TDMS Study 96001-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest STODDARD SOLVENT (TYPE IIC) DATE: 09/25/02
EXPERIMENT: 96001 TEST: 06 TIME: 11:12:26
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-75410 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C96001
PATHOLOGIST: GRUMBEIN, SONDR CAS: 64742-88-7
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest STODDARD SOLVENT (TYPE IIC) DATE: 09/25/02
EXPERIMENT: 96001 TEST: 06 TIME: 11:12:26
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75410 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C96001
PATHOLOGIST: GRUMBEIN, SONDR CAS: 64742-88-7
STODDARD SOLVENT (TYPE IIC)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 458 499 525 534 540 600 603 617 628 632 |
| 644 651 681 687 694 710 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 550 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 398 403 517 534 566 576 582 618 646 659 |
| 673 673 675 676 683 695 695 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1100 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 1 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 400 470 478 484 509 527 527 617 628 644 |
| 650 653 667 681 698 702 702 703 707 709 |
| 709 723 |
| CENSORED DEATHS |
| 75 |
| |
==================================================================================
STODDARD SOLVENT (TYPE IIC)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2200 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 365 506 521 550 557 563 575 593 593 593 |
| 626 645 653 655 669 681 710 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
STODDARD SOLVENT (TYPE IIC)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 90.0 86.0 76.0 68.0 |
| | |
| | |
|550 | 100.0 100.0 100.0 100.0 96.0 96.0 92.0 86.0 80.0 64.0 |
|MG/M3 | |
| | |
|1100 | 100.0 100.0 100.0 100.0 98.0 91.8 85.7 85.7 75.5 55.1 |
|MG/M3 | |
| | |
|2200 | 100.0 100.0 100.0 98.0 98.0 98.0 94.0 80.0 72.0 64.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 550 1100 2200 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 64.0% 55.1% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.690 P=0.860 P=0.320 P=0.791 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 606.4 610.7 617.6 599.1 |
|NATURAL DEATHS (C) | (18.8) (22.8) (21.2) (20.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 689.8 686.4 666.9 682.2 |
|(STANDARD ERROR) | (10.1) (11.4) (17.1) (11.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
STODDARD SOLVENT (TYPE IIC)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 424 492 530 590 594 618 649 668 681 683 |
| 694 702 708 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 550 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 366 455 470 557 578 586 597 620 637 653 |
| 653 666 675 677 688 695 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1100 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 15 506 535 557 563 590 600 634 639 652 |
| 655 659 664 673 675 695 703 703 704 705 |
| 708 714 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
STODDARD SOLVENT (TYPE IIC)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2200 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 282 408 465 503 554 634 639 672 694 695 |
| 705 707 708 709 724 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
STODDARD SOLVENT (TYPE IIC)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.0 98.0 94.0 90.0 86.0 72.0 |
| | |
| | |
|550 | 100.0 100.0 100.0 100.0 98.0 94.0 94.0 86.0 78.0 68.0 |
|MG/M3 | |
| | |
|1100 | 98.0 98.0 98.0 98.0 98.0 98.0 94.0 86.0 74.0 54.0 |
|MG/M3 | |
| | |
|2200 | 100.0 100.0 100.0 98.0 96.0 94.0 92.0 90.0 86.0 68.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 550 1100 2200 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.0% 68.0% 54.0% 68.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.757 P=0.715 P=0.104 P=0.845 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 625.7 598.3 620.5 614.0 |
|NATURAL DEATHS (C) | (24.2) (23.7) (30.4) (33.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 700.8 687.9 679.6 692.9 |
|(STANDARD ERROR) | ( 9.4) (11.5) (15.9) (13.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
STODDARD SOLVENT (TYPE IIC)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
550 MG/M3 = 2
1100 MG/M3 = 3
2200 MG/M3 = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 23 1
|
| 4 22 1 3 14
| 2 33 142 1
95 +
| 33 2 1 1 4
| 11442
| 3 3
90 + 3 3 1 42 2 1
|
P | 4 22 11
E | 3 42 4 1 1
R 85 +
C | 11 2
E | 11 2 2
N | 3 3
T 80 + 4 4113 2 2
|
S | 4 113
U | 14 1
R 75 + 3 3
V | 3 11
I | 4 42211
V | 3 3
A 70 + 4 2 131
L |
| 4 1 1
| 2 4 2
65 +
| 2 2
|
| 33
60 +
|
| 3 3
|
55 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 27 obs hidden.
STODDARD SOLVENT (TYPE IIC)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
550 MG/M3 = 2
1100 MG/M3 = 3
2200 MG/M3 = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 3 4 2 1
|
| 3 4 2 4 1 2 1 3
| 4 2 42 1 3 13
95 +
| 42 4 13 2 1
| 4 23 2
|
90 + 43 22 1 1 4
|
| 2 32 1 441
| 2 2 341 1
P 85 +
E | 2 23 1 1 4
R | 23 2
C |
E 80 + 1 14
N |
T | 2 32 11
| 22 11
S 75 +
U | 3 3 1 1
R | 2 2 4 1 1
V |
I 70 + 3 22
V |
A | 23 4 2
L |
65 +
|
|
|
60 + 33
|
|
| 3 3
55 +
| 3 3
|
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 21 obs hidden.