TDMS Study 93029-03 Pathology Tables
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 Facility: National Center for Toxicological Research Chemical CAS #: 129-73-7 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5| | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4| | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + + + + + | Sarcoma | X | Schwannoma Malignant, Metastatic, | | Uterus | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Schwannoma Malignant, Metastatic, | | Uterus | X | Acinar Cell, Adenoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5| | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4| | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Forestomach, Leukemia Mononuclear | X | Glandular, Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Leukemia Mononuclear | X | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + I + + + + + + + + + + + + +| Cortex, Leukemia Mononuclear | X X| Medulla, Leukemia Mononuclear | X X | |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + I + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + I + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + M M + + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + I + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5| | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4| | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | Schwannoma Malignant, Metastatic, | | Uterus | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X | Leukemia Mononuclear | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| |__________________________________________________________________________| Oviduct | | Leiomyoma | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | Leukemia Mononuclear | X| Polyp Stromal | X X X X| Sarcoma Stromal | | Schwannoma Malignant | X | Bilateral, Polyp Stromal | | |__________________________________________________________________________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5| | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4| | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Leukemia Mononuclear | | Mandibular, Leukemia Mononuclear | X X | Mediastinal, Leukemia Mononuclear | X X | Mesenteric, Leukemia Mononuclear | X X | Mesenteric, Schwannoma Malignant, | | Metastatic, Uterus | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Thymus | + + + + + + + M + + + + + M + + + + + + + + + M +| Leukemia Mononuclear | X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X X X X X X X X | Leukemia Mononuclear | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Leukemia Mononuclear | X | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5| | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4| | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Leukemia Mononuclear | X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Lids, Sarcoma | X | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lacrimal Gland | + + + | |__________________________________________________________________________| Zymbal's Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5| | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4| | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| Sarcoma | X | Renal Tubule, Carcinoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 7 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L | | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + | 46 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Hepatocellular Adenoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X | 17 | |__________________________________________________________________________|____________| Mesentery | + | 8 | Sarcoma | | 1 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | Acinar Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L | | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Forestomach, Leukemia Mononuclear | | 1 | Glandular, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Aorta, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Cortex, Leukemia Mononuclear | X X | 4 | Medulla, Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L | | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | A + + + M + + + + + + + + + + + + + + + M + + | 42 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X | 26 | |__________________________________________________________________________|____________| Thyroid Gland | A + + + + + + + + + + + + + + + + + + + + + + | 46 | C-Cell, Adenoma | X X | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 1 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Adenoma | X X X X | 7 | Carcinoma | X | 2 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Oviduct | + | 1 | Leiomyoma | X | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leiomyoma | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L | | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 2 | Polyp Stromal | X X X X X | 9 | Sarcoma Stromal | X | 1 | Schwannoma Malignant | | 1 | Bilateral, Polyp Stromal | X | 1 | |__________________________________________________________________________|____________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Lumbar, Leukemia Mononuclear | X X | 2 | Mandibular, Leukemia Mononuclear | X X | 4 | Mediastinal, Leukemia Mononuclear | X | 3 | Mesenteric, Leukemia Mononuclear | X X | 4 | Mesenteric, Schwannoma Malignant, | | | Metastatic, Uterus | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X X X X X X X | 17 | |__________________________________________________________________________|____________| Thymus | + + + + + M + + + + + + M + + + + + M + + + M | 41 | Leukemia Mononuclear | | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L | | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Fibroadenoma | X X X X X X X X X X X | 20 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Basal Cell Adenoma | X | 1 | Leukemia Mononuclear | | 1 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A | 0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L | | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Alveolar/Bronchiolar Adenoma | X | 1 | Leukemia Mononuclear | X X X X | 9 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Lids, Sarcoma | | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Lacrimal Gland | + + + + + + + | 10 | |__________________________________________________________________________|____________| Zymbal's Gland | + + + + + M + + + + + + + + + + + + + + + + + | 46 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 2 | Sarcoma | | 1 | Renal Tubule, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X X X X X X X | 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1| | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6| | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| Ileum, Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Mesentery | + + + | Leukemia Mononuclear | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 14 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1| | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6| | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Parathyroid Gland | + M M M + + + + + + + M + M M + + M + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + M + + + + + + + + + M + + + + + + + + + + + + +| C-Cell, Adenoma | X X | C-Cell, Carcinoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 15 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1| | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6| | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X | Carcinoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X X X | Bilateral, Polyp Stromal | X | Cervix, Squamous Cell Papilloma | X | Endometrium, Adenoma | | Endometrium, Carcinoma | X | |__________________________________________________________________________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Leukemia Mononuclear | X X | Mesenteric, Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | X | Thoracic, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________|__________________________________________________________________________| Page 16 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1| | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6| | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | |__________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Adenoma | X | Carcinoma | X | Fibroadenoma | X X X X X X X X | Leukemia Mononuclear | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Fibroma | | Keratoacanthoma | | Sarcoma | X X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cerebrum, Leukemia Mononuclear | X | |__________________________________________________________________________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1| | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6| | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | |__________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Leukemia Mononuclear | X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | | Pinna, Neural Crest Tumor | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lacrimal Gland | + + | |__________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 18 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1| | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6| | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Leukemia Mononuclear | X | Transitional Epithelium, Carcinoma | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Leukemia Mononuclear | X X X X X X | __________________________________________|__________________________________________________________________________| Page 19 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L | | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Ileum, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Hepatocellular Adenoma | X X | 3 | Leukemia Mononuclear | X X | 8 | |__________________________________________________________________________|____________| Mesentery | + + + + | 7 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L | | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + + + + + + M + M + + + + + + M | 37 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + I + + + + + + + + + + + + | 47 | Leukemia Mononuclear | | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X | 23 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L | | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Adenoma | X X X X X | 7 | C-Cell, Carcinoma | | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Adenoma | X X X | 8 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | Polyp Stromal | X X X X X X | 10 | Bilateral, Polyp Stromal | X | 2 | Cervix, Squamous Cell Papilloma | | 1 | Endometrium, Adenoma | X | 1 | Endometrium, Carcinoma | | 1 | |__________________________________________________________________________|____________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L | | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Mandibular, Leukemia Mononuclear | X | 3 | Mesenteric, Leukemia Mononuclear | | 2 | Pancreatic, Leukemia Mononuclear | X | 1 | Renal, Leukemia Mononuclear | | 1 | Thoracic, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X | 8 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M | 46 | Adenoma | | 1 | Carcinoma | | 1 | Fibroadenoma | X X X X | 12 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Basal Cell Adenoma | X | 1 | Fibroma | X | 1 | Keratoacanthoma | X | 1 | Sarcoma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L | | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Cerebrum, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Alveolar/Bronchiolar Adenoma | | 2 | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L | | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | + | 1 | Pinna, Neural Crest Tumor | X | 1 | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Lacrimal Gland | + + + + | 6 | |__________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + M + | 47 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | | 1 | Transitional Epithelium, Carcinoma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Hemangiosarcoma | | 1 | Leukemia Mononuclear | X X | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| | 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 272 PPM | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1| | 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| |__________________________________________________________________________| Mesentery | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Sarcoma | | |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Glandular, Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 26 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| | 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 272 PPM | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1| | 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Squamous Cell Carcinoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Endocardium, Schwannoma Malignant | X | Myocardium, Schwannoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Medulla, Pheochromocytoma Malignant | | Medulla, Pheochromocytoma Benign | X | |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + M + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + M + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + M + + M + + + + + + + + + + + + + + + M + + + +| |__________________________________________________________________________| Pituitary Gland | M + + + M + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Bilateral, C-Cell, Adenoma | X | Bilateral, C-Cell, Carcinoma | X | C-Cell, Adenoma | X X | Follicular Cell, Carcinoma | | __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| | 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 272 PPM | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1| | 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | | Abdominal, Lipoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Polyp Stromal | X X X X X X X X X| Schwannoma Malignant | X | Bilateral, Polyp Stromal | X X | |__________________________________________________________________________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Leukemia Mononuclear | X| Mandibular, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | | Mesenteric, Leukemia Mononuclear | X| Pancreatic, Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| | 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 272 PPM | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1| | 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| |__________________________________________________________________________| Thymus | + M + + + M + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Fibroadenoma | X X X X | Fibroadenoma, Multiple | X X | Leukemia Mononuclear | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranial Nerve, Schwannoma Malignant | X | |__________________________________________________________________________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 29 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| | 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 272 PPM | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1| | 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | |__________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Lacrimal Gland | + + + + + | |__________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________|__________________________________________________________________________| Page 30 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| | 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 272 PPM | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1| | 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Mesenchymal Tumor Benign | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L | | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X | 5 | |__________________________________________________________________________|____________| Mesentery | + | 1 | |__________________________________________________________________________|____________| Pancreas | + + M + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 1 | Sarcoma | X | 1 | |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Glandular, Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L | | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 1 | Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Endocardium, Schwannoma Malignant | | 1 | Myocardium, Schwannoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Medulla, Pheochromocytoma Malignant | X | 1 | Medulla, Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 46 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M + M + M + + + M + + M + + | 40 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + | 45 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L | | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma | X X X X X X X | 17 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + I + + + + + | 47 | Leukemia Mononuclear | X | 1 | Bilateral, C-Cell, Adenoma | | 1 | Bilateral, C-Cell, Carcinoma | | 1 | C-Cell, Adenoma | X X | 4 | Follicular Cell, Carcinoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 1 | Abdominal, Lipoma | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + + + | 46 | Adenoma | X | 3 | Carcinoma | X | 2 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 1 | Polyp Stromal | X X X X X X X | 16 | Schwannoma Malignant | | 1 | Bilateral, Polyp Stromal | X | 3 | |__________________________________________________________________________|____________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L | | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Lumbar, Leukemia Mononuclear | X | 2 | Mandibular, Leukemia Mononuclear | X | 1 | Mediastinal, Leukemia Mononuclear | X | 1 | Mesenteric, Leukemia Mononuclear | X X X | 4 | Pancreatic, Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X | 5 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + M + + + + + + + + + M + | 44 | Leukemia Mononuclear | X X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Adenoma | | 1 | Carcinoma | X | 2 | Fibroadenoma | X X X X X | 9 | Fibroadenoma, Multiple | X | 3 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Fibrous Histiocytoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L | | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + M + | 47 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Cranial Nerve, Schwannoma Malignant | | 1 | |__________________________________________________________________________|____________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Alveolar/Bronchiolar Adenoma | X | 3 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | X X X | 4 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L | | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Lacrimal Gland | + + + | 8 | |__________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 1 | Mesenchymal Tumor Benign | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| DAY ON TEST | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3| | 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 543 PPM | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5| | 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| Colon, Adenocarcinoma | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X X| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Mesentery | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Parotid Gland, Adenoma | X | |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 38 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| DAY ON TEST | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3| | 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 543 PPM | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5| | 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cortex, Leukemia Mononuclear | X X X | Medulla, Leukemia Mononuclear | X X | |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + M + + + M M M + + + M M + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| DAY ON TEST | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3| | 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 543 PPM | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5| | 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | X | Leukemia Mononuclear | X | Polyp Stromal | X X X X X X X| Sarcoma Stromal | X | Bilateral, Polyp Stromal | | Endometrium, Adenoma | X | |__________________________________________________________________________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Leukemia Mononuclear | X X | Mesenteric, Leukemia Mononuclear | X X X | Thoracic, Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Thymus | M M + M + + + + + + + M + + + + + + + M + + + + M| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| DAY ON TEST | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3| | 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 543 PPM | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5| | 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Fibroadenoma | X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | X| Fibroma | X | Keratoacanthoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 41 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7| DAY ON TEST | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3| | 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 543 PPM | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5| | 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lacrimal Gland | + + + | |__________________________________________________________________________| Zymbal's Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________|__________________________________________________________________________| Page 42 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L | | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Colon, Adenocarcinoma | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Hepatocellular Adenoma | X | 3 | Leukemia Mononuclear | X X | 8 | |__________________________________________________________________________|____________| Mesentery | + + + | 4 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Parotid Gland, Adenoma | | 1 | |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L | | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Cortex, Leukemia Mononuclear | X | 4 | Medulla, Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + M + + + + + + + + + + M M + M + | 36 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + I + + + + + + + + + + + + + + + + + + | 46 | Pars Distalis, Adenoma | X X X X X X X X X X X | 20 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L | | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Bilateral, C-Cell, Adenoma | | 1 | C-Cell, Adenoma | X X | 4 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Adenoma | X X X | 6 | Carcinoma | X X | 2 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leiomyoma | | 1 | Leukemia Mononuclear | | 1 | Polyp Stromal | X X X X X X X X X | 16 | Sarcoma Stromal | | 1 | Bilateral, Polyp Stromal | X | 1 | Endometrium, Adenoma | | 1 | |__________________________________________________________________________|____________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L | | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Mandibular, Leukemia Mononuclear | X | 3 | Mesenteric, Leukemia Mononuclear | | 3 | Thoracic, Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X | 8 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + | 42 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Adenoma | X | 2 | Carcinoma | X X | 2 | Fibroadenoma | X X X X X X X | 13 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Basal Cell Carcinoma | | 1 | Fibroma | | 1 | Keratoacanthoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L | | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 4 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L | | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Lacrimal Gland | + | 4 | |__________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + M + | 46 | Adenoma | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3| | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| Cecum, Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| Duodenum, Leukemia Mononuclear | X | Ileum, Leiomyoma | | Ileum, Leukemia Mononuclear | X | Jejunum, Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + | Mesothelioma Malignant | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3| | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Forestomach, Leukemia Mononuclear | X | Glandular, Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Leukemia Mononuclear | X X | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cortex, Adenoma | X | Cortex, Leukemia Mononuclear | X X X | Medulla, Leukemia Mononuclear | X X | Medulla, Pheochromocytoma Benign | X | |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Leukemia Mononuclear | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + M + M + +| __________________________________________|__________________________________________________________________________| Page 50 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3| | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Pituitary Gland | + + M + + + + + + + + + M + + + + + + + M + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | | Pelvic, Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X X| Leukemia Mononuclear | X X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X X | __________________________________________|__________________________________________________________________________| Page 51 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3| | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Leukemia Mononuclear | X | Deep Cervical, Leukemia Mononuclear | X | Lumbar, Leukemia Mononuclear | X | Mandibular, Leukemia Mononuclear | X X| Mediastinal, Leukemia Mononuclear | X | Mesenteric, Leukemia Mononuclear | X X X X X X X| Renal, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thymus | + + M + M + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M + M M + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | Keratoacanthoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Sternum, Leukemia Mononuclear | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 52 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3| | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Leukemia Mononuclear | X | Cerebellum, Leukemia Mononuclear | X | Cerebrum, Leukemia Mononuclear | X | |__________________________________________________________________________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| Thoracic, Leukemia Mononuclear | X | |__________________________________________________________________________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 53 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3| | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Ear | + | Pinna, Neural Crest Tumor | X | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lids, Sarcoma | X | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Zymbal's Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| Mesothelioma Malignant | | __________________________________________|__________________________________________________________________________| Page 54 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | | DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | | | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L | | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Cecum, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + | 47 | Duodenum, Leukemia Mononuclear | | 1 | Ileum, Leiomyoma | X | 1 | Ileum, Leukemia Mononuclear | | 1 | Jejunum, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Hepatocellular Adenoma | X | 2 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X | 27 | |__________________________________________________________________________|____________| Mesentery | + + | 5 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 55 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | | DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | | | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L | | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Leukemia Mononuclear | | 3 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Forestomach, Leukemia Mononuclear | | 1 | Glandular, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Aorta, Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Cortex, Adenoma | | 1 | Cortex, Leukemia Mononuclear | X X | 5 | Medulla, Leukemia Mononuclear | X X X X | 6 | Medulla, Pheochromocytoma Benign | X X | 3 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | | DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | | | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L | | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + + + | 47 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Adenoma | X X X | 5 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + M + + + M + + M + + + + M + + M + + + M M + | 38 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 | Leukemia Mononuclear | | 1 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X | 30 | |__________________________________________________________________________|____________| Thyroid Gland | I + + + + + + + + + + + + + + + + + + + + + + | 47 | C-Cell, Adenoma | X X | 6 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 1 | Pelvic, Mesothelioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | + + + + + + + + + + + + + + M + + + + + + + + | 46 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Mesothelioma Malignant | X X | 2 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Adenoma | X X X | 5 | Carcinoma | X X X | 6 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 57 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | | DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | | | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L | | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Mesothelioma Malignant | X X | 2 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X | 22 | Interstitial Cell, Adenoma | X X X X X X X X | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Axillary, Leukemia Mononuclear | | 1 | Deep Cervical, Leukemia Mononuclear | | 1 | Lumbar, Leukemia Mononuclear | | 1 | Mandibular, Leukemia Mononuclear | X | 3 | Mediastinal, Leukemia Mononuclear | X | 2 | Mesenteric, Leukemia Mononuclear | X X | 9 | Renal, Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 58 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | | DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | | | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L | | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X X X X X | 29 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + M M + + M + | 43 | Leukemia Mononuclear | X | 6 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + M M + + + + + + + + + | 43 | Fibroadenoma | X | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Fibroma | X X X | 4 | Keratoacanthoma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Sternum, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Brain Stem, Leukemia Mononuclear | | 1 | Cerebellum, Leukemia Mononuclear | | 1 | Cerebrum, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | | DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | | | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L | | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | | | | Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Thoracic, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Alveolar/Bronchiolar Adenoma | | 1 | Leukemia Mononuclear | X X X X X | 19 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | Pinna, Neural Crest Tumor | | 1 | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | Lids, Sarcoma | | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | | DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | | | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L | | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Zymbal's Gland | + + + + + + + + + M + + + + + + + + + + + + + | 46 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X | 4 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X X X X X X X X X | 29 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2| | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4| | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| Rectum, Sarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| Ileum, Leiomyoma | X| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X X X | Sarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Mesentery | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Sarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 62 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2| | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4| | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Medulla, Pheochromocytoma | | Benign | | Cortex, Adenoma | X | Cortex, Leukemia Mononuclear | X | Medulla, Leukemia Mononuclear | X X | Medulla, Pheochromocytoma Malignant | | Medulla, Pheochromocytoma Benign | X X | |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + I + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | | |__________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + M + + + + + + + + M +| |__________________________________________________________________________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 63 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2| | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4| | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | + + + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Penis | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Sarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 64 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2| | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4| | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| Inguinal, Leukemia Mononuclear | | Mandibular, Leukemia Mononuclear | | Mesenteric, Leukemia Mononuclear | X X X | Pancreatic, Leukemia Mononuclear | X | Thoracic, Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + M + + + + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | |__________________________________________________________________________| Thymus | M M + + + + + + + + + + + M + M + + + + + + + +| Fibrous Histiocytoma | | Histiocytic Sarcoma | X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + M| Fibroadenoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | Fibrous Histiocytoma | | Keratoacanthoma | X X X | Lipoma | X | Sarcoma | X | Squamous Cell Papilloma | | Face, Squamous Cell Papilloma | X | Sebaceous Gland, Adenoma | | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2| | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4| | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Femur, Sarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Cerebrum, Astrocytoma Malignant | | |__________________________________________________________________________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X | Sarcoma, Metastatic, Skin | X | Alveolar/Bronchiolar, Adenoma | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| Page 66 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2| | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4| | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + M + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Papilloma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L | | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Rectum, Sarcoma, Metastatic, Skin | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Ileum, Leiomyoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 46 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Hepatocellular Adenoma | X | 2 | Leukemia Mononuclear | X X X X X X X | 15 | Sarcoma, Metastatic, Skin | | 1 | |__________________________________________________________________________|____________| Mesentery | + + | 3 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | X | 1 | Sarcoma, Metastatic, Skin | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 68 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L | | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Bilateral, Medulla, Pheochromocytoma | | | Benign | X | 1 | Cortex, Adenoma | | 1 | Cortex, Leukemia Mononuclear | X | 2 | Medulla, Leukemia Mononuclear | X | 3 | Medulla, Pheochromocytoma Malignant | X X | 2 | Medulla, Pheochromocytoma Benign | X X X | 5 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 46 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L | | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Adenoma | X | 2 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + M + + + + + + + M + + + + + | 41 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 | Leukemia Mononuclear | X | 1 | Pars Distalis, Adenoma | X X X X X X X X X X | 19 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | C-Cell, Adenoma | X X X X | 7 | C-Cell, Carcinoma | X | 2 | Follicular Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | + + + + M + + + + + + + + + + + + + + + + + + | 45 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Sarcoma, Metastatic, Skin | X | 2 | |__________________________________________________________________________|____________| Penis | + | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Adenoma | | 2 | Sarcoma, Metastatic, Skin | X | 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 70 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L | | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X | 30 | Interstitial Cell, Adenoma | X X X X X X | 12 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Inguinal, Leukemia Mononuclear | X | 1 | Mandibular, Leukemia Mononuclear | X | 1 | Mesenteric, Leukemia Mononuclear | X X | 5 | Pancreatic, Leukemia Mononuclear | X | 2 | Thoracic, Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 45 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | X X X X X X X X | 16 | |__________________________________________________________________________|____________| Thymus | + + + + + + + M + + + + + + + + + + + + + + + | 42 | Fibrous Histiocytoma | X | 1 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 71 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L | | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + M + + + M + + + + M + + + + + + + + M + | 41 | Fibroadenoma | X | 2 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Fibroma | | 1 | Fibrous Histiocytoma | X | 1 | Keratoacanthoma | | 3 | Lipoma | X X | 3 | Sarcoma | X X | 3 | Squamous Cell Papilloma | X | 1 | Face, Squamous Cell Papilloma | | 1 | Sebaceous Gland, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Femur, Sarcoma, Metastatic, Skin | | 1 | |__________________________________________________________________________|____________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Cerebrum, Astrocytoma Malignant | X | 1 | |__________________________________________________________________________|____________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 72 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L | | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X | 8 | Sarcoma, Metastatic, Skin | | 1 | Alveolar/Bronchiolar, Adenoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Zymbal's Gland | + + + + + + I + M M + + + + + + + + + + + + + | 43 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 73 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L | | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | X X X X X X X X | 16 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 74 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3| | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8| | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| Colon, Adenoma | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + A +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Mesentery | + + + + | Leukemia Mononuclear | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + M +| Glandular, Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________|__________________________________________________________________________| Page 75 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3| | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8| | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + M +| |__________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cortex, Adenoma | X | Cortex, Leukemia Mononuclear | X X | Medulla, Leukemia Mononuclear | X X X | Medulla, Pheochromocytoma Benign | | |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + M + + + + + + + M M + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 76 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3| | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8| | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Adenoma | X X X X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X X X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Leukemia Mononuclear | X X X X | Mediastinal, Leukemia Mononuclear | X | Mesenteric, Leukemia Mononuclear | X X X X X X | Pancreatic, Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| Page 77 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3| | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8| | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + M + + + M + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Fibroadenoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + I + + + + +| Basal Cell Carcinoma | X | Fibroma | | Fibrous Histiocytoma | X | Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Leukemia Mononuclear | X X | __________________________________________|__________________________________________________________________________| Page 78 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3| | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8| | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Cerebellum, Leukemia Mononuclear | X X X | Cerebrum, Leukemia Mononuclear | X X | |__________________________________________________________________________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| Thoracic, Leukemia Mononuclear | X | |__________________________________________________________________________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + + | Pinna, Neural Crest Tumor | X | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________|__________________________________________________________________________| Page 79 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3| | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2| 272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8| | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | |__________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Urethra | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | Mesothelioma Malignant | | __________________________________________|__________________________________________________________________________| Page 80 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L | | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Colon, Adenoma | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 46 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Hepatocellular Adenoma | X X X | 3 | Leukemia Mononuclear | X X X X X X X X | 19 | |__________________________________________________________________________|____________| Mesentery | + + | 6 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 3 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 81 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L | | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Glandular, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 5 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Cortex, Adenoma | | 1 | Cortex, Leukemia Mononuclear | | 2 | Medulla, Leukemia Mononuclear | X | 4 | Medulla, Pheochromocytoma Benign | X X | 2 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Adenoma | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L | | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Parathyroid Gland | + + + M + M + M + + + + + + + + + + + M + M + | 40 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | Pars Distalis, Adenoma | X X X X X X X X X X | 21 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | C-Cell, Adenoma | X X X | 7 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | + + + + + + + + + + + + + M + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Adenoma | X X X X | 7 | Carcinoma | X | 4 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Mesothelioma Malignant | X | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X | 38 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 83 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L | | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Interstitial Cell, Adenoma | X X | 5 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 3 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Mandibular, Leukemia Mononuclear | X | 5 | Mediastinal, Leukemia Mononuclear | | 1 | Mesenteric, Leukemia Mononuclear | | 6 | Pancreatic, Leukemia Mononuclear | X | 2 | Renal, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | X X X X X X X X | 19 | |__________________________________________________________________________|____________| Thymus | M + + + + + + + + + + + + + + + + + + + + M + | 43 | Leukemia Mononuclear | X | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + M | 46 | Carcinoma | | 1 | Fibroadenoma | | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Basal Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 84 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L | | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Fibroma | X | 1 | Fibrous Histiocytoma | | 1 | Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Brain Stem, Leukemia Mononuclear | | 2 | Cerebellum, Leukemia Mononuclear | | 3 | Cerebrum, Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + M + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Thoracic, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 85 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L | | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Alveolar/Bronchiolar Adenoma | X X | 3 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | X X | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 2 | Pinna, Neural Crest Tumor | | 1 | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Zymbal's Gland | + + + M + + + + + + + + + + + + + + + + + + + | 47 | Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 | Leukemia Mononuclear | | 3 | |__________________________________________________________________________|____________| Urethra | + | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 86 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | | _____________________________________________________________________________________________________________________ T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L | | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Leukemia Mononuclear | X X X X X X X X | 19 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 87 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0| | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6| | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| Ileum, Leukemia Mononuclear | X | Jejunum, Leiomyoma | X | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Mesentery | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Acinar Cell, Adenocarcinoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | X| |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 88 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0| | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6| | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Sarcoma, Metastatic, Skin | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Cortex, Leukemia Mononuclear | X X | Medulla, Leukemia Mononuclear | X | Medulla, Pheochromocytoma Malignant | X X | Medulla, Pheochromocytoma Complex | X | Medulla, Pheochromocytoma Benign | | |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + M + + + + + + + M + M + +| |__________________________________________________________________________| Pituitary Gland | + + + M + M + + + + + + + + + + + + + + + + + +| Craniopharyngioma | | Pars Distalis, Adenoma | X X X X X X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 89 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0| | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6| | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + +| Fibrous Histiocytoma | X| Bilateral, Follicular Cell, Carcinoma| | C-Cell, Adenoma | X X | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X X X | Squamous Cell Papilloma | X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| Page 90 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0| | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6| | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Leukemia Mononuclear | X | Mandibular, Leukemia Mononuclear | X X | Mediastinal, Leukemia Mononuclear | X | Mesenteric, Leukemia Mononuclear | X X X | Pancreatic, Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Pancreas | X | Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Thymus | + + + + M + + + + + + + + M + + + + + + M + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + M + M + + + + + + + + + + M M + M + +| Fibroadenoma | X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Fibroma | X X X| Fibrous Histiocytoma | X | Keratoacanthoma | X | Sarcoma | | Squamous Cell Carcinoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Sternum, Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| Page 91 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0| | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6| | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | |__________________________________________________________________________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Leukemia Mononuclear | X | Cerebellum, Leukemia Mononuclear | X | Cerebrum, Leukemia Mononuclear | X X | |__________________________________________________________________________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Leukemia Mononuclear | X X X X X | Sarcoma, Metastatic, Skin | | Squamous Cell Carcinoma, Metastatic, | | Preputial Gland | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 92 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 _____________________________________________________________________________________________________________________ | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0| | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6| | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | X| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Mesothelioma Malignant | X | __________________________________________|__________________________________________________________________________| Page 93 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L | | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Ileum, Leukemia Mononuclear | | 1 | Jejunum, Leiomyoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 46 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | Hepatocellular Adenoma | X X | 2 | Leukemia Mononuclear | X | 6 | |__________________________________________________________________________|____________| Mesentery | + + | 3 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Acinar Cell, Adenocarcinoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 94 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L | | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Fibrous Histiocytoma | | 1 | |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | | 1 | Sarcoma, Metastatic, Skin | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Cortex, Leukemia Mononuclear | | 2 | Medulla, Leukemia Mononuclear | | 1 | Medulla, Pheochromocytoma Malignant | X | 3 | Medulla, Pheochromocytoma Complex | | 1 | Medulla, Pheochromocytoma Benign | X X X | 3 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 95 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L | | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adenoma | X X X | 4 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M | 42 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 | Craniopharyngioma | X | 1 | Pars Distalis, Adenoma | X X X X X X | 13 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 | Fibrous Histiocytoma | | 1 | Bilateral, Follicular Cell, Carcinoma| X | 1 | C-Cell, Adenoma | X X | 4 | Follicular Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Adenoma | X | 3 | Carcinoma | X X X X X | 9 | Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 96 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L | | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X | 39 | Interstitial Cell, Adenoma | X | 6 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Lumbar, Leukemia Mononuclear | | 1 | Mandibular, Leukemia Mononuclear | | 2 | Mediastinal, Leukemia Mononuclear | | 1 | Mesenteric, Leukemia Mononuclear | | 3 | Pancreatic, Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Adenocarcinoma, Metastatic, Pancreas | | 1 | Leukemia Mononuclear | X X | 7 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + + + + M + | 42 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 97 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L | | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + | 41 | Fibroadenoma | X X | 4 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Basal Cell Adenoma | X | 1 | Fibroma | X X | 5 | Fibrous Histiocytoma | | 1 | Keratoacanthoma | X | 2 | Sarcoma | X X X X | 4 | Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Sternum, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Brain Stem, Leukemia Mononuclear | | 1 | Cerebellum, Leukemia Mononuclear | | 1 | Cerebrum, Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 98 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L | | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | | | | Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Alveolar/Bronchiolar Adenoma | X X | 4 | Leukemia Mononuclear | | 5 | Sarcoma, Metastatic, Skin | X | 1 | Squamous Cell Carcinoma, Metastatic, | | | Preputial Gland | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Fibrous Histiocytoma | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + | 47 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 99 NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03 Route: DOSED FEED Time: 15:01:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L | | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 47 | Leukemia Mononuclear | X X | 7 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 100 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------