TDMS Study 96001-05 Pathology Tables
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
FINAL/RATS
Facility: Battelle Northwest
Chemical CAS #: 64742-88-7
Lock Date: 09/24/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 12 19 15 23
Natural Death 2 1 3 2
Survivors
Terminal Sacrifice 36 30 32 25
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (50) (50)
Periesophageal Tissue, Necrosis, Fatty 1 [4.0]
Intestine Small, Jejunum (49) (49) (47) (48)
Ulcer 1 [4.0]
Liver (49) (50) (50) (50)
Angiectasis 1 [2.0] 2 [2.5] 2 [1.5] 2 [2.5]
Basophilic Focus 2 [2.0] 3 [1.5] 1 [1.5] 1 [1.0]
Clear Cell Focus 7 [2.0] 7 [2.4] 6 [2.0] 2 [1.0]
Clear Cell Focus, Multiple 2 [2.5] 1 [1.0] 1 [3.0]
Degeneration, Cystic 1 [2.0]
Hematopoietic Cell Proliferation 1 [4.0]
Hemorrhage 1 [4.0]
Hepatodiaphragmatic Nodule 5 [4.0] 9 [4.0] 5 [4.0] 6 [3.5]
Necrosis 2 [3.0]
Thrombosis 1 [4.0]
Vacuolization Cytoplasmic 2 [3.5] 5 [3.2] 6 [2.8] 1 [1.0]
Bile Duct, Cyst 1
Hepatocyte, Regeneration 3 [4.0]
Serosa, Fibrosis 1 [2.0] 1 [3.0]
Mesentery (11) (15) (23) (14)
Necrosis 11 [2.9] 15 [2.9] 23 [3.2] 13 [2.9]
Pancreas (49) (50) (50) (50)
Acinus, Atrophy 2 [2.0] 1 [3.0] 1 [4.0]
Artery, Thrombosis 1 [4.0]
Stomach, Forestomach (49) (50) (50) (50)
Hyperplasia, Squamous 1 [3.0]
Ulcer 2 [4.0] 2 [3.0]
Stomach, Glandular (49) (50) (50) (50)
Necrosis 1 [1.0]
Tongue (1) (3) (1)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Epithelium, Hyperkeratosis 1 [2.0]
Epithelium, Hyperplasia 3 [3.7] 1 [4.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50) (50)
Cardiomyopathy 1 [2.0] 1 [2.0] 2 [1.5]
Atrium, Thrombosis 2 [3.5] 1 [3.0] 2 [3.5] 1 [3.0]
Myocardium, Degeneration 1 [3.0]
Ventricle, Hypertrophy 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hyperplasia 1 [4.0]
Necrosis 1 [4.0] 1 [1.0] 2 [3.5]
Vacuolization Cytoplasmic 9 [2.1] 4 [1.8] 15 [2.3] 12 [2.3]
Adrenal Medulla (50) (50) (50) (50)
Atrophy 1 [3.0]
Degeneration, Cystic 1 [4.0]
Hyperplasia 4 [3.5] 2 [3.5] 7 [2.3] 4 [1.8]
Parathyroid Gland (49) (49) (49) (50)
Hyperplasia 1 [2.0]
Pituitary Gland (49) (50) (50) (50)
Mineralization 1 [4.0]
Pars Distalis, Angiectasis 2 [3.5] 2 [2.5] 2 [2.5]
Pars Distalis, Cyst 5 3 3 3
Pars Distalis, Hemorrhage 1 [4.0]
Pars Distalis, Hyperplasia 9 [2.9] 9 [2.9] 8 [3.0] 8 [3.1]
Thyroid Gland (49) (50) (50) (50)
C-Cell, Hyperplasia 11 [1.6] 6 [2.3] 4 [2.3] 5 [2.6]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Cyst 1
Hyperplasia 2 [2.0] 3 [3.0] 3 [2.0] 1 [2.0]
Inflammation, Chronic 1 [4.0] 1 [2.0] 1 [4.0]
Metaplasia, Squamous 1 [4.0]
Ovary (50) (50) (50) (50)
Cyst 8 9 8 5
Uterus (49) (50) (50) (50)
Atrophy 1 [4.0]
Decidual Reaction 1 [4.0]
Degeneration 1 [4.0]
Hemorrhage 1 [4.0] 1 [4.0] 1 [4.0] 3 [4.0]
Necrosis 2 [4.0]
Prolapse 1
Capillary, Myometrium, Hyperplasia 1 [4.0]
Endometrium, Hyperplasia 1 [1.0] 1 [3.0] 1 [3.0]
Endometrium, Hyperplasia, Cystic 1 [1.0] 5 [3.0] 2 [2.5]
Endometrium, Inflammation, Suppurative 1 [4.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia, Reticulum Cell 1 [4.0]
Lymph Node (5) (5) (5) (4)
Pancreatic, Infiltration Cellular, Histiocyte 1 [4.0]
Lymph Node, Bronchial (12) (7) (8) (11)
Infiltration Cellular, Histiocyte 1 [4.0]
Pigmentation 2 [2.5]
Lymph Node, Mesenteric (50) (50) (50) (49)
Necrosis 1 [4.0]
Lymph Node, Mediastinal (45) (39) (42) (45)
Angiectasis 1 [4.0]
Hemorrhage 1 [3.0]
Hyperplasia, Lymphoid 1 [2.0]
Spleen (49) (50) (50) (50)
Accessory Spleen 1 2
Fibrosis 1 [2.0] 1 [2.0] 1 [3.0]
Hematopoietic Cell Proliferation 2 [4.0] 1 [4.0] 2 [4.0]
Hemorrhage 1 [4.0] 1 [4.0] 2 [4.0] 1 [4.0]
Necrosis 2 [4.0] 1 [4.0] 3 [3.7]
Thrombosis 1 [4.0]
Thymus (47) (47) (46) (48)
Cyst 1
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 1 [1.0] 2 [2.0] 2 [2.5]
Inflammation, Chronic 1 [3.0]
Epithelium, Hyperplasia 1 [3.0]
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 [4.0] 1 [4.0] 1 [4.0]
Hyperkeratosis 1 [4.0] 1 [4.0]
Inflammation, Chronic 1 [1.0]
Inflammation, Granulomatous 1 [4.0]
Ulcer 1 [4.0] 1 [4.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Compression 9 [2.8] 8 [2.8] 3 [3.0] 6 [2.8]
Gliosis 1 [4.0]
Hemorrhage 4 [2.8] 3 [3.0] 6 [3.0] 1 [3.0]
Necrosis 1 [4.0]
Cerebellum, Developmental Malformation 1 [2.0]
Cerebellum, Gliosis 1 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (50) (50) (49)
Foreign Body 2 [4.0] 1 [4.0] 2 [3.0] 1 [4.0]
Inflammation, Chronic 3 [2.0] 1 [2.0]
Epiglottis, Metaplasia, Squamous 1 [4.0] 1 [2.0]
Respiratory Epithelium, Hyperplasia 1 [1.0]
Lung (49) (50) (50) (50)
Hemorrhage 1 [1.0] 2 [1.5] 1 [1.0] 1 [2.0]
Necrosis 1 [4.0]
Alveolar Epithelium, Hyperplasia 3 [1.0] 1 [1.0] 1 [2.0] 3 [1.0]
Alveolar Epithelium, Metaplasia, Squamous 1 [1.0]
Alveolus, Infiltration Cellular, Histiocyte 22 [1.3] 14 [1.4] 13 [1.3] 15 [1.3]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolus, Proteinosis 1 [1.0]
Bronchiole, Hyperplasia, Focal 1 [2.0]
Interstitium, Fibrosis 2 [2.0] 2 [1.5] 2 [1.5] 2 [1.5]
Vein, Fibrosis 1 [4.0]
Nose (49) (50) (49) (50)
Foreign Body 2 [1.0] 2 [3.0]
Inflammation, Suppurative 1 [3.0] 5 [1.8] 3 [2.0]
Goblet Cell, Hyperplasia 1 [2.0] 3 [2.3] 3 [2.3] 1 [2.0]
Nasolacrimal Duct, Inflammation, Suppurative 2 [2.5] 1 [3.0] 1 [3.0]
Olfactory Epithelium, Degeneration, Hyaline 12 [1.5] 18 [1.2] 15 [1.3] 28 [1.5]
Olfactory Epithelium, Hyperplasia 1 [2.0]
Respiratory Epithelium, Metaplasia, Squamous 2 [2.0]
Pleura (48) (50) (50) (50)
Fibrosis 18 [1.5] 6 [1.3] 9 [1.6] 12 [1.3]
Inflammation, Chronic 21 [1.5] 20 [1.4] 13 [1.6] 5 [1.6]
Mesothelium, Hyperplasia 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (50) (50) (49)
Atrophy 1 [4.0]
Anterior Chamber, Inflammation, Suppurative 1 [1.0]
Cornea, Hyperplasia 1 [2.0]
Lens, Cataract 3 [3.3] 2 [4.0] 1 [3.0] 4 [3.8]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Cyst 2 1
Fibrosis 1 [4.0]
Infarct 1 [2.0] 1 [3.0]
Nephropathy, Chronic 42 [1.7] 44 [1.8] 46 [2.0] 44 [1.8]
Cortex, Infarct 1 [3.0]
Cortex, Inflammation, Suppurative 1 [1.0]
Cortex, Renal Tubule, Accumulation, Hyaline
Droplet 1 [3.0]
Cortex, Renal Tubule, Hyperplasia 1 [1.0]
Cortex, Renal Tubule, Inflammation 1 [2.0]
Papilla, Mineralization 3 [1.3] 1 [2.0] 1 [1.0]
Pelvis, Transitional Epithelium, Hyperplasia 4 [1.3] 3 [1.7] 7 [1.4] 3 [1.7]
Pelvis, Transitional Epithelium,
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Mineralization 25 [1.2] 23 [1.3] 27 [1.1] 27 [1.2]
Urinary Bladder (49) (50) (50) (50)
Hemorrhage 1 [3.0]
Muscularis, Hyperplasia 1 [2.0]
Muscularis, Infiltration Cellular, Histiocyte 1 [1.0]
Transitional Epithelium, Hyperplasia 1 [3.0] 2 [1.0]
Transitional Epithelium, Ulcer 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 18 27 21 27
Natural Death 3 4 8 7
Survivors
Terminal Sacrifice 29 19 21 16
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Hemorrhage 1 [3.0]
Intestine Large, Cecum (49) (49) (48) (48)
Atrophy 1 [3.0]
Necrosis 1 [4.0]
Epithelium, Cyst 1
Liver (50) (50) (50) (50)
Angiectasis 1 [2.0]
Basophilic Focus 1 [2.0]
Clear Cell Focus 6 [1.5] 4 [1.5] 3 [3.0] 3 [2.5]
Eosinophilic Focus 1 [3.0]
Hemorrhage 1 [3.0]
Hepatodiaphragmatic Nodule 7 [4.0] 3 [4.0] 5 [4.0] 3 [3.7]
Inflammation, Granulomatous 1 [2.0] 1 [2.0] 1 [2.0]
Necrosis 1 [3.0] 1 [4.0]
Thrombosis 1 [3.0]
Vacuolization Cytoplasmic 3 [3.3] 3 [2.3] 1 [4.0] 2 [3.0]
Bile Duct, Hyperplasia 3 [3.0] 2 [3.0]
Hepatocyte, Regeneration 1 [4.0]
Periportal, Pigmentation 1 [4.0] 2 [4.0]
Mesentery (7) (11) (11) (13)
Necrosis 7 [2.6] 11 [2.8] 11 [3.0] 12 [2.6]
Pancreas (50) (50) (50) (50)
Acinus, Atrophy 2 [3.0] 2 [3.0] 1 [3.0] 2 [3.5]
Stomach, Forestomach (50) (50) (49) (50)
Hyperplasia, Squamous 1 [3.0] 1 [3.0]
Ulcer 2 [4.0] 3 [4.0] 2 [4.0] 1 [4.0]
Stomach, Glandular (50) (50) (49) (50)
Erosion 1 [4.0] 3 [2.7]
Hyperplasia 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mineralization 1 [4.0]
Ulcer 1 [3.0] 1 [3.0] 2 [3.5]
Tongue (1) (1) (3)
Epithelium, Hyperkeratosis 1 [3.0]
Epithelium, Hyperplasia 1 [4.0] 1 [3.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Mineralization 1 [4.0]
Pulmonary Artery, Thrombosis 1 [4.0]
Heart (50) (50) (50) (50)
Cardiomyopathy 13 [1.5] 4 [2.3] 5 [2.0] 9 [2.2]
Artery, Mineralization 1 [4.0]
Atrium, Thrombosis 1 [2.0] 1 [4.0] 5 [3.0]
Myocardium, Thrombosis 1 [4.0]
Ventricle, Thrombosis 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Mineralization 1 [3.0]
Necrosis 1 [1.0] 1 [2.0] 1 [3.0]
Vacuolization Cytoplasmic 15 [1.6] 5 [2.6] 14 [2.1] 10 [2.2]
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 12 [2.5] 14 [2.6] 23 [2.6] 15 [2.2]
Mineralization 1 [4.0]
Necrosis 2 [4.0]
Thrombosis 1 [4.0]
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 [3.0] 1 [4.0] 1 [3.0]
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Cyst 1 1 1
Pars Distalis, Hemorrhage 1 [2.0] 1 [4.0] 3 [4.0]
Pars Distalis, Hyperplasia 4 [3.0] 5 [3.0] 6 [2.7] 5 [2.8]
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 8 [2.1] 4 [2.8] 6 [2.0] 11 [1.8]
Follicular Cell, Hyperplasia 1 [3.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (14) (41) (41) (32)
Inflammation, Granulomatous 1 [3.0]
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 [4.0]
Preputial Gland (50) (50) (50) (50)
Cyst 1 1 1 1
Hyperplasia 1 [3.0] 1 [4.0] 2 [2.5]
Inflammation, Suppurative 4 [3.0]
Prostate (50) (50) (50) (50)
Hyperplasia 1 [2.0] 1 [3.0] 3 [3.0]
Inflammation, Suppurative 10 [2.4] 10 [2.0] 14 [1.9] 12 [2.6]
Seminal Vesicle (50) (50) (50) (50)
Dilatation 1 [4.0] 1 [4.0]
Hyperplasia 1 [4.0]
Testes (50) (50) (50) (50)
Artery, Inflammation, Chronic Active 2 [2.5] 2 [2.5] 1 [3.0] 2 [2.5]
Germinal Epithelium, Atrophy 11 [3.9] 9 [3.6] 15 [3.5] 11 [3.8]
Interstitial Cell, Hyperplasia 5 [3.0] 4 [2.3] 2 [3.5] 2 [3.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Thrombosis 1 [2.0]
Myeloid Cell, Hyperplasia 1 [4.0]
Lymph Node (7) (16) (11) (17)
Hyperplasia, Lymphoid 1 [3.0]
Deep Cervical, Angiectasis 1 [3.0]
Deep Cervical, Ectasia 1 [4.0]
Pancreatic, Angiectasis 1 [4.0]
Pancreatic, Ectasia 1 [4.0] 1 [4.0]
Pancreatic, Infiltration Cellular, Histiocyte 1 [4.0]
Pancreatic, Pigmentation 1 [4.0] 1 [4.0]
Thoracic, Ectasia 1 [4.0]
Lymph Node, Bronchial (15) (12) (16) (13)
Fibrosis 1 [2.0]
Hematopoietic Cell Proliferation 1 [3.0]
Hyperplasia, Lymphoid 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Infiltration Cellular, Histiocyte 1 [2.0] 1 [3.0]
Pigmentation 1 [2.0] 1 [3.0]
Lymph Node, Mandibular (2)
Hematopoietic Cell Proliferation 1 [4.0]
Lymph Node, Mesenteric (50) (50) (50) (50)
Hyperplasia, Lymphoid 1 [4.0]
Necrosis 2 [3.5]
Lymph Node, Mediastinal (42) (44) (43) (40)
Angiectasis 2 [3.0]
Hyperplasia, Lymphoid 1 [3.0] 1 [3.0] 1 [3.0]
Infiltration Cellular 1 [3.0]
Infiltration Cellular, Histiocyte 1 [4.0]
Pigmentation 1 [2.0]
Spleen (50) (50) (50) (50)
Accessory Spleen 1 3 1
Fibrosis 2 [3.5] 3 [3.7] 4 [3.3] 6 [2.8]
Hematopoietic Cell Proliferation 1 [4.0] 2 [3.5]
Hemorrhage 2 [3.0] 2 [4.0] 4 [3.5] 1 [4.0]
Necrosis 3 [3.7] 3 [4.0]
Thrombosis 1 [4.0]
Thymus (49) (49) (47) (50)
Cyst 1
Thrombosis 1 [3.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 3 [4.0] 2 [3.5] 3 [4.0] 2 [2.5]
Hyperplasia 1 [4.0]
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 5 [4.0] 2 [4.0] 2 [2.5] 3 [4.0]
Hyperkeratosis 1 [4.0] 1 [3.0] 2 [3.5]
Hyperplasia 1 [3.0]
Inflammation, Chronic 2 [3.0]
Inflammation, Granulomatous 1 [4.0]
Ulcer 1 [4.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 1 [3.0] 1 [3.0] 1 [3.0] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Rib, Cartilage, Degeneration 1 [3.0]
Turbinate, Cartilage, Hyperplasia 1 [4.0]
Skeletal Muscle (1) (1) (1) (1)
Hemorrhage 1 [3.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 13 [3.1] 15 [3.3] 10 [3.3] 9 [3.3]
Hemorrhage 4 [3.3] 4 [3.3] 5 [3.6] 3 [3.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Foreign Body 1 [4.0] 2 [4.0] 2 [4.0] 3 [3.7]
Inflammation, Chronic 2 [3.0]
Inflammation, Suppurative 2 [3.0] 2 [2.5]
Epiglottis, Metaplasia, Squamous 1 [2.0]
Lung (50) (50) (50) (49)
Foreign Body 1 [1.0]
Hemorrhage 5 [2.0] 5 [2.0] 6 [3.2] 4 [2.3]
Inflammation, Suppurative 2 [3.0]
Alveolar Epithelium, Hyperplasia 10 [1.5] 3 [2.3] 6 [2.8] 7 [2.6]
Alveolar Epithelium, Metaplasia, Squamous 2 [2.0]
Alveolus, Foreign Body 1 [2.0]
Alveolus, Infiltration Cellular, Histiocyte 13 [1.4] 11 [1.8] 7 [1.7] 5 [1.4]
Alveolus, Mineralization 1 [4.0]
Alveolus, Proteinosis 1 [2.0]
Interstitium, Fibrosis 1 [4.0] 5 [1.4] 2 [2.0] 1 [2.0]
Nose (50) (50) (50) (50)
Foreign Body 2 [3.0] 3 [3.0] 1 [3.0] 2 [2.5]
Inflammation, Suppurative 4 [2.8] 4 [2.5] 2 [1.5] 5 [2.0]
Glands, Hyperplasia 1 [3.0]
Goblet Cell, Hyperplasia 1 [3.0] 1 [1.0] 1 [3.0] 4 [2.0]
Nasolacrimal Duct, Inflammation, Suppurative 1 [2.0]
Olfactory Epithelium, Degeneration, Hyaline 2 [2.0] 8 [1.3] 2 [1.5] 3 [1.7]
Respiratory Epithelium, Hyperplasia 4 [2.3] 1 [3.0] 1 [1.0] 1 [2.0]
Turbinate, Hyperplasia, Atypical 1 [4.0]
Turbinate, Necrosis 1 [3.0]
Pleura (50) (50) (50) (50)
Fibrosis 2 [1.0] 12 [1.6] 5 [1.6] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 12
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 12:20:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Chronic 11 [1.4] 2 [2.5] 1 [1.0] 5 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (49) (50)
Atrophy 1 [4.0]
Inflammation, Suppurative 1 [3.0]
Lens, Cataract 6 [3.2] 1 [2.0] 3 [3.7] 2 [4.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 2
Hemorrhage 1 [4.0]
Nephropathy, Chronic 50 [2.0] 49 [2.3] 50 [2.5] 50 [2.8]
Cortex, Infarct 2 [3.5] 1 [4.0] 1 [3.0] 2 [4.0]
Cortex, Renal Tubule, Accumulation, Hyaline
Droplet 2 [2.5] 5 [3.0] 3 [3.0] 2 [3.0]
Cortex, Renal Tubule, Casts Granular 1 [3.0] 1 [1.0] 3 [1.0]
Cortex, Renal Tubule, Hyperplasia 1 [3.0] 8 [2.3] 23 [2.4]
Cortex, Renal Tubule, Mineralization 1 [2.0]
Medulla, Casts Granular 3 [2.0] 1 [1.0] 3 [1.7]
Papilla, Mineralization 1 [1.0] 8 [1.1] 30 [1.9] 39 [2.2]
Papilla, Necrosis 1 [4.0]
Pelvis, Dilatation 1 [4.0] 1 [4.0] 1 [2.0]
Pelvis, Transitional Epithelium, Hyperplasia 2 [2.0] 8 [2.1] 5 [3.0]
Renal Tubule, Mineralization 1 [4.0]
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 1 [4.0] 1 [4.0] 1 [4.0]
Inflammation, Chronic 1 [4.0]
Muscularis, Transitional Epithelium,
Mineralization 1 [4.0]
Transitional Epithelium, Hyperplasia 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 13
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