TDMS Study 93029-04 Pathology Tables
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
Facility: National Center for Toxicological Research
Chemical CAS #: 129-73-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|
| 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A A + + A + + + + + + + + + + + + + + + + + +|
Polyarteritis | |
|__________________________________________________________________________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + +|
Rectum, Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Intestine Large, Cecum | + A A + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + A A + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + A A + + + + + A + + + + + + + + + + + + + + +|
Ileum, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + A A + + M + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A A + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A A + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Lymphocytic | 1 2 2 |
Inflammation, Chronic Active, Focal | 2 1 1 2 2 1 1 2 |
Mineralization, Focal | 1 |
Necrosis | 2 |
Tension Lipidosis | 2 1 2 1 |
Vacuolization Cytoplasmic | 2 2 |
Bile Duct, Cyst | 3 3 |
Oval Cell, Hyperplasia | 2 |
|__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|
| 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + A + + + + + + A + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 |
Infiltration Cellular, Lymphocytic | 1 1 2 |
Acinus, Atrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Parotid Gland, Atrophy | 1 |
Acinus, Submandibular Gland, Atrophy | 2 |
Parotid Gland, Infiltration Cellular,| |
Lymphocytic | 1 1 1 1 1 |
Parotid Gland, Vacuolization | |
Cytoplasmic | 2|
Submandibular Gland, Infiltration | |
Cellular, Lymphocytic | 2 1 2 2 1 2 1 2 1 2 1 2 |
|__________________________________________________________________________|
Stomach | + + A + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Hyperkeratosis, Focal | 1 |
Forestomach, Infiltration Cellular, | |
Lymphocytic | |
Forestomach, Epithelium, Hyperplasia,| |
Diffuse | |
Forestomach, Epithelium, Hyperplasia,| |
Focal | 2 |
Glandular, Infiltration Cellular, | |
Lymphocytic | 2 |
Glandular, Ulcer | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + A M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|
| 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | |
Atrium Left, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + M + + + + + + + + + + + +|
Cortex, Accessory Adrenal Cortical | |
Nodule | X X |
Cortex, Cyst | X |
Cortex, Hyperplasia, Focal | 1 |
Cortex, Hypertrophy, Focal | 1 |
Cortex, Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + A + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Cyst | 2 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + A + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 1 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2|
|__________________________________________________________________________|
Ovary | + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|
| 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Angiectasis | |
Atrophy | 2 2 2 2 1 2 2 2 2 2 2 2 2 1 1 1 1 2 2|
Cyst | X X X X X X X X|
Hemorrhage | 2 |
Thrombosis | 3 |
Bilateral, Cyst | X X |
|__________________________________________________________________________|
Uterus | + A + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis, Focal | 3 |
Hyperplasia, Cystic | 2 1 4 2 1 4 2 1 2 2 4 2 3 2 4 3 3 2 3 3|
|__________________________________________________________________________|
Vagina | + A + + + + + + M + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Femoral, Infarct | 2 |
Myeloid Cell, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Cyst | |
Lumbar, Hematopoietic Cell | |
Proliferation | |
Lumbar, Hyperplasia, Lymphoid | 3 |
Mandibular, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
Mesenteric, Hemorrhage | 1 |
Mesenteric, Hyperplasia, Lymphoid | 1 3 |
Renal, Hyperplasia, Lymphoid | 3 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + A + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|
| 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Spleen | + + A + + + + + A + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 4 3 4 1 2 |
Hyperplasia, Lymphoid | 3 2 3 3 2 3 |
Proliferation Connective Tissue, | |
Focal | 1 |
|__________________________________________________________________________|
Thymus | + A M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | X |
Ectopic Parathyroid Gland | X X |
Hyperplasia, Lymphoid | 1 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + A + + + + + + + + + + + + + + + + + + + + + +|
Face, Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 1 1 2|
Sternum, Degeneration, Cystic | |
Sternum, Fibrous Osteodystrophy | 1 1 2 1 1 2 1 1 1 2|
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Mineralization | 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|
| 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
Thoracic, Axon, Degeneration | 1 1 1 |
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Infiltration Cellular, Histiocytic | |
Infiltration Cellular, Lymphocytic | 2 2 2 2 2 1 3 2 |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | |
Vein, Thrombosis | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Lens, Cataract | 3 3 3 4 |
Cornea, Inflammation, Chronic | 2 |
Lens, Cataract | 2 3 1 2 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocytic | 1 2 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 2| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 9| 1| 3| 8| 8| 9| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 5| 8| 8| 9| 2| 2| 5| 8| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|
| 3| 7| 3| 5| 9| 0| 3| 9| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | 1 |
Infarct | |
Infiltration Cellular, Lymphocytic | 3 2 1 1 1 |
Nephropathy | 3 |
Papilla, Casts Protein | 1 |
Pelvis, Dilatation | 4 3 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
|__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + +|
Inclusion Body Intracytoplasmic | 1 1 1 1 1 1 1 1 1|
Infiltration Cellular, Lymphocytic | 1 3 2 1 1 1 1 2 2 1 1 1 1|
__________________________________________|__________________________________________________________________________
Page 8
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| | L |
| 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
Polyarteritis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Rectum, Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
Ileum, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 43 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Basophilic Focus | | 1 |
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Infiltration Cellular, Lymphocytic | 1 2 1 1 2 | 8 1.5|
Inflammation, Chronic Active, Focal | 2 1 1 1 2 1 1 | 15 1.4|
Mineralization, Focal | | 1 1.0|
Necrosis | | 1 2.0|
Tension Lipidosis | 2 2 1 2 2 1 | 10 1.6|
Vacuolization Cytoplasmic | | 2 2.0|
Bile Duct, Cyst | 1 | 3 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| | L |
| 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Oval Cell, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Cytoplasmic Alteration | | 1 1.0|
Infiltration Cellular, Lymphocytic | 1 2 1 2 | 7 1.4|
Acinus, Atrophy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Acinus, Parotid Gland, Atrophy | | 1 1.0|
Acinus, Submandibular Gland, Atrophy | | 1 2.0|
Parotid Gland, Infiltration Cellular,| | |
Lymphocytic | 2 1 1 2 | 9 1.2|
Parotid Gland, Vacuolization | | |
Cytoplasmic | 2 | 2 2.0|
Submandibular Gland, Infiltration | | |
Cellular, Lymphocytic | 1 1 1 1 2 2 1 2 2 2 2 1 2 1 2 1 2 1 2 2 3 | 33 1.6|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Forestomach, Hyperkeratosis, Focal | | 1 1.0|
Forestomach, Infiltration Cellular, | | |
Lymphocytic | 2 | 1 2.0|
Forestomach, Epithelium, Hyperplasia,| | |
Diffuse | 3 | 1 3.0|
Forestomach, Epithelium, Hyperplasia,| | |
Focal | 2 2 | 3 2.0|
Glandular, Infiltration Cellular, | | |
Lymphocytic | | 1 2.0|
Glandular, Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| | L |
| 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Artery, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Polyarteritis | 3 | 1 3.0|
Atrium Left, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Cortex, Accessory Adrenal Cortical | | |
Nodule | X | 3 |
Cortex, Cyst | | 1 |
Cortex, Hyperplasia, Focal | 1 | 2 1.0|
Cortex, Hypertrophy, Focal | 2 | 2 1.5|
Cortex, Subcapsular, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 | 42 1.9|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + | 45 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + M M | 42 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + M + M + + M M + + + | 41 |
Pars Distalis, Hyperplasia, Focal | 1 | 3 1.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| | L |
| 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + | 46 |
Follicular Cell, Cyst | 1 2 2 | 7 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + | 45 |
Duct, Cyst | 1 3 2 1 1 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 | 44 1.9|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Angiectasis | 2 | 1 2.0|
Atrophy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 | 42 1.9|
Cyst | X X X X X X | 14 |
Hemorrhage | 3 1 1 | 4 1.8|
Thrombosis | 3 3 | 3 3.0|
Bilateral, Cyst | X X X X X | 7 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Adenomyosis, Focal | | 1 3.0|
Hyperplasia, Cystic | 2 2 1 1 1 4 2 3 3 3 2 1 3 2 4 2 2 4 2 3 3 1 | 42 2.4|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Angiectasis, Focal | | 1 2.0|
Femoral, Infarct | | 1 2.0|
Myeloid Cell, Hyperplasia | 2 3 | 4 2.3|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| | L |
| 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lumbar, Cyst | X | 1 |
Lumbar, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Lumbar, Hyperplasia, Lymphoid | | 1 3.0|
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Mesenteric, Hemorrhage | | 1 1.0|
Mesenteric, Hyperplasia, Lymphoid | 2 2 3 | 5 2.2|
Renal, Hyperplasia, Lymphoid | | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Hematopoietic Cell Proliferation | 1 2 3 2 | 11 2.5|
Hyperplasia, Lymphoid | 1 2 2 1 2 2 2 2 | 14 2.1|
Proliferation Connective Tissue, | | |
Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + M + + + + + | 43 |
Atrophy | 2 | 2 2.0|
Cyst | X | 2 |
Ectopic Parathyroid Gland | X X | 4 |
Hyperplasia, Lymphoid | | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Face, Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| | L |
| 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Femur, Fibrous Osteodystrophy | 1 3 1 1 1 | 8 1.4|
Sternum, Degeneration, Cystic | 1 | 1 1.0|
Sternum, Fibrous Osteodystrophy | 1 1 1 1 1 3 1 1 1 1 1 3 2 2 1 2 | 26 1.4|
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1 | 15 1.0|
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Thoracic, Axon, Degeneration | 1 1 1 1 1 1 1 1 1 | 12 1.0|
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hemorrhage, Focal | | 1 2.0|
Infiltration Cellular, Histiocytic | 1 | 1 1.0|
Infiltration Cellular, Lymphocytic | 1 2 1 2 2 | 13 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| | L |
| 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Inflammation, Chronic, Focal | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Vein, Thrombosis | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Bilateral, Lens, Cataract | | 4 3.3|
Cornea, Inflammation, Chronic | | 1 2.0|
Lens, Cataract | | 5 1.8|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocytic | 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Glomerulosclerosis | | 1 1.0|
Infarct | 1 1 | 2 1.0|
Infiltration Cellular, Lymphocytic | 1 2 1 1 | 9 1.4|
Nephropathy | | 1 3.0|
Papilla, Casts Protein | | 1 1.0|
Pelvis, Dilatation | | 2 3.5|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Inclusion Body Intracytoplasmic | 1 1 1 1 1 | 14 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 7| 0| 0| 1| 1| 1| 1| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| | L |
| 9| 8| 9| 0| 1| 2| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Infiltration Cellular, Lymphocytic | 1 1 2 2 1 1 2 1 2 1 1 1 1 1 2 2 | 29 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
91 PPM | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|
| 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
Infiltration Cellular, Lymphocytic | |
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Rectum, Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Hyperplasia, Lymphoid | 1 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | |
Hematopoietic Cell Proliferation | 3 3 |
Infiltration Cellular, Lymphocytic | |
Inflammation, Chronic Active, Focal | 1 1 1 1 2 1 2 |
Tension Lipidosis | 1 1 1 1 1 1 1 1|
Vacuolization Cytoplasmic | 1 |
Bile Duct, Cyst | 2 |
|__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 2 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
91 PPM | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|
| 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Cyst | |
Cytoplasmic Alteration | 1 |
Infiltration Cellular, Lymphocytic | 2 1 |
Acinus, Atrophy | 2 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Parotid Gland, Atrophy | 2 4 |
Acinus, Submandibular Gland, Atrophy | 3 |
Parotid Gland, Infiltration Cellular,| |
Lymphocytic | 1 2 1 1 1 |
Submandibular Gland, Infiltration | |
Cellular, Lymphocytic | 2 1 2 1 2 2 2 2 1 1 1 1 2 1 2 2 2|
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Epithelium, Hyperplasia,| |
Focal | 2 |
Glandular, Infiltration Cellular, | |
Lymphocytic | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Embolus Bacterial | 4 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Acute, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
91 PPM | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|
| 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Accessory Adrenal Cortical | |
Nodule | X |
Cortex, Hypertrophy, Focal | |
Cortex, Subcapsular, Hyperplasia | 2 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2|
Medulla, Hyperplasia, Focal | |
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + M + + + + + + + + + + + +|
Infiltration Cellular, Lymphocytic | 3 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
Follicular Cell, Cyst | 2 1 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Duct, Cyst | 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Angiectasis | |
Atrophy | 2 2 2 3 1 2 2 2 2 2 2 2 1 2 2 2 3 2 1 2 2 2 1|
Cyst | X X X X X X X X X X|
Hemorrhage | 1 |
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
91 PPM | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|
| 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Bilateral, Cyst | X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hyperplasia, Cystic | 3 1 4 2 4 4 4 4 2 3 2 2 3 2 2 2 3 3 3 2 2 2 3 4|
Thrombosis | 4 |
Endometrium, Metaplasia | |
|__________________________________________________________________________|
Vagina | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Myeloid Cell, Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Lymphoid | 3|
Mesenteric, Hemorrhage | |
Mesenteric, Hyperplasia, Lymphoid | 2 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 4 3 3 2 2 |
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Plasma Cell | 4 |
|__________________________________________________________________________|
Thymus | + + + + M + + M + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | X |
Ectopic Parathyroid Gland | X X X |
Hyperplasia, Lymphoid | 1 |
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
91 PPM | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|
| 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 1 1 |
Sternum, Degeneration, Cystic | 1 1 1 |
Sternum, Fibrous Osteodystrophy | 1 1 2 1 1 2 |
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thoracic, Axon, Degeneration | 1 1 |
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Crystals | |
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
91 PPM | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|
| 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Infiltration Cellular, Histiocytic | 1 |
Infiltration Cellular, Lymphocytic | 1 2 1 1 |
Inflammation, Chronic, Focal | |
Leukocytosis | 3 1 |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Lens, Cataract | 3 1 2 1 |
Lens, Cataract | 3 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 |
Infiltration Cellular, Lymphocytic | 2 2 1 1 1 1 |
Acinus, Dilatation | |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Lymphocytic | 1 1 1 1 |
Nephropathy | 1 1 |
Glomerulus, Casts Protein | |
Pelvis, Dilatation | 3 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Hypertrophy | 1|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 7| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 0| 5| 0| 8| 9| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
91 PPM | 1| 2| 3| 3| 3| 3| 5| 5| 5| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1|
| 6| 4| 1| 4| 6| 7| 6| 7| 8| 9| 0| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inclusion Body Intracytoplasmic | 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 2|
Infiltration Cellular, Lymphocytic | 1 2 1 1 1 1 1 1 |
__________________________________________|__________________________________________________________________________
Page 23
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
91 PPM | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocytic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Rectum, Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + | 47 |
Ileum, Hyperplasia, Lymphoid | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Basophilic Focus | | 2 |
Clear Cell Focus | X | 1 |
Hematopoietic Cell Proliferation | | 2 3.0|
Infiltration Cellular, Lymphocytic | 1 2 | 2 1.5|
Inflammation, Chronic Active, Focal | 1 1 1 2 1 2 | 13 1.3|
Tension Lipidosis | 1 1 1 2 | 12 1.1|
Vacuolization Cytoplasmic | | 1 1.0|
Bile Duct, Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
91 PPM | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | | 2 |
Fat, Necrosis, Focal | | 2 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cyst | 2 2 | 2 2.0|
Cytoplasmic Alteration | | 1 1.0|
Infiltration Cellular, Lymphocytic | 1 1 1 1 1 1 1 | 9 1.1|
Acinus, Atrophy | | 2 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Acinus, Parotid Gland, Atrophy | 2 | 3 2.7|
Acinus, Submandibular Gland, Atrophy | | 1 3.0|
Parotid Gland, Infiltration Cellular,| | |
Lymphocytic | 1 1 1 1 | 9 1.1|
Submandibular Gland, Infiltration | | |
Cellular, Lymphocytic | 2 2 1 2 1 1 1 1 2 2 1 2 1 | 30 1.5|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Forestomach, Epithelium, Hyperplasia,| | |
Focal | 2 1 1 | 4 1.5|
Glandular, Infiltration Cellular, | | |
Lymphocytic | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Foreign Body | 1 | 3 1.0|
Artery, Inflammation, Chronic | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
91 PPM | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Aorta, Embolus Bacterial | | 1 4.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cardiomyopathy | 1 | 1 1.0|
Inflammation, Acute, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cortex, Accessory Adrenal Cortical | | |
Nodule | | 1 |
Cortex, Hypertrophy, Focal | 1 3 | 2 2.0|
Cortex, Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 47 1.9|
Medulla, Hyperplasia, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M M + M M + + + + + + | 42 |
Infiltration Cellular, Lymphocytic | | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + M + M + + + + + + | 45 |
Pars Distalis, Hyperplasia, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Ultimobranchial Cyst | X | 2 |
Follicular Cell, Cyst | 2 1 1 | 10 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
91 PPM | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M | 46 |
Inflammation, Chronic | 2 | 1 2.0|
Duct, Cyst | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 46 1.9|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Abscess | X | 1 |
Angiectasis | 2 | 1 2.0|
Atrophy | 1 2 1 1 2 1 1 2 2 2 2 2 2 2 1 2 1 1 2 1 2 1 | 45 1.7|
Cyst | X X X X X X | 16 |
Hemorrhage | 3 | 2 2.0|
Bilateral, Cyst | X | 3 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 2 1 | 4 1.8|
Hyperplasia, Cystic | 2 2 3 3 1 1 3 2 2 3 3 2 1 4 2 3 2 3 2 4 2 2 | 46 2.6|
Thrombosis | | 1 4.0|
Endometrium, Metaplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Fibrosis | | 1 3.0|
Myeloid Cell, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inguinal, Hyperplasia, Lymphoid | 1 | 1 1.0|
Mandibular, Hyperplasia, Lymphoid | 3 2 | 3 2.7|
Mesenteric, Hemorrhage | 2 | 1 2.0|
Mesenteric, Hyperplasia, Lymphoid | | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
91 PPM | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Angiectasis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 3 2 | 9 2.6|
Hyperplasia, Lymphoid | 1 2 | 4 1.8|
Infiltration Cellular, Plasma Cell | | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + | 45 |
Atrophy | 2 | 2 2.5|
Cyst | | 1 |
Ectopic Parathyroid Gland | X X X X | 7 |
Hyperplasia, Lymphoid | 1 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Femur, Fibrous Osteodystrophy | | 2 1.0|
Sternum, Degeneration, Cystic | | 3 1.0|
Sternum, Fibrous Osteodystrophy | 1 1 1 2 1 2 1 1 2 1 2 1 2 2 1 | 21 1.4|
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
91 PPM | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1 1 1 | 18 1.0|
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + M + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Thoracic, Axon, Degeneration | 1 1 3 1 1 1 1 1 1 | 11 1.2|
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Crystals | 2 | 1 2.0|
Infiltration Cellular, Histiocytic | 1 | 2 1.0|
Infiltration Cellular, Lymphocytic | 3 3 1 | 7 1.7|
Inflammation, Chronic, Focal | 1 | 1 1.0|
Leukocytosis | | 2 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Bilateral, Lens, Cataract | 3 | 5 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
91 PPM | 1| 1| 2| 2| 4| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | L |
| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 3| 4| 3| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Lens, Cataract | 2 1 | 4 1.8|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Atrophy | 1 | 1 1.0|
Hyperplasia | | 1 2.0|
Infiltration Cellular, Lymphocytic | 2 2 2 | 9 1.6|
Acinus, Dilatation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + M + + + + + + | 47 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, Lymphocytic | 1 | 5 1.0|
Nephropathy | | 2 1.0|
Glomerulus, Casts Protein | 2 | 1 2.0|
Pelvis, Dilatation | | 1 3.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 2 2.5|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
Renal Tubule, Hypertrophy | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inclusion Body Intracytoplasmic | 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 2 1 | 33 1.2|
Infiltration Cellular, Lymphocytic | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 | 22 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
204 PPM | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
Cecum, Polyarteritis | 2 |
Colon, Angiectasis | 2 |
Rectum, Polyarteritis | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Hyperplasia, Lymphoid | 2 |
Jejunum, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Eosinophilic Focus, Single | |
Hematopoietic Cell Proliferation | 1 2 4 |
Infarct | |
Infiltration Cellular, Lymphocytic | 2 2 |
Inflammation, Chronic Active, Focal | 1 1 1 1 1 1 1 |
Tension Lipidosis | 2 2 1 |
Bile Duct, Cyst | 2 |
|__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
204 PPM | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 |
Infiltration Cellular, Lymphocytic | 1 1 |
Polyarteritis | 3 |
Acinus, Atrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Parotid Gland, Necrosis, | |
Focal | 2 1 |
Parotid Gland, Infiltration Cellular,| |
Lymphocytic | 1 1 1 2 2 |
Parotid Gland, Vacuolization | |
Cytoplasmic | 2|
Sublingual Gland, Infiltration | |
Cellular, Lymphocytic | 1 |
Submandibular Gland, Infiltration | |
Cellular, Lymphocytic | 1 2 1 1 2 1 1 1 2 1 1 2 1 1 2 1 1 1 2 |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Foreign Body | |
Forestomach, Inflammation, Chronic | |
Active | 2 |
Forestomach, Epithelium, Hyperplasia,| |
Focal | 2 3 1 3 |
Glandular, Infiltration Cellular, | |
Lymphocytic | 1 |
Glandular, Polyarteritis | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Artery, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
204 PPM | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
|__________________________________________________________________________|
Blood Vessel | M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Cortex, Hypertrophy, Focal| |
Cortex, Accessory Adrenal Cortical | |
Nodule | |
Cortex, Hematopoietic Cell | |
Proliferation | 1 |
Cortex, Hyperplasia, Focal | 2 |
Cortex, Hypertrophy, Focal | 3|
Cortex, Polyarteritis | 3 |
Cortex, Subcapsular, Hyperplasia | 1 1 2 2 3 2 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + M + + + + + + + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + M + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | 3 |
Ultimobranchial Cyst | |
Follicular Cell, Cyst | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
204 PPM | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Duct, Cyst | 2 3 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2 2 2 1|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 1 2 2 3 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 |
Cyst | X X X X X X X X|
Hemorrhage | |
Mineralization | 1 |
Bilateral, Cyst | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hyperplasia, Cystic | 1 1 1 1 2 1 2 3 2 3 3 2 2 2 2 2 3 3 2 3 3 2 4 1|
Polyarteritis | 2 |
Thrombosis | |
Stroma, Fibrosis | 3|
Stroma, Hyperplasia | |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Myeloid Cell, Hyperplasia | 3 3 4 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | 3 2 4 |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
Mesenteric, Hemorrhage | |
Mesenteric, Hyperplasia, Lymphoid | 4 2 |
Mesenteric, Infiltration Cellular, | |
Plasma Cell | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
204 PPM | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 1 3 3 2 3 2 2 2 |
Hyperplasia, Lymphoid | 2 3 2 |
|__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | X |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 2 1 |
Sternum, Degeneration, Cystic | |
Sternum, Fibrous Osteodystrophy | 1 1 1 1 3 2 1 |
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
Cerebrum, Polyarteritis | |
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
204 PPM | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
Thoracic, Axon, Degeneration | 1 1 |
|__________________________________________________________________________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocytic | 2 2 3 2 1 2 2 |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Lens, Cataract | 3 2 2 |
Lens, Cataract | 3 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
Infiltration Cellular, Lymphocytic | 1 1 1 1 1 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 1| 4| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 9| 2| 2| 2| 7| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 3| 8| 6| 0| 7| 5| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
204 PPM | 0| 1| 1| 2| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 6| 4| 7| 6| 8| 2| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 6| 8| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Infiltration Cellular, Lymphocytic | 1 1 1 2 1 1 1 1 1 |
Nephropathy | |
Polyarteritis | 3 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 |
Renal Tubule, Necrosis | 2 |
Renal Tubule, Pigmentation | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Inclusion Body Intracytoplasmic | 2 1 2 3 2 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
Infiltration Cellular, Lymphocytic | 1 1 1 1 2 1 1 1 |
Polyarteritis | 1 |
Submucosa, Edema | 3 |
__________________________________________|__________________________________________________________________________
Page 37
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
204 PPM | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + M + + + + + M | 44 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cecum, Polyarteritis | | 1 2.0|
Colon, Angiectasis | | 1 2.0|
Rectum, Polyarteritis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + M + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Ileum, Hyperplasia, Lymphoid | 2 1 | 3 1.7|
Jejunum, Hyperplasia, Lymphoid | 1 | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus, Single | X | 1 |
Hematopoietic Cell Proliferation | | 3 2.3|
Infarct | 4 | 1 4.0|
Infiltration Cellular, Lymphocytic | | 2 2.0|
Inflammation, Chronic Active, Focal | 1 1 1 1 1 1 2 1 1 | 16 1.1|
Tension Lipidosis | 1 1 2 1 1 1 | 9 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
204 PPM | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Bile Duct, Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cytoplasmic Alteration | | 1 1.0|
Infiltration Cellular, Lymphocytic | 1 1 | 4 1.0|
Polyarteritis | | 1 3.0|
Acinus, Atrophy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Acinus, Parotid Gland, Necrosis, | | |
Focal | 1 | 3 1.3|
Parotid Gland, Infiltration Cellular,| | |
Lymphocytic | 2 2 1 | 8 1.5|
Parotid Gland, Vacuolization | | |
Cytoplasmic | | 1 2.0|
Sublingual Gland, Infiltration | | |
Cellular, Lymphocytic | 1 | 2 1.0|
Submandibular Gland, Infiltration | | |
Cellular, Lymphocytic | 2 2 2 2 3 2 2 1 2 2 2 1 1 2 2 2 | 35 1.6|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Forestomach, Foreign Body | 2 | 1 2.0|
Forestomach, Inflammation, Chronic | | |
Active | 2 | 2 2.0|
Forestomach, Epithelium, Hyperplasia,| | |
Focal | 2 2 2 3 | 8 2.3|
Glandular, Infiltration Cellular, | | |
Lymphocytic | | 1 1.0|
Glandular, Polyarteritis | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
204 PPM | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Foreign Body | | 1 1.0|
Artery, Inflammation, Chronic | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Bilateral, Cortex, Hypertrophy, Focal| 2 | 1 2.0|
Cortex, Accessory Adrenal Cortical | | |
Nodule | X | 1 |
Cortex, Hematopoietic Cell | | |
Proliferation | | 1 1.0|
Cortex, Hyperplasia, Focal | 2 | 2 2.0|
Cortex, Hypertrophy, Focal | | 1 3.0|
Cortex, Polyarteritis | | 1 3.0|
Cortex, Subcapsular, Hyperplasia | 2 2 2 1 2 2 2 1 2 1 2 2 2 2 2 1 2 2 1 2 2 2 | 46 1.8|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + M + M + + + + + + + + + | 41 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
204 PPM | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + | 44 |
Pars Distalis, Hyperplasia, Focal | 1 1 2 | 3 1.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Polyarteritis | | 1 3.0|
Ultimobranchial Cyst | X X | 2 |
Follicular Cell, Cyst | 1 1 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + M + | 44 |
Inflammation, Subacute | | 1 2.0|
Duct, Cyst | 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2 1 2 2 2 2 2 | 41 1.9|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Angiectasis | 2 2 | 2 2.0|
Atrophy | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 | 44 1.9|
Cyst | X X X X X X X X X | 17 |
Hemorrhage | 1 1 | 2 1.0|
Mineralization | | 1 1.0|
Bilateral, Cyst | X | 2 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Angiectasis | 1 2 | 3 1.3|
Hyperplasia, Cystic | 3 2 3 3 2 1 2 4 4 2 3 2 2 4 2 4 2 3 3 1 2 4 3 | 47 2.4|
Polyarteritis | | 1 2.0|
Thrombosis | 3 2 2 | 3 2.3|
Stroma, Fibrosis | | 1 3.0|
Stroma, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
204 PPM | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Fibrosis | | 1 3.0|
Myeloid Cell, Hyperplasia | | 4 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Mandibular, Hyperplasia, Lymphoid | 3 2 3 2 2 | 8 2.6|
Mesenteric, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Mesenteric, Hemorrhage | 2 | 1 2.0|
Mesenteric, Hyperplasia, Lymphoid | 2 | 3 2.7|
Mesenteric, Infiltration Cellular, | | |
Plasma Cell | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + | 45 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hematopoietic Cell Proliferation | 2 1 1 1 2 2 2 | 17 2.1|
Hyperplasia, Lymphoid | 1 1 2 3 3 | 8 2.1|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M | 45 |
Atrophy | | 1 2.0|
Cyst | X | 2 |
Ectopic Parathyroid Gland | X X X X | 4 |
Hyperplasia, Lymphoid | 2 1 2 3 | 5 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
204 PPM | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Femur, Fibrous Osteodystrophy | 3 1 1 | 5 1.6|
Sternum, Degeneration, Cystic | 1 | 1 1.0|
Sternum, Fibrous Osteodystrophy | 1 2 1 1 1 1 1 2 1 2 2 1 | 19 1.4|
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1 1 1 | 21 1.0|
Cerebrum, Polyarteritis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Thoracic, Axon, Degeneration | 1 1 1 1 1 1 1 | 9 1.0|
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infiltration Cellular, Lymphocytic | 1 1 | 9 1.8|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
204 PPM | 2| 2| 2| 2| 2| 2| 2| 5| 5| 5| 5| 5| 6| 6| 9| 9| 9| 9| 9| 9| 9| 9| 9| | L |
| 2| 3| 4| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 1| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Bilateral, Lens, Cataract | | 3 2.3|
Lens, Cataract | 1 1 | 4 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | | 1 2.0|
Infiltration Cellular, Lymphocytic | 1 2 1 | 8 1.1|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Infarct | | 1 1.0|
Infiltration Cellular, Lymphocytic | 1 1 1 1 1 2 | 15 1.1|
Nephropathy | 1 1 1 | 3 1.0|
Polyarteritis | | 1 3.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 2.0|
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Inclusion Body Intracytoplasmic | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 44 1.9|
Infiltration Cellular, Lymphocytic | 1 1 2 1 1 1 1 1 1 1 1 2 1 1 3 1 | 24 1.2|
Polyarteritis | | 1 1.0|
Submucosa, Edema | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
408 PPM | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|
| 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Mucosa, Hyperplasia, Focal | 1 1 |
|__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + +|
Colon, Proliferation Connective | |
Tissue | 2 |
|__________________________________________________________________________|
Intestine Large, Cecum | A + M + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | A A A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + +|
Ileum, Hyperplasia, Lymphoid | |
Jejunum, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | A + M + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | A + A + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Basophilic Focus, Two | X |
Eosinophilic Focus, Single | |
Hematopoietic Cell Proliferation | 1 1 4 |
Infiltration Cellular, Lymphocytic | 2 1 1 1 |
Inflammation, Chronic Active, Focal | 1 1 1 1 2 1 |
Leukocytosis | 2 |
Tension Lipidosis | 1 1 1 |
Bile Duct, Cyst | |
Serosa, Fibrosis | |
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
408 PPM | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|
| 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 2 |
|__________________________________________________________________________|
Pancreas | A A + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Infiltration Cellular, Lymphocytic | 1 2 |
Acinus, Atrophy | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Parotid Gland, Atrophy | |
Acinus, Parotid Gland, Necrosis, | |
Focal | 1 1 |
Acinus, Submandibular Gland, Atrophy | |
Parotid Gland, Infiltration Cellular,| |
Lymphocytic | 1 1 1 2 |
Sublingual Gland, Infiltration | |
Cellular, Lymphocytic | |
Submandibular Gland, Infiltration | |
Cellular, Lymphocytic | 1 2 3 1 2 1 1 2 1 1 1 2 2 2 1 1 |
|__________________________________________________________________________|
Stomach | A + + + + + + + + + + + + + + + + + + + + + + +|
Forestomach, Epithelium, Hyperplasia,| |
Focal | 2 2 2 1 |
|__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 |
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
408 PPM | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|
| 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Accessory Adrenal Cortical | |
Nodule | X |
Cortex, Hematopoietic Cell | |
Proliferation | 3 |
Cortex, Subcapsular, Hyperplasia | 2 2 1 2 2 1 2 2 2 2 2 2 2 1 2 2 2 1 1 3 1 2 2 2|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | A A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M + + + + + + + + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Thymus | X |
Follicular Cell, Cyst | 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + M + +|
Duct, Cyst | 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 1 2 2|
|__________________________________________________________________________|
Ovary | M I M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 3 2 2 3 2|
Cyst | X X X X |
Hemorrhage | |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
408 PPM | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|
| 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Bilateral, Cyst | X X |
|__________________________________________________________________________|
Uterus | A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hyperplasia, Cystic | 2 4 2 1 1 2 3 2 3 2 2 3 2 1 4 2 3 1 3 2 4 2|
Inflammation, Acute | 3 |
|__________________________________________________________________________|
Vagina | M + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 2 3 2 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Plasma Cell | 3 |
Mandibular, Hyperplasia, Lymphoid | |
Mesenteric, Hemorrhage | |
Mesenteric, Hyperplasia, Lymphoid | 3 3 2 |
Mesenteric, Infiltration Cellular, | |
Plasma Cell | 4 |
Thoracic, Hyperplasia, Plasma Cell | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | A A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | A A + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 4 3 1 3 2 1 1 2 3 |
Hyperplasia, Lymphoid | 2 2 3 |
Infiltration Cellular, Plasma Cell | 4 |
|__________________________________________________________________________|
Thymus | + M + + M M + + + + + + + + + + + + + + + + + +|
Cyst | X |
Ectopic Parathyroid Gland | X X X |
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
408 PPM | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|
| 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | A + M + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocytic | |
|__________________________________________________________________________|
Skin | A + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | |
Sternum, Degeneration, Cystic | 1 1 1 |
Sternum, Fibrous Osteodystrophy | 2 1 1 1 1 1 1 2|
|__________________________________________________________________________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + M + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Infiltration Cellular, | |
Lymphocytic | 2 |
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
Thoracic, Infiltration Cellular, | |
Lymphocytic | 1 |
Thoracic, Axon, Degeneration | 1 1 1 1 1 1|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
408 PPM | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|
| 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Crystals | 3 |
Infarct | |
Infiltration Cellular, Histiocytic | 1 1 |
Infiltration Cellular, Lymphocytic | 2 3 1 2 1 1 1 2 |
Inflammation, Chronic, Focal | 1 |
Inflammation, Granulomatous | 2 |
Leukocytosis | 4 |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Mineralization | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
Phthisis Bulbi | |
Bilateral, Lens, Cataract | 3 4 3 3 2 1 1 |
Conjunctiva, Polyarteritis | |
Lens, Cataract | 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 |
Infiltration Cellular, Lymphocytic | 1 1 1 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | 1 |
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 6| 5| 8| 4| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 0| 3| 4| 7| 8| 4| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
408 PPM | 1| 1| 2| 2| 2| 4| 4| 4| 6| 7| 7| 7| 7| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 3|
| 2| 8| 3| 5| 7| 2| 3| 4| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Infarct | |
Infiltration Cellular, Lymphocytic | 1 1 1 1 2 1 |
Nephropathy | 1 |
Glomerulus, Casts Protein | 3 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 2 |
|__________________________________________________________________________|
Urinary Bladder | A A + + + + A + + + + + + + + + + + + + + + + +|
Inclusion Body Intracytoplasmic | 2 2 2 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Infiltration Cellular, Lymphocytic | 1 1 1 2 1 1 3 1 1 1 1|
__________________________________________|__________________________________________________________________________
Page 51
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
408 PPM | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Inflammation, Acute | | 1 2.0|
Mucosa, Hyperplasia, Focal | | 2 1.0|
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Colon, Proliferation Connective | | |
Tissue | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Ileum, Hyperplasia, Lymphoid | 4 | 1 4.0|
Jejunum, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Basophilic Focus | X | 2 |
Basophilic Focus, Two | | 1 |
Eosinophilic Focus, Single | X | 1 |
Hematopoietic Cell Proliferation | | 3 2.0|
Infiltration Cellular, Lymphocytic | 1 1 2 1 | 8 1.3|
Inflammation, Chronic Active, Focal | 1 2 1 1 2 | 11 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
408 PPM | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Leukocytosis | | 1 2.0|
Tension Lipidosis | 1 1 2 1 2 1 | 9 1.2|
Bile Duct, Cyst | 2 | 1 2.0|
Serosa, Fibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Necrosis, Focal | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Cytoplasmic Alteration | 2 1 | 2 1.5|
Infiltration Cellular, Lymphocytic | 1 1 1 1 | 6 1.2|
Acinus, Atrophy | 4 | 2 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Acinus, Parotid Gland, Atrophy | 3 | 1 3.0|
Acinus, Parotid Gland, Necrosis, | | |
Focal | | 2 1.0|
Acinus, Submandibular Gland, Atrophy | 3 | 1 3.0|
Parotid Gland, Infiltration Cellular,| | |
Lymphocytic | 2 1 1 1 2 1 2 | 11 1.4|
Sublingual Gland, Infiltration | | |
Cellular, Lymphocytic | 1 | 1 1.0|
Submandibular Gland, Infiltration | | |
Cellular, Lymphocytic | 1 2 1 2 2 1 1 1 3 1 1 1 1 2 1 | 31 1.5|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Forestomach, Epithelium, Hyperplasia,| | |
Focal | 1 1 | 6 1.5|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
408 PPM | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Foreign Body | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Inflammation, Acute, Focal | | 1 1.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cortex, Accessory Adrenal Cortical | | |
Nodule | | 1 |
Cortex, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Cortex, Subcapsular, Hyperplasia | 2 1 2 2 2 2 2 2 2 1 2 2 2 3 1 2 2 2 2 2 2 2 2 | 47 1.9|
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + | 46 |
Pars Distalis, Hyperplasia, Focal | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Ectopic Thymus | | 1 |
Follicular Cell, Cyst | 1 1 1 1 1 2 | 9 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
408 PPM | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Duct, Cyst | 2 1 2 2 2 2 2 2 1 1 2 2 1 2 1 2 2 2 2 2 2 2 2 | 45 1.8|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
Atrophy | 2 2 2 3 2 2 2 3 2 2 1 2 2 2 1 1 2 2 2 2 2 2 | 41 2.0|
Cyst | X X X X X X | 10 |
Hemorrhage | 1 1 | 2 1.0|
Bilateral, Cyst | X | 3 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Angiectasis | | 1 1.0|
Hyperplasia, Cystic | 2 2 3 4 3 3 3 3 3 2 3 2 2 3 4 2 2 2 3 3 3 | 43 2.5|
Inflammation, Acute | | 1 3.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Epithelium, Hyperplasia | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Myeloid Cell, Hyperplasia | 2 | 6 2.2|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Mandibular, Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Mesenteric, Hemorrhage | 1 | 1 1.0|
Mesenteric, Hyperplasia, Lymphoid | 3 3 2 | 6 2.7|
Mesenteric, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
Thoracic, Hyperplasia, Plasma Cell | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
408 PPM | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Hematopoietic Cell Proliferation | 2 3 3 1 1 2 | 17 2.2|
Hyperplasia, Lymphoid | 1 2 3 3 2 1 | 9 2.1|
Infiltration Cellular, Plasma Cell | | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + | 43 |
Cyst | X | 2 |
Ectopic Parathyroid Gland | X X X X | 7 |
Hyperplasia, Lymphoid | 1 3 1 | 6 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Infiltration Cellular, Lymphocytic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Femur, Fibrous Osteodystrophy | 1 1 1 | 3 1.0|
Sternum, Degeneration, Cystic | 1 1 | 5 1.0|
Sternum, Fibrous Osteodystrophy | 1 1 2 1 1 2 1 2 1 1 1 1 1 | 21 1.2|
|__________________________________________________________________________|____________|
Bone, Femur | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Mineralization | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
408 PPM | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Cerebellum, Infiltration Cellular, | | |
Lymphocytic | | 1 2.0|
Cerebrum, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 | 21 1.0|
|__________________________________________________________________________|____________|
Brain, Brain Stem | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebellum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Brain, Cerebrum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Thoracic, Infiltration Cellular, | | |
Lymphocytic | | 1 1.0|
Thoracic, Axon, Degeneration | 2 1 1 1 1 1 3 1 | 14 1.2|
|__________________________________________________________________________|____________|
Spinal Cord, Thoracic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Crystals | | 1 3.0|
Infarct | 2 | 1 2.0|
Infiltration Cellular, Histiocytic | | 2 1.0|
Infiltration Cellular, Lymphocytic | 1 1 2 1 | 12 1.5|
Inflammation, Chronic, Focal | | 1 1.0|
Inflammation, Granulomatous | | 1 2.0|
Leukocytosis | | 1 4.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Artery, Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 93029-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LEUKOMALACHITE GREEN Date: 06/19/03
Route: DOSED FEED Time: 07:07:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
C57BL/6N XC3H/HEN MTN-NCTR FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
408 PPM | 3| 3| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
| 6| 7| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Phthisis Bulbi | X | 1 |
Bilateral, Lens, Cataract | | 7 2.4|
Conjunctiva, Polyarteritis | 2 | 1 2.0|
Lens, Cataract | 2 2 2 | 4 1.8|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | | 3 1.7|
Infiltration Cellular, Lymphocytic | 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Glomerulosclerosis | | 1 1.0|
Infarct | 1 | 1 1.0|
Infiltration Cellular, Lymphocytic | 1 2 1 2 1 | 11 1.3|
Nephropathy | | 1 1.0|
Glomerulus, Casts Protein | | 1 3.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 | 3 2.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
Inclusion Body Intracytoplasmic | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | 44 2.9|
Infiltration Cellular, Lymphocytic | 1 1 1 2 2 1 2 1 1 2 1 1 1 1 1 | 26 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
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---------- END OF REPORT ----------
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