TDMS Study 96001-06 Pathology Tables
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 11:16:23
FINAL #1 MICE
Facility: Battelle Northwest
Chemical CAS #: 64742-88-7
Lock Date: 09/25/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 11:16:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 6 11 11 10
Natural Death 8 5 12 6
Survivors
Terminal Sacrifice 36 34 27 34
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (43) (45) (44) (47)
Infiltration Cellular, Plasma Cell 1 [3.0]
Intestine Small, Jejunum (43) (47) (43) (47)
Necrosis 1 [3.0]
Intestine Small, Ileum (43) (47) (44) (46)
Inflammation 1 [3.0]
Liver (50) (50) (50) (50)
Angiectasis 1 [2.0] 1 [2.0]
Basophilic Focus 4 [2.3] 5 [2.6] 8 [2.1] 4 [3.0]
Clear Cell Focus 4 [1.5] 2 [2.0] 2 [2.5]
Eosinophilic Focus 4 [2.3] 9 [2.5] 6 [2.5] 11 [2.2]
Fatty Change 2 [2.5] 2 [2.5]
Hematopoietic Cell Proliferation 1 [4.0]
Infarct 1 [4.0]
Inflammation, Granulomatous 1 [2.0]
Inflammation, Suppurative 1 [2.0]
Mixed Cell Focus 1 [2.0] 1 [3.0]
Necrosis 3 [2.0] 3 [2.3] 1 [2.0]
Parasite Metazoan 1 [2.0]
Tension Lipidosis 2 [1.5] 1 [2.0] 2 [2.0]
Centrilobular, Necrosis 1 [1.0] 2 [2.0]
Mesentery (4) (15) (21) (11)
Artery, Mineralization 1 [3.0]
Fat, Hemorrhage 1 [1.0] 1 [2.0] 1 [2.0]
Fat, Necrosis 3 [2.3] 10 [2.3] 15 [2.0] 9 [2.0]
Pancreas (49) (50) (48) (49)
Atrophy 2 [1.0]
Atypia Cellular 1 [1.0]
Inflammation, Suppurative 1 [3.0]
Lipomatosis 1 [4.0] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 11:16:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Hypertrophy 1 [1.0]
Duct, Cyst 2 [3.5] 1 [4.0]
Salivary Glands (50) (49) (49) (50)
Atrophy 1 [2.0] 1 [2.0]
Stomach, Forestomach (49) (50) (49) (50)
Hyperplasia, Squamous 2 [2.5] 2 [1.0] 1 [1.0] 1 [3.0]
Inflammation, Chronic Active 2 [1.5] 1 [1.0]
Ulcer 1 [3.0] 1 [1.0]
Stomach, Glandular (47) (49) (47) (47)
Amyloid Deposition 1 [2.0]
Mineralization 1 [1.0] 1 [1.0] 1 [2.0]
Necrosis 1 [1.0] 1 [1.0] 3 [1.7]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (2)
Aorta, Mineralization 1 [3.0] 2 [2.0]
Heart (50) (50) (50) (50)
Cardiomyopathy 6 [1.2] 6 [1.0] 6 [1.0] 9 [1.2]
Mineralization 3 [1.3] 4 [1.3] 4 [1.5]
Thrombosis 2 [2.0]
Artery, Inflammation 1 [1.0] 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Hematopoietic Cell Proliferation 1 [4.0]
Hyperplasia 4 [1.5] 3 [1.7] 3 [2.0] 6 [2.0]
Hypertrophy 2 [1.5] 3 [1.7] 2 [1.0] 3 [2.0]
Necrosis 1 [2.0]
Vacuolization Cytoplasmic 1 [4.0]
Adrenal Medulla (49) (50) (48) (49)
Hyperplasia 2 [2.0] 3 [2.3] 4 [2.5] 2 [1.5]
Islets, Pancreatic (49) (50) (48) (48)
Hyperplasia 1 [2.0] 1 [3.0]
Pituitary Gland (47) (49) (49) (48)
Angiectasis 1 [2.0]
Pars Distalis, Hyperplasia 10 [1.7] 12 [1.5] 16 [1.7] 16 [2.5]
Pars Intermedia, Hypertrophy 1 [1.0]
Thyroid Gland (50) (49) (47) (48)
Inflammation, Chronic 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 11:16:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicular Cell, Hyperplasia 2 [2.0] 1 [1.0] 3 [1.3]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Inflammation, Acute 1 [3.0]
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (40) (42) (47) (41)
Fibrosis 1 [3.0]
Ovary (49) (50) (48) (49)
Angiectasis 2 [4.0]
Cyst 12 [2.6] 12 [2.3] 9 [2.2] 6 [2.3]
Uterus (49) (50) (49) (49)
Angiectasis 1 [3.0]
Inflammation, Suppurative 1 [2.0]
Endometrium, Hyperplasia, Cystic 5 [4.0] 3 [2.3] 9 [3.0] 8 [3.3]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (48) (50)
Atrophy 1 [2.0] 1 [2.0]
Cytoplasmic Alteration, Focal 1 [2.0]
Hyperplasia 1 [3.0]
Lymph Node (5) (7) (9) (10)
Angiectasis 1 [3.0]
Iliac, Angiectasis 2 [2.5]
Renal, Angiectasis 1 [4.0] 2 [3.0] 1 [4.0] 1 [2.0]
Renal, Ectasia 1 [2.0]
Lymph Node, Mandibular (42) (32) (40) (40)
Infiltration Cellular, Plasma Cell 1 [3.0]
Lymph Node, Mesenteric (47) (49) (47) (50)
Angiectasis 1 [3.0] 1 [3.0]
Lymph Node, Mediastinal (40) (42) (43) (43)
Infiltration Cellular, Polymorphonuclear 1 [3.0]
Spleen (49) (50) (48) (47)
Angiectasis 1 [2.0] 1 [4.0]
Congestion 1 [3.0]
Hematopoietic Cell Proliferation 2 [3.0] 8 [2.6] 5 [2.8] 3 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 11:16:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 [4.0] 1 [2.0] 1 [2.0]
Necrosis 1 [4.0]
Thymus (43) (45) (47) (46)
Atrophy 2 [3.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Infiltration Cellular, Mixed Cell 1 [1.0] 1 [2.0]
Inflammation, Chronic Active 1 [4.0] 1 [1.0] 1 [3.0]
Subcutaneous Tissue, Cyst Epithelial
Inclusion 1 [2.0]
Subcutaneous Tissue, Edema 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fracture 1 1
Skeletal Muscle (1) (1) (1) (2)
Hemorrhage 1 [3.0]
Inflammation, Suppurative 1 [3.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 1 [4.0]
Necrosis 1 [2.0] 1 [2.0]
Artery, Inflammation 1 [1.0]
Meninges, Infiltration Cellular, Mononuclear
Cell 6 [1.2] 2 [1.5] 2 [1.5] 3 [1.3]
Peripheral Nerve (1) (1)
Inflammation, Suppurative 1 [4.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Artery, Inflammation 1 [2.0]
Lung (50) (50) (50) (50)
Hemorrhage 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 11:16:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 1 [1.0] 3 [2.3] 1 [1.0] 3 [1.3]
Alveolus, Infiltration Cellular, Histiocyte 1 [1.0] 1 [1.0]
Nose (49) (50) (50) (49)
Inflammation, Suppurative 1 [2.0] 1 [2.0] 1 [2.0]
Respiratory Epithelium, Degeneration 1 [2.0]
Trachea (49) (50) (49) (47)
Artery, Inflammation 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (46) (49) (45) (46)
Cataract 1 [3.0] 2 [2.0] 2 [2.0]
Inflammation, Chronic 1 [3.0]
Cornea, Inflammation, Chronic Active 1 [3.0] 1 [1.0] 2 [2.0]
Harderian Gland (49) (49) (49) (49)
Hyperplasia 4 [2.0] 3 [2.0] 4 [2.3] 7 [1.7]
Infiltration Cellular 1 [2.0]
Inflammation, Granulomatous 1 [1.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (49)
Amyloid Deposition 1 [3.0]
Cyst 1 [2.0]
Infarct 1 [3.0]
Inflammation, Suppurative 1 [4.0]
Metaplasia, Osseous 2 [1.0] 1 [1.0] 2 [2.5]
Mineralization 1 [2.0] 1 [2.0] 2 [1.0]
Nephropathy 39 [1.1] 32 [1.3] 33 [1.0] 40 [1.1]
Capsule, Fibrosis 1 [2.0]
Papilla, Necrosis 1 [3.0]
Pelvis, Dilatation 1 [2.0]
Renal Tubule, Karyomegaly 1 [1.0]
Renal Tubule, Necrosis 1 [2.0]
Urinary Bladder (48) (50) (49) (48)
Inflammation, Suppurative 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 11:16:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 7 9 16 13
Natural Death 9 9 6 5
Accidently Killed 1
Survivors
Terminal Sacrifice 34 32 27 32
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (39) (36) (41) (43)
Degeneration, Hyaline 1 [2.0]
Hyperplasia 1 [2.0]
Infiltration Cellular, Mixed Cell 1 [2.0]
Inflammation, Chronic Active 1 [3.0]
Intestine Large, Cecum (45) (41) (46) (47)
Hemorrhage 1 [4.0] 1 [2.0]
Intestine Small, Duodenum (46) (41) (46) (47)
Inflammation, Chronic Active 1 [4.0]
Intestine Small, Jejunum (46) (41) (46) (47)
Serosa, Inflammation, Granulomatous 1 [3.0]
Intestine Small, Ileum (45) (41) (46) (47)
Infiltration Cellular, Plasma Cell 1 [2.0]
Inflammation 1 [3.0]
Liver (50) (50) (50) (50)
Amyloid Deposition 1 [3.0]
Basophilic Focus 9 [2.3] 13 [2.3] 17 [2.4] 11 [2.5]
Clear Cell Focus 13 [1.9] 11 [2.0] 15 [2.1] 10 [2.3]
Eosinophilic Focus 5 [1.8] 7 [2.1] 14 [2.2] 9 [1.9]
Fatty Change 1 [2.0] 1 [2.0]
Infarct 1 [2.0] 1 [4.0]
Inflammation, Chronic 1 [2.0]
Mitotic Alteration 1 [3.0]
Mixed Cell Focus 2 [0.0] 1 [2.0] 1 [2.0]
Necrosis 4 [1.5] 4 [2.3] 2 [2.0] 4 [2.0]
Tension Lipidosis 2 [1.0] 3 [1.3] 1 [2.0] 2 [1.5]
Bile Duct, Cyst 1 [2.0]
Centrilobular, Necrosis 1 [2.0] 1 [3.0]
Mesentery (6) (6) (7) (5)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 11:16:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Inflammation 1 [3.0] 1 [3.0]
Fat, Hemorrhage 1 [3.0]
Fat, Necrosis 4 [1.8] 5 [2.0] 5 [2.2] 5 [2.2]
Pancreas (49) (49) (49) (50)
Atrophy 1 [1.0] 1 [1.0]
Salivary Glands (50) (50) (49) (50)
Atrophy 1 [2.0]
Stomach, Forestomach (49) (48) (49) (49)
Hyperplasia, Squamous 5 [2.2] 3 [2.3] 4 [1.8]
Inflammation, Chronic Active 5 [1.6] 1 [3.0] 2 [2.5]
Ulcer 2 [2.0] 1 [2.0] 2 [2.5]
Stomach, Glandular (48) (44) (49) (48)
Degeneration, Hyaline 1 [2.0]
Hyperplasia 1 [2.0]
Mineralization 2 [1.0] 1 [1.0]
Necrosis 2 [1.5] 1 [3.0] 1 [1.0]
Vacuolization Cytoplasmic 1 [2.0]
Tongue (1)
Mineralization 1 [1.0]
Tooth (19) (16) (21) (17)
Malformation 1 [4.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Aorta, Mineralization 1 [3.0]
Heart (50) (50) (50) (50)
Amyloid Deposition 1 [1.0]
Angiectasis 1 [2.0]
Cardiomyopathy 15 [1.3] 12 [1.1] 21 [1.2] 19 [1.1]
Infiltration Cellular, Polymorphonuclear 1 [2.0]
Mineralization 1 [2.0] 2 [1.0] 2 [1.0] 1 [1.0]
Thrombosis 1 [4.0] 1 [3.0] 1 [3.0]
Artery, Inflammation 1 [3.0]
Capillary, Endothelium, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (49) (50)
Atrophy 1 [2.0]
Hyperplasia 13 [2.0] 10 [1.8] 7 [2.0] 15 [1.6]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 11:16:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hypertrophy 30 [1.7] 29 [1.7] 20 [1.8] 20 [1.9]
Adrenal Medulla (48) (49) (49) (50)
Hyperplasia 3 [1.7] 4 [2.3] 3 [1.7] 1 [1.0]
Islets, Pancreatic (48) (49) (49) (50)
Hyperplasia 1 [2.0] 1 [2.0]
Pituitary Gland (49) (49) (48) (46)
Pars Distalis, Hyperplasia 2 [1.5] 2 [2.0] 2 [1.5]
Pars Intermedia, Hyperplasia 1 [2.0]
Thyroid Gland (49) (48) (47) (50)
Follicular Cell, Hyperplasia 3 [1.0] 2 [1.0] 3 [1.0] 2 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1) (1)
Inflammation, Suppurative 1 [3.0]
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2)
Hyperplasia 1 [2.0]
Epididymis (50) (50) (50) (50)
Granuloma Sperm 3 [2.0] 3 [1.7] 2 [2.0]
Infiltration Cellular, Mononuclear Cell 1 [3.0]
Penis (3) (1)
Inflammation, Acute 2 [3.5] 1 [2.0]
Preputial Gland (49) (49) (50) (48)
Ectasia 1 [2.0]
Inflammation, Chronic Active 2 [2.5] 3 [2.0] 2 [3.0] 1 [4.0]
Prostate (46) (50) (50) (50)
Inflammation, Suppurative 1 [2.0] 1 [2.0] 1 [3.0]
Artery, Inflammation 1 [3.0]
Seminal Vesicle (48) (46) (50) (48)
Amyloid Deposition 1 [3.0]
Infiltration Cellular, Mononuclear Cell 1 [2.0]
Inflammation, Chronic 1 [2.0]
Inflammation, Suppurative 1 [3.0]
Testes (50) (50) (50) (50)
Atrophy 2 [2.0] 1 [4.0] 1 [2.0] 2 [3.0]
Mineralization 1 [4.0]
Germinal Epithelium, Degeneration 1 [2.0]
Interstitial Cell, Hyperplasia 2 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 11:16:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (1) (3)
Deep Cervical, Hyperplasia, Lymphoid 1 [3.0]
Lumbar, Infiltration Cellular, Plasma Cell 2 [2.0]
Lymph Node, Mesenteric (48) (46) (48) (48)
Angiectasis 1 [3.0]
Hyperplasia, Lymphoid 1 [3.0]
Infiltration Cellular, Plasma Cell 1 [4.0]
Lymph Node, Mediastinal (39) (40) (36) (43)
Infiltration Cellular, Plasma Cell 1 [2.0]
Spleen (49) (49) (49) (50)
Amyloid Deposition 1 [3.0]
Angiectasis 1 [2.0]
Hematopoietic Cell Proliferation 3 [3.0] 3 [3.3] 2 [3.5]
Thymus (41) (39) (40) (42)
Cyst 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 [3.0]
Infiltration Cellular, Mixed Cell 1 [1.0]
Inflammation, Chronic Active 6 [3.0] 7 [3.4] 11 [3.3] 18 [3.3]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Intervertebral Disc, Necrosis 1 [2.0]
Skeletal Muscle (1)
Inflammation, Suppurative 1 [4.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Inflammation, Granulomatous 1 [2.0]
Meninges, Infiltration Cellular, Mononuclear
Cell 1 [2.0]
Spinal Cord (1)
Degeneration 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 11:16:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50) (50)
Fibrosis 1 [3.0]
Hemorrhage 1 [1.0] 1 [2.0] 2 [2.0]
Inflammation, Chronic Active 1 [1.0]
Thrombosis 1 [1.0] 1 [1.0]
Alveolar Epithelium, Hyperplasia 4 [1.8] 2 [3.0]
Alveolus, Infiltration Cellular, Histiocyte 2 [1.5] 1 [2.0] 3 [2.0] 1 [4.0]
Bronchiole, Hyperplasia 2 [1.0]
Mediastinum, Thrombosis 1 [2.0]
Nose (50) (48) (50) (50)
Inflammation, Suppurative 3 [2.3] 2 [1.5] 1 [2.0] 2 [2.5]
Polyp, Inflammatory 1 [3.0] 1 [3.0]
Olfactory Epithelium, Atrophy 3 [2.3] 1 [2.0] 2 [2.0]
Olfactory Epithelium, Inflammation,
Granulomatous 1 [3.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (46) (46) (47) (46)
Cornea, Inflammation, Chronic Active 3 [2.0] 1 [2.0] 1 [4.0]
Harderian Gland (50) (50) (50) (49)
Hyperplasia 3 [2.3] 4 [2.5] 1 [3.0] 1 [3.0]
Zymbal's Gland (1) (1)
Cyst 1 [3.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Amyloid Deposition 1 [4.0]
Cyst 3 [2.0] 1 [1.0] 3 [1.7] 1 [2.0]
Inflammation, Granulomatous 1 [2.0]
Inflammation, Suppurative 1 [2.0] 2 [2.5] 2 [3.0]
Metaplasia, Osseous 3 [1.0] 4 [1.5] 2 [1.5]
Nephropathy 44 [1.4] 43 [1.5] 42 [1.4] 44 [1.3]
Capsule, Fibrosis 1 [2.0] 1 [2.0]
Papilla, Necrosis 1 [4.0] 1 [4.0]
Pelvis, Dilatation 1 [3.0] 2 [2.0]
Renal Tubule, Hyperplasia 2 [1.0] 1 [2.0]
Renal Tubule, Necrosis 2 [2.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY STODDARD SOLVENT (TYPE IIC) Time: 11:16:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 [2.0] 2 [1.0]
Urinary Bladder (49) (46) (49) (50)
Infiltration Cellular, Mixed Cell 1 [2.0] 1 [3.0]
Inflammation, Acute 1 [2.0]
Inflammation, Chronic Active 1 [4.0] 1 [4.0] 2 [3.0]
Transitional Epithelium, Hyperplasia 1 [2.0] 1 [3.0] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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