TDMS Study 96007-01 Pathology Tables
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 FINAL #3/RATS Facility: Battelle Columbus Laboratory Chemical CAS #: 57465-28-8 Lock Date: 01/09/01 Cage Range: All Reasons For Removal: 25022 Accidently Killed 25018 Dosing Accident 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 001 0 NG/KG Include 003 30 NG/KG Include 004 100 NG/KG Include 005 175 NG/KG Include 006 300 NG/KG Include 007 550 NG/KG Include 008 1000 NG/KG Include 009 1000 NG/KG/STOP Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2| DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0| | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6| | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | |__________________________________________________________________________| Mesentery | + | |__________________________________________________________________________| Oral Mucosa | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| Acinus, Adenoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2| DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0| | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6| | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Heart | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X X X X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X | Pars Distalis, Adenoma, Multiple | X | Pars Intermedia, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| Bilateral, C-Cell, Adenoma | X X | C-Cell, Adenoma | X X X X X X X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + M + + + M + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2| DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0| | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6| | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Vagina | + | Sarcoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + | Renal, Nephroblastoma, Metastatic, | | Kidney | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + + + + + M + + + +| Carcinoma, Metastatic, Mammary Gland | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X X | Fibroadenoma, Multiple | X X X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | | Keratoacanthoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2| DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0| | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6| | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X X | Oligodendroglioma Malignant | X| |__________________________________________________________________________| Peripheral Nerve | + +| |__________________________________________________________________________| Spinal Cord | + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Carcinoma, Metastatic, Mammary Gland | | Osteosarcoma, Metastatic, Bone | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2| DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0| | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6| | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Nephroblastoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7| DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0| | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | |__________________________________________________________________________| Mesentery | | |__________________________________________________________________________| Oral Mucosa | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + M + + + + + + + + + + + + + + +| Acinus, Adenoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 7 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7| DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0| | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + M + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X | Pars Distalis, Adenoma, Multiple | | Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oviduct | | |__________________________________________________________________________| Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +| Polyp Stromal | X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 8 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7| DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0| | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Vagina | | Sarcoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + | Renal, Nephroblastoma, Metastatic, | | Kidney | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| Hemangiosarcoma | X | |__________________________________________________________________________| Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| Carcinoma, Metastatic, Mammary Gland | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X | Carcinoma, Multiple | | Fibroadenoma | X X X X X X X X X| Fibroadenoma, Multiple | X X X X X X X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + M + + + + + + + + + + + + + + +| Fibroma | X | Keratoacanthoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 9 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7| DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0| | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | Oligodendroglioma Malignant | | |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Carcinoma, Metastatic, Mammary Gland | | Osteosarcoma, Metastatic, Bone | X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | X| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + M + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 10 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7| DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0| | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Nephroblastoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 11 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 5| 4| 1| | | DAY ON TEST | 4| 0| 2| | | | 7| 0| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG/KG | 9| 9| 9| | L | | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Hepatocellular Adenoma | | 1 | |__________________________________________________________________________|____________| Mesentery | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + | 51 | Acinus, Adenoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 51 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 52 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 51 | |__________________________________________________________________________|____________| Tooth | | 12 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 5| 4| 1| | | DAY ON TEST | 4| 0| 2| | | | 7| 0| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG/KG | 9| 9| 9| | L | | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 52 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 52 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 52 | Pheochromocytoma Benign | | 8 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 52 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 51 | Pars Distalis, Adenoma | | 14 | Pars Distalis, Adenoma, Multiple | | 1 | Pars Intermedia, Adenoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | Bilateral, C-Cell, Adenoma | | 3 | C-Cell, Adenoma | | 12 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + M + | 50 | |__________________________________________________________________________|____________| Ovary | + + + | 52 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 5| 4| 1| | | DAY ON TEST | 4| 0| 2| | | | 7| 0| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG/KG | 9| 9| 9| | L | | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Oviduct | | 1 | |__________________________________________________________________________|____________| Uterus | + + + | 52 | Polyp Stromal | | 4 | |__________________________________________________________________________|____________| Vagina | | 1 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | | 2 | Renal, Nephroblastoma, Metastatic, | | | Kidney | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + M + | 52 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Spleen | + + + | 52 | |__________________________________________________________________________|____________| Thymus | + + + | 50 | Carcinoma, Metastatic, Mammary Gland | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 52 | Adenoma | | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 5| 4| 1| | | DAY ON TEST | 4| 0| 2| | | | 7| 0| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG/KG | 9| 9| 9| | L | | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Carcinoma | X | 5 | Carcinoma, Multiple | | 1 | Fibroadenoma | | 18 | Fibroadenoma, Multiple | X | 21 | |__________________________________________________________________________|____________| Skin | + + + | 52 | Fibroma | | 1 | Keratoacanthoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Astrocytoma Malignant | | 2 | Oligodendroglioma Malignant | | 1 | |__________________________________________________________________________|____________| Peripheral Nerve | | 2 | |__________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Alveolar/Bronchiolar Adenoma | | 1 | Carcinoma, Metastatic, Mammary Gland | X | 1 | Osteosarcoma, Metastatic, Bone | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 5| 4| 1| | | DAY ON TEST | 4| 0| 2| | | | 7| 0| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG/KG | 9| 9| 9| | L | | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Nose | + + + | 53 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 51 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Hemangiosarcoma | | 1 | Nephroblastoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 51 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5| DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2| | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoma, Metastatic, Uterus| | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoma, Metastatic, Uterus| | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoma, Metastatic, Uterus| | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Granulocytic | | Lymphoma Malignant | X X | |__________________________________________________________________________| Oral Mucosa | | Gingival, Squamous Cell Carcinoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoma, Metastatic, Uterus| | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoma, Metastatic, Uterus| | __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5| DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2| | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tooth | + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | | Leukemia Granulocytic | | Lymphoma Malignant | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +| Adenoma | X X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | | Sarcoma, Metastatic, Brain | | Pars Distalis, Adenoma | X X X X X X X| Pars Intermedia, Adenoma | X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 18 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5| DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2| | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X X X X| C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Oviduct | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | | Lymphoma Malignant | X X | |__________________________________________________________________________| Lymph Node | + + + + + +| Lumbar, Lymphoma Malignant | X | Mediastinal, Lymphoma Malignant | X X | Pancreatic, Lymphoma Malignant | X | Renal, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 19 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5| DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2| | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | | Lymphoma Malignant | X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | | Lymphoma Malignant | X X | Capsule, Carcinoma, Metastatic, | | Uterus | | |__________________________________________________________________________| Thymus | + + M + + + M + + + + + + + + + M + + + + + + + +| Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Carcinoma, Multiple | | Fibroadenoma | X X X X X X X X| Fibroadenoma, Multiple | X X X X X X X | Lymphoma Malignant | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Rhabdomyosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | | __________________________________________|__________________________________________________________________________| Page 20 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5| DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2| | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Meninges, Sarcoma | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X | Leukemia Granulocytic | | Lymphoma Malignant | X X | Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | Nephroblastoma | X | Stromal Nephroma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoma, Metastatic, Uterus| | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | | Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 21 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoma, Metastatic, Uterus| X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoma, Metastatic, Uterus| X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoma, Metastatic, Uterus| X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Granulocytic | X | Lymphoma Malignant | | |__________________________________________________________________________| Oral Mucosa | + | Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoma, Metastatic, Uterus| X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoma, Metastatic, Uterus| X | __________________________________________|__________________________________________________________________________| Page 22 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tooth | + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Leukemia Granulocytic | X | Lymphoma Malignant | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + + + M + + M + + M + + +| Adenoma | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | X | Sarcoma, Metastatic, Brain | X | Pars Distalis, Adenoma | X X X X X X X X | Pars Intermedia, Adenoma | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 23 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X X| C-Cell, Adenoma | X X X X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Polyp Stromal | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | X | Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node | | Lumbar, Lymphoma Malignant | | Mediastinal, Lymphoma Malignant | | Pancreatic, Lymphoma Malignant | | Renal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | X | Lymphoma Malignant | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | X | Lymphoma Malignant | | Capsule, Carcinoma, Metastatic, | | Uterus | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X X | Carcinoma, Multiple | | Fibroadenoma | X X X X X X X X X | Fibroadenoma, Multiple | X X X X X| Lymphoma Malignant | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Rhabdomyosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | X | __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Meninges, Sarcoma | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Leukemia Granulocytic | X | Lymphoma Malignant | | Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + M M + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Nephroblastoma | X | Stromal Nephroma | X | |__________________________________________________________________________| Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoma, Metastatic, Uterus| X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | X | Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 26 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + | 55 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 55 | Serosa, Carcinoma, Metastatic, Uterus| | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 55 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 54 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 55 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 54 | Serosa, Carcinoma, Metastatic, Uterus| | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 54 | Serosa, Carcinoma, Metastatic, Uterus| | 1 | |__________________________________________________________________________|____________| Liver | + + + + + | 55 | Hepatocellular Adenoma | | 2 | Leukemia Granulocytic | | 1 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | Gingival, Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + | 55 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + | 54 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 55 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Serosa, Carcinoma, Metastatic, Uterus| | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 53 | Serosa, Carcinoma, Metastatic, Uterus| | 1 | |__________________________________________________________________________|____________| Tooth | | 12 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + | 55 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Heart | + + + + + | 54 | Lymphoma Malignant | | 2 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 55 | Adenoma | | 1 | Carcinoma | | 1 | Leukemia Granulocytic | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 55 | Lymphoma Malignant | | 1 | Pheochromocytoma Benign | | 3 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 54 | Adenoma | | 2 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adenoma | | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + | 54 | Leukemia Granulocytic | | 1 | Sarcoma, Metastatic, Brain | | 1 | Pars Distalis, Adenoma | X X X | 18 | Pars Intermedia, Adenoma | | 2 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + | 55 | Bilateral, C-Cell, Adenoma | X | 4 | C-Cell, Adenoma | X | 11 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + | 55 | |__________________________________________________________________________|____________| Ovary | + + + + + | 54 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Oviduct | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + | 55 | Carcinoma | | 3 | Polyp Stromal | | 5 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + | 55 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Granulocytic | | 1 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Lymph Node | | 6 | Lumbar, Lymphoma Malignant | | 1 | Mediastinal, Lymphoma Malignant | | 2 | Pancreatic, Lymphoma Malignant | | 1 | Renal, Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 54 | Leukemia Granulocytic | | 1 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Spleen | + + + + + | 55 | Leukemia Granulocytic | | 1 | Lymphoma Malignant | | 2 | Capsule, Carcinoma, Metastatic, | | | Uterus | | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + | 52 | Lymphoma Malignant | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + | 55 | Carcinoma | X | 6 | Carcinoma, Multiple | X | 1 | Fibroadenoma | | 17 | Fibroadenoma, Multiple | X X | 14 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Skin | + + + + + | 55 | Fibroma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + | 55 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Rhabdomyosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + | 55 | Leukemia Granulocytic | | 1 | Meninges, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + | 55 | Alveolar/Bronchiolar Carcinoma | | 1 | Leukemia Granulocytic | | 1 | Lymphoma Malignant | | 2 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + | 54 | |__________________________________________________________________________|____________| Trachea | + + + + + | 55 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Eye | + + + + + | 55 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + | 53 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + | 55 | Lymphoma Malignant | | 2 | Nephroblastoma | | 2 | Stromal Nephroma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + | 54 | Serosa, Carcinoma, Metastatic, Uterus| | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + | 55 | Leukemia Granulocytic | | 1 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7| DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0| | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Islets, | | Pancreatic | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Islets, | | Pancreatic | X | Cholangiocarcinoma | | Hepatocellular Adenoma | X | Schwannoma Malignant, Metastatic, | | Heart | X | |__________________________________________________________________________| Mesentery | + + | Carcinoma, Metastatic, Islets, | | Pancreatic | X | |__________________________________________________________________________| Oral Mucosa | + +| Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 33 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7| DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0| | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Heart | X | |__________________________________________________________________________| Tooth | + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Schwannoma Malignant, Metastatic, | | Heart | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X| Pheochromocytoma Benign | X X X X | Schwannoma Malignant, Metastatic, | | Heart | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X | Pars Intermedia, Adenoma | | __________________________________________|__________________________________________________________________________| Page 34 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7| DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0| | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X X X X | C-Cell, Carcinoma | X X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa-Theca Tumor Malignant | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Polyp Stromal | X X X | Squamous Cell Papilloma | X | |__________________________________________________________________________| Vagina | | Squamous Cell Carcinoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + | Mediastinal, Carcinoma, Metastatic, | | Islets, Pancreatic | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 35 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7| DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0| | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Heart | X | |__________________________________________________________________________| Thymus | + + + + M + M + + + M + + M + + + + M M + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X X X X X | Fibroadenoma | X X X X X X X | Fibroadenoma, Multiple | X X X X X X X X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Subcutaneous Tissue, Fibroma, | | Multiple | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Carcinoma, Metastatic, Islets, | | Pancreatic | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Medulloblastoma Mal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Islets, | | __________________________________________|__________________________________________________________________________| Page 36 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7| DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0| | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Pancreatic | X | Carcinoma, Metastatic, Mammary Gland | | Schwannoma Malignant, Metastatic, | | Heart | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephroblastoma | | Schwannoma Malignant, Metastatic, | | Heart | X | |__________________________________________________________________________| Ureter | + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 37 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4| | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Islets, | | Pancreatic | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Islets, | | Pancreatic | | Cholangiocarcinoma | | Hepatocellular Adenoma | | Schwannoma Malignant, Metastatic, | | Heart | | |__________________________________________________________________________| Mesentery | + + | Carcinoma, Metastatic, Islets, | | Pancreatic | | |__________________________________________________________________________| Oral Mucosa | + | Gingival, Squamous Cell Carcinoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 38 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4| | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Heart | | |__________________________________________________________________________| Tooth | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Schwannoma Malignant, Metastatic, | | Heart | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | Pheochromocytoma Benign | | Schwannoma Malignant, Metastatic, | | Heart | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + M +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X | Pars Intermedia, Adenoma | X | __________________________________________|__________________________________________________________________________| Page 39 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4| | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X X | C-Cell, Adenoma | X X X X X X| C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa-Theca Tumor Malignant | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Polyp Stromal | X X X | Squamous Cell Papilloma | | |__________________________________________________________________________| Vagina | + | Squamous Cell Carcinoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | Mediastinal, Carcinoma, Metastatic, | | Islets, Pancreatic | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 40 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4| | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Heart | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X | Fibroadenoma | X X X X X X X X X X X X| Fibroadenoma, Multiple | X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | | Subcutaneous Tissue, Fibroma, | | Multiple | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Carcinoma, Metastatic, Islets, | | Pancreatic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Medulloblastoma Mal | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Islets, | | __________________________________________|__________________________________________________________________________| Page 41 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4| | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Pancreatic | | Carcinoma, Metastatic, Mammary Gland | X | Schwannoma Malignant, Metastatic, | | Heart | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephroblastoma | | Schwannoma Malignant, Metastatic, | | Heart | | |__________________________________________________________________________| Ureter | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 42 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | Leiomyosarcoma | X | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | Carcinoma, Metastatic, Islets, | | | Pancreatic | | 1 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Carcinoma, Metastatic, Islets, | | | Pancreatic | | 1 | Cholangiocarcinoma | X | 1 | Hepatocellular Adenoma | | 1 | Schwannoma Malignant, Metastatic, | | | Heart | | 1 | |__________________________________________________________________________|____________| Mesentery | | 4 | Carcinoma, Metastatic, Islets, | | | Pancreatic | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | | 3 | Gingival, Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Pancreas | + + + | 53 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | Schwannoma Malignant, Metastatic, | | | Heart | | 1 | |__________________________________________________________________________|____________| Tooth | | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | Schwannoma Malignant | | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Adenoma | | 1 | Schwannoma Malignant, Metastatic, | | | Heart | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | | 4 | Schwannoma Malignant, Metastatic, | | | Heart | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Islets, Pancreatic | + + + | 53 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 48 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Pars Distalis, Adenoma | | 20 | Pars Intermedia, Adenoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + A + | 52 | Bilateral, C-Cell, Adenoma | | 3 | C-Cell, Adenoma | | 12 | C-Cell, Carcinoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 52 | |__________________________________________________________________________|____________| Ovary | + + + | 53 | Granulosa-Theca Tumor Malignant | | 1 | |__________________________________________________________________________|____________| Uterus | + + + | 53 | Carcinoma | | 1 | Polyp Stromal | X | 7 | Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Vagina | | 1 | Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | | 6 | Mediastinal, Carcinoma, Metastatic, | | | Islets, Pancreatic | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 51 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | |__________________________________________________________________________|____________| Spleen | + + + | 52 | Schwannoma Malignant, Metastatic, | | | Heart | | 1 | |__________________________________________________________________________|____________| Thymus | M + + | 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Adenoma | | 2 | Carcinoma | X | 9 | Fibroadenoma | X X | 21 | Fibroadenoma, Multiple | | 14 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Keratoacanthoma | | 1 | Subcutaneous Tissue, Fibroma, | | | Multiple | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Carcinoma, Metastatic, Islets, | | | Pancreatic | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Medulloblastoma Mal | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Carcinoma, Metastatic, Islets, | | | Pancreatic | | 1 | Carcinoma, Metastatic, Mammary Gland | | 1 | Schwannoma Malignant, Metastatic, | | | Heart | | 1 | |__________________________________________________________________________|____________| Nose | + + + | 52 | |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Nephroblastoma | X | 1 | Schwannoma Malignant, Metastatic, | | | Heart | | 1 | |__________________________________________________________________________|____________| Ureter | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6| DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5| | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + M + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + | |__________________________________________________________________________| Oral Mucosa | + + | Gingival, Squamous Cell Carcinoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Carcinoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6| DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5| | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + M + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X| Pars Distalis, Carcinoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | X | __________________________________________|__________________________________________________________________________| Page 50 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6| DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5| | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Hemangiosarcoma | X | Lymphoma Malignant | X | Polyp Stromal | X X X | Sarcoma Stromal | X | Sarcoma Stromal, Multiple | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + | Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X | Fibroadenoma, Multiple | X X X X X X X X X X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 51 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6| DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5| | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Carcinoma, Metastatic, Mammary Gland | X | Lymphoma Malignant | X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | | Mediastinum, Carcinoma, Metastatic, | | Mammary Gland | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephroblastoma | X | Stromal Nephroma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 52 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________|__________________________________________________________________________ | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6| DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5| | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 53 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7| DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2| | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Mesentery | | |__________________________________________________________________________| Oral Mucosa | + + | Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Carcinoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + M + + + + + + + + M + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | __________________________________________|__________________________________________________________________________| Page 54 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7| DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2| | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + M + + + + + + + M + + + + + + + + M + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X| Pars Distalis, Carcinoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + M + + + + + + + + M + + + + + +| Bilateral, C-Cell, Adenoma | X X | C-Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + M M + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +| Granulosa Cell Tumor Benign | | __________________________________________|__________________________________________________________________________| Page 55 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7| DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2| | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + M + + + + + + + + +| Carcinoma | X | Hemangiosarcoma | | Lymphoma Malignant | | Polyp Stromal | | Sarcoma Stromal | | Sarcoma Stromal, Multiple | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + M + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Thymus | M + + + + + + + + + + + + + + M + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Carcinoma, Multiple | | Fibroadenoma | X X X X X X X X X X X | Fibroadenoma, Multiple | X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 56 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7| DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2| | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Carcinoma, Metastatic, Mammary Gland | | Lymphoma Malignant | | Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | X | Mediastinum, Carcinoma, Metastatic, | | Mammary Gland | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephroblastoma | | Stromal Nephroma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 57 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________|__________________________________________________________________________ | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7| DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2| | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 52 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 51 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 51 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Hepatocellular Carcinoma | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | | 2 | |__________________________________________________________________________|____________| Oral Mucosa | | 4 | Gingival, Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Acinus, Carcinoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 51 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Tooth | + | 9 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | | 2 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | Adenoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 46 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Pars Distalis, Adenoma | | 16 | Pars Distalis, Carcinoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 51 | Bilateral, C-Cell, Adenoma | | 2 | C-Cell, Adenoma | X | 11 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 50 | |__________________________________________________________________________|____________| Ovary | + + + | 52 | Granulosa Cell Tumor Benign | | 1 | |__________________________________________________________________________|____________| Uterus | + + + | 52 | Carcinoma | | 1 | Hemangiosarcoma | | 1 | Lymphoma Malignant | | 1 | Polyp Stromal | | 3 | Sarcoma Stromal | | 1 | Sarcoma Stromal, Multiple | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | | 6 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 51 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Spleen | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Thymus | + M + | 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Mammary Gland | + + + | 53 | Carcinoma | X | 4 | Carcinoma, Multiple | | 1 | Fibroadenoma | X X | 21 | Fibroadenoma, Multiple | X | 17 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Alveolar/Bronchiolar Adenoma | | 1 | Carcinoma, Metastatic, Mammary Gland | | 1 | Lymphoma Malignant | | 1 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | | 1 | Mediastinum, Carcinoma, Metastatic, | | | Mammary Gland | | 1 | |__________________________________________________________________________|____________| Nose | + + + | 53 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Nephroblastoma | | 1 | Stromal Nephroma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 52 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7| DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2| | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X X X X| Hepatocellular Adenoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Mesentery | + + + | |__________________________________________________________________________| Oral Mucosa | + | Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Acinus, Adenoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 64 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7| DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2| | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tooth | + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Schwannoma Benign | X | Schwannoma Malignant | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Complex | X | Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + M + + M + + + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X X X | C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7| DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2| | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + M + + + + +| Lymphoma Malignant | | Sarcoma Stromal, Metastatic, Uterus | X | |__________________________________________________________________________| Oviduct | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X X X X X| Sarcoma Stromal | X | Cervix, Sarcoma Stromal | | Cervix, Schwannoma Malignant | X | |__________________________________________________________________________| Vagina | + | Sarcoma Stromal, Metastatic, Uterus | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node | + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Thymus | + + + + + + M + + + + + + M M + + + M + M + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7| DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2| | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Fibroadenoma | X X X X X X X X X X X X | Fibroadenoma, Multiple | X X X X X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X | Medulloblastoma Mal | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | | Lymphoma Malignant | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Peritracheal Tissue, Schwannoma | | Malignant, Metastatic, Heart | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7| DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2| | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Stromal Nephroma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 68 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6| DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4| | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X | Hepatocellular Adenoma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + + | |__________________________________________________________________________| Oral Mucosa | + | Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Acinus, Adenoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 69 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6| DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4| | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tooth | + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Schwannoma Benign | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Complex | | Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X X X X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6| DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4| | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Sarcoma Stromal, Metastatic, Uterus | | |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X | Sarcoma Stromal | | Cervix, Sarcoma Stromal | X | Cervix, Schwannoma Malignant | | |__________________________________________________________________________| Vagina | | Sarcoma Stromal, Metastatic, Uterus | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node | + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + + + + + M + M + + M + + + + + M M + + + M + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6| DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4| | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Fibroadenoma | X X X X X X X X X X X X| Fibroadenoma, Multiple | X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | Medulloblastoma Mal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Peritracheal Tissue, Schwannoma | | Malignant, Metastatic, Heart | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 72 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6| DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4| | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Stromal Nephroma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 73 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Cholangiocarcinoma | | 5 | Hepatocellular Adenoma | | 2 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + | 7 | |__________________________________________________________________________|____________| Oral Mucosa | | 2 | Gingival, Squamous Cell Carcinoma | | 2 | |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Lymphoma Malignant | | 1 | Acinus, Adenoma | | 2 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 52 | Carcinoma | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 74 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Forestomach | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Tooth | + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | Lymphoma Malignant | | 1 | Schwannoma Benign | | 1 | Schwannoma Malignant | | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Carcinoma | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Pheochromocytoma Complex | | 1 | Pheochromocytoma Benign | | 2 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Pars Distalis, Adenoma | X X | 22 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 75 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | Bilateral, C-Cell, Adenoma | | 3 | C-Cell, Adenoma | X X | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | |__________________________________________________________________________|____________| Ovary | + + + | 52 | Lymphoma Malignant | | 1 | Sarcoma Stromal, Metastatic, Uterus | | 1 | |__________________________________________________________________________|____________| Oviduct | | 1 | |__________________________________________________________________________|____________| Uterus | + + + | 53 | Polyp Stromal | | 8 | Sarcoma Stromal | | 1 | Cervix, Sarcoma Stromal | | 1 | Cervix, Schwannoma Malignant | | 1 | |__________________________________________________________________________|____________| Vagina | | 1 | Sarcoma Stromal, Metastatic, Uterus | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 76 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Lymph Node | | 4 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 52 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Spleen | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Thymus | M + + | 41 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Adenoma | | 1 | Fibroadenoma | X X | 26 | Fibroadenoma, Multiple | X | 13 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Fibrous Histiocytoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Astrocytoma Malignant | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 77 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | | | | Medulloblastoma Mal | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Cystic Keratinizing Epithelioma | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Nose | + + + | 52 | |__________________________________________________________________________|____________| Trachea | + + + | 53 | Peritracheal Tissue, Schwannoma | | | Malignant, Metastatic, Heart | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | |__________________________________________________________________________|____________| Eye | + + + | 53 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | |__________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Lymphoma Malignant | | 1 | Stromal Nephroma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 52 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 78 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | _____________________________________________________________________________________________________________________ T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 79 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2| | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + M + + + + + + + +| Cholangiocarcinoma | X X | Cholangiocarcinoma, Multiple | X X X| Cholangioma | | Hepatocellular Adenoma | X X | |__________________________________________________________________________| Mesentery | + + + + + + +| Sarcoma, Metastatic, Kidney | X | Sarcoma Stromal, Metastatic, Uterus | | |__________________________________________________________________________| Oral Mucosa | + + + + +| Gingival, Squamous Cell Carcinoma | X| |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + M + + + + + + + +| Sarcoma Stromal, Metastatic, Uterus | | |__________________________________________________________________________| Salivary Glands | + + M + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 80 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2| | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tooth | + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + M + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + M + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +| Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + M + M + + + + + + M + M + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X| Pars Distalis, Adenoma, Multiple | X | Pars Distalis, Carcinoma | | |__________________________________________________________________________| Thyroid Gland | + + M + M + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | Carcinoma | X | __________________________________________|__________________________________________________________________________| Page 81 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2| | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + M + + + + + + + +| Cystadenoma | X| |__________________________________________________________________________| Oviduct | + + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + M + + + + + + + +| Adenoma | | Carcinoma | X | Polyp Stromal | X | Sarcoma Stromal | | Schwannoma Malignant | | Squamous Cell Papilloma | | Cervix, Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + | Lumbar, Sarcoma Stromal, Metastatic, | | Uterus | | Mediastinal, Carcinoma, Metastatic, | | Thyroid Gland | X | Pancreatic, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + M + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + M + + + + + + + +| Sarcoma Stromal, Metastatic, Uterus | | |__________________________________________________________________________| Thymus | + + + + M + M + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| Page 82 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2| | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Carcinoma | X | Fibroadenoma | X X X X X X X X X X | Fibroadenoma, Multiple | X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | X | Squamous Cell Carcinoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + M + + + + + + + + + + + M + + + + + + + +| Adenocarcinoma, Mucinous | X | Cystic Keratinizing Epithelioma | X X | Cystic Keratinizing Epithelioma, | | Multiple | X X | Sarcoma, Metastatic, Kidney | X | Sarcoma Stromal, Metastatic, Uterus | | Squamous Cell Carcinoma | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + M + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 83 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2| | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Eye | + + M + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + M + + + + + + + +| Stromal Nephroma | X | Transitional Epithelium, Carcinoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 84 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2| | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + M + + + + + + + + + +| Cholangiocarcinoma | | Cholangiocarcinoma, Multiple | X | Cholangioma | X | Hepatocellular Adenoma | X | |__________________________________________________________________________| Mesentery | + + + + + | Sarcoma, Metastatic, Kidney | | Sarcoma Stromal, Metastatic, Uterus | X | |__________________________________________________________________________| Oral Mucosa | + | Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma Stromal, Metastatic, Uterus | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 85 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2| | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + M| Adenoma | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X| Pars Distalis, Adenoma, Multiple | | Pars Distalis, Carcinoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X X X| C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | | Carcinoma | | __________________________________________|__________________________________________________________________________| Page 86 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2| | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Polyp Stromal | X X X | Sarcoma Stromal | X | Schwannoma Malignant | X | Squamous Cell Papilloma | X | Cervix, Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | Lumbar, Sarcoma Stromal, Metastatic, | | Uterus | X | Mediastinal, Carcinoma, Metastatic, | | Thyroid Gland | | Pancreatic, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma Stromal, Metastatic, Uterus | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| Page 87 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2| | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Fibroadenoma | X X X X X X X X X X X X X | Fibroadenoma, Multiple | X X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Squamous Cell Carcinoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Mucinous | | Cystic Keratinizing Epithelioma | X | Cystic Keratinizing Epithelioma, | | Multiple | X X X X X | Sarcoma, Metastatic, Kidney | | Sarcoma Stromal, Metastatic, Uterus | X | Squamous Cell Carcinoma | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 88 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2| | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Stromal Nephroma | | Transitional Epithelium, Carcinoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 89 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 51 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 51 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 51 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | |__________________________________________________________________________|____________| Liver | + + + | 51 | Cholangiocarcinoma | | 2 | Cholangiocarcinoma, Multiple | | 4 | Cholangioma | | 1 | Hepatocellular Adenoma | X | 4 | |__________________________________________________________________________|____________| Mesentery | + | 13 | Sarcoma, Metastatic, Kidney | | 1 | Sarcoma Stromal, Metastatic, Uterus | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | | 6 | Gingival, Squamous Cell Carcinoma | | 2 | |__________________________________________________________________________|____________| Pancreas | + + + | 52 | Sarcoma Stromal, Metastatic, Uterus | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 51 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 90 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Forestomach | + + + | 51 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 51 | |__________________________________________________________________________|____________| Tooth | + + | 9 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 51 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 52 | Adenoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 52 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | | 4 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 52 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 47 | Adenoma | | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Pars Distalis, Adenoma | X | 13 | Pars Distalis, Adenoma, Multiple | | 1 | Pars Distalis, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 91 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Bilateral, C-Cell, Adenoma | | 2 | C-Cell, Adenoma | X | 10 | C-Cell, Carcinoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 52 | |__________________________________________________________________________|____________| Ovary | + + + | 52 | Cystadenoma | | 1 | |__________________________________________________________________________|____________| Oviduct | | 3 | |__________________________________________________________________________|____________| Uterus | + + + | 52 | Adenoma | | 1 | Carcinoma | | 1 | Polyp Stromal | X | 5 | Sarcoma Stromal | X | 2 | Schwannoma Malignant | | 1 | Squamous Cell Papilloma | | 1 | Cervix, Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | + | 7 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 92 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Lumbar, Sarcoma Stromal, Metastatic, | | | Uterus | | 1 | Mediastinal, Carcinoma, Metastatic, | | | Thyroid Gland | | 1 | Pancreatic, Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 51 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 51 | |__________________________________________________________________________|____________| Spleen | + + + | 52 | Sarcoma Stromal, Metastatic, Uterus | | 1 | |__________________________________________________________________________|____________| Thymus | + + + | 49 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 52 | Carcinoma | | 1 | Fibroadenoma | X | 24 | Fibroadenoma, Multiple | | 5 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Fibrous Histiocytoma | | 1 | Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 93 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | | | | Brain | + + + | 53 | Carcinoma, Metastatic, Pituitary | | | Gland | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 51 | Adenocarcinoma, Mucinous | | 1 | Cystic Keratinizing Epithelioma | | 3 | Cystic Keratinizing Epithelioma, | | | Multiple | X | 8 | Sarcoma, Metastatic, Kidney | | 1 | Sarcoma Stromal, Metastatic, Uterus | | 1 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + | 53 | |__________________________________________________________________________|____________| Trachea | + + + | 52 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 52 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 52 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 52 | Stromal Nephroma | | 1 | Transitional Epithelium, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 52 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 94 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | _____________________________________________________________________________________________________________________ T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 95 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X X X | Cholangiocarcinoma, Multiple | X X X X X X X | Cholangioma | | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X | Hepatocholangioma | X X | Hepatocholangioma, Multiple | X | Leukemia Mononuclear | | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + | Lymphoma Malignant | X | |__________________________________________________________________________| Oral Mucosa | + + | Gingival, Squamous Cell Carcinoma | X X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 96 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Acinus, Carcinoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Tooth | + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Lymphoma Malignant | X | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + M + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + M + + M + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M M M + + + M + + + M + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 97 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | X | Pars Distalis, Adenoma | X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + A + + + + + + + + M + + + + + + A + + + +| Adenoma | X | C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Oviduct | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma, Multiple | | Lymphoma Malignant | X | Polyp Stromal | X X X | |__________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node | + + + + | Mediastinal, Lymphoma Malignant | X | Pancreatic, Lymphoma Malignant | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 98 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Spleen | + M + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + + + M + + M + + + + + M + + + M + + + + + M +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Fibroadenoma | X X X | Lymphoma Malignant | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 99 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lung | + + + + + + + + + + + + + M + + + + + + + + + + +| Carcinoma, Metastatic, Adrenal Cortex| X | Cystic Keratinizing Epithelioma | X X X | Cystic Keratinizing Epithelioma, | | Multiple | X X X X X X X X X X X X X X X| Lymphoma Malignant | X | Squamous Cell Carcinoma | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + M + + + + + + + + + + +| Optic Nerve, Squamous Cell Carcinoma,| | Metastatic, Oral Mucosa | X | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Nephroblastoma | X | Stromal Nephroma | | |__________________________________________________________________________| Ureter | + + + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 100 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________|__________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 101 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6| DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1| | 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X X X X | Cholangiocarcinoma, Multiple | X X X X X X| Cholangioma | X | Hepatocellular Adenoma | X X | Hepatocellular Adenoma, Multiple | | Hepatocholangioma | | Hepatocholangioma, Multiple | | Leukemia Mononuclear | X | Lymphoma Malignant | | |__________________________________________________________________________| Mesentery | + +| Lymphoma Malignant | | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X X X X X| |__________________________________________________________________________| Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 102 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6| DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1| | 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Acinus, Carcinoma | | |__________________________________________________________________________| Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Tooth | + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Lymphoma Malignant | | |__________________________________________________________________________| Heart | + + + M + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + M + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 103 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6| DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1| | 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | | Pars Distalis, Adenoma | X X | |__________________________________________________________________________| Thyroid Gland | + + + M + + A + + + + + + + + + + + + + + + + + +| Adenoma | | C-Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma, Multiple | X | Lymphoma Malignant | | Polyp Stromal | X | |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node | + + + + + + + +| Mediastinal, Lymphoma Malignant | | Pancreatic, Lymphoma Malignant | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 104 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6| DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1| | 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant | | |__________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + M + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Fibroadenoma | X X X X X X X X| Lymphoma Malignant | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 105 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6| DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1| | 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lung | + + + M + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Adrenal Cortex| | Cystic Keratinizing Epithelioma | X X | Cystic Keratinizing Epithelioma, | | Multiple | X X X X X X X X X X X X X X| Lymphoma Malignant | | Squamous Cell Carcinoma | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Optic Nerve, Squamous Cell Carcinoma,| | Metastatic, Oral Mucosa | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Nephroblastoma | X | Stromal Nephroma | X | |__________________________________________________________________________| Ureter | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 106 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________|__________________________________________________________________________ | 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6| DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1| | 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 107 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 6| 2| 5| | | DAY ON TEST | 0| 4| 7| | | | 3| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| | A | 1000 | 4| 4| 4| | L | NG/KG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Cholangiocarcinoma | | 7 | Cholangiocarcinoma, Multiple | X X | 15 | Cholangioma | | 1 | Hepatocellular Adenoma | | 6 | Hepatocellular Adenoma, Multiple | | 1 | Hepatocholangioma | | 2 | Hepatocholangioma, Multiple | | 1 | Leukemia Mononuclear | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | | 11 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | | 11 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 108 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 6| 2| 5| | | DAY ON TEST | 0| 4| 7| | | | 3| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| | A | 1000 | 4| 4| 4| | L | NG/KG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Gingival, Squamous Cell Carcinoma | | 7 | |__________________________________________________________________________|____________| Pancreas | + + + | 51 | Lymphoma Malignant | | 1 | Acinus, Carcinoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 51 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Tooth | + | 19 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | Aorta, Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Heart | + + + | 51 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Adenoma | | 2 | Carcinoma | | 2 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 109 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 6| 2| 5| | | DAY ON TEST | 0| 4| 7| | | | 3| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| | A | 1000 | 4| 4| 4| | L | NG/KG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Medulla | + + + | 53 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 51 | Adenoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 46 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | | 1 | Pars Distalis, Adenoma | | 6 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 48 | Adenoma | | 1 | C-Cell, Adenoma | X | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 51 | |__________________________________________________________________________|____________| Ovary | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Oviduct | | 1 | |__________________________________________________________________________|____________| Uterus | + + + | 53 | Adenoma, Multiple | | 1 | Lymphoma Malignant | | 1 | Polyp Stromal | | 4 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 110 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 6| 2| 5| | | DAY ON TEST | 0| 4| 7| | | | 3| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| | A | 1000 | 4| 4| 4| | L | NG/KG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node | | 12 | Mediastinal, Lymphoma Malignant | | 1 | Pancreatic, Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 51 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Spleen | + + + | 52 | Leukemia Mononuclear | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Thymus | M M + | 44 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Carcinoma | | 1 | Fibroadenoma | | 11 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 111 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 6| 2| 5| | | DAY ON TEST | 0| 4| 7| | | | 3| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| | A | 1000 | 4| 4| 4| | L | NG/KG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Skin | + + + | 53 | Keratoacanthoma | | 1 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 51 | Carcinoma, Metastatic, Adrenal Cortex| | 1 | Cystic Keratinizing Epithelioma | | 5 | Cystic Keratinizing Epithelioma, | | | Multiple | X | 30 | Lymphoma Malignant | | 1 | Squamous Cell Carcinoma | | 2 | |__________________________________________________________________________|____________| Nose | + + + | 53 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Trachea | + + + | 52 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 112 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 6| 2| 5| | | DAY ON TEST | 0| 4| 7| | | | 3| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| | A | 1000 | 4| 4| 4| | L | NG/KG | 4| 6| 7| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Ear | | 2 | |__________________________________________________________________________|____________| Eye | + + + | 52 | Optic Nerve, Squamous Cell Carcinoma,| | | Metastatic, Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 52 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Lymphoma Malignant | | 1 | Nephroblastoma | | 2 | Stromal Nephroma | | 1 | |__________________________________________________________________________|____________| Ureter | | 3 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | Leukemia Mononuclear | | 1 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 113 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 2| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| 4| DAY ON TEST | 2| 8| 0| 2| 2| 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 5| 9| 2| 3| 1| | 7| 4| 2| 7| 7| 8| 7| 1| 7| 4| 7| 8| 8| 8| 8| 9| 7| 8| 9| 9| 9| 2| 8| 7| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X | |__________________________________________________________________________| Oral Mucosa | + + + + | Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 114 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 2| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| 4| DAY ON TEST | 2| 8| 0| 2| 2| 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 5| 9| 2| 3| 1| | 7| 4| 2| 7| 7| 8| 7| 1| 7| 4| 7| 8| 8| 8| 8| 9| 7| 8| 9| 9| 9| 2| 8| 7| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | Bilateral, Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | M + + + + + + + + M + + + + M + + M + + + + + + M| Adenoma | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + M| Bilateral, C-Cell, Adenoma | X X X X | C-Cell, Adenoma | X X X X X X X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa-Theca Tumor Benign | X | |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________|__________________________________________________________________________| Page 115 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 2| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| 4| DAY ON TEST | 2| 8| 0| 2| 2| 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 5| 9| 2| 3| 1| | 7| 4| 2| 7| 7| 8| 7| 1| 7| 4| 7| 8| 8| 8| 8| 9| 7| 8| 9| 9| 9| 2| 8| 7| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | | Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + M M + + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Fibroadenoma | X X X X X X X X X | Fibroadenoma, Multiple | X X X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 116 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 _____________________________________________________________________________________________________________________ | 7| 2| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| 4| DAY ON TEST | 2| 8| 0| 2| 2| 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 5| 9| 2| 3| 1| | 7| 4| 2| 7| 7| 8| 7| 1| 7| 4| 7| 8| 8| 8| 8| 9| 7| 8| 9| 9| 9| 2| 8| 7| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 117 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 4| 3| 3| 7| 7| 6| 7| 5| 6| 7| 6| 7| 5| 7| 7| 3| 6| 5| 5| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 5| 2| 3| 2| 2| 1| 2| 5| 2| 2| 6| 2| 7| 2| 2| 2| 1| 3| 9| 2| 2| 1| 2| 2| | | 7| 4| 0| 7| 8| 9| 8| 7| 4| 5| 8| 0| 9| 4| 8| 7| 8| 8| 7| 3| 9| 7| 1| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| A | 1000 NG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma | X | 2 | |__________________________________________________________________________|____________| Oral Mucosa | + + | 6 | Gingival, Squamous Cell Carcinoma | X | 2 | |__________________________________________________________________________|____________| Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tooth | + + + + + + + | 12 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 118 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 4| 3| 3| 7| 7| 6| 7| 5| 6| 7| 6| 7| 5| 7| 7| 3| 6| 5| 5| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 5| 2| 3| 2| 2| 1| 2| 5| 2| 2| 6| 2| 7| 2| 2| 2| 1| 3| 9| 2| 2| 1| 2| 2| | | 7| 4| 0| 7| 8| 9| 8| 7| 4| 5| 8| 0| 9| 4| 8| 7| 8| 8| 7| 3| 9| 7| 1| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| A | 1000 NG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | | | | Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 2 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | X X | 2 | Bilateral, Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X| 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 44 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | Pars Distalis, Adenoma | X X X X X X X X | 17 | |__________________________________________________________________________|____________| Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 | Bilateral, C-Cell, Adenoma | X | 5 | C-Cell, Adenoma | X X X X | 11 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 119 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 4| 3| 3| 7| 7| 6| 7| 5| 6| 7| 6| 7| 5| 7| 7| 3| 6| 5| 5| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 5| 2| 3| 2| 2| 1| 2| 5| 2| 2| 6| 2| 7| 2| 2| 2| 1| 3| 9| 2| 2| 1| 2| 2| | | 7| 4| 0| 7| 8| 9| 8| 7| 4| 5| 8| 0| 9| 4| 8| 7| 8| 8| 7| 3| 9| 7| 1| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| A | 1000 NG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Clitoral Gland | + M + M + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa-Theca Tumor Benign | | 1 | |__________________________________________________________________________|____________| Oviduct | + | 2 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Polyp Stromal | X X X| 5 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + | 2 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Thymus | + M + M + + + + + + + + + + + + + + M + + + + + +| 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X X X | 4 | Fibroadenoma | X X X X X X | 15 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 120 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 4| 3| 3| 7| 7| 6| 7| 5| 6| 7| 6| 7| 5| 7| 7| 3| 6| 5| 5| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 5| 2| 3| 2| 2| 1| 2| 5| 2| 2| 6| 2| 7| 2| 2| 2| 1| 3| 9| 2| 2| 1| 2| 2| | | 7| 4| 0| 7| 8| 9| 8| 7| 4| 5| 8| 0| 9| 4| 8| 7| 8| 8| 7| 3| 9| 7| 1| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| A | 1000 NG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Fibroadenoma, Multiple | X X X X X | 13 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Mammary Gland | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 121 NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:42:15 __________________________________________________________________________________________________________________________________ | 7| 4| 3| 3| 7| 7| 6| 7| 5| 6| 7| 6| 7| 5| 7| 7| 3| 6| 5| 5| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 5| 2| 3| 2| 2| 1| 2| 5| 2| 2| 6| 2| 7| 2| 2| 2| 1| 3| 9| 2| 2| 1| 2| 2| | | 7| 4| 0| 7| 8| 9| 8| 7| 4| 5| 8| 0| 9| 4| 8| 7| 8| 8| 7| 3| 9| 7| 1| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| A | 1000 NG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 122 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------