TDMS Study 96007-01 Pathology Tables
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
FINAL #3/RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57465-28-8
Lock Date: 01/09/01
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25018 Dosing Accident
25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 NG/KG
Include 003 30 NG/KG
Include 004 100 NG/KG
Include 005 175 NG/KG
Include 006 300 NG/KG
Include 007 550 NG/KG
Include 008 1000 NG/KG
Include 009 1000 NG/KG/STOP
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 30 NG/KG 100 175 300 550
NG/KG NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 98 98 98 98 98 98
Early Deaths
Moribund Sacrifice 25 18 21 19 27 18
Natural Death 10 9 6 11 9 12
Accidently Killed 1 3
Dosing Accident 2 1 1
Survivors
Natural Death 1 1
Terminal Sacrifice 15 24 25 22 16 23
Animals Examined Microscopically 53 55 53 53 53 53
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (52) (55) (53) (53) (53) (51)
Serosa, Carcinoma, Metastatic, Uterus 1 (2%)
Intestine Large, Rectum (52) (55) (53) (52) (53) (52)
Intestine Small, Duodenum (52) (55) (52) (53) (53) (51)
Intestine Small, Jejunum (52) (54) (53) (53) (53) (51)
Leiomyosarcoma 2 (4%)
Serosa, Carcinoma, Metastatic, Uterus 1 (2%)
Intestine Small, Ileum (52) (54) (52) (51) (53) (52)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Serosa, Carcinoma, Metastatic, Uterus 1 (2%)
Liver (53) (55) (53) (53) (53) (51)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Cholangiocarcinoma 1 (2%) 5 (9%) 2 (4%)
Cholangiocarcinoma, Multiple 4 (8%)
Cholangioma 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 2 (4%) 1 (2%) 2 (4%) 4 (8%)
Schwannoma Malignant, Metastatic, Heart 1 (2%)
Mesentery (1) (4) (2) (7) (13)
Carcinoma, Metastatic, Islets, Pancreatic 1 (25%)
Sarcoma, Metastatic, Kidney 1 (8%)
Sarcoma Stromal, Metastatic, Uterus 1 (8%)
Oral Mucosa (1) (1) (3) (4) (2) (6)
Gingival, Squamous Cell Carcinoma 1 (100%) 1 (33%) 1 (25%) 2 (100%) 2 (33%)
Pancreas (51) (55) (53) (53) (53) (52)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Page 2
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 30 NG/KG 100 175 300 550
NG/KG NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Acinus, Adenoma 1 (2%) 2 (4%)
Acinus, Carcinoma 1 (2%)
Salivary Glands (51) (54) (53) (51) (52) (51)
Carcinoma 1 (2%)
Stomach, Forestomach (52) (55) (53) (53) (53) (51)
Serosa, Carcinoma, Metastatic, Uterus 1 (2%)
Stomach, Glandular (51) (53) (53) (53) (53) (51)
Schwannoma Malignant, Metastatic, Heart 1 (2%)
Serosa, Carcinoma, Metastatic, Uterus 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (53) (55) (53) (53) (53) (53)
Heart (52) (54) (53) (53) (53) (51)
Schwannoma Benign 1 (2%)
Schwannoma Malignant 1 (2%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (52) (55) (53) (53) (53) (52)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (2%)
Schwannoma Malignant, Metastatic, Heart 1 (2%)
Adrenal Medulla (52) (55) (53) (53) (53) (52)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 8 (15%) 3 (5%) 4 (8%) 2 (4%) 2 (4%) 4 (8%)
Schwannoma Malignant, Metastatic, Heart 1 (2%)
Islets, Pancreatic (52) (54) (53) (53) (53) (52)
Adenoma 2 (4%) 1 (2%)
Carcinoma 1 (2%)
Parathyroid Gland (47) (50) (48) (46) (49) (47)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (51) (54) (53) (53) (53) (53)
Sarcoma, Metastatic, Brain 1 (2%)
Pars Distalis, Adenoma 14 (27%) 18 (33%) 20 (38%) 16 (30%) 22 (42%) 13 (25%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (2%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 2 (4%) 1 (2%)
Thyroid Gland (52) (55) (52) (51) (52) (50)
Bilateral, C-Cell, Adenoma 3 (6%) 4 (7%) 3 (6%) 2 (4%) 3 (6%) 2 (4%)
Page 3
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 30 NG/KG 100 175 300 550
NG/KG NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
C-Cell, Adenoma 12 (23%) 11 (20%) 12 (23%) 11 (22%) 9 (17%) 10 (20%)
C-Cell, Carcinoma 1 (2%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (52) (54) (53) (52) (52) (52)
Cystadenoma 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Granulosa-Theca Tumor Malignant 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Uterus (52) (55) (53) (52) (53) (52)
Adenoma 1 (2%)
Carcinoma 3 (5%) 1 (2%) 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%)
Polyp Stromal 4 (8%) 5 (9%) 7 (13%) 3 (6%) 8 (15%) 5 (10%)
Sarcoma Stromal 1 (2%) 1 (2%) 2 (4%)
Sarcoma Stromal, Multiple 1 (2%)
Schwannoma Malignant 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Cervix, Sarcoma Stromal 1 (2%)
Cervix, Schwannoma Malignant 1 (2%) 1 (2%)
Vagina (1) (1) (1)
Sarcoma 1 (100%)
Sarcoma Stromal, Metastatic, Uterus 1 (100%)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (53) (55) (53) (53) (53) (53)
Lymph Node (2) (6) (6) (6) (4) (7)
Lumbar, Sarcoma Stromal, Metastatic, Uterus 1 (14%)
Mediastinal, Carcinoma, Metastatic, Islets,
Pancreatic 1 (17%)
Mediastinal, Carcinoma, Metastatic, Thyroid
Gland 1 (14%)
Page 4
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 30 NG/KG 100 175 300 550
NG/KG NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Renal, Nephroblastoma, Metastatic, Kidney 1 (50%)
Lymph Node, Mandibular (52) (53) (51) (51) (52) (51)
Osteosarcoma, Metastatic, Bone 1 (2%)
Lymph Node, Mesenteric (52) (54) (52) (52) (53) (51)
Hemangiosarcoma 1 (2%)
Spleen (52) (55) (52) (53) (53) (52)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Schwannoma Malignant, Metastatic, Heart 1 (2%)
Capsule, Carcinoma, Metastatic, Uterus 1 (2%)
Thymus (50) (52) (46) (48) (41) (49)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (52) (55) (53) (53) (53) (52)
Adenoma 2 (4%) 2 (4%) 1 (2%)
Carcinoma 5 (10%) 6 (11%) 9 (17%) 4 (8%) 1 (2%)
Carcinoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Fibroadenoma 18 (35%) 17 (31%) 21 (40%) 21 (40%) 26 (49%) 24 (46%)
Fibroadenoma, Multiple 21 (40%) 14 (25%) 14 (26%) 17 (32%) 13 (25%) 5 (10%)
Skin (52) (55) (53) (53) (53) (53)
Fibroma 1 (2%) 1 (2%)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (53) (55) (53) (53) (53) (53)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (1)
Carcinoma, Metastatic, Islets, Pancreatic 1 (100%)
Rhabdomyosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 30 NG/KG 100 175 300 550
NG/KG NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (53) (55) (53) (53) (53) (53)
Astrocytoma Malignant 2 (4%) 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%)
Medulloblastoma Mal 1 (2%) 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Meninges, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (53) (55) (53) (53) (53) (51)
Adenocarcinoma, Mucinous 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%) 1 (2%) 1 (2%)
Cystic Keratinizing Epithelioma 1 (2%) 3 (6%)
Cystic Keratinizing Epithelioma, Multiple 8 (16%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Sarcoma, Metastatic, Kidney 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Schwannoma Malignant, Metastatic, Heart 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
Mediastinum, Carcinoma, Metastatic, Mammary
Gland 1 (2%)
Nose (53) (54) (52) (53) (52) (53)
Osteosarcoma, Metastatic, Bone 1 (2%)
Trachea (53) (55) (53) (53) (53) (52)
Peritracheal Tissue, Schwannoma Malignant,
Metastatic, Heart 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 30 NG/KG 100 175 300 550
NG/KG NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (53) (55) (53) (53) (53) (52)
Hemangiosarcoma 1 (2%)
Nephroblastoma 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Schwannoma Malignant, Metastatic, Heart 1 (2%)
Stromal Nephroma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (51) (54) (53) (52) (52) (52)
Serosa, Carcinoma, Metastatic, Uterus 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(53) *(55) *(53) *(53) *(53) *(53)
Leukemia Granulocytic 1 (2%)
Lymphoma Malignant 2 (4%) 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 7
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 30 NG/KG 100 175 300 550
NG/KG NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 51 51 47 49 50
Total Primary Neoplasms 103 104 113 93 110 111
Total Animals with Benign Neoplasms 45 45 48 45 46 45
Total Benign Neoplasms 89 81 89 75 90 85
Total Animals with Malignant Neoplasms 13 19 18 15 16 23
Total Malignant Neoplasms 14 23 24 18 20 26
Total Animals with Metastatic Neoplasms 3 3 3 3 2 4
Total Metastatic Neoplasm 6 9 14 4 3 9
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 8
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 1000 1000 NG/
NG/KG KG/STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 98 50
Early Deaths
Natural Death 12 6
Moribund Sacrifice 34 15
Dosing Accident 1
Survivors
Terminal Sacrifice 7 28
Animals Examined Microscopically 53 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (53) (50)
Intestine Small, Duodenum (53) (50)
Intestine Small, Jejunum (53) (50)
Liver (53) (50)
Cholangiocarcinoma 7 (13%) 2 (4%)
Cholangiocarcinoma, Multiple 15 (28%)
Cholangioma 1 (2%)
Hepatocellular Adenoma 6 (11%)
Hepatocellular Adenoma, Multiple 1 (2%)
Hepatocholangioma 2 (4%)
Hepatocholangioma, Multiple 1 (2%)
Mesentery (11)
Oral Mucosa (11) (6)
Gingival, Squamous Cell Carcinoma 7 (64%) 2 (33%)
Pancreas (51) (48)
Acinus, Carcinoma 1 (2%)
Salivary Glands (51) (49)
Stomach, Forestomach (53) (50)
Stomach, Glandular (53) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (53) (50)
Heart (51) (50)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 1000 1000 NG/
NG/KG KG/STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (53) (50)
Adenoma 2 (4%) 2 (4%)
Carcinoma 2 (4%) 1 (2%)
Adrenal Medulla (53) (50)
Pheochromocytoma Benign 2 (4%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (51) (50)
Adenoma 1 (2%) 1 (2%)
Parathyroid Gland (46) (44)
Adenoma 1 (2%)
Pituitary Gland (53) (48)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
Pars Distalis, Adenoma 6 (11%) 17 (35%)
Thyroid Gland (48) (47)
Adenoma 1 (2%)
Bilateral, C-Cell, Adenoma 5 (11%)
C-Cell, Adenoma 9 (19%) 11 (23%)
C-Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (53) (50)
Granulosa-Theca Tumor Benign 1 (2%)
Uterus (53) (50)
Adenoma 1 (2%)
Adenoma, Multiple 1 (2%)
Polyp Stromal 4 (8%) 5 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (53) (50)
Lymph Node (12) (2)
Lymph Node, Mandibular (51) (49)
Lymph Node, Mesenteric (53) (50)
Page 10
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 1000 1000 NG/
NG/KG KG/STOP
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Spleen (52) (50)
Thymus (44) (43)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (53) (50)
Carcinoma 1 (2%) 4 (8%)
Fibroadenoma 11 (21%) 15 (30%)
Fibroadenoma, Multiple 13 (26%)
Skin (53) (50)
Keratoacanthoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (53) (50)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (53) (50)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (51) (50)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Carcinoma, Metastatic, Adrenal Cortex 1 (2%)
Cystic Keratinizing Epithelioma 5 (10%)
Cystic Keratinizing Epithelioma, Multiple 30 (59%)
Squamous Cell Carcinoma 2 (4%)
Nose (53) (50)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 1000 1000 NG/
NG/KG KG/STOP
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (52) (50)
Optic Nerve, Squamous Cell Carcinoma,
Metastatic, Oral Mucosa 1 (2%)
Harderian Gland (52) (50)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (53) (50)
Nephroblastoma 2 (4%)
Stromal Nephroma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(53) *(50)
Leukemia Mononuclear 1 (2%)
Lymphoma Malignant 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:43:31
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 1000 1000 NG/
NG/KG KG/STOP
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 44
Total Primary Neoplasms 123 89
Total Animals with Benign Neoplasms 42 41
Total Benign Neoplasms 82 76
Total Animals with Malignant Neoplasms 33 12
Total Malignant Neoplasms 41 13
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 5 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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