TDMS Study 93029-03 Pathology Tables
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
Facility: National Center for Toxicological Research
Chemical CAS #: 129-73-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to days on test
Page 1
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 7| 8| 8| 2| 3| 5| 6| 6| 6| 7| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 8| 5| 9| 7| 5| 3| 2| 2| 9| 3| 4| 8| 9| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 2| 1| 1| 2| 1| 1| 1| 2| 2| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3|
0 PPM | 2| 1| 2| 3| 2| 2| 4| 3| 3| 3| 5| 6| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 3| 9|
| 0| 9| 2| 4| 5| 6| 8| 0| 1| 4| 3| 8| 0| 1| 2| 7| 8| 9| 0| 1| 2| 3| 4| 8| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
Sarcoma | X |
Schwannoma Malignant, Metastatic, | |
Uterus | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Uterus | X |
Acinar Cell, Adenoma | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 7| 8| 8| 2| 3| 5| 6| 6| 6| 7| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 8| 5| 9| 7| 5| 3| 2| 2| 9| 3| 4| 8| 9| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 2| 1| 1| 2| 1| 1| 1| 2| 2| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3|
0 PPM | 2| 1| 2| 3| 2| 2| 4| 3| 3| 3| 5| 6| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 3| 9|
| 0| 9| 2| 4| 5| 6| 8| 0| 1| 4| 3| 8| 0| 1| 2| 7| 8| 9| 0| 1| 2| 3| 4| 8| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M A + M + + + + M + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + A + M + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
Schwannoma Malignant, Metastatic, | |
Uterus | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 7| 8| 8| 2| 3| 5| 6| 6| 6| 7| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 8| 5| 9| 7| 5| 3| 2| 2| 9| 3| 4| 8| 9| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 2| 1| 1| 2| 1| 1| 1| 2| 2| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3|
0 PPM | 2| 1| 2| 3| 2| 2| 4| 3| 3| 3| 5| 6| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 3| 9|
| 0| 9| 2| 4| 5| 6| 8| 0| 1| 4| 3| 8| 0| 1| 2| 7| 8| 9| 0| 1| 2| 3| 4| 8| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X|
Carcinoma | X |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | |
Leiomyoma | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
Polyp Stromal | X X X |
Sarcoma Stromal | X |
Schwannoma Malignant | X |
Bilateral, Polyp Stromal | |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Schwannoma Malignant, | |
Metastatic, Uterus | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + M + + + + + + + + M + + + + + M + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 7| 8| 8| 2| 3| 5| 6| 6| 6| 7| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 8| 5| 9| 7| 5| 3| 2| 2| 9| 3| 4| 8| 9| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 2| 1| 1| 2| 1| 1| 1| 2| 2| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3|
0 PPM | 2| 1| 2| 3| 2| 2| 4| 3| 3| 3| 5| 6| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 3| 9|
| 0| 9| 2| 4| 5| 6| 8| 0| 1| 4| 3| 8| 0| 1| 2| 7| 8| 9| 0| 1| 2| 3| 4| 8| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X X X X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 7| 8| 8| 2| 3| 5| 6| 6| 6| 7| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 8| 5| 9| 7| 5| 3| 2| 2| 9| 3| 4| 8| 9| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 2| 1| 1| 2| 1| 1| 1| 2| 2| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3|
0 PPM | 2| 1| 2| 3| 2| 2| 4| 3| 3| 3| 5| 6| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 3| 9|
| 0| 9| 2| 4| 5| 6| 8| 0| 1| 4| 3| 8| 0| 1| 2| 7| 8| 9| 0| 1| 2| 3| 4| 8| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lids, Sarcoma | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + + + + + M + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | X |
Renal Tubule, Carcinoma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 9| 9| 9| 9| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| | L |
| 6| 7| 8| 9| 7| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hepatocellular Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Mesentery | + | 8 |
Sarcoma | | 1 |
Schwannoma Malignant, Metastatic, | | |
Uterus | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Schwannoma Malignant, Metastatic, | | |
Uterus | | 1 |
Acinar Cell, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 9| 9| 9| 9| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| | L |
| 6| 7| 8| 9| 7| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + I + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + I + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + I + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + M | 42 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X | 26 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
C-Cell, Adenoma | X X | 4 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 9| 9| 9| 9| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| | L |
| 6| 7| 8| 9| 7| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Schwannoma Malignant, Metastatic, | | |
Uterus | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenoma | X X X X X | 7 |
Carcinoma | X | 2 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Oviduct | + | 1 |
Leiomyoma | X | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leiomyoma | | 1 |
Polyp Stromal | X X X X X X | 9 |
Sarcoma Stromal | | 1 |
Schwannoma Malignant | | 1 |
Bilateral, Polyp Stromal | X | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mesenteric, Schwannoma Malignant, | | |
Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 9| 9| 9| 9| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| | L |
| 6| 7| 8| 9| 7| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + M + + + + + + + + + + + M + + | 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Fibroadenoma | X X X X X X X X X X X | 20 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basal Cell Adenoma | X | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 9| 9| 9| 9| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| | L |
| 6| 7| 8| 9| 7| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lids, Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lacrimal Gland | + + + + + + | 10 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | A |
0 PPM | 9| 9| 9| 9| 3| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| | L |
| 6| 7| 8| 9| 7| 6| 7| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
Sarcoma | | 1 |
Renal Tubule, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 6| 0| 2| 5| 8| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 1| 5| 5| 7| 3| 0| 9| 4| 6| 5| 2| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 2| 1| 1| 1| 2| 2| 2| 1| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
91 PPM | 0| 1| 2| 3| 2| 3| 3| 6| 6| 6| 7| 0| 3| 4| 4| 4| 4| 4| 0| 3| 4| 4| 4| 4| 4|
| 1| 8| 3| 9| 9| 8| 7| 1| 6| 7| 2| 5| 9| 0| 1| 2| 3| 4| 0| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
|__________________________________________________________________________|
Mesentery | + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 6| 0| 2| 5| 8| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 1| 5| 5| 7| 3| 0| 9| 4| 6| 5| 2| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 2| 1| 1| 1| 2| 2| 2| 1| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
91 PPM | 0| 1| 2| 3| 2| 3| 3| 6| 6| 6| 7| 0| 3| 4| 4| 4| 4| 4| 0| 3| 4| 4| 4| 4| 4|
| 1| 8| 3| 9| 9| 8| 7| 1| 6| 7| 2| 5| 9| 0| 1| 2| 3| 4| 0| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M M + M + + + + + M + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 6| 0| 2| 5| 8| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 1| 5| 5| 7| 3| 0| 9| 4| 6| 5| 2| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 2| 1| 1| 1| 2| 2| 2| 1| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
91 PPM | 0| 1| 2| 3| 2| 3| 3| 6| 6| 6| 7| 0| 3| 4| 4| 4| 4| 4| 0| 3| 4| 4| 4| 4| 4|
| 1| 8| 3| 9| 9| 8| 7| 1| 6| 7| 2| 5| 9| 0| 1| 2| 3| 4| 0| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X X|
Bilateral, Polyp Stromal | |
Cervix, Squamous Cell Papilloma | |
Endometrium, Adenoma | |
Endometrium, Carcinoma | X |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Fibroadenoma | X X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Fibroma | X |
Keratoacanthoma | |
Sarcoma | X X |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 6| 0| 2| 5| 8| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 1| 5| 5| 7| 3| 0| 9| 4| 6| 5| 2| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 2| 1| 1| 1| 2| 2| 2| 1| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
91 PPM | 0| 1| 2| 3| 2| 3| 3| 6| 6| 6| 7| 0| 3| 4| 4| 4| 4| 4| 0| 3| 4| 4| 4| 4| 4|
| 1| 8| 3| 9| 9| 8| 7| 1| 6| 7| 2| 5| 9| 0| 1| 2| 3| 4| 0| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
Pinna, Neural Crest Tumor | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 6| 0| 2| 5| 8| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 1| 5| 5| 7| 3| 0| 9| 4| 6| 5| 2| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 2| 1| 1| 1| 2| 2| 2| 1| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
91 PPM | 0| 1| 2| 3| 2| 3| 3| 6| 6| 6| 7| 0| 3| 4| 4| 4| 4| 4| 0| 3| 4| 4| 4| 4| 4|
| 1| 8| 3| 9| 9| 8| 7| 1| 6| 7| 2| 5| 9| 0| 1| 2| 3| 4| 0| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + + + |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Carcinoma | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 4| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8| 8| 8| 1| 1| 1| 1| 1| 1| 1| 1| | L |
| 5| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hepatocellular Adenoma | X X X | 3 |
|__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 4| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8| 8| 8| 1| 1| 1| 1| 1| 1| 1| 1| | L |
| 5| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + M + M + + M + + + + + + + + M + M | 37 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + + | 47 |
Pars Distalis, Adenoma | X X X X X X X X X X X X | 23 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + | 46 |
C-Cell, Adenoma | X | 7 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 4| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8| 8| 8| 1| 1| 1| 1| 1| 1| 1| 1| | L |
| 5| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenoma | X X X X X X | 8 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Polyp Stromal | X X X X X | 10 |
Bilateral, Polyp Stromal | X X | 2 |
Cervix, Squamous Cell Papilloma | X | 1 |
Endometrium, Adenoma | X | 1 |
Endometrium, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 4| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8| 8| 8| 1| 1| 1| 1| 1| 1| 1| 1| | L |
| 5| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Mammary Gland | M + + + + + + + M + + + + + + + + + + + + + + | 46 |
Adenoma | | 1 |
Carcinoma | | 1 |
Fibroadenoma | X X X X X | 12 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basal Cell Adenoma | X | 1 |
Fibroma | | 1 |
Keratoacanthoma | X | 1 |
Sarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 4| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8| 8| 8| 1| 1| 1| 1| 1| 1| 1| 1| | L |
| 5| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X | 2 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
Pinna, Neural Crest Tumor | X | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lacrimal Gland | + + + | 6 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Transitional Epithelium, Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________ T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| | A |
91 PPM | 4| 5| 5| 5| 5| 5| 5| 5| 8| 8| 8| 8| 8| 8| 8| 1| 1| 1| 1| 1| 1| 1| 1| | L |
| 5| 0| 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Hemangiosarcoma | | 1 |
Leukemia Mononuclear | X X X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 1| 4| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 7| 8| 9| 2| 5| 7| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 0| 2| 9| 6| 7| 6| 8| 9| 9| 9| 9| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 2| 1| 2| 2| 1| 1| 2| 2| 2| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
272 PPM | 0| 1| 1| 2| 4| 4| 3| 3| 5| 6| 6| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
| 3| 1| 8| 0| 3| 7| 5| 9| 9| 2| 3| 5| 0| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 1| 4| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 7| 8| 9| 2| 5| 7| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 0| 2| 9| 6| 7| 6| 8| 9| 9| 9| 9| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 2| 1| 2| 2| 1| 1| 2| 2| 2| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
272 PPM | 0| 1| 1| 2| 4| 4| 3| 3| 5| 6| 6| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
| 3| 1| 8| 0| 3| 7| 5| 9| 9| 2| 3| 5| 0| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endocardium, Schwannoma Malignant | |
Myocardium, Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Medulla, Pheochromocytoma Malignant | X|
Medulla, Pheochromocytoma Benign | |
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M + + + + + + + + + M + M + + M + +|
|__________________________________________________________________________|
Pituitary Gland | M + + + + + + M + + M + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + I + + + + +|
Bilateral, C-Cell, Adenoma | X |
Bilateral, C-Cell, Carcinoma | |
C-Cell, Adenoma | X X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Lipoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 1| 4| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 7| 8| 9| 2| 5| 7| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 0| 2| 9| 6| 7| 6| 8| 9| 9| 9| 9| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 2| 1| 2| 2| 1| 1| 2| 2| 2| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
272 PPM | 0| 1| 1| 2| 4| 4| 3| 3| 5| 6| 6| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
| 3| 1| 8| 0| 3| 7| 5| 9| 9| 2| 3| 5| 0| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Clitoral Gland | + + + + + + + + M + + M + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X X X X X X |
Schwannoma Malignant | |
Bilateral, Polyp Stromal | X |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + M + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Fibroadenoma | X X X X X|
Fibroadenoma, Multiple | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 1| 4| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 7| 8| 9| 2| 5| 7| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 0| 2| 9| 6| 7| 6| 8| 9| 9| 9| 9| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 2| 1| 2| 2| 1| 1| 2| 2| 2| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
272 PPM | 0| 1| 1| 2| 4| 4| 3| 3| 5| 6| 6| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
| 3| 1| 8| 0| 3| 7| 5| 9| 9| 2| 3| 5| 0| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranial Nerve, Schwannoma Malignant | X |
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Thyroid Gland | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 1| 4| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 7| 8| 9| 2| 5| 7| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 0| 2| 9| 6| 7| 6| 8| 9| 9| 9| 9| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 2| 1| 2| 2| 1| 1| 2| 2| 2| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
272 PPM | 0| 1| 1| 2| 4| 4| 3| 3| 5| 6| 6| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
| 3| 1| 8| 0| 3| 7| 5| 9| 9| 2| 3| 5| 0| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + + |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenchymal Tumor Benign | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2| 2| 2| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2| 2| 2| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Endocardium, Schwannoma Malignant | X | 1 |
Myocardium, Schwannoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + M + + + + + + + + + + + + + + + + + + + + | 47 |
Medulla, Pheochromocytoma Malignant | | 1 |
Medulla, Pheochromocytoma Benign | X | 1 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + M + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + + + M + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + M + M + + | 40 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Pars Distalis, Adenoma | X X X X X X X X X X | 17 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Bilateral, C-Cell, Adenoma | | 1 |
Bilateral, C-Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2| 2| 2| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Adenoma | X X | 4 |
Follicular Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Abdominal, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Adenoma | X X | 3 |
Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Polyp Stromal | X X X X X X X | 16 |
Schwannoma Malignant | X | 1 |
Bilateral, Polyp Stromal | X X | 3 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2| 2| 2| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + | 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | | 1 |
Carcinoma | X | 2 |
Fibroadenoma | X X X X | 9 |
Fibroadenoma, Multiple | X X | 3 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Fibrous Histiocytoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cranial Nerve, Schwannoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2| 2| 2| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X X | 3 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lacrimal Gland | + + + + + + | 8 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + M + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| | A |
272 PPM | 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 9| 9| 9| 9| 9| 9| 9| 2| 2| 2| 2| 2| 2| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Mesenchymal Tumor Benign | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 7| 8| 3| 3| 4| 4| 5| 6| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 4| 6| 0| 5| 2| 3| 0| 8| 4| 9| 6| 9| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 2| 1| 2| 1| 1| 1| 2| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
543 PPM | 1| 1| 1| 3| 2| 4| 2| 2| 3| 4| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5| 8| 8| 9| 9|
| 7| 2| 3| 1| 1| 2| 7| 8| 2| 9| 6| 3| 3| 4| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Colon, Adenocarcinoma | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Adenoma | |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 7| 8| 3| 3| 4| 4| 5| 6| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 4| 6| 0| 5| 2| 3| 0| 8| 4| 9| 6| 9| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 2| 1| 2| 1| 1| 1| 2| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
543 PPM | 1| 1| 1| 3| 2| 4| 2| 2| 3| 4| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5| 8| 8| 9| 9|
| 7| 2| 3| 1| 1| 2| 7| 8| 2| 9| 6| 3| 3| 4| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + + + M + + + + + + + + M + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + I + + + +|
Pars Distalis, Adenoma | X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X|
Carcinoma | X X |
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 7| 8| 3| 3| 4| 4| 5| 6| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 4| 6| 0| 5| 2| 3| 0| 8| 4| 9| 6| 9| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 2| 1| 2| 1| 1| 1| 2| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
543 PPM | 1| 1| 1| 3| 2| 4| 2| 2| 3| 4| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5| 8| 8| 9| 9|
| 7| 2| 3| 1| 1| 2| 7| 8| 2| 9| 6| 3| 3| 4| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
Polyp Stromal | X X X X X X |
Sarcoma Stromal | X |
Bilateral, Polyp Stromal | X |
Endometrium, Adenoma | |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | M M M + + + M + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
Fibroadenoma | X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Fibroma | X |
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 7| 8| 3| 3| 4| 4| 5| 6| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 4| 6| 0| 5| 2| 3| 0| 8| 4| 9| 6| 9| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 2| 1| 2| 1| 1| 1| 2| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
543 PPM | 1| 1| 1| 3| 2| 4| 2| 2| 3| 4| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5| 8| 8| 9| 9|
| 7| 2| 3| 1| 1| 2| 7| 8| 2| 9| 6| 3| 3| 4| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 7| 8| 3| 3| 4| 4| 5| 6| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 4| 6| 0| 5| 2| 3| 0| 8| 4| 9| 6| 9| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 1| 1| 2| 1| 2| 1| 1| 1| 2| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
543 PPM | 1| 1| 1| 3| 2| 4| 2| 2| 3| 4| 3| 3| 4| 4| 5| 5| 5| 5| 5| 5| 5| 8| 8| 9| 9|
| 7| 2| 3| 1| 1| 2| 7| 8| 2| 9| 6| 3| 3| 4| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + + |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 9| 9| 9| 6| 6| 6| 6| 6| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Colon, Adenocarcinoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hepatocellular Adenoma | X X | 3 |
|__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Parotid Gland, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 9| 9| 9| 6| 6| 6| 6| 6| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M M M + + + + + + + + M M + M + | 36 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + | 46 |
Pars Distalis, Adenoma | X X X X X X X X X X X X | 20 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Bilateral, C-Cell, Adenoma | X | 1 |
C-Cell, Adenoma | X | 4 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 9| 9| 9| 6| 6| 6| 6| 6| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenoma | X X | 6 |
Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leiomyoma | | 1 |
Polyp Stromal | X X X X X X X X X X | 16 |
Sarcoma Stromal | | 1 |
Bilateral, Polyp Stromal | | 1 |
Endometrium, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 9| 9| 9| 6| 6| 6| 6| 6| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Adenoma | | 2 |
Carcinoma | X | 2 |
Fibroadenoma | X X X X X X X X | 13 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basal Cell Carcinoma | | 1 |
Fibroma | | 1 |
Keratoacanthoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
543 PPM | 9| 9| 9| 6| 6| 6| 6| 6| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 3| 3| 3| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lacrimal Gland | + + | 4 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + M + | 46 |
Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 6| 7| 9| 1| 1| 2| 3| 3| 5| 5| 6| 6| 6| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3|
| 1| 4| 4| 7| 9| 3| 3| 3| 2| 9| 3| 9| 2| 2| 6| 0| 8| 1| 6| 7| 8| 5| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 2| 2| 3| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 2| 3| 2|
0 PPM | 1| 3| 3| 8| 2| 2| 3| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 0| 7|
| 7| 0| 2| 2| 6| 5| 7| 8| 0| 5| 8| 5| 0| 2| 1| 8| 0| 2| 8| 6| 7| 8| 3| 9| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Leiomyoma | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X X |
Histiocytic Sarcoma | |
|__________________________________________________________________________|
Mesentery | + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 6| 7| 9| 1| 1| 2| 3| 3| 5| 5| 6| 6| 6| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3|
| 1| 4| 4| 7| 9| 3| 3| 3| 2| 9| 3| 9| 2| 2| 6| 0| 8| 1| 6| 7| 8| 5| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 2| 2| 3| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 2| 3| 2|
0 PPM | 1| 3| 3| 8| 2| 2| 3| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 0| 7|
| 7| 0| 2| 2| 6| 5| 7| 8| 0| 5| 8| 5| 0| 2| 1| 8| 0| 2| 8| 6| 7| 8| 3| 9| 4|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Adenoma | |
Medulla, Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + M + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + I + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X|
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 6| 7| 9| 1| 1| 2| 3| 3| 5| 5| 6| 6| 6| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3|
| 1| 4| 4| 7| 9| 3| 3| 3| 2| 9| 3| 9| 2| 2| 6| 0| 8| 1| 6| 7| 8| 5| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 2| 2| 3| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 2| 3| 2|
0 PPM | 1| 3| 3| 8| 2| 2| 3| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 0| 7|
| 7| 0| 2| 2| 6| 5| 7| 8| 0| 5| 8| 5| 0| 2| 1| 8| 0| 2| 8| 6| 7| 8| 3| 9| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + M + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M + + + M + + + M + + + + + + + + + + + + + + M +|
Fibroadenoma | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 6| 7| 9| 1| 1| 2| 3| 3| 5| 5| 6| 6| 6| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3|
| 1| 4| 4| 7| 9| 3| 3| 3| 2| 9| 3| 9| 2| 2| 6| 0| 8| 1| 6| 7| 8| 5| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 2| 2| 3| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 2| 3| 2|
0 PPM | 1| 3| 3| 8| 2| 2| 3| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 0| 7|
| 7| 0| 2| 2| 6| 5| 7| 8| 0| 5| 8| 5| 0| 2| 1| 8| 0| 2| 8| 6| 7| 8| 3| 9| 4|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
Pinna, Neural Crest Tumor | |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 6| 7| 9| 1| 1| 2| 3| 3| 5| 5| 6| 6| 6| 9| 9| 0| 0| 1| 1| 2| 3| 3| 3|
| 1| 4| 4| 7| 9| 3| 3| 3| 2| 9| 3| 9| 2| 2| 6| 0| 8| 1| 6| 7| 8| 5| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 2| 2| 3| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 2| 3| 2|
0 PPM | 1| 3| 3| 8| 2| 2| 3| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 0| 7|
| 7| 0| 2| 2| 6| 5| 7| 8| 0| 5| 8| 5| 0| 2| 1| 8| 0| 2| 8| 6| 7| 8| 3| 9| 4|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lids, Sarcoma | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X |
Mesothelioma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| | A |
0 PPM | 7| 7| 7| 7| 8| 8| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 1| 1| 1| 1| | L |
| 6| 7| 8| 9| 0| 1| 0| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + | 47 |
Ileum, Leiomyoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hepatocellular Adenoma | | 2 |
Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + | 5 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| | A |
0 PPM | 7| 7| 7| 7| 8| 8| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 1| 1| 1| 1| | L |
| 6| 7| 8| 9| 0| 1| 0| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cortex, Adenoma | X | 1 |
Medulla, Pheochromocytoma Benign | X X | 3 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + M + | 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | X X X | 5 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + M + + M M M + + + + M + M + + M + | 38 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + | 45 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X | 30 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
C-Cell, Adenoma | X X | 6 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| | A |
0 PPM | 7| 7| 7| 7| 8| 8| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 1| 1| 1| 1| | L |
| 6| 7| 8| 9| 0| 1| 0| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + M + + + + M + + + | 46 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | X X X X | 5 |
Carcinoma | X X X X | 6 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X | 22 |
Interstitial Cell, Adenoma | X X X X X X X | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| | A |
0 PPM | 7| 7| 7| 7| 8| 8| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 1| 1| 1| 1| | L |
| 6| 7| 8| 9| 0| 1| 0| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Thymus | + + + + + + + M + + M + + + + + + + + + + + M | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + | 43 |
Fibroadenoma | X | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Fibroma | X X X | 4 |
Keratoacanthoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| | A |
0 PPM | 7| 7| 7| 7| 8| 8| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 1| 1| 1| 1| | L |
| 6| 7| 8| 9| 0| 1| 0| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
Pinna, Neural Crest Tumor | X | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lids, Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + M + + + + + + + + + + + + + + + + + + + | 46 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________ T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| | A |
0 PPM | 7| 7| 7| 7| 8| 8| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 1| 1| 1| 1| | L |
| 6| 7| 8| 9| 0| 1| 0| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 9| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X X X X X X | 29 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 4| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 8| 6| 7| 0| 0| 1| 2| 2| 3| 6| 7| 9| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 9| 4| 6| 5| 0| 9| 6| 7| 1| 7| 9| 4| 9| 9| 2| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 2| 0| 2| 0| 0| 0| 2| 2| 2| 2| 2| 0| 2| 3| 3| 0| 2| 2| 2| 2| 2| 2| 2|
91 PPM | 0| 1| 3| 2| 3| 2| 2| 2| 4| 4| 5| 5| 5| 5| 7| 0| 0| 5| 8| 8| 8| 8| 8| 8| 8|
| 1| 5| 3| 4| 5| 8| 9| 7| 0| 4| 1| 4| 6| 3| 2| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
Rectum, Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Leiomyoma | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 4| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 8| 6| 7| 0| 0| 1| 2| 2| 3| 6| 7| 9| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 9| 4| 6| 5| 0| 9| 6| 7| 1| 7| 9| 4| 9| 9| 2| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 2| 0| 2| 0| 0| 0| 2| 2| 2| 2| 2| 0| 2| 3| 3| 0| 2| 2| 2| 2| 2| 2| 2|
91 PPM | 0| 1| 3| 2| 3| 2| 2| 2| 4| 4| 5| 5| 5| 5| 7| 0| 0| 5| 8| 8| 8| 8| 8| 8| 8|
| 1| 5| 3| 4| 5| 8| 9| 7| 0| 4| 1| 4| 6| 3| 2| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Medulla, Pheochromocytoma | |
Benign | |
Cortex, Adenoma | |
Medulla, Pheochromocytoma Malignant | X X |
Medulla, Pheochromocytoma Benign | X X X|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + + + + + + M + + + + + + + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 4| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 8| 6| 7| 0| 0| 1| 2| 2| 3| 6| 7| 9| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 9| 4| 6| 5| 0| 9| 6| 7| 1| 7| 9| 4| 9| 9| 2| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 2| 0| 2| 0| 0| 0| 2| 2| 2| 2| 2| 0| 2| 3| 3| 0| 2| 2| 2| 2| 2| 2| 2|
91 PPM | 0| 1| 3| 2| 3| 2| 2| 2| 4| 4| 5| 5| 5| 5| 7| 0| 0| 5| 8| 8| 8| 8| 8| 8| 8|
| 1| 5| 3| 4| 5| 8| 9| 7| 0| 4| 1| 4| 6| 3| 2| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + + + + M + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Penis | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | M + M + + + + + + + + + + + + + + + + M + + + +|
Fibrous Histiocytoma | X |
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 4| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 8| 6| 7| 0| 0| 1| 2| 2| 3| 6| 7| 9| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 9| 4| 6| 5| 0| 9| 6| 7| 1| 7| 9| 4| 9| 9| 2| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 2| 0| 2| 0| 0| 0| 2| 2| 2| 2| 2| 0| 2| 3| 3| 0| 2| 2| 2| 2| 2| 2| 2|
91 PPM | 0| 1| 3| 2| 3| 2| 2| 2| 4| 4| 5| 5| 5| 5| 7| 0| 0| 5| 8| 8| 8| 8| 8| 8| 8|
| 1| 5| 3| 4| 5| 8| 9| 7| 0| 4| 1| 4| 6| 3| 2| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + M M + M + + + + M + + + +|
Fibroadenoma | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Fibrous Histiocytoma | X |
Keratoacanthoma | X |
Lipoma | X |
Sarcoma | X |
Squamous Cell Papilloma | |
Face, Squamous Cell Papilloma | |
Sebaceous Gland, Adenoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Sarcoma, Metastatic, Skin | X |
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Astrocytoma Malignant | X |
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 4| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 8| 6| 7| 0| 0| 1| 2| 2| 3| 6| 7| 9| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 7| 7| 9| 4| 6| 5| 0| 9| 6| 7| 1| 7| 9| 4| 9| 9| 2| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 2| 0| 2| 0| 0| 0| 2| 2| 2| 2| 2| 0| 2| 3| 3| 0| 2| 2| 2| 2| 2| 2| 2|
91 PPM | 0| 1| 3| 2| 3| 2| 2| 2| 4| 4| 5| 5| 5| 5| 7| 0| 0| 5| 8| 8| 8| 8| 8| 8| 8|
| 1| 5| 3| 4| 5| 8| 9| 7| 0| 4| 1| 4| 6| 3| 2| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Histiocytic Sarcoma | X |
Sarcoma, Metastatic, Skin | X |
Alveolar/Bronchiolar, Adenoma | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + M + + + + + + + + + + + + + + + + I + M M + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Papilloma | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| | A |
91 PPM | 1| 6| 7| 7| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 1| 1| 1| 1| 2| | L |
| 8| 9| 0| 1| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 5| 6| 7| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Rectum, Sarcoma, Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Ileum, Leiomyoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hepatocellular Adenoma | X | 2 |
Sarcoma, Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + | 3 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Sarcoma, Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| | A |
91 PPM | 1| 6| 7| 7| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 1| 1| 1| 1| 2| | L |
| 8| 9| 0| 1| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 5| 6| 7| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Bilateral, Medulla, Pheochromocytoma | | |
Benign | X | 1 |
Cortex, Adenoma | X | 1 |
Medulla, Pheochromocytoma Malignant | | 2 |
Medulla, Pheochromocytoma Benign | X X | 5 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + I + + + + + | 46 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenoma | X | 2 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + M + + + + + + + + + + + + | 41 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| | A |
91 PPM | 1| 6| 7| 7| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 1| 1| 1| 1| 2| | L |
| 8| 9| 0| 1| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 5| 6| 7| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Pars Distalis, Adenoma | X X X X X X X X | 19 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
C-Cell, Adenoma | X X X X X | 7 |
C-Cell, Carcinoma | X | 2 |
Follicular Cell, Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Sarcoma, Metastatic, Skin | X | 2 |
|__________________________________________________________________________|____________|
Penis | + | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenoma | X X | 2 |
Sarcoma, Metastatic, Skin | X | 2 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X | 30 |
Interstitial Cell, Adenoma | X X X X X | 12 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| | A |
91 PPM | 1| 6| 7| 7| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 1| 1| 1| 1| 2| | L |
| 8| 9| 0| 1| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 5| 6| 7| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + | 45 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + M + + + + + + + + + + | 42 |
Fibrous Histiocytoma | | 1 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + | 41 |
Fibroadenoma | X | 2 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Fibroma | X | 1 |
Fibrous Histiocytoma | | 1 |
Keratoacanthoma | X X | 3 |
Lipoma | X X | 3 |
Sarcoma | X X | 3 |
Squamous Cell Papilloma | X | 1 |
Face, Squamous Cell Papilloma | X | 1 |
Sebaceous Gland, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| | A |
91 PPM | 1| 6| 7| 7| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 1| 1| 1| 1| 2| | L |
| 8| 9| 0| 1| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 5| 6| 7| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Femur, Sarcoma, Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cerebrum, Astrocytoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Histiocytic Sarcoma | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
Alveolar/Bronchiolar, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 65
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| | A |
91 PPM | 1| 6| 7| 7| 6| 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 1| 1| 1| 1| 2| | L |
| 8| 9| 0| 1| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| 5| 6| 7| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 43 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Histiocytic Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Transitional Epithelium, Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | X X X X X X | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 4| 9| 2| 5| 6| 6| 9| 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 9| 7| 3| 9| 9| 2| 2| 8| 8| 1| 3| 2| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 2| 2| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
272 PPM | 1| 1| 1| 1| 1| 4| 4| 3| 4| 4| 5| 6| 6| 7| 8| 9| 9| 9| 9| 9| 7| 7| 7| 7| 7|
| 1| 2| 3| 9| 8| 1| 6| 4| 3| 9| 1| 0| 9| 1| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Colon, Adenoma | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X X|
|__________________________________________________________________________|
Mesentery | + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 4| 9| 2| 5| 6| 6| 9| 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 9| 7| 3| 9| 9| 2| 2| 8| 8| 1| 3| 2| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 2| 2| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
272 PPM | 1| 1| 1| 1| 1| 4| 4| 3| 4| 4| 5| 6| 6| 7| 8| 9| 9| 9| 9| 9| 7| 7| 7| 7| 7|
| 1| 2| 3| 9| 8| 1| 6| 4| 3| 9| 1| 0| 9| 1| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Adenoma | |
Medulla, Pheochromocytoma Benign | X X|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + M + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 4| 9| 2| 5| 6| 6| 9| 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 9| 7| 3| 9| 9| 2| 2| 8| 8| 1| 3| 2| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 2| 2| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
272 PPM | 1| 1| 1| 1| 1| 4| 4| 3| 4| 4| 5| 6| 6| 7| 8| 9| 9| 9| 9| 9| 7| 7| 7| 7| 7|
| 1| 2| 3| 9| 8| 1| 6| 4| 3| 9| 1| 0| 9| 1| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X X |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Fibroadenoma | |
|__________________________________________________________________________|
Skin | + + + + + I + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 4| 9| 2| 5| 6| 6| 9| 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 9| 7| 3| 9| 9| 2| 2| 8| 8| 1| 3| 2| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 2| 2| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
272 PPM | 1| 1| 1| 1| 1| 4| 4| 3| 4| 4| 5| 6| 6| 7| 8| 9| 9| 9| 9| 9| 7| 7| 7| 7| 7|
| 1| 2| 3| 9| 8| 1| 6| 4| 3| 9| 1| 0| 9| 1| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Basal Cell Carcinoma | X |
Fibroma | X |
Fibrous Histiocytoma | |
Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Thyroid Gland | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 70
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 4| 9| 2| 5| 6| 6| 9| 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 9| 7| 3| 9| 9| 2| 2| 8| 8| 1| 3| 2| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 2| 2| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
272 PPM | 1| 1| 1| 1| 1| 4| 4| 3| 4| 4| 5| 6| 6| 7| 8| 9| 9| 9| 9| 9| 7| 7| 7| 7| 7|
| 1| 2| 3| 9| 8| 1| 6| 4| 3| 9| 1| 0| 9| 1| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + + |
Pinna, Neural Crest Tumor | X |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urethra | +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
Mesothelioma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | A |
272 PPM | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| | L |
| 7| 8| 3| 4| 5| 6| 7| 7| 8| 9| 0| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Colon, Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hepatocellular Adenoma | X | 3 |
|__________________________________________________________________________|____________|
Mesentery | + | 6 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | A |
272 PPM | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| | L |
| 7| 8| 3| 4| 5| 6| 7| 7| 8| 9| 0| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cortex, Adenoma | X | 1 |
Medulla, Pheochromocytoma Benign | | 2 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + M + + + + M + M + + + + + + + + M | 40 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Pars Distalis, Adenoma | X X X X X X X X X X X X | 21 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
C-Cell, Adenoma | X X X X | 7 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | A |
272 PPM | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| | L |
| 7| 8| 3| 4| 5| 6| 7| 7| 8| 9| 0| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + M + + + | 47 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | X X X X X X | 7 |
Carcinoma | X | 4 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X | 38 |
Interstitial Cell, Adenoma | X X X | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | A |
272 PPM | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| | L |
| 7| 8| 3| 4| 5| 6| 7| 7| 8| 9| 0| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Thymus | M + + + + + + + M + + + + + + + + + + + + + M | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + M + + + + + + + + + + + | 46 |
Carcinoma | X | 1 |
Fibroadenoma | X | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Basal Cell Carcinoma | | 1 |
Fibroma | | 1 |
Fibrous Histiocytoma | X | 1 |
Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | A |
272 PPM | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| | L |
| 7| 8| 3| 4| 5| 6| 7| 7| 8| 9| 0| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + M + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X X X | 3 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 2 |
Pinna, Neural Crest Tumor | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| | A |
272 PPM | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| | L |
| 7| 8| 3| 4| 5| 6| 7| 7| 8| 9| 0| 1| 2| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Urethra | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X | 19 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 7| 0| 0| 4| 4| 5| 6| 6| 6| 7| 7| 8| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3|
| 7| 5| 5| 1| 5| 5| 8| 0| 1| 1| 6| 9| 7| 8| 7| 3| 7| 4| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 2| 0| 0| 0| 0| 0| 2| 0| 0| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 3| 5| 4| 4| 4| 5| 6| 6| 7| 8| 9| 9| 9| 9| 9| 0| 3|
| 2| 4| 6| 6| 1| 3| 2| 7| 9| 2| 4| 6| 7| 7| 5| 4| 0| 7| 5| 6| 7| 8| 9| 0| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
Jejunum, Leiomyoma | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | |
Hepatocellular Adenoma | |
|__________________________________________________________________________|
Mesentery | + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Adenocarcinoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 7| 0| 0| 4| 4| 5| 6| 6| 6| 7| 7| 8| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3|
| 7| 5| 5| 1| 5| 5| 8| 0| 1| 1| 6| 9| 7| 8| 7| 3| 7| 4| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 2| 0| 0| 0| 0| 0| 2| 0| 0| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 3| 5| 4| 4| 4| 5| 6| 6| 7| 8| 9| 9| 9| 9| 9| 0| 3|
| 2| 4| 6| 6| 1| 3| 2| 7| 9| 2| 4| 6| 7| 7| 5| 4| 0| 7| 5| 6| 7| 8| 9| 0| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Medulla, Pheochromocytoma Malignant | X X |
Medulla, Pheochromocytoma Complex | X |
Medulla, Pheochromocytoma Benign | |
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + M + M + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + M M + + + + + + + + + + + + + + + + +|
Craniopharyngioma | |
Pars Distalis, Adenoma | X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Bilateral, Follicular Cell, Carcinoma| |
C-Cell, Adenoma | X |
Follicular Cell, Adenoma | |
__________________________________________|__________________________________________________________________________|
Page 79
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 7| 0| 0| 4| 4| 5| 6| 6| 6| 7| 7| 8| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3|
| 7| 5| 5| 1| 5| 5| 8| 0| 1| 1| 6| 9| 7| 8| 7| 3| 7| 4| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 2| 0| 0| 0| 0| 0| 2| 0| 0| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 3| 5| 4| 4| 4| 5| 6| 6| 7| 8| 9| 9| 9| 9| 9| 0| 3|
| 2| 4| 6| 6| 1| 3| 2| 7| 9| 2| 4| 6| 7| 7| 5| 4| 0| 7| 5| 6| 7| 8| 9| 0| 6|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X X |
Squamous Cell Papilloma | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 7| 0| 0| 4| 4| 5| 6| 6| 6| 7| 7| 8| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3|
| 7| 5| 5| 1| 5| 5| 8| 0| 1| 1| 6| 9| 7| 8| 7| 3| 7| 4| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 2| 0| 0| 0| 0| 0| 2| 0| 0| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 3| 5| 4| 4| 4| 5| 6| 6| 7| 8| 9| 9| 9| 9| 9| 0| 3|
| 2| 4| 6| 6| 1| 3| 2| 7| 9| 2| 4| 6| 7| 7| 5| 4| 0| 7| 5| 6| 7| 8| 9| 0| 6|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Adenocarcinoma, Metastatic, Pancreas | X |
|__________________________________________________________________________|
Thymus | + + + + M + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + M + + + M + + M + + M + + + M M + + + + + +|
Fibroadenoma | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Fibroma | X X X |
Fibrous Histiocytoma | |
Keratoacanthoma | |
Sarcoma | X |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
_____________________________________________________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 7| 0| 0| 4| 4| 5| 6| 6| 6| 7| 7| 8| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3|
| 7| 5| 5| 1| 5| 5| 8| 0| 1| 1| 6| 9| 7| 8| 7| 3| 7| 4| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 2| 0| 0| 0| 0| 0| 2| 0| 0| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 3| 5| 4| 4| 4| 5| 6| 6| 7| 8| 9| 9| 9| 9| 9| 0| 3|
| 2| 4| 6| 6| 1| 3| 2| 7| 9| 2| 4| 6| 7| 7| 5| 4| 0| 7| 5| 6| 7| 8| 9| 0| 6|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Sarcoma, Metastatic, Skin | X |
Squamous Cell Carcinoma, Metastatic, | |
Preputial Gland | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________|__________________________________________________________________________
| 0| 4| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 7| 0| 0| 4| 4| 5| 6| 6| 6| 7| 7| 8| 9| 0| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3|
| 7| 5| 5| 1| 5| 5| 8| 0| 1| 1| 6| 9| 7| 8| 7| 3| 7| 4| 3| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 2| 0| 0| 0| 0| 0| 2| 0| 0| 0| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3|
543 PPM | 0| 1| 1| 3| 3| 3| 3| 3| 3| 5| 4| 4| 4| 5| 6| 6| 7| 8| 9| 9| 9| 9| 9| 0| 3|
| 2| 4| 6| 6| 1| 3| 2| 7| 9| 2| 4| 6| 7| 7| 5| 4| 0| 7| 5| 6| 7| 8| 9| 0| 6|
_____________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 3| 3| 7| 8| 8| 7| 7| 8| 8| 8| 8| 8| 8| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 3| 8| 9| 0| 1| 2| 3| 4| 5| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Jejunum, Leiomyoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | X | 1 |
Hepatocellular Adenoma | X X | 2 |
|__________________________________________________________________________|____________|
Mesentery | + | 3 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Acinar Cell, Adenocarcinoma | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Fibrous Histiocytoma | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 84
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 3| 3| 7| 8| 8| 7| 7| 8| 8| 8| 8| 8| 8| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 3| 8| 9| 0| 1| 2| 3| 4| 5| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Sarcoma, Metastatic, Skin | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Medulla, Pheochromocytoma Malignant | X | 3 |
Medulla, Pheochromocytoma Complex | | 1 |
Medulla, Pheochromocytoma Benign | X X X | 3 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenoma | X X | 4 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + M + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 85
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 3| 3| 7| 8| 8| 7| 7| 8| 8| 8| 8| 8| 8| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 3| 8| 9| 0| 1| 2| 3| 4| 5| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Craniopharyngioma | X | 1 |
Pars Distalis, Adenoma | X X X X X X X X X | 13 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Fibrous Histiocytoma | | 1 |
Bilateral, Follicular Cell, Carcinoma| X | 1 |
C-Cell, Adenoma | X X X | 4 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenoma | X | 3 |
Carcinoma | X X X X X X X | 9 |
Squamous Cell Papilloma | X | 1 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X | 39 |
Interstitial Cell, Adenoma | X X | 6 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 86
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 3| 3| 7| 8| 8| 7| 7| 8| 8| 8| 8| 8| 8| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 3| 8| 9| 0| 1| 2| 3| 4| 5| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenocarcinoma, Metastatic, Pancreas | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + M + + + + + + + + + + + + + M | 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 41 |
Fibroadenoma | X X X | 4 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Basal Cell Adenoma | X | 1 |
Fibroma | X X | 5 |
Fibrous Histiocytoma | X | 1 |
Keratoacanthoma | X X | 2 |
Sarcoma | X X X | 4 |
Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 87
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 3| 3| 7| 8| 8| 7| 7| 8| 8| 8| 8| 8| 8| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 3| 8| 9| 0| 1| 2| 3| 4| 5| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Alveolar/Bronchiolar Adenoma | X | 4 |
Sarcoma, Metastatic, Skin | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Preputial Gland | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Fibrous Histiocytoma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 88
NTP Experiment-Test: 93029-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/18/03
Route: DOSED FEED Time: 15:14:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS-NCTR MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
543 PPM | 3| 3| 7| 8| 8| 7| 7| 8| 8| 8| 8| 8| 8| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| | L |
| 7| 8| 9| 0| 3| 8| 9| 0| 1| 2| 3| 4| 5| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | X X | 7 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 89
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---------- END OF REPORT ----------
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