%) 6 (12%) 9 (18%) 3 (15%)
Cortex, Renal Tubule, Adenoma, Multiple 1 (5%)
Cortex, Renal Tubule, Carcinoma 1 (2%) 4 (8%) 1 (5%)
Pelvis, Transitional Epithelium, Carcinoma 1 (2%)
Pelvis, Transitional Epithelium, Papilloma 1 (2%)
Renal Tubule, Adenoma 1 (5%)
Urinary Bladder (50) (49) (49) (49) (20)
Transitional Epithelium, Carcinoma 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(49) *(50) *(20)
Histiocytic Sarcoma 2 (4%)
Leukemia Mononuclear 19 (38%) 23 (46%) 27 (55%) 25 (50%) 10 (50%)
Lymphoma Malignant 1 (2%) 1 (2%)
Mesothelioma Malignant 1 (2%) 2 (4%) 2 (4%) 5 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DECALIN Date: 08/24/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 49 50 20
Total Primary Neoplasms 127 145 154 161 62
Total Animals with Benign Neoplasms 47 49 49 48 20
Total Benign Neoplasms 94 111 111 102 45
Total Animals with Malignant Neoplasms 27 28 32 42 13
Total Malignant Neoplasms 32 34 42 59 17
Total Animals with Metastatic Neoplasms 5 2 4
Total Metastatic Neoplasm 18 2 16
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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