TDMS Study 96007-01 Pathology Tables
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 53 WEEK SSAC Facility: Battelle Columbus Laboratory Chemical CAS #: 57465-28-8 Lock Date: 01/09/01 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 02/25/99 - 02/26/99 Treatment Groups: Include 001 0 NG/KG Include 002 10 NG/KG Include 003 30 NG/KG Include 004 100 NG/KG Include 005 175 NG/KG Include 006 300 NG/KG Include 007 550 NG/KG Include 008 1000 NG/KG Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 NG/KG | 2| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 7| 8| | L | | 4| 1| 2| 3| 4| 5| 7| 8| 0| 4| 0| 6| 2| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + | 8 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 2 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 NG/KG | 2| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 7| 8| | L | | 4| 1| 2| 3| 4| 5| 7| 8| 0| 4| 0| 6| 2| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Vagina | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| |__________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 3 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 10 NG/KG | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 4| 4| | L | | 2| 4| 5| 2| 3| 4| 5| 2| 2| 3| 4| 5| 2| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 4 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 10 NG/KG | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 4| 4| | L | | 2| 4| 5| 2| 3| 4| 5| 2| 2| 3| 4| 5| 2| 6| 8| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| |__________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30 NG/KG | 0| 2| 4| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| | L | | 9| 9| 6| 3| 6| 1| 2| 4| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + | 7 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Uterus | + + | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30 NG/KG | 0| 2| 4| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| | L | | 9| 9| 6| 3| 6| 1| 2| 4| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| |__________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 100 | 0| 1| 2| 2| 2| 2| 2| 3| 5| 5| 6| 8| 9| | L | NG/KG | 2| 4| 0| 6| 7| 8| 9| 0| 8| 9| 0| 9| 2| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + | 1 | Fibroadenoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 100 | 0| 1| 2| 2| 2| 2| 2| 3| 5| 5| 6| 8| 9| | L | NG/KG | 2| 4| 0| 6| 7| 8| 9| 0| 8| 9| 0| 9| 2| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| |__________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 175 | 1| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| 9| 9| | L | NG/KG | 2| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 0| 4| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + M + + + + + + | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + | 2 | Fibroadenoma | X | 1 | Fibroadenoma, Multiple | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 175 | 1| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| 9| 9| | L | NG/KG | 2| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 0| 4| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| |__________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 300 | 2| 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| | L | NG/KG | 0| 8| 4| 2| 6| 8| 0| 4| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Uterus | + + | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 300 | 2| 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| | L | NG/KG | 0| 8| 4| 2| 6| 8| 0| 4| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| |__________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 550 | 0| 1| 1| 2| 3| 3| 5| 9| 9| 9| 9| 9| 9| | L | NG/KG | 8| 7| 8| 0| 3| 6| 4| 1| 2| 3| 4| 5| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + + | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Spleen | + | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + | 1 | Fibroadenoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A | 550 | 0| 1| 1| 2| 3| 3| 5| 9| 9| 9| 9| 9| 9| | L | NG/KG | 8| 7| 8| 0| 3| 6| 4| 1| 2| 3| 4| 5| 8| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| |__________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 5| 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | A | 1000 | 4| 4| 4| 4| 5| 6| 6| 0| 1| 1| 1| 2| 4| | L | NG/KG | 6| 7| 8| 9| 0| 2| 8| 3| 2| 3| 4| 8| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + | 8 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02 Route: GAVAGE Time: 15:36:03 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 5| 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | A | 1000 | 4| 4| 4| 4| 5| 6| 6| 0| 1| 1| 1| 2| 4| | L | NG/KG | 6| 7| 8| 9| 0| 2| 8| 3| 2| 3| 4| 8| 5| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Vagina | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Thymus | + + + + M + + + | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| |__________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------