TDMS Study 96007-01 Pathology Tables
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
53 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57465-28-8
Lock Date: 01/09/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 02/25/99 - 02/26/99
Treatment Groups: Include 001 0 NG/KG
Include 002 10 NG/KG
Include 003 30 NG/KG
Include 004 100 NG/KG
Include 005 175 NG/KG
Include 006 300 NG/KG
Include 007 550 NG/KG
Include 008 1000 NG/KG
Page 1
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG/KG | 2| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 7| 8| | L |
| 4| 1| 2| 3| 4| 5| 7| 8| 0| 4| 0| 6| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X X | 2 |
Inflammation | 1 2 1 1 1 1 1 1 | 8 1.1|
Mixed Cell Focus | X X X | 3 |
Mixed Cell Focus, Multiple | X | 1 |
Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Hypertrophy | 1 1 2 1 2 | 5 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
Pars Distalis, Hyperplasia | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
C-Cell, Hyperplasia | 1 2 | 2 1.5|
Follicular Cell, Hypertrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG/KG | 2| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 7| 8| | L |
| 4| 1| 2| 3| 4| 5| 7| 8| 0| 4| 0| 6| 2| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 4 | 8 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Inflammation, Suppurative | 1 1 1 | 3 1.0|
Metaplasia, Squamous | 3 2 2 2 2 4 4 3 | 8 2.8|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 3 2 1 2 2 2 2 | 7 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
Galactocele | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 | 3 1.0|
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG/KG | 2| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 7| 8| | L |
| 4| 1| 2| 3| 4| 5| 7| 8| 0| 4| 0| 6| 2| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
10 NG/KG | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 4| 4| | L |
| 2| 4| 5| 2| 3| 4| 5| 2| 2| 3| 4| 5| 2| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X X | 2 |
Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0|
Mixed Cell Focus | X X X | 3 |
Mixed Cell Focus, Multiple | X X | 2 |
Hepatocyte, Hypertrophy | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 1 3 2 2 1 1 | 6 1.7|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 3 |
Follicular Cell, Hypertrophy | 1 2 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 | 7 4.0|
Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
10 NG/KG | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 4| 4| | L |
| 2| 4| 5| 2| 3| 4| 5| 2| 2| 3| 4| 5| 2| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Atrophy | 2 2 2 2 3 | 5 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
30 NG/KG | 0| 2| 4| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 9| 9| 6| 3| 6| 1| 2| 4| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Inflammation | 1 1 1 1 1 2 1 1 | 8 1.1|
Mixed Cell Focus | X | 1 |
Mixed Cell Focus, Multiple | X X | 2 |
Pigmentation | 1 1 1 | 3 1.0|
Hepatocyte, Hypertrophy | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + | 1 |
Follicular Cell, Hypertrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 | 7 4.0|
|__________________________________________________________________________|____________|
Uterus | + + | 2 |
Inflammation, Suppurative | 2 1 | 2 1.5|
Metaplasia, Squamous | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
30 NG/KG | 0| 2| 4| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 9| 9| 6| 3| 6| 1| 2| 4| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 2 2 2 2 2 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 | 0| 1| 2| 2| 2| 2| 2| 3| 5| 5| 6| 8| 9| | L |
NG/KG | 2| 4| 0| 6| 7| 8| 9| 0| 8| 9| 0| 9| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X | 1 |
Cholangiofibrosis | 1 | 1 1.0|
Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0|
Mixed Cell Focus, Multiple | X X X X X X | 6 |
Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0|
Hepatocyte, Hypertrophy | 1 2 1 1 1 | 5 1.2|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Hyperplasia | 2 1 1 | 3 1.3|
Hypertrophy | 1 1 1 | 3 1.0|
Vacuolization Cytoplasmic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 3 |
Follicular Cell, Hypertrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 4 | 8 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 | 0| 1| 2| 2| 2| 2| 2| 3| 5| 5| 6| 8| 9| | L |
NG/KG | 2| 4| 0| 6| 7| 8| 9| 0| 8| 9| 0| 9| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | + + + + + + + + | 8 |
Atrophy | 3 2 2 2 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 | 5 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
175 | 1| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| 9| 9| | L |
NG/KG | 2| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 0| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X X | 2 |
Eosinophilic Focus | X | 1 |
Eosinophilic Focus, Multiple | X | 1 |
Fatty Change, Diffuse | 1 1 | 2 1.0|
Inflammation | 1 1 1 1 1 1 1 2 | 8 1.1|
Mixed Cell Focus | X X X | 3 |
Mixed Cell Focus, Multiple | X X X | 3 |
Pigmentation | 1 2 1 1 1 1 1 | 7 1.1|
Toxic Hepatopathy | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 1 1 1 1 1 1 | 6 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 3 |
Follicular Cell, Hypertrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
175 | 1| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| 9| 9| | L |
NG/KG | 2| 5| 6| 7| 8| 5| 6| 7| 8| 9| 0| 0| 4| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Atrophy | 4 4 4 4 4 4 | 6 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + | 7 |
Atrophy | 2 3 2 2 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 1 | 4 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 | 1 1.0|
Interstitium, Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
300 | 2| 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| | L |
NG/KG | 0| 8| 4| 2| 6| 8| 0| 4| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Clear Cell Focus | X | 1 |
Clear Cell Focus, Multiple | X | 1 |
Hepatocyte, Multinucleate | 1 | 1 1.0|
Inflammation | 2 1 1 1 1 2 1 1 | 8 1.3|
Mixed Cell Focus | X X | 2 |
Mixed Cell Focus, Multiple | X X X X | 4 |
Pigmentation | 1 1 2 1 1 2 1 1 | 8 1.3|
Bile Duct, Cyst | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 1 1 1 1 1 1 1 | 7 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
Inflammation, Chronic Active | 1 | 1 1.0|
Acinus, Atrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 1 1 1 3 | 4 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 3 |
Follicular Cell, Hypertrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
300 | 2| 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| | L |
NG/KG | 0| 8| 4| 2| 6| 8| 0| 4| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 4 | 8 4.0|
|__________________________________________________________________________|____________|
Uterus | + + | 2 |
Inflammation, Suppurative | 2 2 | 2 2.0|
Metaplasia, Squamous | 4 2 | 2 3.0|
Endometrium, Hyperplasia, Cystic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 3 2 3 2 2 3 2 | 7 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 | 2 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
300 | 2| 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| | L |
NG/KG | 0| 8| 4| 2| 6| 8| 0| 4| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
550 | 0| 1| 1| 2| 3| 3| 5| 9| 9| 9| 9| 9| 9| | L |
NG/KG | 8| 7| 8| 0| 3| 6| 4| 1| 2| 3| 4| 5| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X | 1 |
Cholangiofibrosis | 2 | 1 2.0|
Clear Cell Focus | X | 1 |
Eosinophilic Focus, Multiple | X | 1 |
Fatty Change, Diffuse | 1 | 1 1.0|
Fatty Change, Focal | 1 | 1 1.0|
Hepatocyte, Multinucleate | 1 1 1 | 3 1.0|
Inflammation | 2 2 2 1 1 2 1 2 | 8 1.6|
Mixed Cell Focus | X | 1 |
Mixed Cell Focus, Multiple | X X X X X X X | 7 |
Necrosis | 1 | 1 1.0|
Pigmentation | 2 2 2 1 1 2 2 2 | 8 1.8|
Toxic Hepatopathy | 1 1 1 2 | 4 1.3|
Bile Duct, Hyperplasia | 1 1 1 1 | 4 1.0|
Hepatocyte, Hypertrophy | 1 1 2 1 1 1 2 3 | 8 1.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
Acinus, Vacuolization Cytoplasmic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Hyperplasia | 2 3 | 2 2.5|
Hypertrophy | 1 1 1 1 2 | 5 1.2|
|__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
Follicular Cell, Hypertrophy | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
550 | 0| 1| 1| 2| 3| 3| 5| 9| 9| 9| 9| 9| 9| | L |
NG/KG | 8| 7| 8| 0| 3| 6| 4| 1| 2| 3| 4| 5| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 | 7 4.0|
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + | 1 |
Infarct | 3 | 1 3.0|
Pigmentation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 4 3 4 3 3 2 3 4 | 8 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 | 3 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 5| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
550 | 0| 1| 1| 2| 3| 3| 5| 9| 9| 9| 9| 9| 9| | L |
NG/KG | 8| 7| 8| 0| 3| 6| 4| 1| 2| 3| 4| 5| 8| | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | A |
1000 | 4| 4| 4| 4| 5| 6| 6| 0| 1| 1| 1| 2| 4| | L |
NG/KG | 6| 7| 8| 9| 0| 2| 8| 3| 2| 3| 4| 8| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X X | 2 |
Eosinophilic Focus, Multiple | X X X | 3 |
Fatty Change, Diffuse | 1 1 1 1 1 1 1 1 | 8 1.0|
Hepatocyte, Multinucleate | 3 2 2 2 1 2 2 2 | 8 2.0|
Inflammation | 1 2 1 2 1 2 2 2 | 8 1.6|
Mixed Cell Focus, Multiple | X X X X X X X X | 8 |
Pigmentation | 3 2 2 3 2 2 2 3 | 8 2.4|
Toxic Hepatopathy | 3 2 2 4 1 2 3 3 | 8 2.5|
Vacuolization Cytoplasmic | 1 | 1 1.0|
Bile Duct, Hyperplasia | 2 1 1 2 1 1 | 6 1.3|
Hepatocyte, Hypertrophy | 4 2 3 3 2 2 3 3 | 8 2.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
Inflammation, Chronic Active | 1 | 1 1.0|
Acinus, Atrophy | 1 | 1 1.0|
Acinus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 | 6 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Atrophy | 2 | 1 2.0|
Degeneration, Cystic | 2 1 | 2 1.5|
Hyperplasia | 2 2 3 | 3 2.3|
Hypertrophy | 1 3 1 2 2 | 5 1.8|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | A |
1000 | 4| 4| 4| 4| 5| 6| 6| 0| 1| 1| 1| 2| 4| | L |
NG/KG | 6| 7| 8| 9| 0| 2| 8| 3| 2| 3| 4| 8| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Medulla | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
Follicular Cell, Hypertrophy | 1 1 2 1 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 3 | 7 3.9|
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Inflammation, Suppurative | 2 | 1 2.0|
Metaplasia, Squamous | 2 1 3 2 1 1 4 | 7 2.0|
Cervix, Cyst | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + M + + + | 7 |
Atrophy | 4 4 4 4 4 2 4 | 7 3.7|
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:42:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | A |
1000 | 4| 4| 4| 4| 5| 6| 6| 0| 1| 1| 1| 2| 4| | L |
NG/KG | 6| 7| 8| 9| 0| 2| 8| 3| 2| 3| 4| 8| 5| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 6 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 1 1 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
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