TDMS Study 93029-03 Pathology Tables
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
Facility: National Center for Toxicological Research
Chemical CAS #: 129-73-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|
DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|
| 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|
| 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Rectum, Inflammation | 2 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Lymphoid Tissue, Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Basophilic Focus, Multiple | X X X X X X X X X X X X |
Degeneration, Cystic | 2 1 |
Developmental Malformation | X X X |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X |
Infiltration Cellular, Lymphocyte | 2 1 |
Inflammation, Focal, Granulomatous | 2 2 2 2 3 1 |
Mixed Cell Focus | |
Necrosis | 2 |
Tension Lipidosis | |
Vacuolization Cytoplasmic | 1 3 3 2 |
Bile Duct, Hyperplasia | 2 2 2 1 1 1 |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|
DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|
| 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|
| 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Necrosis | 3 2 2 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Acinus, Atrophy | 2 1 2 2 1 2 3 1 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Edema | 2 |
Forestomach, Inflammation | 3 3 |
Forestomach, Epithelium, Hyperplasia | 3 3 |
Glandular, Edema | 3 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 2 2 1 2 1 2 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + I + + + + + + + + + + + + +|
Cortex, Angiectasis | 1 1 |
Cortex, Degeneration | |
Cortex, Hyperplasia, Focal | 1 2 1 |
Cortex, Hypertrophy, Focal | 1 |
Cortex, Vacuolization Cytoplasmic | 2 3|
Medulla, Hyperplasia | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|
DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|
| 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|
| 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Gland, Cortex | + + + + + + + + + + + I + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + I + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + I + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Pars Distalis, Cyst | X X X|
Pars Distalis, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Inflammation | 2 2 3 2 1 1 1 1 1 2 3 2 2 3 2 1|
Duct, Dilatation | 2 2 2 3 3 2 3 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 2 |
Cyst | X X X X |
Infiltration Cellular, Lymphocyte | |
|__________________________________________________________________________|
Oviduct | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Cervix, Hypertrophy | X |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|
DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|
| 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|
| 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Endometrium, Hyperplasia, Cystic | 2 1 |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Exudate, Mucous | |
Inflammation, Suppurative | 2 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Ectasia | |
Lumbar, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Infiltration Cellular, | |
Plasma Cell | 2|
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 |
Mesenteric, Ectasia | |
Mesenteric, Hyperplasia, Lymphoid | |
Renal, Ectasia | |
Renal, Hemorrhage | 2 |
Renal, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 2 |
Pigmentation | |
|__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + M + + + + + + + + + M +|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|
DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|
| 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|
| 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X |
Hyperplasia | 2 2 2 1 2 1 2 3 1|
Duct, Dilatation | 2 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Epidermis, Hyperplasia | 3 |
Epidermis, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 3 |
Femur, Osteopetrosis | |
Sternum, Fibrous Osteodystrophy | 3 |
Sternum, Osteopetrosis | |
Turbinate, Osteopetrosis | |
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Hemorrhage | |
Brain Stem, Hypothalamus, Compression| 3 2 3 2 |
Cerebrum, Hemorrhage | 1|
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|
DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|
| 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|
| 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 |
Bilateral, Cataract | 2 |
Bilateral, Retina, Degeneration | 3 |
Conjunctiva, Inflammation | |
Retina, Autolysis | X X X |
Sclera, Metaplasia, Osseous | 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 1 1 1 1 |
|__________________________________________________________________________|
Lacrimal Gland | + + + |
Infiltration Cellular, Lymphocyte | |
Metaplasia | 2 2 2 |
|__________________________________________________________________________|
Zymbal's Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|
DAY ON TEST | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|
| 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
0 PPM | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|
| 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Mineralization | 2 2 2 2 2 2 2 2 2 2 3 2 2 1 2 2 2 2 2 2 1 2 2 2 2|
Necrosis, Focal | 1 |
Nephropathy | 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 3 1 |
Pigmentation | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 8
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L |
| 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Rectum, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ileum, Lymphoid Tissue, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basophilic Focus | X X | 3 |
Basophilic Focus, Multiple | X X X X X X X X | 20 |
Degeneration, Cystic | 3 | 3 2.0|
Developmental Malformation | X X X X | 7 |
Eosinophilic Focus | X X X | 3 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X | 4 |
Infiltration Cellular, Lymphocyte | | 2 1.5|
Inflammation, Focal, Granulomatous | 1 1 4 1 | 10 1.9|
Mixed Cell Focus | X | 1 |
Necrosis | 2 1 2 | 4 1.8|
Tension Lipidosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L |
| 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Vacuolization Cytoplasmic | 1 | 5 2.0|
Bile Duct, Hyperplasia | 2 1 2 1 2 1 1 2 2 1 | 16 1.5|
|__________________________________________________________________________|____________|
Mesentery | + | 8 |
Fat, Necrosis | 2 | 6 2.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation | | 1 2.0|
Acinus, Atrophy | 2 3 2 2 2 1 2 3 2 3 3 | 20 2.1|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | | 2 2.0|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Forestomach, Edema | | 1 2.0|
Forestomach, Inflammation | | 2 3.0|
Forestomach, Epithelium, Hyperplasia | | 2 3.0|
Glandular, Edema | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | 1 2 1 1 1 1 1 2 1 2 1 1 1 2 1 2 2 | 35 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L |
| 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cortex, Angiectasis | 1 1 2 2 3 2 | 8 1.6|
Cortex, Degeneration | 3 | 1 3.0|
Cortex, Hyperplasia, Focal | 1 | 4 1.3|
Cortex, Hypertrophy, Focal | 2 | 2 1.5|
Cortex, Vacuolization Cytoplasmic | | 2 2.5|
Medulla, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | A + + + M + + + + + + + + + + + + + + + M + + | 42 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Angiectasis | 1 | 3 1.3|
Pars Distalis, Cyst | X X X X X | 8 |
Pars Distalis, Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | A + + + + + + + + + + + + + + + + + + + + + + | 46 |
C-Cell, Hyperplasia | 1 1 1 2 1 1 2 1 | 13 1.4|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 3 3 | 4 2.8|
Inflammation | 2 2 2 2 2 3 1 | 23 1.9|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L |
| 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Duct, Dilatation | 2 2 2 2 3 2 2 3 2 2 2 3 2 3 3 3 2 | 25 2.4|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 2 | 6 2.0|
Cyst | X X X X | 8 |
Infiltration Cellular, Lymphocyte | 3 3 2 | 3 2.7|
|__________________________________________________________________________|____________|
Oviduct | + | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation | 1 | 1 1.0|
Cervix, Hypertrophy | X X X X | 5 |
Endometrium, Hyperplasia, Cystic | 2 | 3 1.7|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cyst | X | 1 |
Exudate, Mucous | 3 | 1 3.0|
Inflammation, Suppurative | | 3 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 1 | 4 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lumbar, Ectasia | 3 | 1 3.0|
Lumbar, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mandibular, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mandibular, Infiltration Cellular, | | |
Plasma Cell | 2 2 2 | 4 2.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L |
| 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mesenteric, Ectasia | 2 2 | 2 2.0|
Mesenteric, Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal, Ectasia | 2 | 1 2.0|
Renal, Hemorrhage | | 1 2.0|
Renal, Hyperplasia, Lymphoid | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hematopoietic Cell Proliferation | | 3 3.0|
Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + M + + + + + M + + + M | 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Galactocele | X X X X X | 7 |
Hyperplasia | 1 2 2 1 2 3 1 3 3 2 2 2 3 2 2 2 | 25 2.0|
Duct, Dilatation | 2 2 2 2 2 2 2 | 10 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation | 2 | 2 2.5|
Epidermis, Hyperplasia | 2 2 | 3 2.3|
Epidermis, Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Femur, Fibrous Osteodystrophy | 2 | 2 2.5|
Femur, Osteopetrosis | 3 | 1 3.0|
Sternum, Fibrous Osteodystrophy | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L |
| 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Sternum, Osteopetrosis | 3 | 1 3.0|
Turbinate, Osteopetrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mineralization, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Brain Stem, Hemorrhage | 2 | 1 2.0|
Brain Stem, Hypothalamus, Compression| 2 3 1 2 2 2 2 | 11 2.2|
Cerebrum, Hemorrhage | | 1 1.0|
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 | 4 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3| | L |
| 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Nasolacrimal Duct, Inflammation | 2 2 2 1 2 1 2 2 2 1 1 2 2 | 21 1.8|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cataract | 2 | 2 2.0|
Bilateral, Cataract | | 1 2.0|
Bilateral, Retina, Degeneration | 2 1 2 | 4 2.0|
Conjunctiva, Inflammation | 2 | 1 2.0|
Retina, Autolysis | X X | 5 |
Sclera, Metaplasia, Osseous | | 1 1.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 2 1 1 1 1 2 | 19 1.3|
|__________________________________________________________________________|____________|
Lacrimal Gland | + + + + + + + | 10 |
Infiltration Cellular, Lymphocyte | 2 2 1 | 3 1.7|
Metaplasia | 2 2 2 2 2 2 2 | 10 2.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + M + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infarct | | 1 2.0|
Mineralization | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2 2 2 2 1 2 2 | 47 1.9|
Necrosis, Focal | | 1 1.0|
Nephropathy | 1 1 2 1 1 1 1 1 1 1 2 1 2 1 1 2 1 | 34 1.2|
Pigmentation | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|
| 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|
| 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Lymphoid Tissue, Hyperplasia | 2 |
Colon, Lymphoid Tissue, Hyperplasia | 2 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Lymphoid Tissue, Hyperplasia | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X X X X X X X X X X |
Degeneration, Cystic | 1 1 |
Developmental Malformation | X X X |
Eosinophilic Focus | X X X X |
Eosinophilic Focus, Multiple | X X |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Lymphocyte | |
Inflammation, Focal, Granulomatous | 1 2 3 2 2 2 1 1 2 |
Necrosis | 2 |
Tension Lipidosis | 3 |
Vacuolization Cytoplasmic | 1 3|
Bile Duct, Hyperplasia | 1 1 2 1 2 1 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|
| 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|
| 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Mesentery | + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Acinus, Atrophy | 1 2 2 1 1 2 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Hypertrophy, Focal | 2 |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 1 2 2 2 1 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Angiectasis | |
Cortex, Atrophy | |
Cortex, Hyperplasia, Focal | 2 2 |
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|
| 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|
| 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + M M M + + + + + + + M + M M + + M + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + M + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 1 2 2 1 2 2 2 3 1 2 1 1 2 2 2|
Duct, Dilatation | 2 2 2 2 3 2 3 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Cyst | X X X X |
Infiltration Cellular, Lymphocyte | 3 |
Periovarian Tissue, Hemorrhage | 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | X |
Hemorrhage | 3 |
Cervix, Hypertrophy | |
Endometrium, Hyperplasia, Cystic | 3 |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Mucous | 2|
Inflammation, Suppurative | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|
| 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|
| 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Myeloid Cell, Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Lymphoid | 2 |
Mandibular, Infiltration Cellular, | |
Plasma Cell | 3 2 2 2 3 |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Ectasia | |
Mesenteric, Hemorrhage | |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 |
Hyperplasia, Focal | |
Pigmentation | 2 |
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Galactocele | X X |
Hyperplasia | 2 2 2 3 2|
Infiltration Cellular, Lymphocyte | 2 |
Duct, Dilatation | 2 2 2 2 2 2 4 2|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|
| 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|
| 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Epidermis, Hyperplasia | 2 |
Epidermis, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | 3 4 |
Maxilla, Inflammation, Chronic | 3 |
Sternum, Fibrous Osteodystrophy | |
Sternum, Osteopetrosis | 3 4 |
Turbinate, Osteopetrosis | 3 4 |
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Hypothalamus, Compression| 3 2|
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|
| 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|
| 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Alveolus, Inflammation, Multifocal | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Cyst Epithelial | |
Inclusion | |
Nasolacrimal Duct, Inflammation | 2 2 1 1 2 2|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Phthisis Bulbi | |
Bilateral, Cataract | 2 |
Bilateral, Retina, Degeneration | 2 2 2 |
Retina, Autolysis | X |
Retina, Degeneration | 1 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Histiocyte | 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 2 1 1 2 1 2 1 |
|__________________________________________________________________________|
Lacrimal Gland | + + |
Infiltration Cellular, Lymphocyte | |
Metaplasia | 1 2 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|
| 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|
| 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 1 |
Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2|
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | 2 |
__________________________________________|__________________________________________________________________________
Page 22
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L |
| 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cecum, Lymphoid Tissue, Hyperplasia | | 1 2.0|
Colon, Lymphoid Tissue, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ileum, Lymphoid Tissue, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basophilic Focus | X X | 4 |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X | 26 |
Degeneration, Cystic | | 2 1.0|
Developmental Malformation | X X | 5 |
Eosinophilic Focus | | 4 |
Eosinophilic Focus, Multiple | X X X X X X | 8 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 3 1.0|
Inflammation, Focal, Granulomatous | 2 2 1 2 2 3 1 1 1 1 | 19 1.7|
Necrosis | 1 | 2 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L |
| 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Tension Lipidosis | 2 | 2 2.5|
Vacuolization Cytoplasmic | 1 1 1 | 5 1.4|
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 2 1 1 | 18 1.2|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 7 |
Accessory Spleen | X | 2 |
Fat, Necrosis | 2 2 3 | 5 2.4|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 | 2 1.0|
Acinus, Atrophy | 2 1 1 1 1 1 1 1 | 16 1.3|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Parotid Gland, Hypertrophy, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | 2 2 2 2 1 2 2 2 1 1 2 1 2 2 2 1 1 1 2 | 35 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cortex, Angiectasis | 2 2 2 2 2 2 2 1 2 2 | 10 1.9|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L |
| 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Cortex, Atrophy | 2 | 1 2.0|
Cortex, Hyperplasia, Focal | | 2 2.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + M + M + + + + + + M | 37 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + I + + + + + + + + + + + + | 47 |
Angiectasis | 3 | 1 3.0|
Pars Distalis, Cyst | X X X | 4 |
Pars Distalis, Hyperplasia | 2 2 | 4 2.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
C-Cell, Hyperplasia | 1 | 5 1.0|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 2 2 2 2 | 4 2.0|
Inflammation | 2 2 2 3 2 2 3 2 1 2 2 2 3 2 2 2 | 31 1.9|
Duct, Dilatation | 2 3 2 3 3 3 2 3 3 2 2 2 3 2 2 2 | 24 2.4|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 3 3 2 | 5 2.4|
Cyst | X | 5 |
Infiltration Cellular, Lymphocyte | 3 2 | 3 2.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L |
| 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Periovarian Tissue, Hemorrhage | | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Decidual Reaction | | 1 |
Hemorrhage | | 1 3.0|
Cervix, Hypertrophy | X X X X X | 5 |
Endometrium, Hyperplasia, Cystic | 2 2 | 3 2.3|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Exudate, Mucous | | 1 2.0|
Inflammation, Suppurative | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 1 1 | 2 1.0|
Myeloid Cell, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Bronchial, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
Mandibular, Infiltration Cellular, | | |
Plasma Cell | 2 2 2 | 8 2.3|
Mediastinal, Ectasia | 2 | 1 2.0|
Mediastinal, Hemorrhage | 2 2 | 3 2.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mesenteric, Ectasia | 3 | 1 3.0|
Mesenteric, Hemorrhage | 2 | 1 2.0|
Pancreatic, Hemorrhage | 2 | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L |
| 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hematopoietic Cell Proliferation | 2 | 4 2.0|
Hyperplasia, Focal | 4 | 1 4.0|
Pigmentation | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cyst | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M | 46 |
Galactocele | | 2 |
Hyperplasia | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1 | 20 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Duct, Dilatation | 3 2 2 2 2 | 13 2.2|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Abscess | | 1 3.0|
Epidermis, Hyperplasia | | 1 2.0|
Epidermis, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Femur, Osteopetrosis | 3 3 | 4 3.3|
Maxilla, Inflammation, Chronic | | 1 3.0|
Sternum, Fibrous Osteodystrophy | 1 | 1 1.0|
Sternum, Osteopetrosis | 3 3 | 4 3.3|
Turbinate, Osteopetrosis | 2 | 3 3.0|
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L |
| 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Brain Stem, Hypothalamus, Compression| 2 2 2 1 | 6 2.0|
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar Epithelium, Hyperplasia | 1 2 | 3 1.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 | 3 1.0|
Alveolus, Inflammation, Multifocal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | | 1 2.0|
Nasolacrimal Duct, Cyst Epithelial | | |
Inclusion | X | 1 |
Nasolacrimal Duct, Inflammation | 2 2 2 1 2 2 2 2 1 2 2 1 1 | 19 1.7|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4| | L |
| 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Phthisis Bulbi | X | 1 |
Bilateral, Cataract | | 1 2.0|
Bilateral, Retina, Degeneration | 2 | 4 2.0|
Retina, Autolysis | | 1 |
Retina, Degeneration | 2 | 3 1.3|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Focal, | | |
Histiocyte | | 1 1.0|
Infiltration Cellular, Lymphocyte | 2 1 2 1 1 1 1 1 2 1 1 1 1 1 | 26 1.3|
|__________________________________________________________________________|____________|
Lacrimal Gland | + + + + | 6 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Metaplasia | 2 2 2 2 | 6 1.8|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + M + | 47 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hydronephrosis | | 1 1.0|
Mineralization | 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 2 2 2 | 46 1.9|
Nephropathy | 1 1 1 1 1 1 2 2 1 2 1 2 2 1 1 | 31 1.2|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hemorrhage | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8|
| 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
272 PPM | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Inflammation | |
Colon, Lymphoid Tissue, Hyperplasia | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Dilatation | |
Ileum, Inflammation | |
Ileum, Lymphoid Tissue, Hyperplasia | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Basophilic Focus, Multiple | X |
Degeneration, Cystic | 1 |
Developmental Malformation | X |
Eosinophilic Focus | X X X X X X |
Eosinophilic Focus, Multiple | X X X X |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X X |
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Focal, Granulomatous | 2 2 1 1 2 2 2 2 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 1 2 2 1 2 2 2 2 2 2 |
Bile Duct, Cyst | |
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8|
| 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
272 PPM | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Hyperplasia | 2 2 2 2 2 1 2 2 1 1 |
Centrilobular, Necrosis | |
|__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | 1 |
Acinus, Atrophy | 2 1 2 2 3 2 1 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Inflammation | 2 |
Forestomach, Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 1 1 2 2 1 1 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cortex, Accessory Adrenal Cortical | |
Nodule | X X |
Cortex, Angiectasis | 2 |
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8|
| 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
272 PPM | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Cortex, Hyperplasia, Focal | 1 |
Cortex, Hypertrophy, Focal | 2 |
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + M + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | M + + + M + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 3 |
Inflammation | 2 2 1 2 2 1 2 2 1 2 2 2 1 2|
Duct, Dilatation | 2 3 2 2 2 3 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 2 2 |
Cyst | X X X X X X |
Infiltration Cellular, Lymphocyte | 2 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Hypertrophy | |
Endometrium, Hyperplasia, Cystic | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8|
| 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
272 PPM | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Mandibular, Ectasia | 2 |
Mandibular, Hyperplasia, Lymphoid | 2 2|
Mandibular, Infiltration Cellular, | |
Plasma Cell | 2 2 2 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Angiectasis | 2 |
Mesenteric, Ectasia | 2 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 |
Pigmentation | 2 3 3 |
Stromal Hyperplasia | |
|__________________________________________________________________________|
Thymus | + M + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8|
| 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
272 PPM | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Hyperplasia | 1 3 2 2 2 1 |
Duct, Dilatation | 1 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Epidermis, Hyperplasia | 2 |
Epidermis, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | 2 |
Sternum, Osteopetrosis | 2 |
Turbinate, Osteopetrosis | 2 |
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Hypothalamus, Compression| 2 2 |
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8|
| 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
272 PPM | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1|
| 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | 1 1 1 2 3 2 1 2 1 2|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Phthisis Bulbi | |
Bilateral, Retina, Degeneration | 1 2 2 |
Retina, Autolysis | |
Retina, Degeneration | 2 1 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular, Lymphocyte | 2 1 2 2 1 1 2 1 1 2 2 |
|__________________________________________________________________________|
Lacrimal Gland | + + + + + |
Metaplasia | 3 2 2 2 2 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2|
Infiltration Cellular, Lymphocyte | |
Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2|
Nephropathy | 1 1 1 1 1 2 1 2 1 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________|__________________________________________________________________________
Page 35
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L |
| 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cecum, Inflammation | 4 | 1 4.0|
Colon, Lymphoid Tissue, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ileum, Dilatation | 2 | 1 2.0|
Ileum, Inflammation | 4 | 1 4.0|
Ileum, Lymphoid Tissue, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basophilic Focus | X | 2 |
Basophilic Focus, Multiple | X | 2 |
Degeneration, Cystic | 1 2 2 2 | 5 1.6|
Developmental Malformation | X X | 3 |
Eosinophilic Focus | X X X X X X X | 13 |
Eosinophilic Focus, Multiple | X X X | 7 |
Hematopoietic Cell Proliferation | 1 1 | 3 1.0|
Hepatodiaphragmatic Nodule | X | 5 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 | 7 1.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L |
| 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation, Focal, Granulomatous | 2 2 1 2 1 2 2 1 2 1 1 | 20 1.7|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 3 2 2 1 2 2 | 17 1.8|
Bile Duct, Cyst | X X | 2 |
Bile Duct, Hyperplasia | 1 2 2 1 2 1 1 1 1 | 19 1.5|
Centrilobular, Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + M + + + + + + + + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | 1 1 | 3 1.0|
Inflammation | | 1 1.0|
Acinus, Atrophy | 2 3 2 2 2 1 2 3 | 17 1.9|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Forestomach, Inflammation | | 1 2.0|
Forestomach, Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Epithelium, Hyperplasia, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L |
| 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Cardiomyopathy | 2 1 1 2 1 1 1 2 1 2 2 2 1 1 1 2 2 1 | 33 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cortex, Accessory Adrenal Cortical | | |
Nodule | X | 3 |
Cortex, Angiectasis | 2 | 2 2.0|
Cortex, Hyperplasia, Focal | 2 1 2 | 4 1.5|
Cortex, Hypertrophy, Focal | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + M + M + + + M + + M + + | 40 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + | 45 |
Angiectasis | 4 | 1 4.0|
Pars Distalis, Cyst | X X X X X | 6 |
Pars Distalis, Hyperplasia | 2 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + I + + + + + | 47 |
C-Cell, Hyperplasia | 1 | 6 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L |
| 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Hyperplasia | 4 | 5 2.6|
Inflammation | 1 2 2 3 3 2 2 3 | 22 1.9|
Duct, Dilatation | 2 2 2 2 2 2 3 2 3 2 3 | 18 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 2 2 4 3 | 10 2.3|
Cyst | X X X X | 10 |
Infiltration Cellular, Lymphocyte | 2 | 3 2.3|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cervix, Hypertrophy | X X | 2 |
Endometrium, Hyperplasia, Cystic | 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | | 1 3.0|
Metaplasia, Squamous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 3 1 3 1 | 4 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Mandibular, Ectasia | 2 | 2 2.0|
Mandibular, Hyperplasia, Lymphoid | 3 2 | 4 2.3|
Mandibular, Infiltration Cellular, | | |
Plasma Cell | | 4 2.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mesenteric, Angiectasis | | 1 2.0|
Mesenteric, Ectasia | 3 3 | 4 2.5|
Mesenteric, Hyperplasia, Lymphoid | | 2 2.0|
Pancreatic, Hyperplasia, Lymphoid | 2 | 2 2.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L |
| 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hematopoietic Cell Proliferation | 3 3 | 6 2.5|
Pigmentation | | 3 2.7|
Stromal Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + M + | 44 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 2 2 2 2 2 1 2 2 3 1 3 1 1 | 19 1.8|
Duct, Dilatation | 2 2 2 2 | 7 1.9|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation | | 1 2.0|
Epidermis, Hyperplasia | 2 2 | 3 2.0|
Epidermis, Necrosis | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Femur, Osteopetrosis | 3 3 | 3 2.7|
Sternum, Osteopetrosis | 3 3 2 | 4 2.5|
Turbinate, Osteopetrosis | 2 3 2 | 4 2.3|
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + M + | 47 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L |
| 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Brain Stem, Hypothalamus, Compression| 3 3 1 | 5 2.2|
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 | 10 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Nasolacrimal Duct, Inflammation | 2 1 2 2 2 2 1 1 | 18 1.6|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Phthisis Bulbi | X | 1 |
Bilateral, Retina, Degeneration | 2 2 | 5 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| | L |
| 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Retina, Autolysis | X | 1 |
Retina, Degeneration | 2 2 2 | 6 1.7|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 1 2 1 2 1 1 | 22 1.4|
|__________________________________________________________________________|____________|
Lacrimal Gland | + + + | 8 |
Metaplasia | 2 2 2 | 8 2.1|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hydronephrosis | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Mineralization | 2 2 3 1 1 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 | 47 1.9|
Nephropathy | 1 1 1 3 1 1 1 1 2 1 1 1 2 1 1 1 | 27 1.2|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|
DAY ON TEST | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|
| 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|
| 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Colon, Lymphoid Tissue, Hyperplasia | 2 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Degeneration, Cystic | |
Developmental Malformation | X X |
Eosinophilic Focus | |
Eosinophilic Focus, Multiple | X X|
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Focal, Granulomatous | 2 1 1 1 1 |
Necrosis | 1 |
Tension Lipidosis, Multiple | |
Vacuolization Cytoplasmic | 2 1 2 2 2 2 2 |
Bile Duct, Hyperplasia | 1 1 1 1 2 1 |
Centrilobular, Necrosis | 3 2 |
|__________________________________________________________________________|
Mesentery | + |
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|
DAY ON TEST | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|
| 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|
| 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Accessory Spleen | |
Fat, Necrosis | 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | 2 2 1 4 1 1 1 3|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Inflammation | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 2 2 2 2 2 2 2 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Angiectasis | |
Cortex, Hyperplasia, Focal | 1 1 |
Cortex, Thrombosis | 3 |
Cortex, Vacuolization Cytoplasmic | 2 |
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|
DAY ON TEST | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|
| 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|
| 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + M + + + M M M + + + M M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation | 2 1 3 3 3 2 2 2 3 2 2 1 3 |
Duct, Dilatation | 2 2 2 2 |
Duct, Hyperplasia | 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 3 |
Cyst | X X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | X |
Hemorrhage | |
Thrombosis | |
Bilateral, Horn, Dilatation | 3 |
Cervix, Hypertrophy | |
Endometrium, Hyperplasia, Cystic | 3 2 1 |
Endometrium, Hyperplasia | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|
DAY ON TEST | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|
| 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|
| 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 2 2 |
Prolapse | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
Myelostromal Proliferation | 4 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Ectasia | 2 |
Mandibular, Hyperplasia, Lymphoid | 2 |
Mediastinal, Ectasia | 2 |
Mediastinal, Hemorrhage | |
Mesenteric, Ectasia | |
Mesenteric, Hemorrhage | 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 2|
Pancreatic, Ectasia | 3|
Pancreatic, Hemorrhage | 2|
Pancreatic, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 3 2 2 |
Pigmentation | 2 |
|__________________________________________________________________________|
Thymus | M M + M + + + + + + + M + + + + + + + M + + + + M|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|
DAY ON TEST | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|
| 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|
| 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 2 2 2 2 2|
Duct, Dilatation | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Multifocal | 2 |
Inflammation | |
Epidermis, Hyperplasia | |
Epidermis, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | |
Femur, Fracture Healed | X |
Femur, Osteopetrosis | |
Mandible, Osteopetrosis | |
Sternum, Osteopetrosis | |
Turbinate, Osteopetrosis | |
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Hypothalamus, Compression| 2 3 2|
Cerebrum, Hemorrhage | 1 |
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|
DAY ON TEST | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|
| 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|
| 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
Alveolar Epithelium, Metaplasia, | |
Focal, Squamous | |
Alveolus, Infiltration Cellular, | |
Multifocal | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 |
Alveolus, Inflammation, Multifocal | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | 2 1 2 2 2 1 2 |
Respiratory Epithelium, Concretion | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 3 2 1 |
Phthisis Bulbi | |
Bilateral, Cataract | |
Bilateral, Retina, Degeneration | 1 |
Cornea, Neovascularization | |
Retina, Autolysis | X X X |
Retina, Degeneration | 3 3 1 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 2 2 1 1 1 |
Inflammation | 1 |
|__________________________________________________________________________|
Lacrimal Gland | + + + |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|
DAY ON TEST | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|
| 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|
| 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Infiltration Cellular, Lymphocyte | 2 2 |
Metaplasia | 2 2 2 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2 1 2 2 2 2 2 2|
Nephropathy | 1 1 1 1 1 1 1 2 1 1|
Pigmentation | 2 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________|__________________________________________________________________________
Page 49
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Colon, Lymphoid Tissue, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X | 1 |
Degeneration, Cystic | 2 2 2 | 3 2.0|
Developmental Malformation | X X X | 5 |
Eosinophilic Focus | X X X X X | 5 |
Eosinophilic Focus, Multiple | X X X X X X X X X | 11 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 4 1.0|
Inflammation, Focal, Granulomatous | 1 2 1 1 1 1 1 1 | 13 1.2|
Necrosis | 1 2 | 3 1.3|
Tension Lipidosis, Multiple | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 2 1 2 1 2 2 2 1 1 1 1 2 2 2 | 22 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Bile Duct, Hyperplasia | 1 1 2 2 1 1 1 1 2 2 1 1 | 18 1.3|
Centrilobular, Necrosis | | 2 2.5|
|__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Accessory Spleen | X | 1 |
Fat, Necrosis | 3 3 | 3 2.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Acinus, Atrophy | 2 3 1 2 1 2 2 2 1 3 | 18 1.9|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Forestomach, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | 1 1 2 1 1 2 2 1 1 1 2 1 1 2 1 2 | 30 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cortex, Angiectasis | 1 2 1 | 3 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Cortex, Hyperplasia, Focal | 1 1 1 | 5 1.0|
Cortex, Thrombosis | | 1 3.0|
Cortex, Vacuolization Cytoplasmic | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M + + + + + + + + + + M M + M + | 36 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + I + + + + + + + + + + + + + + + + + + | 46 |
Angiectasis | 2 2 | 2 2.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 2 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
C-Cell, Hyperplasia | 2 | 1 2.0|
Follicle, Cyst | 1 1 | 2 1.0|
Follicular Cell, Hyperplasia | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 2 2 | 3 1.7|
Inflammation | 1 3 1 3 2 2 2 1 2 2 1 2 3 3 2 | 28 2.1|
Duct, Dilatation | 2 2 2 2 2 2 2 2 2 2 3 | 15 2.1|
Duct, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Atrophy | 3 1 3 | 7 2.1|
Cyst | X | 4 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Decidual Reaction | | 1 |
Hemorrhage | 3 | 1 3.0|
Thrombosis | X | 1 |
Bilateral, Horn, Dilatation | | 1 3.0|
Cervix, Hypertrophy | X X X X X | 5 |
Endometrium, Hyperplasia, Cystic | 2 3 2 2 | 7 2.1|
Endometrium, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | | 2 2.0|
Prolapse | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 3 | 3 2.0|
Myelostromal Proliferation | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mandibular, Ectasia | 2 | 2 2.0|
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Ectasia | | 1 2.0|
Mediastinal, Hemorrhage | 3 | 1 3.0|
Mesenteric, Ectasia | 3 2 | 2 2.5|
Mesenteric, Hemorrhage | 2 | 2 2.0|
Mesenteric, Hyperplasia, Lymphoid | | 2 2.0|
Pancreatic, Ectasia | | 1 3.0|
Pancreatic, Hemorrhage | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | | 1 2.0|
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 5 2.4|
Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + | 42 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | 2 2 2 1 1 3 2 2 2 2 1 2 3 | 22 2.0|
Duct, Dilatation | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperkeratosis, Multifocal | | 1 2.0|
Inflammation | 2 | 1 2.0|
Epidermis, Hyperplasia | 2 2 2 | 3 2.0|
Epidermis, Necrosis | 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cranium, Osteopetrosis | 3 | 1 3.0|
Femur, Fracture Healed | | 1 |
Femur, Osteopetrosis | 3 | 1 3.0|
Mandible, Osteopetrosis | 3 | 1 3.0|
Sternum, Osteopetrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Turbinate, Osteopetrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Brain Stem, Hypothalamus, Compression| 1 2 | 5 2.0|
Cerebrum, Hemorrhage | | 1 1.0|
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Alveolar Epithelium, Metaplasia, | | |
Focal, Squamous | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Multifocal | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 1 2 | 6 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolus, Inflammation, Multifocal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Nasolacrimal Duct, Inflammation | 1 1 1 1 2 2 2 1 2 1 1 1 | 19 1.5|
Respiratory Epithelium, Concretion | | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cataract | 1 1 | 5 1.6|
Phthisis Bulbi | X X | 2 |
Bilateral, Cataract | 1 1 | 2 1.0|
Bilateral, Retina, Degeneration | 2 3 3 2 2 2 | 7 2.1|
Cornea, Neovascularization | 2 | 1 2.0|
Retina, Autolysis | | 3 |
Retina, Degeneration | 2 2 2 3 1 | 9 2.1|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 2 1 | 21 1.2|
Inflammation | | 1 1.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | + | 4 |
Infiltration Cellular, Lymphocyte | | 2 2.0|
Metaplasia | 2 | 4 2.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + M + | 46 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mineralization | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 | 48 1.9|
Nephropathy | 1 1 1 1 2 2 2 1 1 2 1 1 1 1 1 1 1 1 1 | 29 1.2|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Pigmentation | | 2 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|
| 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|
0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|
| 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Lymphoid Tissue, Hyperplasia | 2 3 2 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Lymphoid Tissue, Hyperplasia | 2 |
Jejunum, Lymphoid Tissue, Hyperplasia| |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Developmental Malformation | X |
Eosinophilic Focus | X X |
Eosinophilic Focus, Multiple | X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Inflammation, Focal, Granulomatous | 2 |
Mixed Cell Focus | |
Necrosis | |
Vacuolization Cytoplasmic | 3 3 2 1 2 |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 2 3 3 2 3 2 2 3 2 3 2 2 1 2 2 3 2 2 3 2 2 3|
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|
| 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|
0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|
| 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | 2 2 2 2 2 3 2 2 2 2 1 2 2 1 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Edema | 3 |
Forestomach, Inflammation | 2 2 |
Forestomach, Epithelium, Hyperplasia | |
Glandular, Edema | 3 |
Glandular, Erosion | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2 2 3 2 |
Atrium, Thrombosis | X |
Ventricle Right, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Vacuolization Cytoplasmic | 2 |
Medulla, Hyperplasia | |
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|
| 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|
0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|
| 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + M + M + +|
Hyperplasia, Focal | 3 2 |
|__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + M + + + + + + + M + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 3 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
Abdominal, Pigmentation | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Decreased Secretory Fluid | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Cyst | X |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | |
Infiltration Cellular, Chronic | 2 |
Inflammation | 3 2 2 2 2 2 3 3 2 2 2 1 4 2 1 1 2 1 2 |
Duct, Ectasia | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decreased Secretory Fluid | 2 |
Inflammation | 2 3 3 2 2 1 1 3 2 3 2 2 2 2 2 2 4|
Ventral, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|
| 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|
0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|
| 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decreased Secretory Fluid | 3 3 3 3 2 2 2 2 2 3 2 2 2|
Lumen, Distended | |
Serosa, Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Interstitial Cell, Hyperplasia | 2 2 1 1 1 2 2 2 2 2 |
Seminiferous Tubule, Atrophy | 2 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
Lumbar, Hyperplasia, Lymphoid | |
Mandibular, Ectasia | |
Mandibular, Hemorrhage | 2 |
Mandibular, Infiltration Cellular, | |
Plasma Cell | 2 2 |
Mediastinal, Ectasia | |
Mesenteric, Ectasia | 3 2 3 |
Mesenteric, Hemorrhage | |
Mesenteric, Hyperplasia, Lymphoid | 2 |
Mesenteric, Infiltration Cellular, | |
Plasma Cell | 2 |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Infiltration Cellular, | |
Plasma Cell | 2 |
Renal, Hemorrhage | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|
| 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|
0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|
| 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 |
Hematopoietic Cell Proliferation | |
Pigmentation | 2 |
Stromal Hyperplasia | |
|__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M + M M + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X X X |
Hyperplasia | |
Duct, Dilatation | 2 1 2 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 3 |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | |
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Hemorrhage | 2 |
Brain Stem, Hypothalamus, Compression| 3 2 2 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|
| 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|
0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|
| 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | 2 1 2 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Inflammation,| |
Chronic | 2 |
Septum, Inflammation, Chronic | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | |
Hemorrhage | 3 |
Inflammation | 3 |
Bilateral, Cataract | 2 |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|
DAY ON TEST | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|
| 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|
0 PPM | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|
| 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Bilateral, Retina, Degeneration | |
Cornea, Edema | |
Retina, Autolysis | X |
Retina, Degeneration | 3 |
Sclera, Metaplasia, Osseous | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1|
Inflammation | 2 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Nephropathy | 2 2 2 2 1 2 1 1 2 2 2 2 2 1 2 3 2 2 2 3 1 1|
Pigmentation | 1 2 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 64
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | |
| 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L |
| 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cecum, Lymphoid Tissue, Hyperplasia | | 3 2.3|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + | 47 |
Ileum, Lymphoid Tissue, Hyperplasia | 2 2 2 | 4 2.0|
Jejunum, Lymphoid Tissue, Hyperplasia| 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Degeneration, Cystic | 2 2 2 | 4 2.0|
Developmental Malformation | | 1 |
Eosinophilic Focus | | 2 |
Eosinophilic Focus, Multiple | | 1 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X | 2 |
Inflammation, Focal, Granulomatous | 2 2 | 3 2.0|
Mixed Cell Focus | X | 1 |
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 2 1 2 | 9 2.0|
Bile Duct, Cyst | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | |
| 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L |
| 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Bile Duct, Hyperplasia | 3 1 2 1 3 2 2 2 3 1 3 2 2 4 2 2 3 1 2 | 41 2.2|
|__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Necrosis | 3 | 3 2.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Acinus, Atrophy | 2 2 3 2 1 2 2 2 2 1 2 1 2 | 28 1.9|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Forestomach, Edema | 3 | 2 3.0|
Forestomach, Inflammation | | 2 2.0|
Forestomach, Epithelium, Hyperplasia | 1 | 1 1.0|
Glandular, Edema | | 1 3.0|
Glandular, Erosion | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 | 37 1.9|
Atrium, Thrombosis | | 1 |
Ventricle Right, Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | |
| 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L |
| 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cortex, Vacuolization Cytoplasmic | | 1 2.0|
Medulla, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + + + | 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + + M + + + + M + + M + + + M M + | 38 |
Hyperplasia, Focal | | 2 2.5|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | I + + + + + + + + + + + + + + + + + + + + + + | 47 |
C-Cell, Hyperplasia | 2 2 1 | 8 1.8|
Follicular Cell, Hyperplasia | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Abdominal, Pigmentation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + M + + + + + + + + | 46 |
Decreased Secretory Fluid | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Serosa, Cyst | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | |
| 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L |
| 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 2 | 1 2.0|
Hyperplasia | 1 | 1 1.0|
Infiltration Cellular, Chronic | | 1 2.0|
Inflammation | 2 2 2 2 3 1 3 2 2 1 3 3 2 2 3 2 | 35 2.1|
Duct, Ectasia | 3 3 3 2 2 2 2 | 7 2.4|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Decreased Secretory Fluid | | 1 2.0|
Inflammation | 3 2 2 2 2 2 1 2 1 2 2 3 | 29 2.1|
Ventral, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Decreased Secretory Fluid | 2 2 2 3 2 2 3 2 2 3 3 2 2 2 2 | 28 2.3|
Lumen, Distended | 3 | 1 3.0|
Serosa, Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mineralization | 1 | 1 1.0|
Interstitial Cell, Hyperplasia | 2 2 2 1 1 2 2 | 17 1.7|
Seminiferous Tubule, Atrophy | 3 3 2 3 2 3 2 | 11 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | | 1 1.0|
Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
Lumbar, Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Mandibular, Ectasia | 2 3 3 | 3 2.7|
Mandibular, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | |
| 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L |
| 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mandibular, Infiltration Cellular, | | |
Plasma Cell | 2 2 2 | 5 2.0|
Mediastinal, Ectasia | 2 | 1 2.0|
Mesenteric, Ectasia | 2 | 4 2.5|
Mesenteric, Hemorrhage | 2 | 1 2.0|
Mesenteric, Hyperplasia, Lymphoid | | 1 2.0|
Mesenteric, Infiltration Cellular, | | |
Plasma Cell | 2 | 2 2.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Pancreatic, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Renal, Hemorrhage | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Fibrosis | 2 2 | 5 2.0|
Hematopoietic Cell Proliferation | 2 2 | 2 2.0|
Pigmentation | 3 3 | 3 2.7|
Stromal Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + M M + + M + | 43 |
Ectopic Parathyroid Gland | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + M M + + + + + + + + + | 43 |
Galactocele | X X | 6 |
Hyperplasia | 1 2 2 3 1 | 5 1.8|
Duct, Dilatation | 3 3 2 2 2 2 2 | 12 2.1|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | |
| 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L |
| 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Abscess | | 1 3.0|
Cyst Epithelial Inclusion | X | 2 |
Hyperkeratosis | | 1 3.0|
Epidermis, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Femur, Fibrous Osteodystrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Brain Stem, Hemorrhage | | 1 2.0|
Brain Stem, Hypothalamus, Compression| 2 2 2 3 3 | 9 2.3|
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | |
| 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L |
| 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 3 | 3 1.7|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Nasolacrimal Duct, Inflammation | 1 2 2 1 2 2 2 | 10 1.7|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
Respiratory Epithelium, Inflammation,| | |
Chronic | | 1 2.0|
Septum, Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cataract | 3 1 3 | 3 2.3|
Hemorrhage | 2 | 2 2.5|
Inflammation | | 1 3.0|
Bilateral, Cataract | 2 | 2 2.0|
Bilateral, Retina, Degeneration | 1 | 1 1.0|
Cornea, Edema | X | 1 |
Retina, Autolysis | X X X | 4 |
Retina, Degeneration | 4 2 2 1 2 1 4 | 8 2.4|
Sclera, Metaplasia, Osseous | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 1 1 1 1 2 1 1 | 16 1.2|
Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| | |
| 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 PPM | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8| | L |
| 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Zymbal's Gland | + + + + + + + + + M + + + + + + + + + + + + + | 46 |
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Nephropathy | 1 2 1 3 3 3 2 2 1 2 1 3 3 2 2 2 3 2 2 2 1 | 43 1.9|
Pigmentation | | 3 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|
| 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|
| 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Lymphoid Tissue, Hyperplasia | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
Duodenum, Autolysis | 3 |
Ileum, Lymphoid Tissue, Hyperplasia | 2 |
Jejunum, Autolysis | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Degeneration, Cystic | 1 2 1 1 1 1 1 2 1 1|
Developmental Malformation | X|
Eosinophilic Focus | X X X |
Eosinophilic Focus, Multiple | X X X |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Focal, Granulomatous | 1 |
Vacuolization Cytoplasmic | 3 2 1 2 2 2 1 1 2 2 |
Bile Duct, Hyperplasia | 2 1 2 3 3 2 2 3 2 3 2 2 2 1 3 2 3 3 2 2 1|
Centrilobular, Necrosis | |
|__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|
| 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|
| 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Acinus, Atrophy | 2 2 2 2 2 2 2 2 |
Artery, Inflammation, Chronic | |
Artery, Media, Hypertrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Edema | 3|
Forestomach, Inflammation | 2 |
Forestomach, Necrosis | |
Glandular, Edema | 3|
Glandular, Erosion | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 1 2 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Hyperplasia, Focal | 2 1 1 |
Cortex, Hypertrophy, Focal | 1 |
Cortex, Vacuolization Cytoplasmic | 2 2 |
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|
| 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|
| 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + I + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + M + + + + + + + + M +|
Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Infiltration Cellular, Histiocytic | 2 |
Pigmentation | 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 1 1 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
|__________________________________________________________________________|
Penis | |
Thrombosis | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 2 1 2 1 2 1 2 1 2 3 3 2 2 2 2 2 2|
Duct, Ectasia | 2 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|
| 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|
| 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Decreased Secretory Fluid | 2 |
Inflammation | 2 2 1 2 2 2 2 2 2 1|
Ventral, Hyperplasia | 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Decreased Secretory Fluid | 2 2 3 2 1 3 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 2 2 2 1 2 |
Seminiferous Tubule, Atrophy | 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Myeloid Cell, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Lymphoid | 2 |
Lumbar, Pigmentation | 3 |
Mandibular, Ectasia | 2 3 |
Mandibular, Hyperplasia, Lymphoid | 2 |
Mandibular, Infiltration Cellular, | |
Plasma Cell | 2 2 |
Mediastinal, Hemorrhage | |
Mesenteric, Congestion | 2 |
Mesenteric, Ectasia | 2 2 |
Mesenteric, Hemorrhage | 2 2|
Pancreatic, Hyperplasia, Lymphoid | 2 |
Pancreatic, Pigmentation | 3 |
Renal, Hemorrhage | |
Renal, Hyperplasia, Lymphoid | 2 |
Renal, Infiltration Cellular, | |
Diffuse, Histiocytic | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|
| 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|
| 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | 3 2 3 |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 |
Infarct | |
Pigmentation | 3 2 |
|__________________________________________________________________________|
Thymus | M M + + + + + + + + + + + M + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + M|
Galactocele | X |
Hyperplasia | 2 2 |
Duct, Dilatation | 2 3 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X |
Foot, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Fibrous Osteodystrophy | 2 |
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Hemorrhage | 3 3 |
Brain Stem, Hypothalamus, Compression| 3 3|
Cerebrum, Hydrocephalus | 3|
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|
| 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|
| 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Cerebrum, Hypothalamus, Compression | 3 |
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
Thoracic, Hemorrhage | 2 |
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinum, Hemorrhage | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Nasolacrimal Duct, Inflammation | 2 2 2 2 2 2|
Respiratory Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 1 2 1 |
Retina, Autolysis | X X X X |
Retina, Degeneration | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|
| 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|
91 PPM | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|
| 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 2 2|
Inflammation | |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 3 1 2 1 2 2 3 2 2 2 3 2 3 2 2 2 2 3 2 1 1 2|
Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation | |
__________________________________________|__________________________________________________________________________
Page 79
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L |
| 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cecum, Lymphoid Tissue, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Duodenum, Autolysis | | 1 3.0|
Ileum, Lymphoid Tissue, Hyperplasia | | 1 2.0|
Jejunum, Autolysis | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Basophilic Focus | X | 2 |
Degeneration, Cystic | 1 2 1 1 1 2 2 1 | 18 1.3|
Developmental Malformation | | 1 |
Eosinophilic Focus | X X X X X | 8 |
Eosinophilic Focus, Multiple | X X X | 6 |
Hepatodiaphragmatic Nodule | | 2 |
Inflammation, Focal, Granulomatous | | 1 1.0|
Vacuolization Cytoplasmic | 3 1 1 1 2 3 2 2 2 2 2 | 21 1.9|
Bile Duct, Hyperplasia | 3 3 3 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 | 42 2.1|
Centrilobular, Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L |
| 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Necrosis | 2 3 | 3 2.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | 1 | 2 1.0|
Acinus, Atrophy | 2 2 1 2 2 2 2 2 | 16 1.9|
Artery, Inflammation, Chronic | 3 | 1 3.0|
Artery, Media, Hypertrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Forestomach, Edema | | 1 3.0|
Forestomach, Inflammation | | 1 2.0|
Forestomach, Necrosis | 2 | 1 2.0|
Glandular, Edema | | 1 3.0|
Glandular, Erosion | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cardiomyopathy | 2 2 2 2 2 1 2 2 2 2 2 2 1 3 2 3 2 2 | 36 1.9|
Atrium, Thrombosis | X X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L |
| 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cortex, Hyperplasia, Focal | 2 2 | 5 1.6|
Cortex, Hypertrophy, Focal | | 1 1.0|
Cortex, Vacuolization Cytoplasmic | | 2 2.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + M + + + + + + + M + + + + + | 41 |
Hyperplasia, Focal | 4 | 2 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Angiectasis | | 2 1.5|
Infiltration Cellular, Histiocytic | | 1 2.0|
Pigmentation | | 1 2.0|
Pars Distalis, Cyst | X X | 3 |
Pars Distalis, Hyperplasia | 2 2 | 7 1.7|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
C-Cell, Hyperplasia | 2 2 3 1 | 6 1.7|
Follicular Cell, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + + + + M + + + + + + + + + + + + + + + + + + | 45 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L |
| 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Granuloma Sperm | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Penis | + | 1 |
Thrombosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 2 | 1 2.0|
Inflammation | 2 3 3 2 2 1 1 1 2 1 2 3 2 3 3 3 1 2 3 | 36 2.0|
Duct, Ectasia | 2 3 3 3 4 3 | 8 2.8|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Decreased Secretory Fluid | | 1 2.0|
Inflammation | 3 1 1 1 1 3 2 1 2 2 3 | 21 1.8|
Ventral, Hyperplasia | 2 1 | 3 1.3|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Decreased Secretory Fluid | 2 3 2 3 2 2 2 2 2 2 2 2 3 2 2 2 3 2 | 31 2.2|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Interstitial Cell, Hyperplasia | 2 2 1 2 2 | 11 1.7|
Seminiferous Tubule, Atrophy | 2 2 3 3 | 7 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Atrophy | | 1 2.0|
Myeloid Cell, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Lumbar, Hyperplasia, Lymphoid | | 1 2.0|
Lumbar, Pigmentation | | 1 3.0|
Mandibular, Ectasia | 3 2 2 | 5 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L |
| 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mandibular, Hyperplasia, Lymphoid | 2 | 2 2.0|
Mandibular, Infiltration Cellular, | | |
Plasma Cell | 2 2 2 2 | 6 2.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mesenteric, Congestion | | 1 2.0|
Mesenteric, Ectasia | 3 3 3 2 | 6 2.5|
Mesenteric, Hemorrhage | 3 | 3 2.3|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Pigmentation | | 1 3.0|
Renal, Hemorrhage | 2 2 | 2 2.0|
Renal, Hyperplasia, Lymphoid | 2 | 2 2.0|
Renal, Infiltration Cellular, | | |
Diffuse, Histiocytic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Angiectasis | 2 | 1 2.0|
Fibrosis | 2 4 2 | 6 2.7|
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infarct | X | 1 |
Pigmentation | | 2 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + M + + + + M + + + + + + + + M + | 41 |
Galactocele | | 1 |
Hyperplasia | 2 3 | 4 2.3|
Duct, Dilatation | 2 2 2 | 6 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L |
| 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cyst Epithelial Inclusion | | 2 |
Foot, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Sternum, Fibrous Osteodystrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Brain Stem, Hemorrhage | | 2 3.0|
Brain Stem, Hypothalamus, Compression| 3 3 | 4 3.0|
Cerebrum, Hydrocephalus | | 1 3.0|
Cerebrum, Hypothalamus, Compression | | 1 3.0|
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Thoracic, Hemorrhage | | 1 2.0|
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L |
| 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Granuloma | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 1 2 | 4 1.8|
Mediastinum, Hemorrhage | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Inflammation, Suppurative | | 1 1.0|
Nasolacrimal Duct, Inflammation | 2 2 1 2 1 2 2 1 2 | 15 1.8|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cataract | | 3 1.3|
Retina, Autolysis | X | 5 |
Retina, Degeneration | 2 1 2 | 3 1.7|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 2 1 1 | 16 1.3|
Inflammation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + I + M M + + + + + + + + + + + + + | 43 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Nephropathy | 2 2 1 2 2 2 1 2 2 1 2 2 1 3 2 3 2 2 3 2 3 3 | 45 2.0|
Pigmentation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
91 PPM | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7| | L |
| 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hemorrhage | | 1 3.0|
Inflammation | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|
| 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|
272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|
| 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Colon, Serosa, Dilatation | |
Colon, Lymphoid Tissue, Hyperplasia | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Hyperplasia | |
Ileum, Inflammation | 2 |
Ileum, Lymphoid Tissue, Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 1 2 |
Eosinophilic Focus | X X |
Eosinophilic Focus, Multiple | X X X X X |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Focal, Granulomatous | 2 |
Necrosis | 2 |
Pigmentation | 1 |
Vacuolization Cytoplasmic | 2 2 2 3 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 1 1 2 2 2 2 3 2 2 1 2 2 3 2 1 2 3 2 2|
Centrilobular, Necrosis | 3 |
|__________________________________________________________________________|
Mesentery | + + + + |
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|
| 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|
272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|
| 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Accessory Spleen | |
Polyarteritis | 3 |
Fat, Necrosis | 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Hyperplasia | 3 |
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | 1 2 2 2 2 2 1 2 1 |
Artery, Inflammation, Chronic | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + M +|
Forestomach, Edema | 2 |
Forestomach, Inflammation | 2|
Forestomach, Epithelium, Hyperplasia | 2|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + |
Gingiva, Hyperplasia | 3 |
Gingiva, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 1 2 2 2 1 2 2 2 2 2 2 1 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|
| 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|
272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|
| 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Accessory Adrenal Cortical | |
Nodule | X |
Cortex, Hyperplasia, Focal | |
Cortex, Vacuolization Cytoplasmic | 2 2 1|
Medulla, Hyperplasia | |
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + M M + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 1 2 2 2 2 2 1 2 1 3 1 2 2 2 1|
Duct, Ectasia | 2 |
__________________________________________|__________________________________________________________________________|
Page 90
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|
| 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|
272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|
| 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 1 2 3 2 1 2 2 2 2 2 1|
Ventral, Hyperplasia | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Decreased Secretory Fluid | 2 3 2 2 3 3 2 3 2 3 2 2 2 2|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Interstitial Cell, Hyperplasia | 2 1 1 3 1 |
Seminiferous Tubule, Atrophy | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Deep Cervical, Infiltration Cellular,| |
Plasma Cell | 3 |
Lumbar, Hematopoietic Cell | |
Proliferation | 2 |
Lumbar, Hyperplasia, Lymphoid | 3 |
Mandibular, Ectasia | 2 2 3 |
Mandibular, Hyperplasia, Lymphoid | 2 |
Mandibular, Infiltration Cellular, | |
Plasma Cell | 2 2 2 3 |
Mediastinal, Hemorrhage | 2 |
Mesenteric, Ectasia | 3 3 2 3 |
Mesenteric, Hemorrhage | 2 2 |
Mesenteric, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 91
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|
| 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|
272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|
| 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal | |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + M + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X X X |
Hyperplasia | 2 |
Duct, Dilatation | 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + I + + + + +|
Inflammation, Chronic | 3 |
Inflammation | 3 |
Foot, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Mandibular, Proliferation | |
Fiber, Mandibular, Hypertrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Hypothalamus, Compression| 2 2 3 2|
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|
| 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|
272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|
| 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Alveolar Epithelium, Hyperplasia | 3 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Alveolus, Inflammation, Multifocal | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | 2 2 1 2 |
Respiratory Epithelium, Hyperplasia | |
Septum, Inflammation, Chronic | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + + |
Canal, External Ear, Exudate | 2 |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 2 |
Bilateral, Cataract | 2 |
Retina, Autolysis | X X X |
Retina, Degeneration | 1 |
Sclera, Metaplasia, Osseous | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 93
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|
| 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|
272 PPM | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|
| 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 1 4 2 2 2 2 2 2 3 3 2 2 3 3 3 2 2 2 2 3|
Pigmentation | 2 |
Cortex, Cyst | |
Renal Tubule, Hyperplasia | 2 |
|__________________________________________________________________________|
Urethra | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 94
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L |
| 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Artery, Colon, Serosa, Dilatation | X | 1 |
Colon, Lymphoid Tissue, Hyperplasia | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ileum, Hyperplasia | 3 | 1 3.0|
Ileum, Inflammation | | 1 2.0|
Ileum, Lymphoid Tissue, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Degeneration, Cystic | 1 2 2 1 1 1 1 1 | 13 1.5|
Eosinophilic Focus | X X X X X X X | 9 |
Eosinophilic Focus, Multiple | X X X X X | 10 |
Hepatodiaphragmatic Nodule | X | 3 |
Inflammation, Focal, Granulomatous | | 1 2.0|
Necrosis | | 1 2.0|
Pigmentation | | 1 1.0|
Vacuolization Cytoplasmic | 2 1 2 2 1 2 | 10 1.9|
Bile Duct, Cyst | X | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L |
| 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Bile Duct, Hyperplasia | 2 2 1 2 2 2 2 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 | 42 1.9|
Centrilobular, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Accessory Spleen | X X | 2 |
Polyarteritis | 2 | 2 2.5|
Fat, Necrosis | | 2 2.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Accessory Spleen | | 1 |
Hyperplasia | | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 2 | 2 1.5|
Acinus, Atrophy | 1 2 1 1 2 2 2 1 2 2 2 2 3 2 1 | 24 1.7|
Artery, Inflammation, Chronic | 1 3 | 2 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Forestomach, Edema | 3 | 2 2.5|
Forestomach, Inflammation | | 1 2.0|
Forestomach, Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tooth | | 1 |
Gingiva, Hyperplasia | | 1 3.0|
Gingiva, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L |
| 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 3 2 3 2 | 40 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cortex, Accessory Adrenal Cortical | | |
Nodule | X | 2 |
Cortex, Hyperplasia, Focal | 1 2 2 | 3 1.7|
Cortex, Vacuolization Cytoplasmic | 1 | 4 1.5|
Medulla, Hyperplasia | 2 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + M + + + + + + + + + + + M + M + | 40 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | X X | 5 |
Pars Distalis, Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 4 1 | 3 2.0|
Follicular Cell, Hyperplasia | 2 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L |
| 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + M + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation | 2 2 2 2 2 2 2 2 1 2 3 3 2 2 1 2 3 3 2 1 3 | 38 1.9|
Duct, Ectasia | 2 3 2 2 3 3 2 3 2 3 | 11 2.5|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation | 2 2 1 3 2 2 2 2 1 | 22 1.9|
Ventral, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 3 | 1 3.0|
Decreased Secretory Fluid | 2 2 2 2 2 2 3 2 3 3 3 3 2 3 3 2 2 3 2 | 33 2.4|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mineralization | | 1 1.0|
Interstitial Cell, Hyperplasia | | 5 1.6|
Seminiferous Tubule, Atrophy | 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Myeloid Cell, Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Axillary, Hyperplasia, Lymphoid | 2 | 1 2.0|
Deep Cervical, Infiltration Cellular,| | |
Plasma Cell | | 1 3.0|
Lumbar, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Lumbar, Hyperplasia, Lymphoid | 2 | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L |
| 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mandibular, Ectasia | 2 3 2 | 6 2.3|
Mandibular, Hyperplasia, Lymphoid | 2 2 | 3 2.0|
Mandibular, Infiltration Cellular, | | |
Plasma Cell | 2 2 2 2 2 2 2 | 11 2.1|
Mediastinal, Hemorrhage | | 1 2.0|
Mesenteric, Ectasia | 3 2 | 6 2.7|
Mesenteric, Hemorrhage | | 2 2.0|
Mesenteric, Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Focal | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + + + + M + | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + M | 46 |
Galactocele | X X | 6 |
Hyperplasia | 2 2 2 | 4 2.0|
Duct, Dilatation | 2 | 3 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Inflammation, Chronic | | 1 3.0|
Inflammation | | 1 3.0|
Foot, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L |
| 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Arteriole, Mandibular, Proliferation | X | 1 |
Fiber, Mandibular, Hypertrophy | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Brain Stem, Hypothalamus, Compression| 2 2 | 6 2.2|
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + M + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | | 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 3 | 4 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 | 2 1.0|
Alveolus, Inflammation, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L |
| 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Nasolacrimal Duct, Inflammation | 2 1 1 2 2 2 2 3 1 1 2 2 | 16 1.8|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
Septum, Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 2 |
Canal, External Ear, Exudate | | 1 2.0|
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cataract | | 2 2.0|
Bilateral, Cataract | | 1 2.0|
Retina, Autolysis | | 3 |
Retina, Degeneration | 2 2 | 3 1.7|
Sclera, Metaplasia, Osseous | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 1 1 1 1 1 2 | 16 1.1|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + M + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Nephropathy | 1 3 2 2 2 2 2 1 2 3 3 2 2 2 2 3 2 2 2 3 2 3 3 | 46 2.2|
Pigmentation | | 1 2.0|
Cortex, Cyst | X | 1 |
Renal Tubule, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
272 PPM | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| | L |
| 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Urethra | + | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|
| 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|
| 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
Colon, Lymphoid Tissue, Hyperplasia | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Lymphoid Tissue, Hyperplasia | 2 3 |
Jejunum, Diverticulum | |
Jejunum, Lymphoid Tissue, Hyperplasia| 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X|
Degeneration, Cystic | 1 2 2 1 1 1 1 2 2 1 |
Developmental Malformation | X |
Eosinophilic Focus | X X X X X|
Eosinophilic Focus, Multiple | X X X X X X X X X |
Infiltration Cellular, Lymphocyte | |
Inflammation, Focal, Granulomatous | |
Mixed Cell Focus | |
Vacuolization Cytoplasmic | 2 2 2 2 2 2 1|
Bile Duct, Hyperplasia | 2 2 1 2 1 2 2 2 2 2 2 3 2 2 2|
Centrilobular, Necrosis | 2 3 3 |
|__________________________________________________________________________|
Mesentery | + |
Polyarteritis | 3 |
__________________________________________|__________________________________________________________________________|
Page 103
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|
| 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|
| 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Infiltration Cellular, Lymphocyte | |
Polyarteritis | |
Acinus, Atrophy | 2 2 2 2 1 2 2 2 2 2 2 2 2|
Artery, Inflammation, Chronic | 3 |
Artery, Media, Hypertrophy | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Inflammation | |
Forestomach, Epithelium, Hyperplasia | |
Glandular, Mineralization | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2|
Atrium, Thrombosis | X X |
Myocardium, Infarct | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Cortex, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________|__________________________________________________________________________|
Page 104
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|
| 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|
| 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Cortex, Cytoplasmic Alteration | 3 |
Cortex, Hyperplasia, Focal | 1 2 |
Cortex, Hypertrophy, Focal | 1 |
Cortex, Vacuolization Cytoplasmic | 2 |
Medulla, Hyperplasia | 2 |
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + M + + + + + + + M + M + +|
Hyperplasia, Focal | |
|__________________________________________________________________________|
Pituitary Gland | + + + M + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 3 2 3 |
Pars Intermedia, Cyst | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + +|
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | 1 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Fat, Necrosis | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + + + + + + + + M + + + + + + + + + + + + + + +|
Decreased Secretory Fluid | 3 2 2 |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________|__________________________________________________________________________|
Page 105
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|
| 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|
| 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia | 2 3|
Inflammation | 2 3 3 1 3 3 3 2 2 3 2 2 3 2 1 |
Duct, Ectasia | 3|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Decreased Secretory Fluid | 2 |
Inflammation | 2 1 3 2 2 2 2 1 2 1 |
Ventral, Hyperplasia | 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Decreased Secretory Fluid | 3 2 3 2 2 3 2 2 2 2 2 3 2 2 2 2 2|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 2 |
Seminiferous Tubule, Atrophy | 2 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia | |
Myeloid Cell, Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Ectasia | 3 |
Mandibular, Hemorrhage | |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Infiltration Cellular, | |
Plasma Cell | 2 2 |
Mediastinal, Hemorrhage | |
Mesenteric, Ectasia | 2 |
Mesenteric, Hemorrhage | 2 |
Mesenteric, Hyperplasia, Lymphoid | |
__________________________________________|__________________________________________________________________________|
Page 106
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|
| 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|
| 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Mesenteric, Infiltration Cellular, | |
Plasma Cell | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 4 2 |
Hematopoietic Cell Proliferation | 3 3 2 2 |
Hyperplasia, Lymphoid | 2 |
Infarct | X X |
Pigmentation | 2 2 |
|__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + M + + + + + + M + + +|
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + M + M + + + + + + + + + + M M + M + +|
Galactocele | X |
Hyperplasia | 2 |
Duct, Dilatation | 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cyst Epithelial Inclusion | X |
Epidermis, Hyperplasia | |
Epidermis, Necrosis | |
Epithelium, Hyperplasia | 2 |
Foot, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 1 |
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 107
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|
| 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|
| 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Brain Stem, Hypothalamus, Compression| 3 |
Cerebrum, Compression | 2 |
Cerebrum, Hemorrhage | 3 |
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 3 1 |
Alveolus, Infiltration Cellular, | |
Histiocytic | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | 2 2 1 2 2 2 1|
Nasolacrimal Duct, Mineralization | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 108
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|
| 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|
| 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | |
Bilateral, Cataract | 2 2 |
Bilateral, Retina, Degeneration | |
Retina, Autolysis | X X X |
Retina, Degeneration | |
Sclera, Metaplasia, Osseous | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 2 2|
Inflammation | 2 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 2|
Nephropathy | 2 1 2 3 1 2 1 3 2 4 3 3 3 3 2 2 4 2 1 2 2 2 2 3|
Thrombosis | 4 |
Cortex, Cyst | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Artery, Inflammation | |
__________________________________________|__________________________________________________________________________
Page 109
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L |
| 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Colon, Lymphoid Tissue, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Ileum, Lymphoid Tissue, Hyperplasia | 2 | 3 2.3|
Jejunum, Diverticulum | X | 1 |
Jejunum, Lymphoid Tissue, Hyperplasia| 2 | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Basophilic Focus | | 2 |
Degeneration, Cystic | 1 1 1 2 1 1 2 2 1 | 19 1.4|
Developmental Malformation | | 1 |
Eosinophilic Focus | X X X | 8 |
Eosinophilic Focus, Multiple | X X X X X X X X X X X X X X X X | 25 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
Mixed Cell Focus | X X | 2 |
Vacuolization Cytoplasmic | 1 2 2 2 2 2 | 13 1.8|
Bile Duct, Hyperplasia | 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 38 1.9|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L |
| 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Centrilobular, Necrosis | | 3 2.7|
|__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Polyarteritis | | 1 3.0|
Fat, Necrosis | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Accessory Spleen | | 1 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Polyarteritis | 3 | 1 3.0|
Acinus, Atrophy | 2 1 2 2 2 3 1 1 2 | 22 1.9|
Artery, Inflammation, Chronic | 2 3 4 | 4 3.0|
Artery, Media, Hypertrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Forestomach, Inflammation | 2 2 | 2 2.0|
Forestomach, Epithelium, Hyperplasia | 2 3 | 2 2.5|
Glandular, Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cardiomyopathy | 2 2 2 2 2 2 2 1 2 2 1 1 3 2 2 2 2 2 2 2 2 2 2 | 40 1.9|
Atrium, Thrombosis | X | 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L |
| 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Myocardium, Infarct | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Degeneration | 3 | 1 3.0|
Cortex, Accessory Adrenal Cortical | | |
Nodule | | 1 |
Cortex, Cytoplasmic Alteration | | 1 3.0|
Cortex, Hyperplasia, Focal | 1 1 1 | 5 1.2|
Cortex, Hypertrophy, Focal | | 1 1.0|
Cortex, Vacuolization Cytoplasmic | 3 | 2 2.5|
Medulla, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M | 42 |
Hyperplasia, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Pars Distalis, Cyst | X X X | 3 |
Pars Distalis, Hyperplasia | 3 2 2 | 7 2.4|
Pars Intermedia, Cyst | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
C-Cell, Hyperplasia | 2 2 | 3 2.0|
Follicle, Cyst | 1 | 3 1.3|
Follicular Cell, Hyperplasia | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L |
| 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Abdominal, Fat, Necrosis | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Decreased Secretory Fluid | | 3 2.3|
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Atrophy | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Atrophy | 2 1 | 3 1.7|
Hyperplasia | 2 | 3 2.3|
Inflammation | 1 2 3 2 1 3 3 2 2 3 1 1 1 2 | 29 2.1|
Duct, Ectasia | 3 2 3 2 3 3 2 2 | 9 2.6|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Decreased Secretory Fluid | | 1 2.0|
Inflammation | 2 2 2 2 2 2 1 2 | 18 1.8|
Ventral, Hyperplasia | 1 2 2 1 2 | 6 1.7|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Atrophy | 3 | 1 3.0|
Decreased Secretory Fluid | 2 2 3 2 3 2 2 2 2 2 3 2 2 2 2 2 2 2 2 | 36 2.2|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Interstitial Cell, Hyperplasia | | 3 1.7|
Seminiferous Tubule, Atrophy | 2 2 3 3 3 | 8 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L |
| 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Atrophy | | 1 2.0|
Hyperplasia | 3 3 | 2 3.0|
Myeloid Cell, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Mandibular, Ectasia | 2 3 2 | 4 2.5|
Mandibular, Hemorrhage | 2 | 1 2.0|
Mandibular, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mandibular, Infiltration Cellular, | | |
Plasma Cell | 2 3 2 3 2 | 7 2.3|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mesenteric, Ectasia | | 1 2.0|
Mesenteric, Hemorrhage | | 1 2.0|
Mesenteric, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mesenteric, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Fibrosis | 1 2 | 5 2.2|
Hematopoietic Cell Proliferation | 1 2 2 2 | 8 2.1|
Hyperplasia, Lymphoid | 2 2 2 | 4 2.0|
Infarct | | 2 |
Pigmentation | | 2 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + M + | 42 |
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L |
| 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + | 41 |
Galactocele | X | 2 |
Hyperplasia | 3 2 1 2 | 5 2.0|
Duct, Dilatation | 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cyst | X | 1 |
Cyst Epithelial Inclusion | | 1 |
Epidermis, Hyperplasia | 3 | 1 3.0|
Epidermis, Necrosis | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
Foot, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Femur, Fibrous Osteodystrophy | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Brain Stem, Hypothalamus, Compression| | 1 3.0|
Cerebrum, Compression | | 1 2.0|
Cerebrum, Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L |
| 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Alveolar Epithelium, Hyperplasia | 4 2 2 | 6 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocytic | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 2 2 | 4 1.8|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Nasolacrimal Duct, Inflammation | 1 1 2 1 3 | 12 1.7|
Nasolacrimal Duct, Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cataract | 3 | 1 3.0|
Bilateral, Cataract | 1 | 3 1.7|
Bilateral, Retina, Degeneration | 4 2 1 2 1 | 5 2.0|
Retina, Autolysis | | 3 |
Retina, Degeneration | 3 1 | 2 2.0|
Sclera, Metaplasia, Osseous | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 1 1 2 1 1 1 | 18 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 93029-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:01:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8| | L |
| 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Duct, Ectasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Accumulation, Hyaline Droplet | | 1 2.0|
Nephropathy | 3 3 2 2 3 2 3 2 3 3 2 3 4 2 3 1 3 3 3 2 3 2 2 | 47 2.4|
Thrombosis | | 1 4.0|
Cortex, Cyst | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Calculus Micro Observation Only | X | 1 |
Artery, Inflammation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------