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TDMS Study 93029-03 Pathology Tables

NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03
Route: DOSED FEED                                                                                                 Time: 15:01:05




       Facility:  National Center for Toxicological Research

       Chemical CAS #:  129-73-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1


NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|             
                             DAY ON TEST   | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|             
                                           | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
    0 PPM                                  | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|             
                                           | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Rectum, Inflammation                 |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Lymphoid Tissue, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                           X                              |             
      Basophilic Focus, Multiple           |                X  X  X        X  X     X     X  X  X  X  X  X            |             
      Degeneration, Cystic                 |                                                          2  1            |             
      Developmental Malformation           |             X  X        X                                                |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |             X                          X                    X            |             
      Infiltration Cellular, Lymphocyte    |                                        2                 1               |             
      Inflammation, Focal, Granulomatous   |                2           2  2  2  3           1                        |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             | 2                                                                        |             
      Tension Lipidosis                    |                                                                          |             
      Vacuolization Cytoplasmic            |                1           3                                   3     2   |             
      Bile Duct, Hyperplasia               |                         2  2                 2     1     1        1      |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +     +     +  +           +                                   +  +      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|             
                             DAY ON TEST   | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|             
                                           | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
    0 PPM                                  | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|             
                                           | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Fat, Necrosis                        |       3     2  2           2                                   3         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                   2      |             
      Acinus, Atrophy                      |                         2        1  2     2     1  2     3           1  2|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                          1                                       |             
                                           |__________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Edema                   |                            2                                             |             
      Forestomach, Inflammation            |                3                                               3         |             
      Forestomach, Epithelium, Hyperplasia |                         3                                      3         |             
      Glandular, Edema                     |                3                                                         |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     2  2  1     2  2  2  1  2  1  2  1  2     2        2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Angiectasis                  |                                                    1  1                  |             
      Cortex, Degeneration                 |                                                                          |             
      Cortex, Hyperplasia, Focal           |                               1                 2     1                  |             
      Cortex, Hypertrophy, Focal           |                                                             1            |             
      Cortex, Vacuolization Cytoplasmic    |                                                                2        3|             
      Medulla, Hyperplasia                 |          2                                                               |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|             
                             DAY ON TEST   | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|             
                                           | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
    0 PPM                                  | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|             
                                           | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                          1   |             
      Pars Distalis, Cyst                  |                         X           X                                   X|             
      Pars Distalis, Hyperplasia           |                                  2                 2                     |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                         2        2        1     1     2                  |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                3                  |             
      Inflammation                         |       2  2     3     2        1  1  1  1  1  2     3     2  2  3  2     1|             
      Duct, Dilatation                     |          2        2                                2  3  3  2  3  2      |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2     2           2                                      2  2      |             
      Cyst                                 |                            X                       X              X  X   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Cervix, Hypertrophy                  |                         X                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|             
                             DAY ON TEST   | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|             
                                           | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
    0 PPM                                  | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|             
                                           | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                          2           1   |             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Exudate, Mucous                      |                                                                          |             
      Inflammation, Suppurative            |             2  3     4                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                      2                    3      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Ectasia                      |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                         2|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                      2   |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                      2   |             
      Mesenteric, Ectasia                  |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    |                               2                                          |             
      Renal, Hyperplasia, Lymphoid         |                               2                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4  3              2                                                      |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|             
                             DAY ON TEST   | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|             
                                           | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
    0 PPM                                  | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|             
                                           | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |             X                                         X                  |             
      Hyperplasia                          |                      2  2  2  1        2           1           2     3  1|             
      Duct, Dilatation                     |             2                    2     2                                 |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                              3                           |             
      Epidermis, Hyperplasia               |                                              3                           |             
      Epidermis, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                                                                   3      |             
      Femur, Osteopetrosis                 |                                                                          |             
      Sternum, Fibrous Osteodystrophy      |                                                                   3      |             
      Sternum, Osteopetrosis               |                                                                          |             
      Turbinate, Osteopetrosis             |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Brain Stem, Hemorrhage               |                                                                          |             
      Brain Stem, Hypothalamus, Compression|             3  2           3                                   2         |             
      Cerebrum, Hemorrhage                 |                                                                         1|             
                                           |__________________________________________________________________________|             
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|             
                             DAY ON TEST   | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|             
                                           | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
    0 PPM                                  | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|             
                                           | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                1                                1                    1   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |       2        2     2                             2  2  2     2        2|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                         2                                                |             
      Bilateral, Cataract                  |                      2                                                   |             
      Bilateral, Retina, Degeneration      |                         3                                                |             
      Conjunctiva, Inflammation            |                                                                          |             
      Retina, Autolysis                    |       X              X                                            X      |             
      Sclera, Metaplasia, Osseous          |                1                                                         |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                2                    2        2  1  1     1  1            |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                        +              +  +               |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Metaplasia                           |                                        2              2  2               |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6|             
                             DAY ON TEST   | 7| 8| 2| 3| 6| 6| 6| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 8| 5|             
                                           | 8| 5| 7| 5| 2| 2| 9| 8| 9| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
    0 PPM                                  | 1| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 2| 3| 4|             
                                           | 9| 2| 5| 6| 0| 1| 4| 0| 1| 2| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 0| 4| 8|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                      2   |             
      Mineralization                       | 2  2  2  2  2  2  2  2  2  2  3  2  2  1  2  2  2  2  2  2  1  2  2  2  2|             
      Necrosis, Focal                      |          1                                                               |             
      Nephropathy                          |       1     2  1        1  2  1  1  1     1  1  1  1  1  1  1  3     1   |             
      Pigmentation                         |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    0 PPM                                  | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3|     |      L     |
                                           | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Rectum, Inflammation                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Ileum, Lymphoid Tissue, Hyperplasia  |                                                                   2      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Basophilic Focus                     |             X        X                                                   |      3     |
      Basophilic Focus, Multiple           | X     X           X        X        X                       X  X  X      |     20     |
      Degeneration, Cystic                 |                                              3                           |      3  2.0|
      Developmental Malformation           | X  X                       X           X                                 |      7     |
      Eosinophilic Focus                   |                                        X                       X  X      |      3     |
      Hematopoietic Cell Proliferation     |                                     1                                    |      1  1.0|
      Hepatodiaphragmatic Nodule           | X                                                                        |      4     |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.5|
      Inflammation, Focal, Granulomatous   |                   1                 1           4              1         |     10  1.9|
      Mixed Cell Focus                     |                            X                                             |      1     |
      Necrosis                             |                2     1                          2                        |      4  1.8|
      Tension Lipidosis                    |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    0 PPM                                  | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3|     |      L     |
                                           | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Vacuolization Cytoplasmic            |                                                                   1      |      5  2.0|
      Bile Duct, Hyperplasia               | 2     1  2           1        2  1        1        2        2     1      |     16  1.5|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   8        |
      Fat, Necrosis                        |             2                                                            |      6  2.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation                         |                                                                          |      1  2.0|
      Acinus, Atrophy                      |       2              3  2     2     2     1  2  3  2           3  3      |     20  2.1|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Forestomach, Edema                   |                                                                          |      1  2.0|
      Forestomach, Inflammation            |                                                                          |      2  3.0|
      Forestomach, Epithelium, Hyperplasia |                                                                          |      2  3.0|
      Glandular, Edema                     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       |    1  2  1  1  1  1        1  2  1  2  1  1     1  2  1     2  2         |     35  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    0 PPM                                  | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3|     |      L     |
                                           | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cortex, Angiectasis                  |                1     1                 2        2           3  2         |      8  1.6|
      Cortex, Degeneration                 |                                     3                                    |      1  3.0|
      Cortex, Hyperplasia, Focal           |                1                                                         |      4  1.3|
      Cortex, Hypertrophy, Focal           |                                              2                           |      2  1.5|
      Cortex, Vacuolization Cytoplasmic    |                                                                          |      2  2.5|
      Medulla, Hyperplasia                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +      |  42        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Angiectasis                          |       1                                                                  |      3  1.3|
      Pars Distalis, Cyst                  |          X     X     X           X                 X                     |      8     |
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      C-Cell, Hyperplasia                  |    1  1  1  2  1                    1     2                    1         |     13  1.4|
      Follicular Cell, Hyperplasia         |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                                                    3  3                  |      4  2.8|
      Inflammation                         |    2     2                          2     2  2  3                 1      |     23  1.9|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    0 PPM                                  | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3|     |      L     |
                                           | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Duct, Dilatation                     |    2  2  2  2  3     2     2  3  2  2     2  3  2  3  3     3     2      |     25  2.4|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                      2                                                   |      6  2.0|
      Cyst                                 |                                              X  X  X        X            |      8     |
      Infiltration Cellular, Lymphocyte    |                            3     3     2                                 |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                             +            |   1        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation                         |                                              1                           |      1  1.0|
      Cervix, Hypertrophy                  |                   X        X                 X     X                     |      5     |
      Endometrium, Hyperplasia, Cystic     |          2                                                               |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cyst                                 |                            X                                             |      1     |
      Exudate, Mucous                      |                         3                                                |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                                           1                              |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Lumbar, Ectasia                      |                                              3                           |      1  3.0|
      Lumbar, Hyperplasia, Lymphoid        |                                              2                           |      1  2.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                    2                     |      1  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |             2                 2                    2                     |      4  2.0|
      Mediastinal, Hemorrhage              |                         2                                                |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    0 PPM                                  | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3|     |      L     |
                                           | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Mesenteric, Ectasia                  |                2                 2                                       |      2  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                        2                                 |      1  2.0|
      Renal, Ectasia                       |                                              2                           |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                              2                           |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.0|
      Pigmentation                         | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M      |  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Galactocele                          |       X     X                    X        X                    X         |      7     |
      Hyperplasia                          |    1           2  2        1     2  3  1  3  3  2  2  2  3  2  2  2      |     25  2.0|
      Duct, Dilatation                     |       2              2  2     2              2  2           2            |     10  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation                         |                   2                                                      |      2  2.5|
      Epidermis, Hyperplasia               |                   2              2                                       |      3  2.3|
      Epidermis, Necrosis                  |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Femur, Fibrous Osteodystrophy        |                                                    2                     |      2  2.5|
      Femur, Osteopetrosis                 |                                                 3                        |      1  3.0|
      Sternum, Fibrous Osteodystrophy      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    0 PPM                                  | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3|     |      L     |
                                           | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
      Sternum, Osteopetrosis               |                                                 3                        |      1  3.0|
      Turbinate, Osteopetrosis             |                                                 2                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Mineralization, Multifocal           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Brain Stem, Hemorrhage               | 2                                                                        |      1  2.0|
      Brain Stem, Hypothalamus, Compression| 2  3        1                          2  2  2        2                  |     11  2.2|
      Cerebrum, Hemorrhage                 |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                   1                                                      |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    0 PPM                                  | 5| 6| 5| 5| 5| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 3| 3|     |      L     |
                                           | 3| 8| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Nasolacrimal Duct, Inflammation      | 2  2     2  1  2  1  2     2                 2  1  1        2     2      |     21  1.8|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cataract                             | 2                                                                        |      2  2.0|
      Bilateral, Cataract                  |                                                                          |      1  2.0|
      Bilateral, Retina, Degeneration      |                                                             2  1  2      |      4  2.0|
      Conjunctiva, Inflammation            | 2                                                                        |      1  2.0|
      Retina, Autolysis                    | X                                                     X                  |      5     |
      Sclera, Metaplasia, Osseous          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |    1  2     1  1     1  1              2  1  1  1  1           2         |     19  1.3|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |       +  +                 +  +  +     +                       +         |  10        |
      Infiltration Cellular, Lymphocyte    |                            2  2                                1         |      3  1.7|
      Metaplasia                           |       2  2                 2  2  2     2                       2         |     10  2.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infarct                              |                                                                          |      1  2.0|
      Mineralization                       | 2  2  2  2  2  2  2     1  2  2  2  2  2  2  1  2  2  2  2  1  2  2      |     47  1.9|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Nephropathy                          |    1  1     2        1        1  1  1  1  1  1  2  1  2  1  1  2  1      |     34  1.2|
      Pigmentation                         | 2                                                                        |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|             
                                           | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|             
                                           | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Lymphoid Tissue, Hyperplasia  |                                        2                                 |             
      Colon, Lymphoid Tissue, Hyperplasia  |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Lymphoid Tissue, Hyperplasia  |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                   X                                               X      |             
      Basophilic Focus, Multiple           |          X           X  X  X     X  X  X  X  X              X  X         |             
      Degeneration, Cystic                 |                                              1                       1   |             
      Developmental Malformation           |          X                          X                          X         |             
      Eosinophilic Focus                   |                         X        X  X              X                     |             
      Eosinophilic Focus, Multiple         |       X                                X                                 |             
      Hematopoietic Cell Proliferation     |                      1                                                   |             
      Hepatodiaphragmatic Nodule           |                                     X                                    |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Focal, Granulomatous   | 1  2     3        2  2           2                 1        1     2      |             
      Necrosis                             |                                        2                                 |             
      Tension Lipidosis                    |                                                             3            |             
      Vacuolization Cytoplasmic            |                                  1                                      3|             
      Bile Duct, Hyperplasia               |       1        1  2        1        2        1                    1      |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|             
                                           | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|             
                                           | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Mesentery                               |                                  +           +  +                        |             
      Accessory Spleen                     |                                                 X                        |             
      Fat, Necrosis                        |                                  3           2                           |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                         1                                                |             
      Acinus, Atrophy                      |                      1        2  2     1  1     2     1        1         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Hypertrophy, Focal    |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1     1     2  2  1  2  2  2  1  1     2     2     2  2  2  2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Angiectasis                  |                                                                          |             
      Cortex, Atrophy                      |                                                                          |             
      Cortex, Hyperplasia, Focal           |                               2              2                           |             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|             
                                           | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|             
                                           | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  +  +  +  +  +  +  +  M  +  M  M  +  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Cyst                  |                                                                X         |             
      Pars Distalis, Hyperplasia           |                                           3              2               |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                      1  1                       1     1                  |             
      Follicle, Cyst                       |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         | 1  2     2     1     2     2  2  3  1           2  1  1        2  2     2|             
      Duct, Dilatation                     |    2                       2              2  2  3           2     3  2   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                                                  2                     |             
      Cyst                                 |             X           X  X           X                                 |             
      Infiltration Cellular, Lymphocyte    |                                              3                           |             
      Periovarian Tissue, Hemorrhage       |             2                                                            |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decidual Reaction                    |          X                                                               |             
      Hemorrhage                           |                                           3                              |             
      Cervix, Hypertrophy                  |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                             3            |             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Mucous                      |                                                                         2|             
      Inflammation, Suppurative            |                   2                                   2                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|             
                                           | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|             
                                           | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Myeloid Cell, Hyperplasia            | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    | 2                                                                        |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     | 3                                   2     2        2     3               |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                            2                                             |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mesenteric, Ectasia                  |                                                                          |             
      Mesenteric, Hemorrhage               |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       2     2                                                  2         |             
      Hyperplasia, Focal                   |                                                                          |             
      Pigmentation                         |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |       X                                               X                  |             
      Hyperplasia                          |                      2     2        2                       3           2|             
      Infiltration Cellular, Lymphocyte    |                            2                                             |             
      Duct, Dilatation                     |    2     2  2  2        2              2           4                    2|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|             
                                           | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|             
                                           | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              | 3                                                                        |             
      Epidermis, Hyperplasia               |                   2                                                      |             
      Epidermis, Necrosis                  |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                                                          3           4   |             
      Maxilla, Inflammation, Chronic       | 3                                                                        |             
      Sternum, Fibrous Osteodystrophy      |                                                                          |             
      Sternum, Osteopetrosis               |                                                          3           4   |             
      Turbinate, Osteopetrosis             |                                                          3           4   |             
                                           |__________________________________________________________________________|             
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Brain Stem, Hypothalamus, Compression|       3                                                                 2|             
                                           |__________________________________________________________________________|             
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|             
                                           | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|             
                                           | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                         1                                                |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                               1                                          |             
      Alveolus, Inflammation, Multifocal   |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2                                                                        |             
      Nasolacrimal Duct, Cyst Epithelial   |                                                                          |             
          Inclusion                        |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                2  2                       1        1  2                 2|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Phthisis Bulbi                       |                                                                          |             
      Bilateral, Cataract                  |       2                                                                  |             
      Bilateral, Retina, Degeneration      |                         2  2  2                                          |             
      Retina, Autolysis                    |       X                                                                  |             
      Retina, Degeneration                 |                                                             1  1         |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                    1                     |             
      Infiltration Cellular, Lymphocyte    |       1     1     1  1        2     2  1  1           2     1  2  1      |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                            +                       +                     |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Metaplasia                           |                            1                       2                     |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 6| 6| 0| 5| 9| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 0| 1| 1|             
                                           | 0| 1| 5| 7| 0| 3| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 5| 9| 4| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 3| 6| 6| 6|             
                                           | 1| 8| 3| 9| 7| 8| 0| 1| 2| 3| 4| 5| 6| 2| 1| 2| 3| 4| 5| 6| 7| 9| 1| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                   1      |             
      Mineralization                       |    2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2     2  2|             
      Nephropathy                          |       2     1           1  1  1  1  1  1  1  1  1  1  1  1  1        1   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   3      |             
      Infiltration Cellular, Lymphocyte    |                         1                                                |             
      Inflammation                         |                                                                   2      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    91 PPM                                 | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4|     |      L     |
                                           | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cecum, Lymphoid Tissue, Hyperplasia  |                                                                          |      1  2.0|
      Colon, Lymphoid Tissue, Hyperplasia  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Ileum, Lymphoid Tissue, Hyperplasia  |          2                                                               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Basophilic Focus                     |       X                                                     X            |      4     |
      Basophilic Focus, Multiple           | X  X     X  X        X  X     X     X        X  X  X  X  X     X  X      |     26     |
      Degeneration, Cystic                 |                                                                          |      2  1.0|
      Developmental Malformation           |    X                                      X                              |      5     |
      Eosinophilic Focus                   |                                                                          |      4     |
      Eosinophilic Focus, Multiple         | X        X        X           X           X                 X            |      8     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Infiltration Cellular, Lymphocyte    |                      1           1                             1         |      3  1.0|
      Inflammation, Focal, Granulomatous   | 2           2              1           2  2        3  1  1  1     1      |     19  1.7|
      Necrosis                             |                   1                                                      |      2  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    91 PPM                                 | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4|     |      L     |
                                           | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Tension Lipidosis                    |                                                 2                        |      2  2.5|
      Vacuolization Cytoplasmic            |             1                       1        1                           |      5  1.4|
      Bile Duct, Hyperplasia               |    1  1  1        1     2        1  1        1  2        1        1      |     18  1.2|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |             +  +  +                                      +               |   7        |
      Accessory Spleen                     |                X                                                         |      2     |
      Fat, Necrosis                        |             2     2                                      3               |      5  2.4|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |                         1                                                |      2  1.0|
      Acinus, Atrophy                      |    2     1     1  1     1                 1           1     1            |     16  1.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Parotid Gland, Hypertrophy, Focal    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       | 2  2  2  2  1  2  2  2     1  1  2  1  2  2     2  1     1  1     2      |     35  1.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cortex, Angiectasis                  |    2                 2  2        2  2  2  2     1  2  2                  |     10  1.9|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    91 PPM                                 | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4|     |      L     |
                                           | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Cortex, Atrophy                      |                               2                                          |      1  2.0|
      Cortex, Hyperplasia, Focal           |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M      |  37        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Angiectasis                          |                                                          3               |      1  3.0|
      Pars Distalis, Cyst                  | X                                      X                 X               |      4     |
      Pars Distalis, Hyperplasia           | 2                                   2                                    |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      C-Cell, Hyperplasia                  |                                                                1         |      5  1.0|
      Follicle, Cyst                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                         2                 2                    2  2      |      4  2.0|
      Inflammation                         |    2  2  2     3     2  2     3  2  1     2  2        2  3  2  2  2      |     31  1.9|
      Duct, Dilatation                     |       2        3     2  3     3  3  2  3  3  2     2  2  3  2  2  2      |     24  2.4|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                            3              3  2                           |      5  2.4|
      Cyst                                 |                         X                                                |      5     |
      Infiltration Cellular, Lymphocyte    |                      3        2                                          |      3  2.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    91 PPM                                 | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4|     |      L     |
                                           | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Periovarian Tissue, Hemorrhage       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Decidual Reaction                    |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Cervix, Hypertrophy                  |                   X        X     X        X                 X            |      5     |
      Endometrium, Hyperplasia, Cystic     | 2                                      2                                 |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Exudate, Mucous                      |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              | 1                             1                                          |      2  1.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Bronchial, Hyperplasia, Lymphoid     |                                           2                              |      1  2.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |       2                    2                                2            |      8  2.3|
      Mediastinal, Ectasia                 |                            2                                             |      1  2.0|
      Mediastinal, Hemorrhage              |                            2                       2                     |      3  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                    2                     |      1  2.0|
      Mesenteric, Ectasia                  |                                                    3                     |      1  3.0|
      Mesenteric, Hemorrhage               |                                                    2                     |      1  2.0|
      Pancreatic, Hemorrhage               |                                                             2            |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    91 PPM                                 | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4|     |      L     |
                                           | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hematopoietic Cell Proliferation     |             2                                                            |      4  2.0|
      Hyperplasia, Focal                   |                                                    4                     |      1  4.0|
      Pigmentation                         |                                                       3                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cyst                                 |                                        X                                 |      2     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M      |  46        |
      Galactocele                          |                                                                          |      2     |
      Hyperplasia                          | 2              2  2     2  2  2  2  2  1  2  2  2     2     2  1         |     20  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Duct, Dilatation                     |                   3        2              2     2           2            |     13  2.2|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Abscess                              |                                                                          |      1  3.0|
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
      Epidermis, Necrosis                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Femur, Osteopetrosis                 |             3  3                                                         |      4  3.3|
      Maxilla, Inflammation, Chronic       |                                                                          |      1  3.0|
      Sternum, Fibrous Osteodystrophy      |    1                                                                     |      1  1.0|
      Sternum, Osteopetrosis               |             3  3                                                         |      4  3.3|
      Turbinate, Osteopetrosis             |                2                                                         |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    91 PPM                                 | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4|     |      L     |
                                           | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5|     |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Brain Stem, Hypothalamus, Compression|                   2        2              2  1                           |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Alveolar Epithelium, Hyperplasia     |             1        2                                                   |      3  1.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1                                      1                                 |      3  1.0|
      Alveolus, Inflammation, Multifocal   |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nasolacrimal Duct, Cyst Epithelial   |                                                                          |            |
          Inclusion                        |                                           X                              |      1     |
      Nasolacrimal Duct, Inflammation      | 2  2        2  1  2  2  2  2  1        2  2     1  1                     |     19  1.7|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Chronic                |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 4| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    91 PPM                                 | 3| 4| 4| 4| 4| 4| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 3| 4| 4| 4| 4| 4| 4|     |      L     |
                                           | 9| 0| 1| 2| 3| 4| 0| 5| 2| 3| 4| 5| 6| 7| 8| 9| 9| 0| 1| 2| 3| 4| 5|     |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                     +                                    |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Phthisis Bulbi                       |                                     X                                    |      1     |
      Bilateral, Cataract                  |                                                                          |      1  2.0|
      Bilateral, Retina, Degeneration      |          2                                                               |      4  2.0|
      Retina, Autolysis                    |                                                                          |      1     |
      Retina, Degeneration                 |                                                    2                     |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  1.0|
      Infiltration Cellular, Lymphocyte    |    2  1     2     1  1     1  1     1     2  1  1     1  1     1         |     26  1.3|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |             +     +                    +           +                     |   6        |
      Infiltration Cellular, Lymphocyte    |                                        1                                 |      1  1.0|
      Metaplasia                           |             2     2                    2           2                     |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hydronephrosis                       |                                                                          |      1  1.0|
      Mineralization                       | 2  2  2  2  1  2  2  2  2  2  2  2  2  1  2  2  2  2  1  2  2  2  2      |     46  1.9|
      Nephropathy                          |    1  1     1  1  1  1  2  2  1  2     1  2  2  1           1            |     31  1.2|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation                         |                      1                                                   |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8|             
                                           | 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    272 PPM                                | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1|             
                                           | 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Inflammation                  |                                                                          |             
      Colon, Lymphoid Tissue, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Dilatation                    |                                                                          |             
      Ileum, Inflammation                  |                                                                          |             
      Ileum, Lymphoid Tissue, Hyperplasia  |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                         X                                                |             
      Basophilic Focus, Multiple           |                                                                      X   |             
      Degeneration, Cystic                 |          1                                                               |             
      Developmental Malformation           |                                                                   X      |             
      Eosinophilic Focus                   |             X     X  X     X                       X     X               |             
      Eosinophilic Focus, Multiple         |                                  X              X              X     X   |             
      Hematopoietic Cell Proliferation     |                               1                                          |             
      Hepatodiaphragmatic Nodule           |       X        X     X                                      X            |             
      Infiltration Cellular, Lymphocyte    |                                  1           2                           |             
      Inflammation, Focal, Granulomatous   |                2  2        1        1           2  2        2  2     2   |             
      Necrosis                             |                                                 2                        |             
      Vacuolization Cytoplasmic            |       1           1     2  2  1     2  2     2     2           2  2      |             
      Bile Duct, Cyst                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8|             
                                           | 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    272 PPM                                | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1|             
                                           | 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Hyperplasia               |       2     2           2  2     2  1  2     2        1              1   |             
      Centrilobular, Necrosis              |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                           1                              |             
      Inflammation                         |       1                                                                  |             
      Acinus, Atrophy                      |             2     1     2  2  3  2  1  1                    1            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                      1                                                   |             
                                           |__________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Inflammation            | 2                                                                        |             
      Forestomach, Epithelium, Hyperplasia | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1  1  2  2  1           1  2  2  1     1           2  2  2  1  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Accessory Adrenal Cortical   |                                                                          |             
          Nodule                           |                                  X                             X         |             
      Cortex, Angiectasis                  |                2                                                         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8|             
                                           | 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    272 PPM                                | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1|             
                                           | 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Cortex, Hyperplasia, Focal           |                                        1                                 |             
      Cortex, Hypertrophy, Focal           |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Cyst                  |                                                          X               |             
      Pars Distalis, Hyperplasia           |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                            2     2                       2     3     1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3              2                 1                 3   |             
      Inflammation                         |    2     2  1     2  2  1     2           2  1  2  2     2        1     2|             
      Duct, Dilatation                     |          2        3  2        2  2              3  2                     |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                       2                 2  2     2     2      |             
      Cyst                                 |    X              X        X  X                 X           X            |             
      Infiltration Cellular, Lymphocyte    |                                                    2     3               |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Hypertrophy                  |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                2                                      2                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8|             
                                           | 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    272 PPM                                | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1|             
                                           | 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         3                                                |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mandibular, Ectasia                  |                                                             2            |             
      Mandibular, Hyperplasia, Lymphoid    |                                     2                                   2|             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |       2                                   2        2  2                  |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mesenteric, Angiectasis              |    2                                                                     |             
      Mesenteric, Ectasia                  |          2                                         2                     |             
      Mesenteric, Hyperplasia, Lymphoid    |          2                                         2                     |             
      Pancreatic, Hyperplasia, Lymphoid    |                            2                                             |             
      Renal, Hyperplasia, Lymphoid         |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2  2  2                          3                              |             
      Pigmentation                         |    2                                         3           3               |             
      Stromal Hyperplasia                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8|             
                                           | 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    272 PPM                                | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1|             
                                           | 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Hyperplasia                          |          1        3     2                 2  2  1                        |             
      Duct, Dilatation                     |          1                             2     2                           |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      2                                                   |             
      Epidermis, Hyperplasia               |                      2                                                   |             
      Epidermis, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                   2                                                      |             
      Sternum, Osteopetrosis               |                   2                                                      |             
      Turbinate, Osteopetrosis             |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Brain Stem, Hypothalamus, Compression|                                        2                          2      |             
                                           |__________________________________________________________________________|             
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 0| 7| 9| 7| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8|             
                                           | 2| 0| 9| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    272 PPM                                | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 9| 9| 9| 9| 9| 9| 9| 1|             
                                           | 3| 1| 0| 5| 9| 5| 7| 8| 9| 0| 1| 2| 3| 4| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          1                             1  1        1  1  1               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |    1                          1  1     2     3     2        1  2     1  2|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Phthisis Bulbi                       |                                                                          |             
      Bilateral, Retina, Degeneration      |             1           2        2                                       |             
      Retina, Autolysis                    |                                                                          |             
      Retina, Degeneration                 |          2        1                                      1               |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Lymphocyte    |             2           1     2  2        1  1     2  1        1  2  2   |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                     +  +           +  +        +         |             
      Metaplasia                           |                                     3  2           2  2        2         |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                         2|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Mineralization                       | 2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  1  2  1  2  2  2  2|             
      Nephropathy                          |                1  1     1        1  1  2     1  2  1        1        1   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    272 PPM                                | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|     |      L     |
                                           | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cecum, Inflammation                  |                      4                                                   |      1  4.0|
      Colon, Lymphoid Tissue, Hyperplasia  |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Ileum, Dilatation                    |                      2                                                   |      1  2.0|
      Ileum, Inflammation                  |                      4                                                   |      1  4.0|
      Ileum, Lymphoid Tissue, Hyperplasia  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Basophilic Focus                     |                                                    X                     |      2     |
      Basophilic Focus, Multiple           |                                     X                                    |      2     |
      Degeneration, Cystic                 |    1              2                                      2        2      |      5  1.6|
      Developmental Malformation           |                X                    X                                    |      3     |
      Eosinophilic Focus                   |    X                 X        X  X                 X  X  X               |     13     |
      Eosinophilic Focus, Multiple         |                   X                    X     X                           |      7     |
      Hematopoietic Cell Proliferation     |                                                    1  1                  |      3  1.0|
      Hepatodiaphragmatic Nodule           |    X                                                                     |      5     |
      Infiltration Cellular, Lymphocyte    |                      1              1        1                 1  1      |      7  1.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    272 PPM                                | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|     |      L     |
                                           | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation, Focal, Granulomatous   |          2  2  1              2  1     2  2        1     2  1     1      |     20  1.7|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                3        2     2  1     2                    2            |     17  1.8|
      Bile Duct, Cyst                      |                                           X  X                           |      2     |
      Bile Duct, Hyperplasia               |                   1     2  2  1           2  1        1  1     1         |     19  1.5|
      Centrilobular, Necrosis              |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                 +                        |   1        |
      Fat, Necrosis                        |                                                 3                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Infiltration Cellular, Lymphocyte    |                            1                 1                           |      3  1.0|
      Inflammation                         |                                                                          |      1  1.0|
      Acinus, Atrophy                      |    2     3     2     2     2  1                 2  3                     |     17  1.9|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Forestomach, Inflammation            |                                                                          |      1  2.0|
      Forestomach, Epithelium, Hyperplasia |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Epithelium, Hyperplasia, Focal       |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    272 PPM                                | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|     |      L     |
                                           | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Cardiomyopathy                       |    2  1  1  2  1  1  1     2  1  2  2        2  1  1     1  2  2  1      |     33  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cortex, Accessory Adrenal Cortical   |                                                                          |            |
          Nodule                           |                                                       X                  |      3     |
      Cortex, Angiectasis                  |                                        2                                 |      2  2.0|
      Cortex, Hyperplasia, Focal           |                2                          1           2                  |      4  1.5|
      Cortex, Hypertrophy, Focal           | 1                                                                        |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  M  +  +  M  +  +      |  40        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Angiectasis                          |                      4                                                   |      1  4.0|
      Pars Distalis, Cyst                  | X  X                       X                                X  X         |      6     |
      Pars Distalis, Hyperplasia           |                            2        2              2                     |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +      |  47        |
      C-Cell, Hyperplasia                  |                1                                                         |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    272 PPM                                | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|     |      L     |
                                           | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Hyperplasia                          |                                                 4                        |      5  2.6|
      Inflammation                         |                1              2  2        3     3     2     2  3         |     22  1.9|
      Duct, Dilatation                     |             2  2  2     2     2  2        3  2        3     2  3         |     18  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                2              2     4  3                                 |     10  2.3|
      Cyst                                 |    X     X     X                                         X               |     10     |
      Infiltration Cellular, Lymphocyte    |                                                                2         |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cervix, Hypertrophy                  |                                                 X           X            |      2     |
      Endometrium, Hyperplasia, Cystic     |    2                                                        2            |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Metaplasia, Squamous                 |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |    3     1        3                    1                                 |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia, Lymphoid                |                                                                   3      |      1  3.0|
      Mandibular, Ectasia                  |                                                       2                  |      2  2.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                 3              2         |      4  2.3|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                                          |      4  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                        3                                 |      1  3.0|
      Mesenteric, Angiectasis              |                                                                          |      1  2.0|
      Mesenteric, Ectasia                  |                      3                                            3      |      4  2.5|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      2  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                     2                                    |      2  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    272 PPM                                | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|     |      L     |
                                           | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hematopoietic Cell Proliferation     |    3                                                              3      |      6  2.5|
      Pigmentation                         |                                                                          |      3  2.7|
      Stromal Hyperplasia                  |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +      |  44        |
      Cyst                                 |                                     X                                    |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          |    2  2  2     2     2           1     2  2     3  1     3  1  1         |     19  1.8|
      Duct, Dilatation                     |                2                       2  2                       2      |      7  1.9|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation                         |                                                                          |      1  2.0|
      Epidermis, Hyperplasia               |                         2  2                                             |      3  2.0|
      Epidermis, Necrosis                  |                         2  1                                             |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Femur, Osteopetrosis                 |                   3                                3                     |      3  2.7|
      Sternum, Osteopetrosis               |                   3                                3           2         |      4  2.5|
      Turbinate, Osteopetrosis             |                   2                                3           2         |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    272 PPM                                | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|     |      L     |
                                           | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Brain Stem, Hypothalamus, Compression|       3        3     1                                                   |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |                         1                                                |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                              1                           |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                     1        1              1  1         |     10  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Nasolacrimal Duct, Inflammation      |          2     1     2        2     2  2              1     1            |     18  1.6|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Phthisis Bulbi                       |                X                                                         |      1     |
      Bilateral, Retina, Degeneration      |                                  2           2                           |      5  1.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 2| 5| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 9| 9| 9| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    272 PPM                                | 4| 4| 5| 6| 6| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|     |      L     |
                                           | 3| 7| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Retina, Autolysis                    |       X                                                                  |      1     |
      Retina, Degeneration                 |    2              2                                            2         |      6  1.7|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          |                   3                                                      |      1  3.0|
      Infiltration Cellular, Lymphocyte    |    1           1     1        1  2     1  2     1     2  1        1      |     22  1.4|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                        +        +  +                     |   8        |
      Metaplasia                           |                                        2        2  2                     |      8  2.1|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                         1                                                |      1  1.0|
      Mineralization                       | 2  2  3  1  1  2  2  1  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2      |     47  1.9|
      Nephropathy                          | 1     1     1  3  1           1  1  1  2  1  1  1  2     1  1  1         |     27  1.2|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |                                     1                                    |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|             
                                           | 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|             
    543 PPM                                | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|             
                                           | 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Colon, Lymphoid Tissue, Hyperplasia  |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Developmental Malformation           |       X                                                        X         |             
      Eosinophilic Focus                   |                                                                          |             
      Eosinophilic Focus, Multiple         |                                              X                          X|             
      Hematopoietic Cell Proliferation     |                      1                                                   |             
      Hepatodiaphragmatic Nodule           |          X                                                               |             
      Infiltration Cellular, Lymphocyte    |                                        1                                 |             
      Inflammation, Focal, Granulomatous   |                   2           1        1  1           1                  |             
      Necrosis                             |    1                                                                     |             
      Tension Lipidosis, Multiple          |                                                                          |             
      Vacuolization Cytoplasmic            |                   2           1        2  2  2     2  2                  |             
      Bile Duct, Hyperplasia               |                               1  1        1           1     2        1   |             
      Centrilobular, Necrosis              |          3           2                                                   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|             
                                           | 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|             
    543 PPM                                | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|             
                                           | 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Acinus, Atrophy                      | 2              2           1        4     1                 1     1     3|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Inflammation            |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  2     2        2     2     2           2  2  2     1     1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Angiectasis                  |                                                                          |             
      Cortex, Hyperplasia, Focal           |                                        1              1                  |             
      Cortex, Thrombosis                   |                               3                                          |             
      Cortex, Vacuolization Cytoplasmic    |                            2                                             |             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|             
                                           | 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|             
    543 PPM                                | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|             
                                           | 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  M  M  +  +  +  M  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Cyst                  |                                  X                                       |             
      Pars Distalis, Hyperplasia           |                         2                                                |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                           2     1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       1                  |             
      Inflammation                         |    2     1  3     3           3  2     2  2     3     2     2  1  3      |             
      Duct, Dilatation                     |          2           2                          2        2               |             
      Duct, Hyperplasia                    |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               2              1        2        3         |             
      Cyst                                 |                         X           X                    X               |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decidual Reaction                    |    X                                                                     |             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bilateral, Horn, Dilatation          | 3                                                                        |             
      Cervix, Hypertrophy                  |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                     3                       2        1   |             
      Endometrium, Hyperplasia             |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|             
                                           | 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|             
    543 PPM                                | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|             
                                           | 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |       2                 2                                                |             
      Prolapse                             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        1                    2            |             
      Myelostromal Proliferation           |                                           4                              |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Ectasia                  |                                     2                                    |             
      Mandibular, Hyperplasia, Lymphoid    |                                              2                           |             
      Mediastinal, Ectasia                 |                                                 2                        |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mesenteric, Ectasia                  |                                                                          |             
      Mesenteric, Hemorrhage               |                            2                                             |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                 2                       2|             
      Pancreatic, Ectasia                  |                                                                         3|             
      Pancreatic, Hemorrhage               |                                                                         2|             
      Pancreatic, Hyperplasia, Lymphoid    |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                              |             
      Fibrosis                             |                                                       1                  |             
      Hematopoietic Cell Proliferation     |    3                 3                    2              2               |             
      Pigmentation                         |          2                                                               |             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|             
                                           | 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|             
    543 PPM                                | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|             
                                           | 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3                 2  2     2        2     2        2     2  2|             
      Duct, Dilatation                     |                                                                2         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Multifocal           |          2                                                               |             
      Inflammation                         |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
      Epidermis, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                                                                          |             
      Femur, Fracture Healed               |          X                                                               |             
      Femur, Osteopetrosis                 |                                                                          |             
      Mandible, Osteopetrosis              |                                                                          |             
      Sternum, Osteopetrosis               |                                                                          |             
      Turbinate, Osteopetrosis             |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Brain Stem, Hypothalamus, Compression|                                                       2        3        2|             
      Cerebrum, Hemorrhage                 |             1                                                            |             
                                           |__________________________________________________________________________|             
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|             
                                           | 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|             
    543 PPM                                | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|             
                                           | 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |    2                                                                     |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Focal, Squamous                 |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          2                                   1                    1      |             
      Alveolus, Inflammation, Multifocal   |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |                   2     1              2     2  2  1                 2   |             
      Respiratory Epithelium, Concretion   |    1                                                                     |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |    3                                               2                 1   |             
      Phthisis Bulbi                       |                                                                          |             
      Bilateral, Cataract                  |                                                                          |             
      Bilateral, Retina, Degeneration      |                                                 1                        |             
      Cornea, Neovascularization           |                                                                          |             
      Retina, Autolysis                    |          X  X                                            X               |             
      Retina, Degeneration                 |    3                                               3              1  2   |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1  1              1                    1  2  2  2     1           1  1   |             
      Inflammation                         |                                        1                                 |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                        +        +                    +   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 3| 8| 3| 4| 4| 7| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 7| 3| 5| 3| 3|             
                                           | 4| 6| 5| 3| 0| 8| 6| 9| 9| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 0| 2| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|             
    543 PPM                                | 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 6| 6| 6| 6| 6| 9| 9| 9| 0| 1| 3| 4| 4| 5| 5|             
                                           | 2| 3| 1| 7| 8| 2| 3| 6| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 7| 1| 2| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                        2        2                        |             
      Metaplasia                           |                                        2        2                    2   |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2  1  2  2  2  2  2  2  2  2  1  2  2  2  1  2  2  2  1  2  2  2  2  2  2|             
      Nephropathy                          |                   1        1  1        1  1  1     1  2        1        1|             
      Pigmentation                         |                   2                 2                                    |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    543 PPM                                | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3|     |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Colon, Lymphoid Tissue, Hyperplasia  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |                         2                                                |      1  2.0|
      Basophilic Focus                     |                                  X                                       |      1     |
      Degeneration, Cystic                 |                                              2     2  2                  |      3  2.0|
      Developmental Malformation           |          X  X                                      X                     |      5     |
      Eosinophilic Focus                   |       X           X     X                 X                 X            |      5     |
      Eosinophilic Focus, Multiple         | X  X                 X     X        X  X     X     X  X                  |     11     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Infiltration Cellular, Lymphocyte    |    1           1                          1                              |      4  1.0|
      Inflammation, Focal, Granulomatous   | 1           2  1  1                 1              1     1     1         |     13  1.2|
      Necrosis                             |                         1                             2                  |      3  1.3|
      Tension Lipidosis, Multiple          |          2                                                               |      1  2.0|
      Vacuolization Cytoplasmic            | 2     2  1  2     1  2  2  2     1  1  1  1           2  2        2      |     22  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    543 PPM                                | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3|     |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Bile Duct, Hyperplasia               |          1           1     2  2  1  1  1  1     2     2     1  1         |     18  1.3|
      Centrilobular, Necrosis              |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                              +        +     +            |   4        |
      Accessory Spleen                     |                                              X                           |      1     |
      Fat, Necrosis                        |                                                       3     3            |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |                                                          1               |      1  1.0|
      Acinus, Atrophy                      | 2  3  1     2     1     2        2        2           1     3            |     18  1.9|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Forestomach, Inflammation            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       |    1  1     2  1     1  2  2     1  1  1  2     1  1     2  1     2      |     30  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cortex, Angiectasis                  |                                           1              2  1            |      3  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    543 PPM                                | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3|     |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Cortex, Hyperplasia, Focal           | 1                    1  1                                                |      5  1.0|
      Cortex, Thrombosis                   |                                                                          |      1  3.0|
      Cortex, Vacuolization Cytoplasmic    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +      |  36        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Angiectasis                          |          2                                      2                        |      2  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           | 2              2              2                                2         |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      C-Cell, Hyperplasia                  |    2                                                                     |      1  2.0|
      Follicle, Cyst                       |                                                    1           1         |      2  1.0|
      Follicular Cell, Hyperplasia         |                                        1                                 |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                         2              2                                 |      3  1.7|
      Inflammation                         | 1  3     1  3           2  2  2  1  2  2  1     2  3     3     2         |     28  2.1|
      Duct, Dilatation                     | 2  2  2     2           2        2  2  2  2     2        3               |     15  2.1|
      Duct, Hyperplasia                    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    543 PPM                                | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3|     |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Atrophy                              |                                                       3        1  3      |      7  2.1|
      Cyst                                 |                      X                                                   |      4     |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Decidual Reaction                    |                                                                          |      1     |
      Hemorrhage                           |                                                             3            |      1  3.0|
      Thrombosis                           |                               X                                          |      1     |
      Bilateral, Horn, Dilatation          |                                                                          |      1  3.0|
      Cervix, Hypertrophy                  |                                           X  X     X  X     X            |      5     |
      Endometrium, Hyperplasia, Cystic     |                                     2           3        2  2            |      7  2.1|
      Endometrium, Hyperplasia             |                                  3                                       |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemorrhage                           |                               3                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Prolapse                             |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                               3                                          |      3  2.0|
      Myelostromal Proliferation           |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Mandibular, Ectasia                  |                         2                                                |      2  2.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                   3                                                      |      1  3.0|
      Mesenteric, Ectasia                  |                                                    3  2                  |      2  2.5|
      Mesenteric, Hemorrhage               |                                                          2               |      2  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      2  2.0|
      Pancreatic, Ectasia                  |                                                                          |      1  3.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    543 PPM                                | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3|     |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                   2                                                      |      5  2.4|
      Pigmentation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  42        |
      Cyst                                 |                                              X                           |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          | 2  2  2  1  1  3        2                 2  2     2  1  2        3      |     22  2.0|
      Duct, Dilatation                     |                      2  2                                                |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperkeratosis, Multifocal           |                                                                          |      1  2.0|
      Inflammation                         |       2                                                                  |      1  2.0|
      Epidermis, Hyperplasia               |       2                                2        2                        |      3  2.0|
      Epidermis, Necrosis                  |    2                                   2        2                        |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cranium, Osteopetrosis               |                   3                                                      |      1  3.0|
      Femur, Fracture Healed               |                                                                          |      1     |
      Femur, Osteopetrosis                 |                   3                                                      |      1  3.0|
      Mandible, Osteopetrosis              |                   3                                                      |      1  3.0|
      Sternum, Osteopetrosis               |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    543 PPM                                | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3|     |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
      Turbinate, Osteopetrosis             |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Brain Stem, Hypothalamus, Compression|                                           1  2                           |      5  2.0|
      Cerebrum, Hemorrhage                 |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Alveolar Epithelium, Hyperplasia     |                                                    2                     |      2  2.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Focal, Squamous                 |          1                                                               |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Multifocal                      |    1                                                                     |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                         2  1                       2                     |      6  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    543 PPM                                | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3|     |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolus, Inflammation, Multifocal   |          1                                                               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Nasolacrimal Duct, Inflammation      | 1  1     1  1     2  2  2           1                 2  1     1  1      |     19  1.5|
      Respiratory Epithelium, Concretion   |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cataract                             |       1                                1                                 |      5  1.6|
      Phthisis Bulbi                       |             X                                         X                  |      2     |
      Bilateral, Cataract                  |                1  1                                                      |      2  1.0|
      Bilateral, Retina, Degeneration      |    2  3           3        2     2                       2               |      7  2.1|
      Cornea, Neovascularization           |                                                       2                  |      1  2.0|
      Retina, Autolysis                    |                                                                          |      3     |
      Retina, Degeneration                 |                2     2  2              3        1                        |      9  2.1|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    | 1  1  1     1     1     1        1     1        1  2        1            |     21  1.2|
      Inflammation                         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |          +                                                               |   4        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.0|
      Metaplasia                           |          2                                                               |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +      |  46        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Mineralization                       | 2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2      |     48  1.9|
      Nephropathy                          | 1  1  1     1     2  2  2  1  1     2  1  1  1  1  1  1  1  1     1      |     29  1.2|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR FEMALE            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    543 PPM                                | 5| 5| 5| 5| 5| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3|     |      L     |
                                           | 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Pigmentation                         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |          1                       1                                       |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|             
                                           | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|             
    0 PPM                                  | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|             
                                           | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Lymphoid Tissue, Hyperplasia  |       2                                3           2                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Lymphoid Tissue, Hyperplasia  |                                                 2                        |             
      Jejunum, Lymphoid Tissue, Hyperplasia|                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       2                                                                  |             
      Developmental Malformation           |                                                                      X   |             
      Eosinophilic Focus                   |                                              X        X                  |             
      Eosinophilic Focus, Multiple         |                                                             X            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                   2      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |    3                          3           2  1     2                     |             
      Bile Duct, Cyst                      |                                                       X                  |             
      Bile Duct, Hyperplasia               | 2     3     3  2     3  2  2  3  2  3  2  2  1  2  2  3  2  2  3  2  2  3|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +  +  +                                             |             
      Fat, Necrosis                        |                      2  2                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|             
                                           | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|             
    0 PPM                                  | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|             
                                           | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Acinus, Atrophy                      | 2     2  2  2  2  3           2     2  2  2     1        2  2  1        2|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Edema                   |                                                                      3   |             
      Forestomach, Inflammation            |    2                                      2                              |             
      Forestomach, Epithelium, Hyperplasia |                                                                          |             
      Glandular, Edema                     |                                                                      3   |             
      Glandular, Erosion                   |                               2                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1  2  2  2  2     2        2  2  2  2  2  2  1  2     2  3  2      |             
      Atrium, Thrombosis                   |                               X                                          |             
      Ventricle Right, Dilatation          |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Vacuolization Cytoplasmic    |          2                                                               |             
      Medulla, Hyperplasia                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|             
                                           | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|             
    0 PPM                                  | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|             
                                           | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +|             
      Hyperplasia, Focal                   |    3                                               2                     |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Cyst                  |                      X                                                   |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                            2              2  1  3  1                     |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abdominal, Pigmentation              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Decreased Secretory Fluid            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Cyst                         |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Chronic       |                                     2                                    |             
      Inflammation                         | 3  2  2     2  2     2  3  3  2  2     2  1  4  2  1     1  2  1  2      |             
      Duct, Ectasia                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decreased Secretory Fluid            |                                  2                                       |             
      Inflammation                         |    2  3        3     2  2  1  1     3  2  3  2  2     2  2  2     2     4|             
      Ventral, Hyperplasia                 |                                                                2         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|             
                                           | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|             
    0 PPM                                  | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|             
                                           | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decreased Secretory Fluid            | 3     3  3                 3     2     2  2  2  2  3           2     2  2|             
      Lumen, Distended                     |                                                                          |             
      Serosa, Inflammation, Chronic        | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Interstitial Cell, Hyperplasia       | 2           2  1  1  1     2  2  2        2                       2      |             
      Seminiferous Tubule, Atrophy         | 2                          2  3                                      3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1                                                            |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mandibular, Ectasia                  |                                                                          |             
      Mandibular, Hemorrhage               |                               2                                          |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                 2              2         |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mesenteric, Ectasia                  |             3                             2                       3      |             
      Mesenteric, Hemorrhage               |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                               2                                          |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                  2                                       |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                     2                                    |             
      Renal, Hemorrhage                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|             
                                           | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|             
    0 PPM                                  | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|             
                                           | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                          2  2     2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pigmentation                         |                                           2                              |             
      Stromal Hyperplasia                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Parathyroid Gland            |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                        X     X           X     X         |             
      Hyperplasia                          |                                                                          |             
      Duct, Dilatation                     |                2     1        2                          2     2         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                      3                                                   |             
      Cyst Epithelial Inclusion            |    X                                                                     |             
      Hyperkeratosis                       |                               3                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Brain Stem, Hemorrhage               |                2                                                         |             
      Brain Stem, Hypothalamus, Compression| 3                       2                 2                    2         |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|             
                                           | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|             
    0 PPM                                  | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|             
                                           | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                  2                                       |             
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                              1                           |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |                2                 1  2                                    |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Chronic                         |                                                             2            |             
      Septum, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                +         |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
      Hemorrhage                           |                                                                      3   |             
      Inflammation                         |                                                                      3   |             
      Bilateral, Cataract                  |          2                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 4| 1| 9| 3| 5| 5| 6| 6| 6| 9| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 6| 6|             
                                           | 1| 3| 9| 2| 9| 3| 2| 6| 2| 0| 8| 1| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2|             
    0 PPM                                  | 1| 2| 2| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 3| 3|             
                                           | 7| 5| 6| 0| 5| 8| 0| 1| 2| 8| 0| 2| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Bilateral, Retina, Degeneration      |                                                                          |             
      Cornea, Edema                        |                                                                          |             
      Retina, Autolysis                    |                X                                                         |             
      Retina, Degeneration                 |          3                                                               |             
      Sclera, Metaplasia, Osseous          |                            2                                             |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                            2                                1           1|             
      Inflammation                         |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   2                                                      |             
      Nephropathy                          | 2  2  2  2  1  2     1  1     2  2  2  2  2  1  2  3  2  2  2  3  1     1|             
      Pigmentation                         |                   1              2  3                                    |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|     |            |
                             DAY ON TEST   | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|     |            |
                                           | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    0 PPM                                  | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8|     |      L     |
                                           | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cecum, Lymphoid Tissue, Hyperplasia  |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +      |  47        |
      Ileum, Lymphoid Tissue, Hyperplasia  |                         2        2              2                        |      4  2.0|
      Jejunum, Lymphoid Tissue, Hyperplasia|                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Degeneration, Cystic                 |          2                                               2  2            |      4  2.0|
      Developmental Malformation           |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Eosinophilic Focus, Multiple         |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                               1                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                         X                                      X         |      2     |
      Inflammation, Focal, Granulomatous   |                                                       2  2               |      3  2.0|
      Mixed Cell Focus                     |    X                                                                     |      1     |
      Necrosis                             |                                           2                              |      1  2.0|
      Vacuolization Cytoplasmic            |             2                 2  1        2                              |      9  2.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|     |            |
                             DAY ON TEST   | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|     |            |
                                           | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    0 PPM                                  | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8|     |      L     |
                                           | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Bile Duct, Hyperplasia               |       3  1  2  1        3  2  2  2  3  1  3  2  2  4  2  2  3  1  2      |     41  2.2|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                      +  +                                                |   5        |
      Fat, Necrosis                        |                      3                                                   |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |                            1                                             |      1  1.0|
      Acinus, Atrophy                      | 2  2  3  2        1  2        2  2  2        1     2        1  2         |     28  1.9|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Forestomach, Edema                   |          3                                                               |      2  3.0|
      Forestomach, Inflammation            |                                                                          |      2  2.0|
      Forestomach, Epithelium, Hyperplasia |                                                                1         |      1  1.0|
      Glandular, Edema                     |                                                                          |      1  3.0|
      Glandular, Erosion                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       | 2  2     2  2  2  2  2     2     2  2  2  2  2     2  1  2  2     2      |     37  1.9|
      Atrium, Thrombosis                   |                                                                          |      1     |
      Ventricle Right, Dilatation          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|     |            |
                             DAY ON TEST   | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|     |            |
                                           | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    0 PPM                                  | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8|     |      L     |
                                           | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cortex, Vacuolization Cytoplasmic    |                                                                          |      1  2.0|
      Medulla, Hyperplasia                 |                                  1                                       |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  M  +  +  +  +  M  +  +  M  +  +  +  M  M  +      |  38        |
      Hyperplasia, Focal                   |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Pars Distalis, Cyst                  |                               X                                          |      2     |
      Pars Distalis, Hyperplasia           |                                                          2               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      C-Cell, Hyperplasia                  |                            2     2                 1                     |      8  1.8|
      Follicular Cell, Hyperplasia         |    1                       1                                             |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                         +                                                |   1        |
      Abdominal, Pigmentation              |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +      |  46        |
      Decreased Secretory Fluid            |       2              3                                                   |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Serosa, Cyst                         |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|     |            |
                             DAY ON TEST   | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|     |            |
                                           | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    0 PPM                                  | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8|     |      L     |
                                           | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                               2                                          |      1  2.0|
      Hyperplasia                          |       1                                                                  |      1  1.0|
      Infiltration Cellular, Chronic       |                                                                          |      1  2.0|
      Inflammation                         | 2     2  2  2  3  1  3  2  2  1  3  3     2     2        3        2      |     35  2.1|
      Duct, Ectasia                        |       3  3           3  2  2                    2              2         |      7  2.4|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Decreased Secretory Fluid            |                                                                          |      1  2.0|
      Inflammation                         |          3     2     2     2     2     2  1           2  1  2  2  3      |     29  2.1|
      Ventral, Hyperplasia                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Decreased Secretory Fluid            | 2  2  2     3  2  2  3  2     2     3     3  2  2  2     2               |     28  2.3|
      Lumen, Distended                     |                                                                3         |      1  3.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Mineralization                       |                                  1                                       |      1  1.0|
      Interstitial Cell, Hyperplasia       | 2  2  2  1                       1  2        2                           |     17  1.7|
      Seminiferous Tubule, Atrophy         |                         3  3        2  3     2           3     2         |     11  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                                                                          |      1  1.0|
      Hyperplasia                          |                                              2     2                     |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Plasma Cell   |                                                    2                     |      1  2.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                    2        2            |      2  2.0|
      Mandibular, Ectasia                  |                2                                         3  3            |      3  2.7|
      Mandibular, Hemorrhage               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|     |            |
                             DAY ON TEST   | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|     |            |
                                           | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    0 PPM                                  | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8|     |      L     |
                                           | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |          2        2     2                                                |      5  2.0|
      Mediastinal, Ectasia                 |                         2                                                |      1  2.0|
      Mesenteric, Ectasia                  |                         2                                                |      4  2.5|
      Mesenteric, Hemorrhage               |                                     2                                    |      1  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                         2                                                |      2  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                    3                     |      1  3.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Fibrosis                             |                                        2                 2               |      5  2.0|
      Hematopoietic Cell Proliferation     |                                              2        2                  |      2  2.0|
      Pigmentation                         | 3                                                                 3      |      3  2.7|
      Stromal Hyperplasia                  |                                  3                                       |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +      |  43        |
      Ectopic Parathyroid Gland            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +      |  43        |
      Galactocele                          |                            X                          X                  |      6     |
      Hyperplasia                          |       1     2                    2                    3  1               |      5  1.8|
      Duct, Dilatation                     | 3  3     2     2        2                             2           2      |     12  2.1|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|     |            |
                             DAY ON TEST   | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|     |            |
                                           | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    0 PPM                                  | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8|     |      L     |
                                           | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Abscess                              |                                                                          |      1  3.0|
      Cyst Epithelial Inclusion            |                X                                                         |      2     |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Epidermis, Hyperplasia               |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Femur, Fibrous Osteodystrophy        |                                                       3                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Brain Stem, Hemorrhage               |                                                                          |      1  2.0|
      Brain Stem, Hypothalamus, Compression|    2     2  2                          3                          3      |      9  2.3|
                                           |__________________________________________________________________________|____________|
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|     |            |
                             DAY ON TEST   | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|     |            |
                                           | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    0 PPM                                  | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8|     |      L     |
                                           | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                              3                           |      2  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    1                                         3                           |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Nasolacrimal Duct, Inflammation      |          1                    2  2     1     2              2     2      |     10  1.7|
      Respiratory Epithelium, Hyperplasia  |                                                             2            |      1  2.0|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Septum, Inflammation, Chronic        |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cataract                             |    3           1                                               3         |      3  2.3|
      Hemorrhage                           |                                                                2         |      2  2.5|
      Inflammation                         |                                                                          |      1  3.0|
      Bilateral, Cataract                  |                                        2                                 |      2  2.0|
      Bilateral, Retina, Degeneration      |                   1                                                      |      1  1.0|
      Cornea, Edema                        |                                                    X                     |      1     |
      Retina, Autolysis                    |          X           X                 X                                 |      4     |
      Retina, Degeneration                 |    4        2  2        1  2  1                                4         |      8  2.4|
      Sclera, Metaplasia, Osseous          |                                                                   2      |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    | 1  1        1  1     1        2  1  1     1  1        2  1        1      |     16  1.2|
      Inflammation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|     |            |
                             DAY ON TEST   | 1| 2| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|     |            |
                                           | 3| 3| 9| 6| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 5| 5| 4| 4| 4| 4| 7|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    0 PPM                                  | 3| 3| 4| 5| 7| 7| 7| 7| 7| 7| 8| 8| 0| 1| 1| 1| 1| 1| 6| 6| 6| 6| 8|     |      L     |
                                           | 7| 8| 5| 8| 3| 4| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2|     |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Inflammation, Chronic                |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Nephropathy                          | 1  2  1  3  3  3  2  2  1  2  1  3  3     2  2  2  3  2  2  2  1         |     43  1.9|
      Pigmentation                         |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|             
                                           | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|             
                                           | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cecum, Lymphoid Tissue, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duodenum, Autolysis                  |                3                                                         |             
      Ileum, Lymphoid Tissue, Hyperplasia  |                                                          2               |             
      Jejunum, Autolysis                   |                3                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X                                                         |             
      Degeneration, Cystic                 |             1        2     1     1        1  1     1  2  1              1|             
      Developmental Malformation           |                                                                         X|             
      Eosinophilic Focus                   |                            X              X                          X   |             
      Eosinophilic Focus, Multiple         |                         X                    X                 X         |             
      Hepatodiaphragmatic Nodule           |                X              X                                          |             
      Inflammation, Focal, Granulomatous   |                                                    1                     |             
      Vacuolization Cytoplasmic            |          3              2     1        2  2  2  1        1  2  2         |             
      Bile Duct, Hyperplasia               |    2  1     2     3  3  2  2  3  2     3  2  2  2  1  3  2  3  3  2  2  1|             
      Centrilobular, Necrosis              |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Fat, Necrosis                        |                                                                2         |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|             
                                           | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|             
                                           | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                        1                                 |             
      Acinus, Atrophy                      |          2  2     2              2  2              2        2  2         |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Artery, Media, Hypertrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Edema                   |                                                                         3|             
      Forestomach, Inflammation            |          2                                                               |             
      Forestomach, Necrosis                |                                                                          |             
      Glandular, Edema                     |                                                                         3|             
      Glandular, Erosion                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2  2  2     2     2  2  2  2  1  2  2  2  2  1  2  1  2     2      |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Hyperplasia, Focal           |                         2           1              1                     |             
      Cortex, Hypertrophy, Focal           |                                  1                                       |             
      Cortex, Vacuolization Cytoplasmic    |          2     2                                                         |             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|             
                                           | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|             
                                           | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Focal                   |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                             1            |             
      Infiltration Cellular, Histiocytic   |                                                                2         |             
      Pigmentation                         |                                                                2         |             
      Pars Distalis, Cyst                  |                                        X                                 |             
      Pars Distalis, Hyperplasia           |       2              2        1           1              2               |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                  1        1                              |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |    +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Thrombosis                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |       2  1           2  1     2  1  2  1  2  3  3     2  2  2  2  2     2|             
      Duct, Ectasia                        |                               2                       2                  |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|             
                                           | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|             
                                           | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decreased Secretory Fluid            |                   2                                                      |             
      Inflammation                         |    2     2  1           2  2  2  2              2                 2     1|             
      Ventral, Hyperplasia                 |                                                       1                  |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decreased Secretory Fluid            |             2     2        3  2  1  3  2  2        2  2     2  2        2|             
                                           |__________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |          1  2        2        2                 1        2               |             
      Seminiferous Tubule, Atrophy         |                      2        3                          2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2                                                   |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Hyperplasia, Lymphoid        |                               2                                          |             
      Lumbar, Pigmentation                 |                               3                                          |             
      Mandibular, Ectasia                  |                                                    2  3                  |             
      Mandibular, Hyperplasia, Lymphoid    |                      2                                                   |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                            2                                   2         |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mesenteric, Congestion               |                                                                   2      |             
      Mesenteric, Ectasia                  |                   2                       2                              |             
      Mesenteric, Hemorrhage               |                                        2                                2|             
      Pancreatic, Hyperplasia, Lymphoid    |                               2                                          |             
      Pancreatic, Pigmentation             |                               3                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                           2                              |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Diffuse, Histiocytic             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|             
                                           | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|             
                                           | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis                             |                               3  2  3                                    |             
      Hematopoietic Cell Proliferation     |                                                          2  2            |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Infarct                              |                                                                          |             
      Pigmentation                         |    3           2                                                         |             
                                           |__________________________________________________________________________|             
   Thymus                                  |    M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Galactocele                          |                                                 X                        |             
      Hyperplasia                          |                            2                    2                        |             
      Duct, Dilatation                     |          2  3                                                     3      |             
                                           |__________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                  X        X                              |             
      Foot, Inflammation, Chronic          |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternum, Fibrous Osteodystrophy      |          2                                                               |             
                                           |__________________________________________________________________________|             
   Bone, Femur                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Brain Stem, Hemorrhage               |    3  3                                                                  |             
      Brain Stem, Hypothalamus, Compression|                                                                   3     3|             
      Cerebrum, Hydrocephalus              |                                                                         3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|             
                                           | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|             
                                           | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
      Cerebrum, Hypothalamus, Compression  |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Brain, Brain Stem                       |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebellum                       |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebrum                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thoracic, Hemorrhage                 |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Spinal Cord, Thoracic                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                             2            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                             2            |             
      Mediastinum, Hemorrhage              |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                1                                                         |             
      Nasolacrimal Duct, Inflammation      |          2                       2     2           2        2           2|             
      Respiratory Epithelium, Hyperplasia  |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                             1     2  1   |             
      Retina, Autolysis                    |    X           X  X                                               X      |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 8| 7| 2| 0| 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 2|             
                                           | 7| 7| 9| 0| 6| 5| 9| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2|             
    91 PPM                                 | 0| 1| 2| 2| 2| 2| 5| 5| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 3| 3| 4|             
                                           | 1| 5| 4| 7| 8| 9| 3| 9| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 3| 5| 0|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Harderian Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                1     2  1        1  1  1                 2              2|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |       1  3  1  2  1  2  2  3  2  2  2  3  2  3  2  2  2  2  3  2  1  1  2|             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       3                                                                  |             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    91 PPM                                 | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7|     |      L     |
                                           | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cecum, Lymphoid Tissue, Hyperplasia  |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Duodenum, Autolysis                  |                                                                          |      1  3.0|
      Ileum, Lymphoid Tissue, Hyperplasia  |                                                                          |      1  2.0|
      Jejunum, Autolysis                   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Basophilic Focus                     |                            X                                             |      2     |
      Degeneration, Cystic                 | 1  2              1     1     1  2                 2        1            |     18  1.3|
      Developmental Malformation           |                                                                          |      1     |
      Eosinophilic Focus                   |                         X        X              X     X  X               |      8     |
      Eosinophilic Focus, Multiple         |                      X                 X                       X         |      6     |
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |             3  1     1  1  2        3        2  2     2        2  2      |     21  1.9|
      Bile Duct, Hyperplasia               | 3  3     3     2  2  2  2  2  2  2  2  1  2  1  2  2  2  2  2  2  2      |     42  2.1|
      Centrilobular, Necrosis              |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    91 PPM                                 | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7|     |      L     |
                                           | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                      +                       +                           |   3        |
      Fat, Necrosis                        |                      2                       3                           |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Infiltration Cellular, Lymphocyte    |                                           1                              |      2  1.0|
      Acinus, Atrophy                      |       2           2        1  2  2     2              2     2            |     16  1.9|
      Artery, Inflammation, Chronic        |                                                                   3      |      1  3.0|
      Artery, Media, Hypertrophy           |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Forestomach, Edema                   |                                                                          |      1  3.0|
      Forestomach, Inflammation            |                                                                          |      1  2.0|
      Forestomach, Necrosis                |             2                                                            |      1  2.0|
      Glandular, Edema                     |                                                                          |      1  3.0|
      Glandular, Erosion                   |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cardiomyopathy                       | 2  2     2  2  2  1  2  2     2  2  2     2     1  3  2     3  2  2      |     36  1.9|
      Atrium, Thrombosis                   |          X  X                                                            |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    91 PPM                                 | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7|     |      L     |
                                           | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cortex, Hyperplasia, Focal           |                         2                          2                     |      5  1.6|
      Cortex, Hypertrophy, Focal           |                                                                          |      1  1.0|
      Cortex, Vacuolization Cytoplasmic    |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +      |  41        |
      Hyperplasia, Focal                   |       4                                                                  |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Angiectasis                          |                                                                          |      2  1.5|
      Infiltration Cellular, Histiocytic   |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                            X     X                                       |      3     |
      Pars Distalis, Hyperplasia           |                         2                                   2            |      7  1.7|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      C-Cell, Hyperplasia                  |                      2                 2           3     1               |      6  1.7|
      Follicular Cell, Hyperplasia         |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    91 PPM                                 | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7|     |      L     |
                                           | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Granuloma Sperm                      |                                        3                                 |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Penis                                   |                                                    +                     |   1        |
      Thrombosis                           |                                                    3                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                                  2                                       |      1  2.0|
      Inflammation                         | 2  3  3  2  2  1  1     1  2  1     2  3  2  3  3     3  1  2     3      |     36  2.0|
      Duct, Ectasia                        |                            2     3        3  3  4                 3      |      8  2.8|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Decreased Secretory Fluid            |                                                                          |      1  2.0|
      Inflammation                         | 3           1  1  1           1        3  2     1  2           2  3      |     21  1.8|
      Ventral, Hyperplasia                 |                                  2                                1      |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Decreased Secretory Fluid            | 2  3  2  3  2           2  2  2  2  2     2  2     3  2  2  2  3  2      |     31  2.2|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Interstitial Cell, Hyperplasia       |                2     2                 1        2  2                     |     11  1.7|
      Seminiferous Tubule, Atrophy         |                   2  2           3                             3         |      7  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Atrophy                              |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                    2                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  2.0|
      Lumbar, Pigmentation                 |                                                                          |      1  3.0|
      Mandibular, Ectasia                  |                         3     2                    2                     |      5  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    91 PPM                                 | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7|     |      L     |
                                           | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Mandibular, Hyperplasia, Lymphoid    |                                                             2            |      2  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |    2     2                          2                             2      |      6  2.0|
      Mediastinal, Hemorrhage              |             2                                                            |      1  2.0|
      Mesenteric, Congestion               |                                                                          |      1  2.0|
      Mesenteric, Ectasia                  |    3        3  3                             2                           |      6  2.5|
      Mesenteric, Hemorrhage               |                3                                                         |      3  2.3|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Pancreatic, Pigmentation             |                                                                          |      1  3.0|
      Renal, Hemorrhage                    |                                     2                    2               |      2  2.0|
      Renal, Hyperplasia, Lymphoid         |                                     2                                    |      2  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Diffuse, Histiocytic             |                                                          3               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Angiectasis                          |             2                                                            |      1  2.0|
      Fibrosis                             |                   2  4                                2                  |      6  2.7|
      Hematopoietic Cell Proliferation     |             2                                                            |      3  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infarct                              |                                                    X                     |      1     |
      Pigmentation                         |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +      |  41        |
      Galactocele                          |                                                                          |      1     |
      Hyperplasia                          |                                  2                                3      |      4  2.3|
      Duct, Dilatation                     | 2           2                          2                                 |      6  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    91 PPM                                 | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7|     |      L     |
                                           | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1|     |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Foot, Inflammation, Chronic          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Sternum, Fibrous Osteodystrophy      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Brain Stem, Hemorrhage               |                                                                          |      2  3.0|
      Brain Stem, Hypothalamus, Compression| 3                                      3                                 |      4  3.0|
      Cerebrum, Hydrocephalus              |                                                                          |      1  3.0|
      Cerebrum, Hypothalamus, Compression  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Thoracic, Hemorrhage                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    91 PPM                                 | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7|     |      L     |
                                           | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1|     |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Granuloma                            |                                                    1                     |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                   3                                                      |      2  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |             2                          1                    2            |      4  1.8|
      Mediastinum, Hemorrhage              |                                  2                                       |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation      | 2     2  1     2  1        2                    2     1           2      |     15  1.8|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cataract                             |                                                                          |      3  1.3|
      Retina, Autolysis                    |       X                                                                  |      5     |
      Retina, Degeneration                 |          2           1                                   2               |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                                                 2                        |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                1  1  2           1  1           2           1  1         |     16  1.3|
      Inflammation                         |    1                                                                     |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  I  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Nephropathy                          | 2  2     1  2  2  2  1  2  2  1  2  2  1  3  2  3  2  2  3  2  3  3      |     45  2.0|
      Pigmentation                         |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 6| 7| 9| 2| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 6| 7| 1| 7| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 5| 5| 5| 4| 5| 5| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    91 PPM                                 | 4| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 0| 0| 1| 1| 1| 1| 1| 2| 6| 7| 7|     |      L     |
                                           | 4| 1| 4| 6| 2| 2| 3| 4| 5| 6| 7| 8| 7| 8| 5| 6| 7| 8| 9| 0| 9| 0| 1|     |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation                         |                                                    3                     |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|             
                                           | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|             
    272 PPM                                | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|             
                                           | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Colon, Serosa, Dilatation    |                                                                          |             
      Colon, Lymphoid Tissue, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Hyperplasia                   |                                                                          |             
      Ileum, Inflammation                  |                                  2                                       |             
      Ileum, Lymphoid Tissue, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |          2                    2  2                    1  2               |             
      Eosinophilic Focus                   |                      X                    X                              |             
      Eosinophilic Focus, Multiple         |                               X     X  X           X  X                  |             
      Hepatodiaphragmatic Nodule           |                                           X                    X         |             
      Inflammation, Focal, Granulomatous   |                2                                                         |             
      Necrosis                             |                                  2                                       |             
      Pigmentation                         |       1                                                                  |             
      Vacuolization Cytoplasmic            |                      2              2  2  3                              |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 1     1  1     2  2  2  2  3  2  2  1  2  2  3  2  1  2  3  2           2|             
      Centrilobular, Necrosis              |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +              +                                               +     +   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|             
                                           | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|             
    272 PPM                                | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|             
                                           | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Accessory Spleen                     |                                                                          |             
      Polyarteritis                        |                3                                                         |             
      Fat, Necrosis                        | 2                                                              3         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                      X   |             
      Hyperplasia                          |                                  3                                       |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Acinus, Atrophy                      |             1           2  2     2  2  2     1           2        1      |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           2                              |             
                                           |__________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Forestomach, Edema                   |                                                                   2      |             
      Forestomach, Inflammation            |                                                                         2|             
      Forestomach, Epithelium, Hyperplasia |                                                                         2|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
      Gingiva, Hyperplasia                 |                                                             3            |             
      Gingiva, Inflammation                |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2  2  1  2  1  2     2  2     1  2  2  2  2  2  2     1     1     2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|             
                                           | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|             
    272 PPM                                | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|             
                                           | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Accessory Adrenal Cortical   |                                                                          |             
          Nodule                           |                                                    X                     |             
      Cortex, Hyperplasia, Focal           |                                                                          |             
      Cortex, Vacuolization Cytoplasmic    |             2                                                     2     1|             
      Medulla, Hyperplasia                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   1      |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Cyst                  |                                  X     X              X                  |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                      1                                                   |             
      Follicular Cell, Hyperplasia         |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  1  1  2     2     2     2  2  1  2  1  3              1  2  2  2     1|             
      Duct, Ectasia                        |                                     2                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|             
                                           | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|             
    272 PPM                                | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|             
                                           | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2     1     2  3  2     1           2  2  2  2        2              1|             
      Ventral, Hyperplasia                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Decreased Secretory Fluid            |          2     3     2        2  3  3        2     3  2  3  2  2     2  2|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          1                                                               |             
      Interstitial Cell, Hyperplasia       | 2  1                       1              3     1                        |             
      Seminiferous Tubule, Atrophy         |          1                                      2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |             2                                               2            |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Deep Cervical, Infiltration Cellular,|                                                                          |             
           Plasma Cell                     |                                                             3            |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                                                                   2      |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                   3      |             
      Mandibular, Ectasia                  |                      2     2           3                                 |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                   2      |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                            2                    2  2        3            |             
      Mediastinal, Hemorrhage              |                                                                   2      |             
      Mesenteric, Ectasia                  |                      3                    3           2     3            |             
      Mesenteric, Hemorrhage               |             2                                                     2      |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|             
                                           | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|             
    272 PPM                                | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|             
                                           | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  2                                       |             
      Hematopoietic Cell Proliferation     |       3                                                                  |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                      X                 X  X     X                        |             
      Hyperplasia                          |                                              2                           |             
      Duct, Dilatation                     |          2           2                                                   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 3                        |             
      Inflammation                         |    3                                                                     |             
      Foot, Inflammation, Chronic          |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Mandibular, Proliferation |                                                                          |             
      Fiber, Mandibular, Hypertrophy       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Brain Stem, Hypothalamus, Compression|                2                             2  3                       2|             
                                           |__________________________________________________________________________|             
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|             
                                           | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|             
    272 PPM                                | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|             
                                           | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   2                                               1      |             
      Alveolar Epithelium, Hyperplasia     |                                  3                    2                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Alveolus, Inflammation, Multifocal   |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |          2     2              1                 2                        |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Septum, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                      +                                               +   |             
      Canal, External Ear, Exudate         |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |    2                       2                                             |             
      Bilateral, Cataract                  |                                                                      2   |             
      Retina, Autolysis                    |    X                                                           X     X   |             
      Retina, Degeneration                 |                                                                   1      |             
      Sclera, Metaplasia, Osseous          |                                        2                                 |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 9| 4| 6| 6| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 0| 2| 2| 3|             
                                           | 5| 9| 7| 9| 3| 2| 8| 8| 1| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 9| 2| 3| 2| 4| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 2|             
    272 PPM                                | 1| 1| 1| 1| 1| 3| 4| 4| 5| 7| 7| 7| 7| 7| 8| 9| 9| 9| 0| 4| 4| 6| 6| 7| 8|             
                                           | 1| 2| 3| 8| 9| 4| 3| 9| 1| 3| 4| 5| 6| 7| 6| 7| 8| 9| 0| 1| 6| 0| 9| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1                       1                             1            |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1     1  2  1  4  2  2  2  2  2  2  3  3  2  2  3  3  3  2  2  2  2     3|             
      Pigmentation                         |    2                                                                     |             
      Cortex, Cyst                         |                                                                          |             
      Renal Tubule, Hyperplasia            |                2                                                         |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    272 PPM                                | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Artery, Colon, Serosa, Dilatation    |                                        X                                 |      1     |
      Colon, Lymphoid Tissue, Hyperplasia  |                            2  3                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Ileum, Hyperplasia                   |                            3                                             |      1  3.0|
      Ileum, Inflammation                  |                                                                          |      1  2.0|
      Ileum, Lymphoid Tissue, Hyperplasia  |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Degeneration, Cystic                 | 1              2     2        1     1  1     1        1                  |     13  1.5|
      Eosinophilic Focus                   |             X        X  X     X  X              X           X            |      9     |
      Eosinophilic Focus, Multiple         |                            X        X     X           X           X      |     10     |
      Hepatodiaphragmatic Nodule           |                                     X                                    |      3     |
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |             2              1        2     2     1           2            |     10  1.9|
      Bile Duct, Cyst                      |                                                                   X      |      1     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    272 PPM                                | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Bile Duct, Hyperplasia               | 2  2     1  2  2  2  2  2  2  1  2  2  2  2  1  2  2  2  2  2  2  2      |     42  1.9|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |             +                                                  +         |   6        |
      Accessory Spleen                     |             X                                                  X         |      2     |
      Polyarteritis                        |                                                                2         |      2  2.5|
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Accessory Spleen                     |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                        1                    2            |      2  1.5|
      Acinus, Atrophy                      |    1  2  1  1     2  2  2           1     2  2  2  2  3     2  1         |     24  1.7|
      Artery, Inflammation, Chronic        |                                                                1  3      |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Forestomach, Edema                   |                               3                                          |      2  2.5|
      Forestomach, Inflammation            |                                                                          |      1  2.0|
      Forestomach, Epithelium, Hyperplasia |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Gingiva, Hyperplasia                 |                                                                          |      1  3.0|
      Gingiva, Inflammation                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    272 PPM                                | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  3  2     3  2      |     40  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cortex, Accessory Adrenal Cortical   |                                                                          |            |
          Nodule                           |                                                       X                  |      2     |
      Cortex, Hyperplasia, Focal           |       1                                            2  2                  |      3  1.7|
      Cortex, Vacuolization Cytoplasmic    |             1                                                            |      4  1.5|
      Medulla, Hyperplasia                 |                         2              2           2                     |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +      |  40        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |                                              2                           |      1  2.0|
      Pars Distalis, Cyst                  |    X  X                                                                  |      5     |
      Pars Distalis, Hyperplasia           |                   2                                         2            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Ultimobranchial Cyst                 |                                                                X         |      1     |
      C-Cell, Hyperplasia                  |                                                       4        1         |      3  2.0|
      Follicular Cell, Hyperplasia         |    2                                                     2               |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    272 PPM                                | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation                         | 2  2  2  2  2  2  2  2  1  2  3  3  2  2  1  2  3  3  2  1  3            |     38  1.9|
      Duct, Ectasia                        |          2  3  2           2  3  3  2           3              2  3      |     11  2.5|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation                         |          2     2     1     3     2              2           2  2  1      |     22  1.9|
      Ventral, Hyperplasia                 |                                                                   2      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                                        3                                 |      1  3.0|
      Decreased Secretory Fluid            | 2  2  2  2  2     2     3  2  3  3  3  3  2  3     3  2  2  3     2      |     33  2.4|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Mineralization                       |                                                                          |      1  1.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      5  1.6|
      Seminiferous Tubule, Atrophy         |          2                                                               |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Myeloid Cell, Hyperplasia            |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Axillary, Hyperplasia, Lymphoid      |    2                                                                     |      1  2.0|
      Deep Cervical, Infiltration Cellular,|                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Lymphoid        |    2                                                                     |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    272 PPM                                | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Mandibular, Ectasia                  |                                           2        3  2                  |      6  2.3|
      Mandibular, Hyperplasia, Lymphoid    |    2                                2                                    |      3  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |             2  2  2        2  2                          2        2      |     11  2.1|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mesenteric, Ectasia                  |                                                 3                 2      |      6  2.7|
      Mesenteric, Hemorrhage               |                                                                          |      2  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                2         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                   3      |      1  3.0|
      Hyperplasia, Lymphoid                |                   2           2                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +      |  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M      |  46        |
      Galactocele                          |                                                             X  X         |      6     |
      Hyperplasia                          | 2                          2                                2            |      4  2.0|
      Duct, Dilatation                     |                                                                2         |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  3.0|
      Foot, Inflammation, Chronic          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    272 PPM                                | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Arteriole, Mandibular, Proliferation |    X                                                                     |      1     |
      Fiber, Mandibular, Hypertrophy       |    X                                                                     |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Brain Stem, Hypothalamus, Compression|                            2                                   2         |      6  2.2|
                                           |__________________________________________________________________________|____________|
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemorrhage                           |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |    2        3                                                            |      4  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                               1                             1            |      2  1.0|
      Alveolus, Inflammation, Multifocal   |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    272 PPM                                | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Nasolacrimal Duct, Inflammation      | 2  1     1  2  2                 2     2     3  1        1     2  2      |     16  1.8|
      Respiratory Epithelium, Hyperplasia  |                                                    2                     |      1  2.0|
      Septum, Inflammation, Chronic        |                                                    2                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
      Canal, External Ear, Exudate         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cataract                             |                                                                          |      2  2.0|
      Bilateral, Cataract                  |                                                                          |      1  2.0|
      Retina, Autolysis                    |                                                                          |      3     |
      Retina, Degeneration                 |    2     2                                                               |      3  1.7|
      Sclera, Metaplasia, Osseous          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Lymphocyte    | 1  1     1     2  1  1  1     1        1     1  1  1        2            |     16  1.1|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Nephropathy                          | 1  3  2  2  2  2  2  1  2  3  3  2  2  2  2  3  2  2  2  3  2  3  3      |     46  2.2|
      Pigmentation                         |                                                                          |      1  2.0|
      Cortex, Cyst                         |                                                             X            |      1     |
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    272 PPM                                | 9| 9| 9| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7|     |      L     |
                                           | 0| 1| 2| 3| 4| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|     |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Urethra                                 |                                                             +            |   1        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|             
                                           | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|             
    543 PPM                                | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|             
                                           | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Colon, Lymphoid Tissue, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ileum, Lymphoid Tissue, Hyperplasia  |                                        2                    3            |             
      Jejunum, Diverticulum                |                                                                          |             
      Jejunum, Lymphoid Tissue, Hyperplasia|                                                          2               |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                       X                 X|             
      Degeneration, Cystic                 |       1                    2     2  1  1     1     1  2           2  1   |             
      Developmental Malformation           |       X                                                                  |             
      Eosinophilic Focus                   |    X        X                 X           X                             X|             
      Eosinophilic Focus, Multiple         |          X     X        X        X           X  X     X           X  X   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            |                               2     2  2  2  2  2                       1|             
      Bile Duct, Hyperplasia               |          2  2  1        2  1     2  2     2  2  2  2  3     2  2        2|             
      Centrilobular, Necrosis              |       2     3                                                     3      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Polyarteritis                        |                                        3                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|             
                                           | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|             
    543 PPM                                | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|             
                                           | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                      X   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Polyarteritis                        |                                                                          |             
      Acinus, Atrophy                      |    2  2  2     2  1     2        2     2        2  2  2  2              2|             
      Artery, Inflammation, Chronic        |    3                                                                     |             
      Artery, Media, Hypertrophy           |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Inflammation            |                                                                          |             
      Forestomach, Epithelium, Hyperplasia |                                                                          |             
      Glandular, Mineralization            |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          2  2  2     2  2  2  2  2  2  2  2  2     2        2     1  2  2|             
      Atrium, Thrombosis                   |                                                       X           X      |             
      Myocardium, Infarct                  |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Cortex, Accessory Adrenal Cortical   |                                                                          |             
          Nodule                           |                                                    X                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|             
                                           | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|             
    543 PPM                                | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|             
                                           | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Cortex, Cytoplasmic Alteration       |                      3                                                   |             
      Cortex, Hyperplasia, Focal           |                                        1                 2               |             
      Cortex, Hypertrophy, Focal           |                                     1                                    |             
      Cortex, Vacuolization Cytoplasmic    |                               2                                          |             
      Medulla, Hyperplasia                 |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |          2              3        2                             3         |             
      Pars Intermedia, Cyst                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      C-Cell, Hyperplasia                  |                                                       2                  |             
      Follicle, Cyst                       |                                           1                    2         |             
      Follicular Cell, Hyperplasia         |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                      +   |             
      Abdominal, Fat, Necrosis             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |    +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decreased Secretory Fluid            |                      3                                   2        2      |             
                                           |__________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 2                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|             
                                           | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|             
    543 PPM                                | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|             
                                           | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Inflammation, Chronic                |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   2      |             
      Hyperplasia                          |                                                                   2     3|             
      Inflammation                         |    2     3  3  1  3  3     3  2  2  3     2  2  3              2  1      |             
      Duct, Ectasia                        |                                                                         3|             
                                           |__________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decreased Secretory Fluid            |                                                          2               |             
      Inflammation                         |       2                    1        3     2     2  2  2     1  2  1      |             
      Ventral, Hyperplasia                 |                                                             2            |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Decreased Secretory Fluid            |          3  2        3  2  2  3  2     2  2  2  2  3     2  2     2  2  2|             
                                           |__________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |    2           1                    2                                    |             
      Seminiferous Tubule, Atrophy         |                                     2     4              3               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                2         |             
      Hyperplasia                          |                                                                          |             
      Myeloid Cell, Hyperplasia            |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Ectasia                  |                                     3                                    |             
      Mandibular, Hemorrhage               |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                            2              2                              |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mesenteric, Ectasia                  |                                                    2                     |             
      Mesenteric, Hemorrhage               |                               2                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|             
                                           | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|             
    543 PPM                                | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|             
                                           | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                2                                                         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                     2  4        2                        |             
      Hematopoietic Cell Proliferation     |       3     3                                      2              2      |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
      Infarct                              |                   X                                   X                  |             
      Pigmentation                         |                         2  2                                             |             
                                           |__________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|             
      Epithelial Cell, Hyperplasia         |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +|             
      Galactocele                          |                                     X                                    |             
      Hyperplasia                          |                                                 2                        |             
      Duct, Dilatation                     |             2                                                  2         |             
                                           |__________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Cyst Epithelial Inclusion            |                   X                                                      |             
      Epidermis, Hyperplasia               |                                                                          |             
      Epidermis, Necrosis                  |                                                                          |             
      Epithelium, Hyperplasia              |                                  2                                       |             
      Foot, Inflammation, Chronic          |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                               1                                          |             
                                           |__________________________________________________________________________|             
   Bone, Femur                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|             
                                           | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|             
    543 PPM                                | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|             
                                           | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Brain Stem, Hypothalamus, Compression|                            3                                             |             
      Cerebrum, Compression                |          2                                                               |             
      Cerebrum, Hemorrhage                 |                            3                                             |             
                                           |__________________________________________________________________________|             
   Brain, Brain Stem                       |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebellum                       |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Brain, Cerebrum                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord, Thoracic                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |          3                                3           1                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocytic                     |                                                                   1      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |       2                    2  1              2                    2  2  1|             
      Nasolacrimal Duct, Mineralization    |             2                                                            |             
                                           |__________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 7| 0| 4| 5| 4| 6| 6| 7| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 6| 9| 1| 0|             
                                           | 7| 5| 5| 5| 8| 5| 0| 1| 6| 9| 7| 5| 5| 5| 5| 5| 5| 5| 5| 4| 1| 1| 8| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|             
    543 PPM                                | 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 7| 7| 8| 8| 8| 8| 8| 8| 8| 3| 5| 5| 6| 6|             
                                           | 2| 4| 6| 1| 2| 3| 7| 9| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 6| 2| 7| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
      Bilateral, Cataract                  |                         2                                2               |             
      Bilateral, Retina, Degeneration      |                                                                          |             
      Retina, Autolysis                    |                         X  X                             X               |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Metaplasia, Osseous          |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1  2  1  1           1  2                                         2|             
      Inflammation                         |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                         2|             
      Nephropathy                          |    2  1  2  3  1  2  1  3  2  4  3  3  3  3  2  2  4  2  1  2  2  2  2  3|             
      Thrombosis                           |    4                                                                     |             
      Cortex, Cyst                         |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    543 PPM                                | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8|     |      L     |
                                           | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Colon, Lymphoid Tissue, Hyperplasia  |                                                       3                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Ileum, Lymphoid Tissue, Hyperplasia  |                                                 2                        |      3  2.3|
      Jejunum, Diverticulum                |                      X                                                   |      1     |
      Jejunum, Lymphoid Tissue, Hyperplasia|                                                 2                        |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Basophilic Focus                     |                                                                          |      2     |
      Degeneration, Cystic                 | 1  1  1     2              1  1     2              2              1      |     19  1.4|
      Developmental Malformation           |                                                                          |      1     |
      Eosinophilic Focus                   |                               X           X  X                           |      8     |
      Eosinophilic Focus, Multiple         | X  X  X  X  X  X  X  X  X              X        X  X  X     X  X  X      |     25     |
      Infiltration Cellular, Lymphocyte    |    1                                                                     |      1  1.0|
      Inflammation, Focal, Granulomatous   |                2                                                         |      1  2.0|
      Mixed Cell Focus                     |                                     X                    X               |      2     |
      Vacuolization Cytoplasmic            |             1     2                 2        2        2        2         |     13  1.8|
      Bile Duct, Hyperplasia               | 2  1  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2      |     38  1.9|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    543 PPM                                | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8|     |      L     |
                                           | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Centrilobular, Necrosis              |                                                                          |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +                 +                                                      |   3        |
      Polyarteritis                        |                                                                          |      1  3.0|
      Fat, Necrosis                        | 3                 3                                                      |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Accessory Spleen                     |                                                                          |      1     |
      Infiltration Cellular, Lymphocyte    |                                              2                           |      1  2.0|
      Polyarteritis                        |                                                       3                  |      1  3.0|
      Acinus, Atrophy                      |    2     1     2        2              2  3                 1  1  2      |     22  1.9|
      Artery, Inflammation, Chronic        |          2  3        4                                                   |      4  3.0|
      Artery, Media, Hypertrophy           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Forestomach, Inflammation            |             2                    2                                       |      2  2.0|
      Forestomach, Epithelium, Hyperplasia |             2                    3                                       |      2  2.5|
      Glandular, Mineralization            |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cardiomyopathy                       | 2  2  2  2  2  2  2  1  2  2  1  1  3  2  2  2  2  2  2  2  2  2  2      |     40  1.9|
      Atrium, Thrombosis                   |                                     X                                    |      3     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    543 PPM                                | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8|     |      L     |
                                           | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Myocardium, Infarct                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Degeneration                         |                                                                3         |      1  3.0|
      Cortex, Accessory Adrenal Cortical   |                                                                          |            |
          Nodule                           |                                                                          |      1     |
      Cortex, Cytoplasmic Alteration       |                                                                          |      1  3.0|
      Cortex, Hyperplasia, Focal           |                                  1                    1           1      |      5  1.2|
      Cortex, Hypertrophy, Focal           |                                                                          |      1  1.0|
      Cortex, Vacuolization Cytoplasmic    |                                     3                                    |      2  2.5|
      Medulla, Hyperplasia                 |                                                             2            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia                          |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M      |  42        |
      Hyperplasia, Focal                   |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Pars Distalis, Cyst                  |       X     X                             X                              |      3     |
      Pars Distalis, Hyperplasia           | 3  2                                                           2         |      7  2.4|
      Pars Intermedia, Cyst                |                      X                                                   |      1     |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      C-Cell, Hyperplasia                  |                                                    2           2         |      3  2.0|
      Follicle, Cyst                       |    1                                                                     |      3  1.3|
      Follicular Cell, Hyperplasia         | 2                                   2                                    |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    543 PPM                                | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8|     |      L     |
                                           | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Abdominal, Fat, Necrosis             |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Decreased Secretory Fluid            |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Atrophy                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Atrophy                              |                               2                       1                  |      3  1.7|
      Hyperplasia                          |                         2                                                |      3  2.3|
      Inflammation                         |    1     2  3  2  1  3  3  2  2  3  1  1              1  2               |     29  2.1|
      Duct, Ectasia                        |             3  2     3  2        3                 3     2  2            |      9  2.6|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Decreased Secretory Fluid            |                                                                          |      1  2.0|
      Inflammation                         |             2           2  2        2              2  2        1  2      |     18  1.8|
      Ventral, Hyperplasia                 | 1  2                          2                                1  2      |      6  1.7|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Atrophy                              |             3                                                            |      1  3.0|
      Decreased Secretory Fluid            | 2  2  3  2  3  2  2  2  2     2  3     2  2  2  2     2  2  2  2         |     36  2.2|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Interstitial Cell, Hyperplasia       |                                                                          |      3  1.7|
      Seminiferous Tubule, Atrophy         | 2                             2  3                    3  3               |      8  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    543 PPM                                | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8|     |      L     |
                                           | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                     3                          3         |      2  3.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Mandibular, Ectasia                  | 2                                                        3     2         |      4  2.5|
      Mandibular, Hemorrhage               |                                     2                                    |      1  2.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                       2                  |      1  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |          2        3     2        3                             2         |      7  2.3|
      Mediastinal, Hemorrhage              |                                           2                              |      1  2.0|
      Mesenteric, Ectasia                  |                                                                          |      1  2.0|
      Mesenteric, Hemorrhage               |                                                                          |      1  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                2         |      1  2.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Fibrosis                             |                      1              2                                    |      5  2.2|
      Hematopoietic Cell Proliferation     |          1           2                    2                    2         |      8  2.1|
      Hyperplasia, Lymphoid                |             2        2                          2                        |      4  2.0|
      Infarct                              |                                                                          |      2     |
      Pigmentation                         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +      |  42        |
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    543 PPM                                | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8|     |      L     |
                                           | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  41        |
      Galactocele                          |                            X                                             |      2     |
      Hyperplasia                          | 3                          2     1                                2      |      5  2.0|
      Duct, Dilatation                     |                            2                             2               |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cyst                                 |                         X                                                |      1     |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Epidermis, Hyperplasia               |                         3                                                |      1  3.0|
      Epidermis, Necrosis                  |                                                                2         |      1  2.0|
      Epithelium, Hyperplasia              |                                        2                                 |      2  2.0|
      Foot, Inflammation, Chronic          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Femur, Fibrous Osteodystrophy        |                                     2                                    |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Bone, Femur                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Brain Stem, Hypothalamus, Compression|                                                                          |      1  3.0|
      Cerebrum, Compression                |                                                                          |      1  2.0|
      Cerebrum, Hemorrhage                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Brain, Brain Stem                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebellum                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Brain, Cerebrum                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    543 PPM                                | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8|     |      L     |
                                           | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord, Thoracic                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Alveolar Epithelium, Hyperplasia     |                                                 4     2  2               |      6  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocytic                     |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1                                   2                 2  2               |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Nasolacrimal Duct, Inflammation      | 1              1  2  1                                   3               |     12  1.7|
      Nasolacrimal Duct, Mineralization    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cataract                             |    3                                                                     |      1  3.0|
      Bilateral, Cataract                  |             1                                                            |      3  1.7|
      Bilateral, Retina, Degeneration      |    4        2  1  2                                1                     |      5  2.0|
      Retina, Autolysis                    |                                                                          |      3     |
      Retina, Degeneration                 |       3  1                                                               |      2  2.0|
      Sclera, Metaplasia, Osseous          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Infiltration Cellular, Lymphocyte    | 1  2     1     1              2  1     1              2  1  1  1         |     18  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 93029-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/18/03    
Route: DOSED FEED                                                                                                 Time: 15:01:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     |            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |            |
                                           | 7| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 3| 3| 4| 4| 4|     |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   FISCHER 344 RATS-NCTR MALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    543 PPM                                | 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 8|     |      L     |
                                           | 0| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3|     |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Inflammation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Duct, Ectasia                        |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  2.0|
      Nephropathy                          | 3  3  2  2  3  2  3  2  3  3  2  3  4  2  3  1  3  3  3  2  3  2  2      |     47  2.4|
      Thrombosis                           |                                                                          |      1  4.0|
      Cortex, Cyst                         |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Calculus Micro Observation Only      |                                                 X                        |      1     |
      Artery, Inflammation                 |                                                             2            |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 117                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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