TDMS Study 96001-05 Pathology Tables
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
FINAL/RATS
Facility: Battelle Northwest
Chemical CAS #: 64742-88-7
Lock Date: 09/24/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 12 19 15 23
Natural Death 2 1 3 2
Survivors
Terminal Sacrifice 36 30 32 25
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (50) (50)
Periesophageal Tissue, Necrosis, Fatty 1 (2%)
Intestine Small, Jejunum (49) (49) (47) (48)
Ulcer 1 (2%)
Liver (49) (50) (50) (50)
Angiectasis 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Basophilic Focus 2 (4%) 3 (6%) 1 (2%) 1 (2%)
Clear Cell Focus 7 (14%) 7 (14%) 6 (12%) 2 (4%)
Clear Cell Focus, Multiple 2 (4%) 1 (2%) 1 (2%)
Degeneration, Cystic 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 5 (10%) 9 (18%) 5 (10%) 6 (12%)
Necrosis 2 (4%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 2 (4%) 5 (10%) 6 (12%) 1 (2%)
Bile Duct, Cyst 1 (2%)
Hepatocyte, Regeneration 3 (6%)
Serosa, Fibrosis 1 (2%) 1 (2%)
Mesentery (11) (15) (23) (14)
Necrosis 11 (100%) 15 (100%) 23 (100%) 13 (93%)
Pancreas (49) (50) (50) (50)
Acinus, Atrophy 2 (4%) 1 (2%) 1 (2%)
Artery, Thrombosis 1 (2%)
Stomach, Forestomach (49) (50) (50) (50)
Hyperplasia, Squamous 1 (2%)
Ulcer 2 (4%) 2 (4%)
Stomach, Glandular (49) (50) (50) (50)
Necrosis 1 (2%)
Tongue (1) (3) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Epithelium, Hyperkeratosis 1 (100%)
Epithelium, Hyperplasia 3 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50) (50)
Cardiomyopathy 1 (2%) 1 (2%) 2 (4%)
Atrium, Thrombosis 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Myocardium, Degeneration 1 (2%)
Ventricle, Hypertrophy 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hyperplasia 1 (2%)
Necrosis 1 (2%) 1 (2%) 2 (4%)
Vacuolization Cytoplasmic 9 (18%) 4 (8%) 15 (30%) 12 (24%)
Adrenal Medulla (50) (50) (50) (50)
Atrophy 1 (2%)
Degeneration, Cystic 1 (2%)
Hyperplasia 4 (8%) 2 (4%) 7 (14%) 4 (8%)
Parathyroid Gland (49) (49) (49) (50)
Hyperplasia 1 (2%)
Pituitary Gland (49) (50) (50) (50)
Mineralization 1 (2%)
Pars Distalis, Angiectasis 2 (4%) 2 (4%) 2 (4%)
Pars Distalis, Cyst 5 (10%) 3 (6%) 3 (6%) 3 (6%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 9 (18%) 9 (18%) 8 (16%) 8 (16%)
Thyroid Gland (49) (50) (50) (50)
C-Cell, Hyperplasia 11 (22%) 6 (12%) 4 (8%) 5 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Cyst 1 (2%)
Hyperplasia 2 (4%) 3 (6%) 3 (6%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Ovary (50) (50) (50) (50)
Cyst 8 (16%) 9 (18%) 8 (16%) 5 (10%)
Uterus (49) (50) (50) (50)
Atrophy 1 (2%)
Decidual Reaction 1 (2%)
Degeneration 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Necrosis 2 (4%)
Prolapse 1 (2%)
Capillary, Myometrium, Hyperplasia 1 (2%)
Endometrium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Endometrium, Hyperplasia, Cystic 1 (2%) 5 (10%) 2 (4%)
Endometrium, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia, Reticulum Cell 1 (2%)
Lymph Node (5) (5) (5) (4)
Pancreatic, Infiltration Cellular, Histiocyte 1 (20%)
Lymph Node, Bronchial (12) (7) (8) (11)
Infiltration Cellular, Histiocyte 1 (9%)
Pigmentation 2 (25%)
Lymph Node, Mesenteric (50) (50) (50) (49)
Necrosis 1 (2%)
Lymph Node, Mediastinal (45) (39) (42) (45)
Angiectasis 1 (3%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Spleen (49) (50) (50) (50)
Accessory Spleen 1 (2%) 2 (4%)
Fibrosis 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 2 (4%)
Hemorrhage 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Necrosis 2 (4%) 1 (2%) 3 (6%)
Thrombosis 1 (2%)
Thymus (47) (47) (46) (48)
Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 1 (2%) 2 (4%) 2 (4%)
Inflammation, Chronic 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%) 1 (2%) 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Granulomatous 1 (2%)
Ulcer 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Compression 9 (18%) 8 (16%) 3 (6%) 6 (12%)
Gliosis 1 (2%)
Hemorrhage 4 (8%) 3 (6%) 6 (12%) 1 (2%)
Necrosis 1 (2%)
Cerebellum, Developmental Malformation 1 (2%)
Cerebellum, Gliosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (50) (50) (49)
Foreign Body 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic 3 (6%) 1 (2%)
Epiglottis, Metaplasia, Squamous 1 (2%) 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%)
Lung (49) (50) (50) (50)
Hemorrhage 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Necrosis 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 1 (2%) 1 (2%) 3 (6%)
Alveolar Epithelium, Metaplasia, Squamous 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 22 (45%) 14 (28%) 13 (26%) 15 (30%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolus, Proteinosis 1 (2%)
Bronchiole, Hyperplasia, Focal 1 (2%)
Interstitium, Fibrosis 2 (4%) 2 (4%) 2 (4%) 2 (4%)
Vein, Fibrosis 1 (2%)
Nose (49) (50) (49) (50)
Foreign Body 2 (4%) 2 (4%)
Inflammation, Suppurative 1 (2%) 5 (10%) 3 (6%)
Goblet Cell, Hyperplasia 1 (2%) 3 (6%) 3 (6%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 1 (2%) 1 (2%)
Olfactory Epithelium, Degeneration, Hyaline 12 (24%) 18 (36%) 15 (31%) 28 (56%)
Olfactory Epithelium, Hyperplasia 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%)
Pleura (48) (50) (50) (50)
Fibrosis 18 (38%) 6 (12%) 9 (18%) 12 (24%)
Inflammation, Chronic 21 (44%) 20 (40%) 13 (26%) 5 (10%)
Mesothelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (50) (50) (49)
Atrophy 1 (2%)
Anterior Chamber, Inflammation, Suppurative 1 (2%)
Cornea, Hyperplasia 1 (2%)
Lens, Cataract 3 (6%) 2 (4%) 1 (2%) 4 (8%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Cyst 2 (4%) 1 (2%)
Fibrosis 1 (2%)
Infarct 1 (2%) 1 (2%)
Nephropathy, Chronic 42 (86%) 44 (88%) 46 (92%) 44 (88%)
Cortex, Infarct 1 (2%)
Cortex, Inflammation, Suppurative 1 (2%)
Cortex, Renal Tubule, Accumulation, Hyaline
Droplet 1 (2%)
Cortex, Renal Tubule, Hyperplasia 1 (2%)
Cortex, Renal Tubule, Inflammation 1 (2%)
Papilla, Mineralization 3 (6%) 1 (2%) 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 4 (8%) 3 (6%) 7 (14%) 3 (6%)
Pelvis, Transitional Epithelium,
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Mineralization 25 (51%) 23 (46%) 27 (54%) 27 (54%)
Urinary Bladder (49) (50) (50) (50)
Hemorrhage 1 (2%)
Muscularis, Hyperplasia 1 (2%)
Muscularis, Infiltration Cellular, Histiocyte 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 2 (4%)
Transitional Epithelium, Ulcer 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 18 27 21 27
Natural Death 3 4 8 7
Survivors
Terminal Sacrifice 29 19 21 16
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Hemorrhage 1 (2%)
Intestine Large, Cecum (49) (49) (48) (48)
Atrophy 1 (2%)
Necrosis 1 (2%)
Epithelium, Cyst 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 1 (2%)
Clear Cell Focus 6 (12%) 4 (8%) 3 (6%) 3 (6%)
Eosinophilic Focus 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 7 (14%) 3 (6%) 5 (10%) 3 (6%)
Inflammation, Granulomatous 1 (2%) 1 (2%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 3 (6%) 3 (6%) 1 (2%) 2 (4%)
Bile Duct, Hyperplasia 3 (6%) 2 (4%)
Hepatocyte, Regeneration 1 (2%)
Periportal, Pigmentation 1 (2%) 2 (4%)
Mesentery (7) (11) (11) (13)
Necrosis 7 (100%) 11 (100%) 11 (100%) 12 (92%)
Pancreas (50) (50) (50) (50)
Acinus, Atrophy 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Stomach, Forestomach (50) (50) (49) (50)
Hyperplasia, Squamous 1 (2%) 1 (2%)
Ulcer 2 (4%) 3 (6%) 2 (4%) 1 (2%)
Stomach, Glandular (50) (50) (49) (50)
Erosion 1 (2%) 3 (6%)
Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mineralization 1 (2%)
Ulcer 1 (2%) 1 (2%) 2 (4%)
Tongue (1) (1) (3)
Epithelium, Hyperkeratosis 1 (33%)
Epithelium, Hyperplasia 1 (100%) 1 (100%) 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Mineralization 1 (2%)
Pulmonary Artery, Thrombosis 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy 13 (26%) 4 (8%) 5 (10%) 9 (18%)
Artery, Mineralization 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (2%) 5 (10%)
Myocardium, Thrombosis 1 (2%)
Ventricle, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Mineralization 1 (2%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 15 (30%) 5 (10%) 14 (28%) 10 (20%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 12 (24%) 14 (28%) 23 (46%) 15 (30%)
Mineralization 1 (2%)
Necrosis 2 (4%)
Thrombosis 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Cyst 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hemorrhage 1 (2%) 1 (2%) 3 (6%)
Pars Distalis, Hyperplasia 4 (8%) 5 (10%) 6 (12%) 5 (10%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 8 (16%) 4 (8%) 6 (12%) 11 (22%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (14) (41) (41) (32)
Inflammation, Granulomatous 1 (3%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%)
Preputial Gland (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Inflammation, Suppurative 4 (8%)
Prostate (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 3 (6%)
Inflammation, Suppurative 10 (20%) 10 (20%) 14 (28%) 12 (24%)
Seminal Vesicle (50) (50) (50) (50)
Dilatation 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Testes (50) (50) (50) (50)
Artery, Inflammation, Chronic Active 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Germinal Epithelium, Atrophy 11 (22%) 9 (18%) 15 (30%) 11 (22%)
Interstitial Cell, Hyperplasia 5 (10%) 4 (8%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Thrombosis 1 (2%)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (7) (16) (11) (17)
Hyperplasia, Lymphoid 1 (6%)
Deep Cervical, Angiectasis 1 (6%)
Deep Cervical, Ectasia 1 (6%)
Pancreatic, Angiectasis 1 (14%)
Pancreatic, Ectasia 1 (14%) 1 (9%)
Pancreatic, Infiltration Cellular, Histiocyte 1 (6%)
Pancreatic, Pigmentation 1 (6%) 1 (6%)
Thoracic, Ectasia 1 (6%)
Lymph Node, Bronchial (15) (12) (16) (13)
Fibrosis 1 (7%)
Hematopoietic Cell Proliferation 1 (7%)
Hyperplasia, Lymphoid 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Infiltration Cellular, Histiocyte 1 (7%) 1 (8%)
Pigmentation 1 (7%) 1 (8%)
Lymph Node, Mandibular (2)
Hematopoietic Cell Proliferation 1 (50%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Hyperplasia, Lymphoid 1 (2%)
Necrosis 2 (4%)
Lymph Node, Mediastinal (42) (44) (43) (40)
Angiectasis 2 (5%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular 1 (2%)
Infiltration Cellular, Histiocyte 1 (3%)
Pigmentation 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 1 (2%) 3 (6%) 1 (2%)
Fibrosis 2 (4%) 3 (6%) 4 (8%) 6 (12%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Hemorrhage 2 (4%) 2 (4%) 4 (8%) 1 (2%)
Necrosis 3 (6%) 3 (6%)
Thrombosis 1 (2%)
Thymus (49) (49) (47) (50)
Cyst 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 3 (6%) 2 (4%) 3 (6%) 2 (4%)
Hyperplasia 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 5 (10%) 2 (4%) 2 (4%) 3 (6%)
Hyperkeratosis 1 (2%) 1 (2%) 2 (4%)
Hyperplasia 1 (2%)
Inflammation, Chronic 2 (4%)
Inflammation, Granulomatous 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Rib, Cartilage, Degeneration 1 (2%)
Turbinate, Cartilage, Hyperplasia 1 (2%)
Skeletal Muscle (1) (1) (1) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 13 (26%) 15 (30%) 10 (20%) 9 (18%)
Hemorrhage 4 (8%) 4 (8%) 5 (10%) 3 (6%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Foreign Body 1 (2%) 2 (4%) 2 (4%) 3 (6%)
Inflammation, Chronic 2 (4%)
Inflammation, Suppurative 2 (4%) 2 (4%)
Epiglottis, Metaplasia, Squamous 1 (2%)
Lung (50) (50) (50) (49)
Foreign Body 1 (2%)
Hemorrhage 5 (10%) 5 (10%) 6 (12%) 4 (8%)
Inflammation, Suppurative 2 (4%)
Alveolar Epithelium, Hyperplasia 10 (20%) 3 (6%) 6 (12%) 7 (14%)
Alveolar Epithelium, Metaplasia, Squamous 2 (4%)
Alveolus, Foreign Body 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 13 (26%) 11 (22%) 7 (14%) 5 (10%)
Alveolus, Mineralization 1 (2%)
Alveolus, Proteinosis 1 (2%)
Interstitium, Fibrosis 1 (2%) 5 (10%) 2 (4%) 1 (2%)
Nose (50) (50) (50) (50)
Foreign Body 2 (4%) 3 (6%) 1 (2%) 2 (4%)
Inflammation, Suppurative 4 (8%) 4 (8%) 2 (4%) 5 (10%)
Glands, Hyperplasia 1 (2%)
Goblet Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Olfactory Epithelium, Degeneration, Hyaline 2 (4%) 8 (16%) 2 (4%) 3 (6%)
Respiratory Epithelium, Hyperplasia 4 (8%) 1 (2%) 1 (2%) 1 (2%)
Turbinate, Hyperplasia, Atypical 1 (2%)
Turbinate, Necrosis 1 (2%)
Pleura (50) (50) (50) (50)
Fibrosis 2 (4%) 12 (24%) 5 (10%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:03:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Chronic 11 (22%) 2 (4%) 1 (2%) 5 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (49) (50)
Atrophy 1 (2%)
Inflammation, Suppurative 1 (2%)
Lens, Cataract 6 (12%) 1 (2%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 2 (4%)
Hemorrhage 1 (2%)
Nephropathy, Chronic 50 (100%) 49 (98%) 50 (100%) 50 (100%)
Cortex, Infarct 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Cortex, Renal Tubule, Accumulation, Hyaline
Droplet 2 (4%) 5 (10%) 3 (6%) 2 (4%)
Cortex, Renal Tubule, Casts Granular 1 (2%) 1 (2%) 3 (6%)
Cortex, Renal Tubule, Hyperplasia 1 (2%) 8 (16%) 23 (46%)
Cortex, Renal Tubule, Mineralization 1 (2%)
Medulla, Casts Granular 3 (6%) 1 (2%) 3 (6%)
Papilla, Mineralization 1 (2%) 8 (16%) 30 (60%) 39 (78%)
Papilla, Necrosis 1 (2%)
Pelvis, Dilatation 1 (2%) 1 (2%) 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 2 (4%) 8 (16%) 5 (10%)
Renal Tubule, Mineralization 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Muscularis, Transitional Epithelium,
Mineralization 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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