TDMS Study 96001-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest STODDARD SOLVENT (TYPE IIC) DATE: 01/08/03
EXPERIMENT: 96001 TEST: 05 TIME: 12:18:19
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-75410 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C96001
PATHOLOGIST: RENNE, ROGER CAS: 64742-88-7
------------------------------------------------------------------------------------------------------------------------------------
FINAL/RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest STODDARD SOLVENT (TYPE IIC) DATE: 01/08/03
EXPERIMENT: 96001 TEST: 05 TIME: 12:18:19
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75410 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C96001
PATHOLOGIST: RENNE, ROGER CAS: 64742-88-7
STODDARD SOLVENT (TYPE IIC)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 476 576 611 611 621 626 656 670 670 670 |
| 674 674 684 691 696 705 712 712 716 717 |
| 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 138 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 31 CENSORED DEATHS 0 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 403 421 472 537 565 579 582 590 605 621 |
| 621 621 625 636 640 642 642 642 642 642 |
| 652 656 656 658 667 670 670 670 671 682 |
| 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 550 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 396 509 529 541 546 556 558 589 593 618 |
| 621 633 642 647 673 675 675 691 696 698 |
| 702 705 708 712 715 715 717 720 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
STODDARD SOLVENT (TYPE IIC)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1100 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 432 465 522 529 548 563 565 578 581 593 |
| 606 610 636 642 645 647 652 667 673 675 |
| 683 684 684 684 691 691 691 698 705 705 |
| 712 712 717 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
STODDARD SOLVENT (TYPE IIC)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 96.0 86.0 58.0 |
| | |
| | |
|138 | 100.0 100.0 100.0 100.0 96.0 94.0 92.0 82.0 52.0 38.0 |
|MG/M3 | |
| | |
|550 | 100.0 100.0 100.0 100.0 98.0 98.0 92.0 82.0 72.0 42.0 |
|MG/M3 | |
| | |
|1100 | 100.0 100.0 100.0 100.0 100.0 96.0 92.0 80.0 66.0 32.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 138 550 1100 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 58.0% 38.0% 42.0% 32.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.057 P=0.014 P=0.125 P=0.007 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 661.6 616.3 638.1 635.6 |
|NATURAL DEATHS (C) | (12.9) (13.0) (15.2) (12.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 700.7 659.1 676.3 665.5 |
|(STANDARD ERROR) | ( 7.2) (11.2) (10.9) (10.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
STODDARD SOLVENT (TYPE IIC)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 481 495 509 537 540 582 606 634 656 656 |
| 698 712 712 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 550 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 481 481 506 537 575 593 606 646 652 656 |
| 656 670 675 691 703 703 719 726 726 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1100 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 401 433 563 565 581 610 610 682 683 689 |
| 695 698 703 705 710 718 722 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
STODDARD SOLVENT (TYPE IIC)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2200 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 285 451 506 509 522 522 537 549 589 606 |
| 611 621 625 647 656 674 682 682 693 694 |
| 696 712 714 718 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
STODDARD SOLVENT (TYPE IIC)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 90.0 88.0 80.0 72.0 |
| | |
| | |
|550 | 100.0 100.0 100.0 100.0 100.0 96.0 92.0 88.0 78.0 60.0 |
|MG/M3 | |
| | |
|1100 | 100.0 100.0 100.0 100.0 98.0 96.0 96.0 90.0 86.0 64.0 |
|MG/M3 | |
| | |
|2200 | 100.0 100.0 100.0 98.0 98.0 96.0 86.0 82.0 70.0 50.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 550 1100 2200 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.0% 60.0% 64.0% 50.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.037 P=0.331 P=0.576 P=0.040 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 610.0 636.6 638.6 608.9 |
|NATURAL DEATHS (C) | (23.1) (18.4) (23.0) (20.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 696.4 692.6 697.1 669.5 |
|(STANDARD ERROR) | ( 9.9) ( 9.8) (10.3) (13.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
STODDARD SOLVENT (TYPE IIC)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
138 MG/M3 = 2
550 MG/M3 = 3
1100 MG/M3 = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 32 4 1
| 32 24 41 3 1
96 + 2 42 3 43 1 1
| 2 4323
| 42 4 2 11
| 3432 2 11
88 + 22 1 1
| 34 42 2 1 1
P | 2 2
E | 4 3 2 2
R 80 + 4 4 11
C | 443 3
E | 42233 11
N | 2233 11
T 72 + 223 3 11
| 11
S | 44 11
U | 4 43 3
R 64 + 44 33 11
V |
I | 2 2 44 33 11
V | 1 1
A 56 + 33
L |
| 2 2 44 33
|
48 +
| 44
| 44 33
| 2 2 3 3
40 + 2 44 2
| 2 2
| 44
| 44
32 + 4 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.
STODDARD SOLVENT (TYPE IIC)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
550 MG/M3 = 2
1100 MG/M3 = 3
2200 MG/M3 = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 3 1
|
| 4 3 3 4 1 1
| 3 4 2 1 1 3
95 +
| 1 1
| 4 4 11 3 2
|
90 + 1 21 2 3
|
| 4 4 1 2 1
| 4 4 13 1 2 3
P 85 +
E | 4 4 1 21
R | 4 4 33
C |
E 80 + 44 1 31
N |
T | 44 2 2 1 1
| 44 22 33
S 75 +
U | 4 4 2 2 1 1
R | 44 2 23 1 1
V |
I 70 + 4 4 33
V |
A | 44 2 23
L | 22
65 +
| 44 3 3
| 44 2 2
|
60 + 2
|
| 4 4
|
55 +
| 44
| 44
|
50 + 4 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 17 obs hidden.