TDMS Study 93029-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: NCTR LEUKOMALACHITE GREEN DATE: 06/19/03
EXPERIMENT: 93029 TEST: 04 TIME: 07:10:43
TEST TYPE: CHRONIC PAGE: 1
CONT: 224-93-00001 ROUTE: DOSED FEED NTP C#: C93029
PATHOLOGIST: MISSING CAS: 129-73-7
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: NCTR LEUKOMALACHITE GREEN DATE: 06/19/03
EXPERIMENT: 93029 TEST: 04 TIME: 07:10:43
TEST TYPE: CHRONIC
CONT: 224-93-00001 ROUTE: DOSED FEED NTP C#: C93029
PATHOLOGIST: MISSING CAS: 129-73-7
LEUKOMALACHITE GREEN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 122 225 498 518 639 682 682 688 695 700 |
| 732 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 91 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 498 590 675 690 708 709 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 204 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 193 498 526 620 627 675 690 700 714 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
LEUKOMALACHITE GREEN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 408 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 444 553 560 584 647 718 718 723 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
LEUKOMALACHITE GREEN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 97.9 95.8 95.8 95.8 95.8 91.7 91.7 89.6 77.1 |
| | |
| | |
|91 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 97.9 95.8 95.8 85.4 |
| | |
| | |
|204 PPM | 100.0 100.0 97.9 97.9 97.9 97.9 93.7 93.7 89.6 81.3 |
| | |
| | |
|408 PPM | 100.0 100.0 100.0 100.0 100.0 97.9 97.9 91.7 89.6 81.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 91 PPM 204 PPM 408 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 77.1% 85.4% 81.3% 81.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.890N P=0.389N P=0.792N P=0.745N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 561.9 657.0 582.6 630.1 |
|NATURAL DEATHS (C) | (62.5) (31.5) (54.9) (33.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 693.8 721.9 704.8 713.7 |
|(STANDARD ERROR) | (17.3) ( 5.8) (13.0) ( 8.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
LEUKOMALACHITE GREEN
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
91 PPM = 2
204 PPM = 3
408 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.00 +1 1 3 4 2
|
| 1 3 1 4 2 4 2
|
P 95.83 + 1 1 3 44 2 2
E |
R | 1 1 3 4 4 3 2 2
C |
E 91.67 + 1 4 33 14 2 2
N |
T | 3 14 31 4
|
S 87.50 + 3 3 2 2
U |
R | 113 44 2
V |
I 83.33 + 11 3
V |
A | 3 4 3
L |
79.17 + 1 1
|
| 1
|
75.00 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.