TDMS Study 96007-01 Pathology Tables
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 FINAL #3/RATS Facility: Battelle Columbus Laboratory Chemical CAS #: 57465-28-8 Lock Date: 01/09/01 Cage Range: All Reasons For Removal: 25022 Accidently Killed 25018 Dosing Accident 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 001 0 NG/KG Include 003 30 NG/KG Include 004 100 NG/KG Include 005 175 NG/KG Include 006 300 NG/KG Include 007 550 NG/KG Include 008 1000 NG/KG Include 009 1000 NG/KG/STOP Page 1 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2| DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0| | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6| | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 1 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 | Basophilic Focus | X | Basophilic Focus, Multiple | X | Clear Cell Focus | X | Clear Cell Focus, Multiple | | Eosinophilic Focus | X | Eosinophilic Focus, Multiple | X X X | Fatty Change, Diffuse | 1 1 1 | Fatty Change, Focal | 2 1 | Hepatodiaphragmatic Nodule | | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 | Mixed Cell Focus | X | Mixed Cell Focus, Multiple | X X X X X X X | Necrosis | 2 3 | Pigmentation | 1 | Bile Duct, Cyst | 1 | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 1 1 | __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2| DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0| | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6| | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Hepatocyte, Degeneration | 2 | |__________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | 4 | |__________________________________________________________________________| Oral Mucosa | | Gingival, Hyperplasia, Squamous | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| Inflammation, Chronic Active | 3 1 1 1 | Acinus, Atrophy | 2 2 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 3 | Hyperplasia, Squamous | 1 2 | Inflammation, Acute | | Mineralization | 2| Ulcer | 2 2 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | Mineralization | 2 | |__________________________________________________________________________| Tooth | + + + | Peridontal Tissue, Inflammation, | | Chronic Active | 3 | Peridontal Tissue, Inflammation, | | Suppurative | 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | 2 1 1 | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2| DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0| | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6| | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | Cardiomyopathy | 1 1 1 1 1| Degeneration | | Mineralization | 2 | Thrombosis | 2 | Epicardium, Inflammation, Suppurative| 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 1 2 | Atrophy | | Degeneration, Cystic | 2 2 2 2 3 | Hyperplasia | 2 2 1 1 3 1 1 2 2 2 2 2 2 | Hypertrophy | 2 2 2 3 1 2 1 2 2 2 2 3 3 1 2 2 1 | Mineralization | | Necrosis | 2 | Vacuolization Cytoplasmic | 1 2 1 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 1 2 3 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | |__________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 2 2 2 3 2 4 2 | Pars Distalis, Hyperplasia | 3 2 2 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| C-Cell, Hyperplasia | 1 2 3 | Follicular Cell, Hypertrophy | 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2| DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0| | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6| | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + M + + + M + + + + + + + + + + + + +| Inflammation | 1 1 2 2 2 2 2 | Duct, Cyst | 1 1 1 2 2 2 2 2 3 2 3 1 2 1 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 | Cyst | 2 2 2 2 2 2 2 | |__________________________________________________________________________| Oviduct | + | Inflammation, Suppurative | 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Granulomatous | 2 | Inflammation, Suppurative | 2 1 3 1 3 2 1 2 3 | Metaplasia, Squamous | 3 2 1 1 1 1 2 1 1 2 3 3 | Endometrium, Hyperplasia, Cystic | 2 2 2 1 1 3 2 3 1 1 2 | Epithelium, Hyperplasia | | |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 4 4 4 3 3 3 4 2 4 3 4 4 4 4 3 3 4 2 3 4 3 4 3 2| |__________________________________________________________________________| Lymph Node | + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | Hyperplasia, Plasma Cell | 2 2 2 3 2 3 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | | Hyperplasia, Histiocytic | 2 1 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2| DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0| | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6| | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Hematopoietic Cell Proliferation | 2 3 3 2 1 2 3 2 2 1 2 1 1 2 2 1 1 1 | Pigmentation | 2 1 1 1 2 1 1 1 2 1 1 1 1 1 2 2 1 2 1 1 1 1 2| |__________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + + + + + M + + + +| Atrophy | 4 3 2 3 4 2 3 2 2 3 3 3 3 2 2 2 2 3 2| Hemorrhage | 3 | Inflammation | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 1 1 2 | Hyperplasia | 1 1 2 1 2 1 2 2 2 1 1 1 1 1 1| Inflammation, Chronic Active | | Inflammation, Granulomatous | 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst, Squamous | 2 | Dermis, Inflammation, Focal | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | |__________________________________________________________________________| Skeletal Muscle | + | Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 1| |__________________________________________________________________________| Peripheral Nerve | + +| |__________________________________________________________________________| Spinal Cord | + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2| DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0| | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6| | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2 2 2 1 2 1| Inflammation, Chronic Active | 2 1 | Inflammation, Granulomatous | 2 | Metaplasia, Squamous | | Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 | Serosa, Inflammation, Suppurative | 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasopharyngeal Duct, Inflammation, | | Suppurative | 4 | Olfactory Epithelium, Inflammation, | | Suppurative | 3 | Respiratory Epithelium, Hyperplasia | 2 | Respiratory Epithelium, Metaplasia | 4 | Turbinate, Inflammation, Suppurative | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | Peritracheal Tissue, Inflammation | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Casts Protein | 1 | Inflammation, Chronic Active | 3 1 | Mineralization | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 4 2 1 1 1 1 2 1 1 2 1 2 1 1 1 1| Pelvis, Dilatation | 2 2 | __________________________________________|__________________________________________________________________________| Page 7 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2| DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0| | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6| | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | Pelvis, Inflammation, Suppurative | 1 | Transitional Epithelium, Hyperplasia | 2 3 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +| Inflammation | 1 1 2 | Transitional Epithelium, Hyperplasia | 2 | __________________________________________|__________________________________________________________________________ Page 8 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7| DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0| | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +| Erosion | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +| Serosa, Inflammation, Chronic Active | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X | Basophilic Focus, Multiple | X X X X| Clear Cell Focus | | Clear Cell Focus, Multiple | X | Eosinophilic Focus | X X X X X | Eosinophilic Focus, Multiple | X X | Fatty Change, Diffuse | 1 | Fatty Change, Focal | | Hepatodiaphragmatic Nodule | X | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X X | Mixed Cell Focus, Multiple | X X X X X X X X X | Necrosis | 2 2 | Pigmentation | | Bile Duct, Cyst | 2 2 | Bile Duct, Fibrosis | 1 1 1 | Bile Duct, Hyperplasia | 2 | __________________________________________|__________________________________________________________________________| Page 9 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7| DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0| | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Hepatocyte, Degeneration | 3 2| |__________________________________________________________________________| Mesentery | | Inflammation, Chronic Active | | |__________________________________________________________________________| Oral Mucosa | + | Gingival, Hyperplasia, Squamous | 2 | |__________________________________________________________________________| Pancreas | + + + + + + + + + M + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Acinus, Atrophy | 2 2| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +| Edema | | Hyperplasia, Squamous | 2| Inflammation, Acute | 1| Mineralization | | Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + M + + + + + + + + + + + + + + +| Erosion | | Mineralization | | |__________________________________________________________________________| Tooth | + + + + + + + + +| Peridontal Tissue, Inflammation, | | Chronic Active | 2 | Peridontal Tissue, Inflammation, | | Suppurative | 1 2 1 1 2 1 1 2| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 10 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7| DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0| | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | Cardiomyopathy | 1 1 1 1 | Degeneration | | Mineralization | | Thrombosis | | Epicardium, Inflammation, Suppurative| | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| Angiectasis | 2 2 2 1 1 1 2 | Atrophy | 1 | Degeneration, Cystic | 2 2 2 2 2 2| Hyperplasia | 3 3 2 2 2 1 1 2 2 | Hypertrophy | 2 1 3 3 2 2 1 2 2 1 1 2 1 2 3 3| Mineralization | 2 | Necrosis | | Vacuolization Cytoplasmic | 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + M + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 2 1 2 | Pars Distalis, Hyperplasia | 4 1 3 2 1 3 2 2 2 2 1 1| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 3 1 2 2 1 1 3 | Follicular Cell, Hypertrophy | 2 1 3 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 11 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7| DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0| | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 3 2 1 1 2 1 1 1 1 1 2 2 1 1 1 2 1 1 1 1| Duct, Cyst | 2 1 2 2 3 3 2 3 3 1 1 2 1 2| |__________________________________________________________________________| Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3| Cyst | 3 2 2 1| |__________________________________________________________________________| Oviduct | | Inflammation, Suppurative | | |__________________________________________________________________________| Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +| Inflammation, Granulomatous | | Inflammation, Suppurative | 1 1 2 | Metaplasia, Squamous | 2 1 1 2 1 1 1 1 1 3 2 2 1 | Endometrium, Hyperplasia, Cystic | 2 1 2 2 2 2 1 1 1 1 2 1 | Epithelium, Hyperplasia | 3 | |__________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 3 3 3 4 4 4 4 4 4 2 4 4 4 4 4 4 2 3| |__________________________________________________________________________| Lymph Node | + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hyperplasia, Plasma Cell | 2 2 3 2 3 2 1 2 2 3 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| Ectasia | 2 | Hemorrhage | 2 2| Hyperplasia, Histiocytic | 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 12 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7| DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0| | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Hematopoietic Cell Proliferation | 2 1 1 1 1 1 2 2 1 1 1 2 3 3 3 2 3 2| Pigmentation | 1 2 2 2 1 2 1 1 2 1 1 1 2 1 2 1 1 1 1 1 1 1 1| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| Atrophy | 2 4 2 2 2 2 2 2 2 2 3 3 3 2 2| Hemorrhage | | Inflammation | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Cyst | 3 2 2 1 | Hyperplasia | 1 1 3 1 1 1 1 3 1 1 2 1 1 3 2| Inflammation, Chronic Active | 3 | Inflammation, Granulomatous | 2 | |__________________________________________________________________________| Skin | + + + + + + + + + M + + + + + + + + + + + + + + +| Cyst, Squamous | | Dermis, Inflammation, Focal | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | |__________________________________________________________________________| Skeletal Muscle | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | | |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 13 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7| DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0| | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Infiltration Cellular, Histiocyte | 3 2 2 2 2 2 1 1 1 1 2 2 1 2 1 1 2 2 1 2 1 | Inflammation, Chronic Active | 1 2 1 | Inflammation, Granulomatous | 2 1 | Metaplasia, Squamous | 2 | Alveolar Epithelium, Hyperplasia | 1 1 1 2 1 1 1 | Serosa, Inflammation, Suppurative | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasopharyngeal Duct, Inflammation, | | Suppurative | | Olfactory Epithelium, Inflammation, | | Suppurative | | Respiratory Epithelium, Hyperplasia | 3 | Respiratory Epithelium, Metaplasia | | Turbinate, Inflammation, Suppurative | 2 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 | Peritracheal Tissue, Inflammation | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + M + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Casts Protein | 2 1 1 | Inflammation, Chronic Active | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 | Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1| Pelvis, Dilatation | | __________________________________________|__________________________________________________________________________| Page 14 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7| DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0| | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | Pelvis, Inflammation, Suppurative | 1 | Transitional Epithelium, Hyperplasia | 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +| Inflammation | 2 | Transitional Epithelium, Hyperplasia | | __________________________________________|__________________________________________________________________________ Page 15 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 5| 4| 1| | | DAY ON TEST | 4| 0| 2| | | | 7| 0| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG/KG | 9| 9| 9| | L | | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 52 | Muscularis, Inflammation | 1 | 2 1.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 52 | Parasite Metazoan | | 2 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 52 | Erosion | | 1 2.0| |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | Serosa, Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Liver | + + + | 53 | Angiectasis | | 3 1.3| Basophilic Focus | | 2 | Basophilic Focus, Multiple | | 5 | Clear Cell Focus | | 1 | Clear Cell Focus, Multiple | | 1 | Eosinophilic Focus | | 6 | Eosinophilic Focus, Multiple | | 5 | Fatty Change, Diffuse | 2 | 5 1.2| Fatty Change, Focal | | 2 1.5| Hepatodiaphragmatic Nodule | | 1 | Inflammation | 1 | 36 1.1| Mixed Cell Focus | | 4 | Mixed Cell Focus, Multiple | X | 17 | Necrosis | | 4 2.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 5| 4| 1| | | DAY ON TEST | 4| 0| 2| | | | 7| 0| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG/KG | 9| 9| 9| | L | | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Pigmentation | | 1 1.0| Bile Duct, Cyst | | 3 1.7| Bile Duct, Fibrosis | | 4 1.0| Bile Duct, Hyperplasia | | 3 1.3| Hepatocyte, Degeneration | | 3 2.3| |__________________________________________________________________________|____________| Mesentery | | 1 | Inflammation, Chronic Active | | 1 4.0| |__________________________________________________________________________|____________| Oral Mucosa | | 1 | Gingival, Hyperplasia, Squamous | | 1 2.0| |__________________________________________________________________________|____________| Pancreas | + + + | 51 | Inflammation, Chronic Active | | 5 1.6| Acinus, Atrophy | | 5 2.0| |__________________________________________________________________________|____________| Salivary Glands | + + + | 51 | Inflammation, Chronic Active | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 52 | Edema | | 1 3.0| Hyperplasia, Squamous | | 3 1.7| Inflammation, Acute | | 1 1.0| Mineralization | | 1 2.0| Ulcer | | 3 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 51 | Erosion | | 1 2.0| Mineralization | | 1 2.0| |__________________________________________________________________________|____________| Tooth | | 12 | Peridontal Tissue, Inflammation, | | | Chronic Active | | 2 2.5| Peridontal Tissue, Inflammation, | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 5| 4| 1| | | DAY ON TEST | 4| 0| 2| | | | 7| 0| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG/KG | 9| 9| 9| | L | | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Suppurative | | 10 1.3| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | Aorta, Mineralization | | 3 1.3| |__________________________________________________________________________|____________| Heart | + + + | 52 | Cardiomyopathy | | 9 1.0| Degeneration | 2 | 1 2.0| Mineralization | | 1 2.0| Thrombosis | | 1 2.0| Epicardium, Inflammation, Suppurative| 2 | 2 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 52 | Angiectasis | | 11 1.5| Atrophy | | 1 1.0| Degeneration, Cystic | | 11 2.1| Hyperplasia | 3 | 23 1.9| Hypertrophy | 2 | 34 1.9| Mineralization | | 1 2.0| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | | 5 1.2| |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 52 | Hyperplasia | | 8 1.5| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 52 | Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 47 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 5| 4| 1| | | DAY ON TEST | 4| 0| 2| | | | 7| 0| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG/KG | 9| 9| 9| | L | | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Pituitary Gland | + + + | 51 | Angiectasis | | 14 2.1| Pars Distalis, Hyperplasia | 1 1 | 18 1.9| |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | C-Cell, Hyperplasia | 3 | 12 1.9| Follicular Cell, Hypertrophy | | 9 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + M + | 50 | Inflammation | 3 | 28 1.5| Duct, Cyst | 2 | 29 1.9| |__________________________________________________________________________|____________| Ovary | + + + | 52 | Atrophy | 4 4 4 | 45 4.0| Cyst | 2 | 12 2.0| |__________________________________________________________________________|____________| Oviduct | | 1 | Inflammation, Suppurative | | 1 2.0| |__________________________________________________________________________|____________| Uterus | + + + | 52 | Inflammation, Granulomatous | | 1 2.0| Inflammation, Suppurative | | 12 1.8| Metaplasia, Squamous | 1 | 26 1.6| Endometrium, Hyperplasia, Cystic | | 23 1.7| Epithelium, Hyperplasia | | 1 3.0| |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 5| 4| 1| | | DAY ON TEST | 4| 0| 2| | | | 7| 0| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG/KG | 9| 9| 9| | L | | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Hyperplasia | 3 3 3 | 47 3.4| |__________________________________________________________________________|____________| Lymph Node | | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + M + | 52 | Ectasia | | 1 2.0| Hyperplasia, Plasma Cell | | 18 2.2| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | Ectasia | | 1 2.0| Hemorrhage | | 2 2.0| Hyperplasia, Histiocytic | | 3 1.7| |__________________________________________________________________________|____________| Spleen | + + + | 52 | Hematopoietic Cell Proliferation | 1 1 1 | 39 1.7| Pigmentation | 1 1 1 | 49 1.3| |__________________________________________________________________________|____________| Thymus | + + + | 50 | Atrophy | 2 2 2 | 37 2.5| Hemorrhage | | 1 3.0| Inflammation | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 52 | Cyst | | 8 1.8| Hyperplasia | 1 1 | 32 1.4| Inflammation, Chronic Active | | 1 3.0| Inflammation, Granulomatous | | 2 2.0| |__________________________________________________________________________|____________| Skin | + + + | 52 | Cyst, Squamous | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 5| 4| 1| | | DAY ON TEST | 4| 0| 2| | | | 7| 0| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG/KG | 9| 9| 9| | L | | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Dermis, Inflammation, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | Inflammation, Chronic Active | | 1 2.0| |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Inflammation, Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Hydrocephalus | | 1 1.0| |__________________________________________________________________________|____________| Peripheral Nerve | | 2 | |__________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Congestion | | 1 3.0| Infiltration Cellular, Histiocyte | | 41 1.7| Inflammation, Chronic Active | | 5 1.4| Inflammation, Granulomatous | | 3 1.7| Metaplasia, Squamous | | 1 2.0| Alveolar Epithelium, Hyperplasia | | 12 1.1| Serosa, Inflammation, Suppurative | 3 | 2 2.5| |__________________________________________________________________________|____________| Nose | + + + | 53 | Nasopharyngeal Duct, Inflammation, | | | Suppurative | | 1 4.0| Olfactory Epithelium, Inflammation, | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 5| 4| 1| | | DAY ON TEST | 4| 0| 2| | | | 7| 0| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG/KG | 9| 9| 9| | L | | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Suppurative | | 1 3.0| Respiratory Epithelium, Hyperplasia | | 2 2.5| Respiratory Epithelium, Metaplasia | | 1 4.0| Turbinate, Inflammation, Suppurative | | 2 2.0| |__________________________________________________________________________|____________| Trachea | + + + | 53 | Inflammation | | 1 2.0| Peritracheal Tissue, Inflammation | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 51 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | Inflammation | | 2 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Casts Protein | | 4 1.3| Inflammation, Chronic Active | | 2 2.0| Mineralization | 1 1 1 | 32 1.0| Nephropathy | 1 | 32 1.3| Pelvis, Dilatation | | 2 2.0| Pelvis, Inflammation, Suppurative | | 2 1.0| Transitional Epithelium, Hyperplasia | | 4 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 51 | Inflammation | | 4 1.5| Transitional Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5| DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2| | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 1 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Inflammation | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 2 2 2 | Basophilic Focus | X X | Basophilic Focus, Multiple | X X X X | Cholangiofibrosis | 2 | Clear Cell Focus | | Eosinophilic Focus | X X| Eosinophilic Focus, Multiple | X X | Fatty Change, Diffuse | 1 1 | Fatty Change, Focal | 1 | Hepatocyte, Multinucleate | | Hepatodiaphragmatic Nodule | | Inflammation | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X X X | Mixed Cell Focus, Multiple | X X X X X X X X X | Necrosis | | __________________________________________|__________________________________________________________________________| Page 23 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5| DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2| | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Pigmentation | 2 1 1 1 1 | Toxic Hepatopathy | 1 1 | Vacuolization Cytoplasmic | 1 | Bile Duct, Cyst | 2 | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 3 1| Hepatocyte, Degeneration | | Hepatocyte, Hypertrophy | 1 1 1 1 1 1 1 1 1 2| Oval Cell, Hyperplasia | | Serosa, Inflammation | 2 | |__________________________________________________________________________| Oral Mucosa | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Inflammation, Chronic Active | 1 | Acinus, Atrophy | 1 2 | Acinus, Hyperplasia | | Artery, Inflammation, Chronic Active | 2 2 | Artery, Mineralization | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +| Cyst | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Hyperkeratosis | 2 | Hyperplasia, Squamous | 2 | Inflammation, Chronic Active | | Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Mineralization | | |__________________________________________________________________________| Tooth | + + + + + + + | Peridontal Tissue, Inflammation, | | Suppurative | 1 1 2 2 1 2 1 | __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5| DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2| | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 | Degeneration | | Inflammation | | Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 2 1 1 1 2 | Atrophy | 4 | Degeneration, Cystic | 2 2 4 3 2 1 2 2 1 | Hyperplasia | 3 4 4 2 2 3 2 2 3 | Hypertrophy | 1 2 3 2 3 2 3 1 2 3 1 3 2 2 2 2 2 | Necrosis | | Vacuolization Cytoplasmic | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 3 1 2 1 2 1 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +| Hyperplasia | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 3 3 | Cyst | 3 2 | Cytoplasmic Alteration | 2 | Vacuolization Cytoplasmic | | Pars Distalis, Hyperplasia | 1 2 2 1 2 2 2 3 2 3 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5| DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2| | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Angiectasis | | C-Cell, Hyperplasia | 1 1 3 3 2 2 1 1 2 2 2 | Follicular Cell, Hypertrophy | 1 1 2 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation | 1 2 1 1 2 1 2 1 2 1 1 1 2 1 2 1| Duct, Cyst | 3 3 3 3 2 2 2 1 1 3 3 2 1 2 2| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| Cyst | 2 3 2 2 | Inflammation, Suppurative | | |__________________________________________________________________________| Oviduct | | Inflammation, Suppurative | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenomyosis | | Cyst | | Inflammation, Suppurative | 3 1 1 3 1 | Metaplasia, Squamous | 4 2 1 3 3 1 1 1 3 2 2 1 2 | Ulcer | 2 | Endometrium, Hyperplasia, Cystic | 2 2 1 1 2 2 3 1 2 3 4 2 3 2 3 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 3 2 4 3 3 4 3 3 3 3 4 3 4 4 3| |__________________________________________________________________________| Lymph Node | + + + + + +| Lumbar, Hyperplasia, Lymphoid | 2| Mediastinal, Ectasia | 2 1 | __________________________________________|__________________________________________________________________________| Page 26 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5| DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2| | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +| Ectasia | | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 2 2 3 2 2 2 2 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 1 3 1 1 1 1 2 3 1 3 1 2 1 2 1 1 1 2 2 2| Necrosis | | Pigmentation | 1 2 2 1 2 1 2 1 1 2 1 1 2 1 2 1 1 1 2 2 1 1 1| Lymphoid Follicle, Atrophy | | |__________________________________________________________________________| Thymus | + + M + + + M + + + + + + + + + M + + + + + + + +| Atrophy | 2 2 2 3 2 2 3 4 2 2 2 4 2 2 2| Hemorrhage | 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 1| Hyperplasia | 1 1 3 2 1 1 2 2 1 1 2 1 1 1 1| Inflammation, Granulomatous | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst, Squamous | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5| DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2| | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Infiltration Cellular, Histiocyte | 2 2 2 2 1 1 2 2 1 2 2 2 2 1 1 2 2 2 1 2 2 2 2| Inflammation, Chronic Active | 1 | Mineralization | | Thrombosis | | Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 2 1 2 2 1 2 1 2 1 1 1 1 | Serosa, Inflammation, Chronic Active | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Inflammation | 2| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Casts Protein | 2 | Inflammation, Chronic Active | 2 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 2 2 2 2 1 1 1 2 1 1 1 1 2| Pelvis, Dilatation | 3 | Pelvis, Inflammation, Chronic Active | 2| Renal Tubule, Accumulation, Hyaline | | Droplet | | Transitional Epithelium, Hyperplasia | 2| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5| DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2| | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | Inflammation | 1 3| Transitional Epithelium, Hyperplasia | 3| __________________________________________|__________________________________________________________________________ Page 29 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Parasite Metazoan | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + M + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Inflammation | 1 | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + + +| Mineralization | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 | Basophilic Focus | | Basophilic Focus, Multiple | X X | Cholangiofibrosis | | Clear Cell Focus | X | Eosinophilic Focus | X X | Eosinophilic Focus, Multiple | X X X X | Fatty Change, Diffuse | 1 1 1 1 | Fatty Change, Focal | 1 2 2 | Hepatocyte, Multinucleate | 1 | Hepatodiaphragmatic Nodule | X | Inflammation | 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 | Mixed Cell Focus | X X | Mixed Cell Focus, Multiple | X X X X X X X| Necrosis | 3 1 | __________________________________________|__________________________________________________________________________| Page 30 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Pigmentation | 1 3 1 1 1 | Toxic Hepatopathy | 2 1 1 | Vacuolization Cytoplasmic | | Bile Duct, Cyst | 3 3 2 3| Bile Duct, Fibrosis | 2 | Bile Duct, Hyperplasia | 1 1 1 | Hepatocyte, Degeneration | 2 | Hepatocyte, Hypertrophy | 2 1 1 1 1 1 1 1 1 1 1 | Oval Cell, Hyperplasia | 1 | Serosa, Inflammation | | |__________________________________________________________________________| Oral Mucosa | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Inflammation, Chronic Active | | Acinus, Atrophy | 1 | Acinus, Hyperplasia | 2 | Artery, Inflammation, Chronic Active | 2 | Artery, Mineralization | 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 1 | Hyperkeratosis | 2 | Hyperplasia, Squamous | 2 2 | Inflammation, Chronic Active | 3 | Ulcer | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | Mineralization | 3 | |__________________________________________________________________________| Tooth | + + + + + | Peridontal Tissue, Inflammation, | | Suppurative | 1 1 2 1 1 | __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | 3 | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 2 1 | Degeneration | 3 | Inflammation | 2 | Mineralization | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 1| Atrophy | 2 | Degeneration, Cystic | 3 2 3 3 3| Hyperplasia | 2 3 4 2 1 2 2 2 1 2 2| Hypertrophy | 2 2 2 1 1 1 2 3 1 1 3 3 3 2 3 2 2 2 3| Necrosis | | Vacuolization Cytoplasmic | 2 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 2 2 3 2 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + + + M + + M + + M + + +| Hyperplasia | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 3 2 1 2 2 2 | Cyst | 2 | Cytoplasmic Alteration | | Vacuolization Cytoplasmic | 2| Pars Distalis, Hyperplasia | 2 3 3 3 4 2 3 3 3| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 32 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Angiectasis | 2| C-Cell, Hyperplasia | 2 2 1 2 3 1 1| Follicular Cell, Hypertrophy | 1 1 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Inflammation | 1 1 1 2 1 2 1 2 1 2 1 1 2 1 1 2 2 | Duct, Cyst | 2 2 2 1 2 2 1 2 2 1 1 2 1 1| |__________________________________________________________________________| Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| Cyst | 2 3 2 2 1 1 2 3 3 2 3| Inflammation, Suppurative | 1 | |__________________________________________________________________________| Oviduct | + | Inflammation, Suppurative | 1 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenomyosis | 2 | Cyst | 3 | Inflammation, Suppurative | 4 2 1 1 1 3 | Metaplasia, Squamous | 2 2 3 1 2 1 2 1 2 1 2 2 3 1 3 3 | Ulcer | | Endometrium, Hyperplasia, Cystic | 2 2 2 2 1 4 1 3 2 2 2 3| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 3 2 4 3 2 3 4 4 4 2 4 2 4 4 2 3 2 | |__________________________________________________________________________| Lymph Node | | Lumbar, Hyperplasia, Lymphoid | | Mediastinal, Ectasia | | __________________________________________|__________________________________________________________________________| Page 33 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| Ectasia | | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 2 2 2 2 2 2| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 3 2 1 2 3 2 2 3 1 1 1 1 2 1 2 1 1| Necrosis | 2 | Pigmentation | 2 1 2 3 1 1 2 2 1 1 1 1 1 1 1 2 1 1 1 2 1 1| Lymphoid Follicle, Atrophy | 3 2 3 3 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 4 4 2 3 2 3 2 3 3 2 2 3 4 2 3| Hemorrhage | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hyperplasia | 1 2 2 1 2 1 1 1 2 1 3 1 1 2 1 1| Inflammation, Granulomatous | 3 3 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst, Squamous | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 34 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Infiltration Cellular, Histiocyte | 2 1 2 3 2 1 1 1 2 2 2 2 1 1 2 2 2 2 2 2 1 1| Inflammation, Chronic Active | 2 1 | Mineralization | 3 | Thrombosis | 2 3 | Alveolar Epithelium, Hyperplasia | | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 1 1 1 2 1 2 1 1 1 1 1| Serosa, Inflammation, Chronic Active | 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Inflammation | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + M M + + + + + + + + + + + + + +| Inflammation | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Casts Protein | 1 1 | Inflammation, Chronic Active | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Nephropathy | 2 1 1 1 1 1 1 2 1 1 1| Pelvis, Dilatation | | Pelvis, Inflammation, Chronic Active | 3 | Renal Tubule, Accumulation, Hyaline | | Droplet | 3 | Transitional Epithelium, Hyperplasia | 3 | |__________________________________________________________________________| Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 35 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9| | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | Inflammation | 1 1 1 2 | Transitional Epithelium, Hyperplasia | | __________________________________________|__________________________________________________________________________ Page 36 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + | 55 | Muscularis, Inflammation | | 1 1.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 55 | Parasite Metazoan | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 55 | Mineralization | | 1 2.0| Parasite Metazoan | X | 2 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 54 | Edema | | 1 2.0| Inflammation | | 1 1.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 55 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 54 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 54 | Mineralization | | 1 2.0| |__________________________________________________________________________|____________| Liver | + + + + + | 55 | Angiectasis | 1 | 8 1.4| Basophilic Focus | X X | 4 | Basophilic Focus, Multiple | | 6 | Cholangiofibrosis | | 1 2.0| Clear Cell Focus | | 1 | Eosinophilic Focus | | 4 | Eosinophilic Focus, Multiple | | 6 | Fatty Change, Diffuse | 1 | 7 1.0| Fatty Change, Focal | 1 1 | 6 1.3| Hepatocyte, Multinucleate | 1 | 2 1.0| Hepatodiaphragmatic Nodule | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Inflammation | 1 1 1 1 | 40 1.1| Mixed Cell Focus | | 6 | Mixed Cell Focus, Multiple | X X | 18 | Necrosis | | 2 2.0| Pigmentation | 1 | 11 1.3| Toxic Hepatopathy | 1 | 6 1.2| Vacuolization Cytoplasmic | | 1 1.0| Bile Duct, Cyst | 1 | 6 2.3| Bile Duct, Fibrosis | 1 2 | 4 1.5| Bile Duct, Hyperplasia | 2 2 | 7 1.6| Hepatocyte, Degeneration | | 1 2.0| Hepatocyte, Hypertrophy | 1 1 | 23 1.1| Oval Cell, Hyperplasia | | 1 1.0| Serosa, Inflammation | | 1 2.0| |__________________________________________________________________________|____________| Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + | 55 | Basophilic Focus | | 1 | Inflammation, Chronic Active | | 1 1.0| Acinus, Atrophy | | 3 1.3| Acinus, Hyperplasia | | 1 2.0| Artery, Inflammation, Chronic Active | 2 | 4 2.0| Artery, Mineralization | | 1 2.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + | 54 | Cyst | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 55 | Erosion | | 1 1.0| Hyperkeratosis | 1 | 3 1.7| Hyperplasia, Squamous | 2 | 4 2.0| Inflammation, Chronic Active | | 1 3.0| Ulcer | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 53 | Erosion | | 1 2.0| Mineralization | | 1 3.0| |__________________________________________________________________________|____________| Tooth | | 12 | Peridontal Tissue, Inflammation, | | | Suppurative | | 12 1.3| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + | 55 | Aorta, Mineralization | | 1 3.0| |__________________________________________________________________________|____________| Heart | + + + + + | 54 | Cardiomyopathy | 1 1 | 16 1.1| Degeneration | | 1 3.0| Inflammation | | 1 2.0| Mineralization | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 55 | Angiectasis | 2 1 1 | 13 1.5| Atrophy | 1 | 3 2.3| Degeneration, Cystic | | 14 2.4| Hyperplasia | 2 | 21 2.4| Hypertrophy | 2 2 2 2 1 | 41 2.0| Necrosis | 2 | 1 2.0| Vacuolization Cytoplasmic | 1 | 3 1.7| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 55 | Hyperplasia | 2 2 2 | 18 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Islets, Pancreatic | + + + + + | 54 | Hyperplasia | | 2 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 50 | Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + | 54 | Angiectasis | 1 2 3 2 | 15 2.1| Cyst | | 3 2.3| Cytoplasmic Alteration | | 1 2.0| Vacuolization Cytoplasmic | | 1 2.0| Pars Distalis, Hyperplasia | 3 | 20 2.5| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + | 55 | Angiectasis | | 1 2.0| C-Cell, Hyperplasia | 1 1 2 | 21 1.7| Follicular Cell, Hypertrophy | 1 1 | 13 1.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + | 55 | Hyperplasia | | 1 2.0| Inflammation | 1 2 2 | 36 1.4| Duct, Cyst | 2 3 3 | 32 2.0| |__________________________________________________________________________|____________| Ovary | + + + + + | 54 | Atrophy | 4 4 4 4 4 | 49 4.0| Cyst | 2 2 | 17 2.2| Inflammation, Suppurative | | 1 1.0| |__________________________________________________________________________|____________| Oviduct | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Inflammation, Suppurative | | 1 1.0| |__________________________________________________________________________|____________| Uterus | + + + + + | 55 | Adenomyosis | | 1 2.0| Cyst | | 1 3.0| Inflammation, Suppurative | 1 | 12 1.8| Metaplasia, Squamous | 2 1 2 2 | 33 1.9| Ulcer | | 1 2.0| Endometrium, Hyperplasia, Cystic | 2 1 2 3 1 | 33 2.1| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + | 55 | Hyperplasia | 4 3 2 | 37 3.2| |__________________________________________________________________________|____________| Lymph Node | | 6 | Lumbar, Hyperplasia, Lymphoid | | 1 2.0| Mediastinal, Ectasia | | 2 1.5| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 53 | Ectasia | 3 | 1 3.0| Hyperplasia, Lymphoid | | 1 2.0| Hyperplasia, Plasma Cell | 2 | 24 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 54 | Hemorrhage | | 3 2.0| |__________________________________________________________________________|____________| Spleen | + + + + + | 55 | Hematopoietic Cell Proliferation | 3 1 1 1 | 43 1.6| Necrosis | | 1 2.0| Pigmentation | 1 1 2 1 1 | 50 1.4| Lymphoid Follicle, Atrophy | 2 | 5 2.6| |__________________________________________________________________________|____________| Thymus | + + + + + | 52 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Atrophy | 2 2 3 | 34 2.6| Hemorrhage | | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + | 55 | Cyst | | 3 1.7| Hyperplasia | 1 1 | 33 1.4| Inflammation, Granulomatous | | 2 3.0| |__________________________________________________________________________|____________| Skin | + + + + + | 55 | Cyst, Squamous | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + | 55 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + | 55 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + | 55 | Congestion | | 1 2.0| Infiltration Cellular, Histiocyte | 2 2 2 2 | 49 1.7| Inflammation, Chronic Active | | 3 1.3| Mineralization | | 1 3.0| Thrombosis | | 2 2.5| Alveolar Epithelium, Hyperplasia | | 1 1.0| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 2 1 1 1 | 29 1.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| | | DAY ON TEST | 2| 8| 2| 2| 2| | | | 2| 0| 9| 7| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 30 NG/KG | 9| 9| 9| 9| 9| | L | | 3| 4| 5| 7| 8| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Serosa, Inflammation, Chronic Active | | 1 2.0| |__________________________________________________________________________|____________| Nose | + + + + + | 54 | Nasolacrimal Duct, Inflammation | | 1 2.0| |__________________________________________________________________________|____________| Trachea | + + + + + | 55 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + | 55 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + | 53 | Inflammation | 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + | 55 | Casts Protein | | 3 1.3| Inflammation, Chronic Active | 2 | 2 2.0| Mineralization | 1 1 1 1 | 39 1.0| Nephropathy | 1 2 1 2 | 29 1.3| Pelvis, Dilatation | | 1 3.0| Pelvis, Inflammation, Chronic Active | | 2 2.5| Renal Tubule, Accumulation, Hyaline | | | Droplet | | 1 3.0| Transitional Epithelium, Hyperplasia | | 2 2.5| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + | 54 | Inflammation | | 6 1.5| Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7| DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0| | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Squamous | 1| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Adenomatous | 3 | Inflammation | 2 | Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | | Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | X X X | Basophilic Focus, Multiple | X X | Cholangiofibrosis | | Cytoplasmic Alteration | | Eosinophilic Focus | X X X X X| Eosinophilic Focus, Multiple | X X X X | Fatty Change, Diffuse | 1 3 1 2 2 1 | Fatty Change, Focal | 1 2 2 1 1 2| Hepatocyte, Multinucleate | 1 1 1 1 1 2| Inflammation | 3 2 1 1 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X X X | Mixed Cell Focus, Multiple | X X X X X X X X X X X X | Necrosis | 1 2 2 | Pigmentation | 2 2 1 1 2 1 1 1 2 1 1 3 2 1 1 1 1 1 1 2| Toxic Hepatopathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________|__________________________________________________________________________| Page 44 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7| DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0| | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Fibrosis | 1 2| Bile Duct, Hyperplasia | 1 2 2 2 | Hepatocyte, Degeneration | | Hepatocyte, Hypertrophy | 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1| Oval Cell, Hyperplasia | 2 1 1 1 1 | |__________________________________________________________________________| Mesentery | + + | Artery, Inflammation, Chronic Active | 3 | Fat, Necrosis | | |__________________________________________________________________________| Oral Mucosa | + +| Gingival, Hyperplasia, Squamous | 1| |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Acinus, Atrophy | 3 | Acinus, Hyperplasia | | Acinus, Vacuolization Cytoplasmic | 1 | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Hyperkeratosis | | Hyperplasia, Squamous | 1 3 | Inflammation, Chronic Active | 2 | Mineralization | 3 | Necrosis, Focal | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Focal | | |__________________________________________________________________________| Tooth | + + + + + + + +| Peridontal Tissue, Inflammation, | | Suppurative | 2 1 2 1 2 1 2 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7| DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0| | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | 3 | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 3 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 2 2 2 1 2 2 2 1 | Atrophy | 2 1 1 | Degeneration, Cystic | 3 3 1 1 2 2 2 3| Hyperplasia | 2 2 1 3 3 2 1 2 3 1 1 | Hypertrophy | 2 2 3 2 1 2 1 2 1 3 2 1 1 3 2 3 2 2 2 1 2| Inflammation, Suppurative | | Vacuolization Cytoplasmic | 1 2 3 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2| Hyperplasia | 2 3 2 1 1 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M + + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 3 1 1 2 2 3 3 3 3 1 | Cyst | 2 | Cytoplasmic Alteration | | Vacuolization Cytoplasmic | | Pars Distalis, Hyperplasia | 2 2 3 2 2 3 2 1 2 3 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 2| C-Cell, Hyperplasia | 1 2 2 2 3 2 1 2 | __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7| DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0| | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Follicle, Cyst | 2 | Follicular Cell, Hyperplasia | 1 | Follicular Cell, Hypertrophy | 1 1 1 2 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| Hyperplasia, Squamous | 1 | Inflammation | 3 1 2 1 2 2 1 2 2 2 2 1 1 2 1 1 2 3 1 2 1| Duct, Cyst | 2 2 3 2 2 2 1 2 3 2 2 3 1 2 2 1 2| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 | Cyst | 3 2 2 2 2 2 1 3 | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | Inflammation, Suppurative | 2 1 3 | Metaplasia, Squamous | 1 3 2 2 2 3 3 4 2 2 2 | Vacuolization Cytoplasmic | 2 | Artery, Inflammation, Chronic Active | | Endometrium, Hyperplasia, Cystic | 2 2 1 1 2 2 1 2 2 2 2 2 2 2 | Epithelium, Necrosis | | |__________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 | Hyperplasia | 3 4 2 3 4 2 3 1 4 4 3 4 3 4 2 3 2| |__________________________________________________________________________| Lymph Node | + + + + | Deep Cervical, Ectasia | 2 | __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7| DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0| | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Inguinal, Hyperplasia, Plasma Cell | 2 | Inguinal, Pigmentation | 2 | Mediastinal, Ectasia | 2 | Mediastinal, Hemorrhage | 2 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 3 2 2 2 2 3 2 2| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 2 1 2 1 1 3 1 1 1 1 2 1 1 2| Hyperplasia, Lymphoid | | Pigmentation | 1 1 2 2 1 2 2 2 1 2 2 2 2 2 1 3 2 2 2 1 1 2 1 2| Lymphoid Follicle, Atrophy | 2 | Red Pulp, Atrophy | 2 | |__________________________________________________________________________| Thymus | + + + + M + M + + + M + + M + + + + M M + + + + +| Atrophy | 4 3 2 2 3 3 4 4 2 3 4 4 2 2 2 2 3 2 2| Fibrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | 1 1 2 1 1 1 1 2 1 2 2 1 2 2 2 2 2| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 48 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7| DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0| | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 2 2| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2 2 1 1 2 2 2 1 1 2 2 2 2 2 1 2 1 2 2 1 2 | Inflammation, Granulomatous | 1 2| Metaplasia, Squamous | | Mineralization | 3 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 2 2 1 1 2 2 2 2 1 2 1 1 2 2 2 1 | Serosa, Fibrosis | 1 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasopharyngeal Duct, Inflammation, | | Suppurative | 3| Olfactory Epithelium, Inflammation, | | Suppurative | 3| Respiratory Epithelium, Hyperplasia | 2| Respiratory Epithelium, Inflammation,| | Suppurative | 3| Turbinate, Inflammation, Suppurative | 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Anterior Chamber, Ciliary Body, | | Cornea, Inflammation, Suppurative| 2 | Retina, Atrophy | 2 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7| DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0| | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 1 1| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | X | Casts Protein | | Inflammation, Chronic Active | | Inflammation, Suppurative | 1 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1| Necrosis | 2 | Nephropathy | 1 1 2 1 1 2 1 1 2 2 2 2 1 3 4 2 1 1 3| Pelvis, Inflammation, Chronic Active | 2 3 | Transitional Epithelium, Hyperplasia | 1 1 2 3 2| |__________________________________________________________________________| Ureter | + | Mineralization | 3 | Transitional Epithelium, Hyperplasia | 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 1 2 2 2 | Transitional Epithelium, Hyperplasia | 2 | __________________________________________|__________________________________________________________________________ Page 50 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4| | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Squamous | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Adenomatous | | Inflammation | | Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 2 | Parasite Metazoan | X X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 1 | Basophilic Focus | X X X | Basophilic Focus, Multiple | X X | Cholangiofibrosis | 2 | Cytoplasmic Alteration | 2 | Eosinophilic Focus | X X | Eosinophilic Focus, Multiple | X X | Fatty Change, Diffuse | 1 1 1 1 1 1 | Fatty Change, Focal | 1 2 | Hepatocyte, Multinucleate | 1 1 1 1 | Inflammation | 2 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X X | Mixed Cell Focus, Multiple | X X X X X X X X X X X X| Necrosis | 2 1| Pigmentation | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 | Toxic Hepatopathy | 1 1 1 1 1 1 | __________________________________________|__________________________________________________________________________| Page 51 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4| | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 1 1 2 | Hepatocyte, Degeneration | 2 | Hepatocyte, Hypertrophy | 1 1 1 1 2 1 1 2 1 1 1 1 1| Oval Cell, Hyperplasia | 1 | |__________________________________________________________________________| Mesentery | + + | Artery, Inflammation, Chronic Active | 3 | Fat, Necrosis | 3 | |__________________________________________________________________________| Oral Mucosa | + | Gingival, Hyperplasia, Squamous | 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Acinus, Atrophy | | Acinus, Hyperplasia | 3 | Acinus, Vacuolization Cytoplasmic | | Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Hyperkeratosis | 2 | Hyperplasia, Squamous | 2 3 1 1 | Inflammation, Chronic Active | 2 | Mineralization | | Necrosis, Focal | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Focal | 2 | |__________________________________________________________________________| Tooth | + + | Peridontal Tissue, Inflammation, | | Suppurative | 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | __________________________________________|__________________________________________________________________________| Page 52 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4| | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 2 2 1 1 1 1 1 1 2 1 1 1| Atrophy | 1 | Degeneration, Cystic | 2 1 | Hyperplasia | 2 3 3 3 2 2 2 2 2 2 3 2 3 3 1 2 | Hypertrophy | 1 3 3 1 1 2 2 3 2 2 2 2 1 3 1 1 1| Inflammation, Suppurative | 1 | Vacuolization Cytoplasmic | 2 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hyperplasia | 1 2 2 2 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | |__________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + M +| Hyperplasia | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 1 3 1 2 2 1 2 3 3 | Cyst | | Cytoplasmic Alteration | 2 | Vacuolization Cytoplasmic | 1 | Pars Distalis, Hyperplasia | 2 2 3 2 2 1 3 3 3 1 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | C-Cell, Hyperplasia | 1 1 1 1 1 1 1 | __________________________________________|__________________________________________________________________________| Page 53 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4| | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Follicle, Cyst | | Follicular Cell, Hyperplasia | | Follicular Cell, Hypertrophy | 1 1 1 1 2 2 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Inflammation | 1 3 3 2 2 2 1 2 2 2 1 1 3 1 1 3 2 1 | Duct, Cyst | 3 3 1 2 2 2 1 2 2 1 2 2 3 1 1 2 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 3 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4| Cyst | 3 3 2 3 2 2 3 2| Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Inflammation, Suppurative | 1 1 1 1 2 1 3 2 | Metaplasia, Squamous | 1 1 2 2 3 1 3 1 2 1 3 3 2| Vacuolization Cytoplasmic | 2 | Artery, Inflammation, Chronic Active | 3 | Endometrium, Hyperplasia, Cystic | 2 1 3 3 3 1 1 2 1 3 1 1 | Epithelium, Necrosis | 2 | |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hyperplasia | 2 4 3 4 4 3 3 4 3 3 4 4 4 4 3 4| |__________________________________________________________________________| Lymph Node | + + | Deep Cervical, Ectasia | | __________________________________________|__________________________________________________________________________| Page 54 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4| | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Inguinal, Hyperplasia, Plasma Cell | | Inguinal, Pigmentation | | Mediastinal, Ectasia | 2 2 | Mediastinal, Hemorrhage | 2 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 2 | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 3 3 2 3 2 2 3| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 2 1 1 3 1 3 2 1 1 1 1 3 2 1 1 2 2 2 1 1 2| Hyperplasia, Lymphoid | 2 | Pigmentation | 2 2 1 1 1 1 1 2 1 1 1 2 2 2 1 1 1 2 2 2 1 2 2 1| Lymphoid Follicle, Atrophy | 2 | Red Pulp, Atrophy | 2 2 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 3 4 3 3 4 3 2 2 3 4 2 2 2 3 2 3 2 2 2| Fibrosis | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 | Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 2| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 2 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 55 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4| | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2 2 1 1 2 2 1 1 2 1 1 2 2 3 2 2 2 2 1 2 3 2| Inflammation, Granulomatous | | Metaplasia, Squamous | 2 | Mineralization | | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 2 2 2 1 1 2 1 1 1 2 2 1 2 2 2 1| Serosa, Fibrosis | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Nasopharyngeal Duct, Inflammation, | | Suppurative | | Olfactory Epithelium, Inflammation, | | Suppurative | | Respiratory Epithelium, Hyperplasia | | Respiratory Epithelium, Inflammation,| | Suppurative | | Turbinate, Inflammation, Suppurative | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Anterior Chamber, Ciliary Body, | | Cornea, Inflammation, Suppurative| | Retina, Atrophy | 2 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 56 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5| DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4| | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | | Casts Protein | 1 | Inflammation, Chronic Active | 3 | Inflammation, Suppurative | 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Necrosis | | Nephropathy | 1 2 1 2 1 1 1 2 1 1 1 3 1 1 1 1 1| Pelvis, Inflammation, Chronic Active | | Transitional Epithelium, Hyperplasia | 2 2 2 | |__________________________________________________________________________| Ureter | | Mineralization | | Transitional Epithelium, Hyperplasia | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 | Transitional Epithelium, Hyperplasia | | __________________________________________|__________________________________________________________________________ Page 57 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | Hyperplasia, Focal, Squamous | | 1 1.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | Hyperplasia, Adenomatous | | 1 3.0| Inflammation | | 1 2.0| Parasite Metazoan | | 2 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | Infiltration Cellular, Lymphocyte | | 1 2.0| Parasite Metazoan | | 3 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Angiectasis | | 4 1.0| Basophilic Focus | | 6 | Basophilic Focus, Multiple | | 4 | Cholangiofibrosis | | 1 2.0| Cytoplasmic Alteration | | 1 2.0| Eosinophilic Focus | | 7 | Eosinophilic Focus, Multiple | | 6 | Fatty Change, Diffuse | 1 2 | 14 1.4| Fatty Change, Focal | | 8 1.5| Hepatocyte, Multinucleate | | 10 1.1| Inflammation | 1 2 | 49 1.2| Mixed Cell Focus | | 7 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 58 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Mixed Cell Focus, Multiple | X | 25 | Necrosis | | 5 1.6| Pigmentation | 1 1 | 41 1.2| Toxic Hepatopathy | 1 1 | 22 1.0| Bile Duct, Fibrosis | | 3 1.3| Bile Duct, Hyperplasia | | 7 1.6| Hepatocyte, Degeneration | | 1 2.0| Hepatocyte, Hypertrophy | 1 1 | 32 1.2| Oval Cell, Hyperplasia | | 6 1.2| |__________________________________________________________________________|____________| Mesentery | | 4 | Artery, Inflammation, Chronic Active | | 2 3.0| Fat, Necrosis | | 1 3.0| |__________________________________________________________________________|____________| Oral Mucosa | | 3 | Gingival, Hyperplasia, Squamous | | 2 1.0| |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Inflammation, Chronic Active | 2 | 3 2.0| Acinus, Atrophy | 2 | 2 2.5| Acinus, Hyperplasia | | 1 3.0| Acinus, Vacuolization Cytoplasmic | | 1 1.0| Artery, Inflammation, Chronic Active | 3 | 2 3.0| |__________________________________________________________________________|____________| Salivary Glands | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | Edema | | 1 2.0| Hyperkeratosis | | 1 2.0| Hyperplasia, Squamous | | 6 1.8| Inflammation, Chronic Active | | 2 2.0| Mineralization | | 1 3.0| Necrosis, Focal | | 1 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 59 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Stomach, Glandular | + + + | 53 | Metaplasia, Focal | | 1 2.0| |__________________________________________________________________________|____________| Tooth | | 10 | Peridontal Tissue, Inflammation, | | | Suppurative | | 10 1.4| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | Aorta, Mineralization | | 1 3.0| |__________________________________________________________________________|____________| Heart | + + + | 53 | Cardiomyopathy | 1 | 17 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Angiectasis | | 25 1.5| Atrophy | 1 | 5 1.2| Degeneration, Cystic | | 10 2.0| Hyperplasia | | 27 2.1| Hypertrophy | 2 1 | 40 1.9| Inflammation, Suppurative | | 1 1.0| Vacuolization Cytoplasmic | | 5 2.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Angiectasis | | 2 2.0| Hyperplasia | | 11 1.7| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | Hyperplasia | | 1 1.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 48 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 60 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Angiectasis | | 22 2.2| Cyst | | 1 2.0| Cytoplasmic Alteration | | 1 2.0| Vacuolization Cytoplasmic | | 1 1.0| Pars Distalis, Hyperplasia | 3 2 | 23 2.2| |__________________________________________________________________________|____________| Thyroid Gland | + A + | 52 | Angiectasis | | 4 2.0| C-Cell, Hyperplasia | 1 2 | 17 1.5| Follicle, Cyst | | 1 2.0| Follicular Cell, Hyperplasia | | 1 1.0| Follicular Cell, Hypertrophy | 1 | 13 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 52 | Hyperplasia, Squamous | | 1 1.0| Inflammation | | 39 1.7| Duct, Cyst | 3 | 34 2.0| |__________________________________________________________________________|____________| Ovary | + + + | 53 | Atrophy | 4 4 4 | 46 4.0| Cyst | 3 | 17 2.4| Artery, Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Uterus | + + + | 53 | Erosion | | 1 2.0| Inflammation, Suppurative | | 11 1.6| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 61 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Metaplasia, Squamous | 2 | 25 2.1| Vacuolization Cytoplasmic | | 2 2.0| Artery, Inflammation, Chronic Active | | 1 3.0| Endometrium, Hyperplasia, Cystic | 2 2 | 28 1.8| Epithelium, Necrosis | | 1 2.0| |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Fibrosis | | 1 3.0| Hyperplasia | 3 4 | 35 3.3| |__________________________________________________________________________|____________| Lymph Node | | 6 | Deep Cervical, Ectasia | | 1 2.0| Inguinal, Hyperplasia, Plasma Cell | | 1 2.0| Inguinal, Pigmentation | | 1 2.0| Mediastinal, Ectasia | | 3 2.0| Mediastinal, Hemorrhage | | 2 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 51 | Ectasia | | 4 2.0| Hyperplasia, Lymphoid | | 1 2.0| Hyperplasia, Plasma Cell | 2 | 31 2.2| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | Atrophy | | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + | 52 | Hematopoietic Cell Proliferation | 2 1 | 46 1.4| Hyperplasia, Lymphoid | | 1 2.0| Pigmentation | 1 1 1 | 51 1.5| Lymphoid Follicle, Atrophy | 2 | 3 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 62 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Red Pulp, Atrophy | 2 | 4 2.0| |__________________________________________________________________________|____________| Thymus | M + + | 46 | Atrophy | 4 | 41 2.8| Fibrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Cyst | | 1 4.0| Hyperplasia | | 30 1.4| |__________________________________________________________________________|____________| Skin | + + + | 53 | Ulcer | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | Osteopetrosis | | 1 2.0| |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Hydrocephalus | | 2 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Infiltration Cellular, Histiocyte | 2 2 | 45 1.7| Inflammation, Granulomatous | | 2 1.5| Metaplasia, Squamous | | 1 2.0| Mineralization | | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 63 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 2 2 | 34 1.6| Serosa, Fibrosis | | 2 1.5| |__________________________________________________________________________|____________| Nose | + + + | 52 | Nasopharyngeal Duct, Inflammation, | | | Suppurative | | 1 3.0| Olfactory Epithelium, Inflammation, | | | Suppurative | | 1 3.0| Respiratory Epithelium, Hyperplasia | | 1 2.0| Respiratory Epithelium, Inflammation,| | | Suppurative | | 1 3.0| Turbinate, Inflammation, Suppurative | | 1 2.0| |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | Atrophy | | 1 3.0| Anterior Chamber, Ciliary Body, | | | Cornea, Inflammation, Suppurative| | 1 2.0| Retina, Atrophy | 3 | 3 2.3| |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | Inflammation | | 6 1.2| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Calculus Micro Observation Only | | 1 | Casts Protein | | 1 1.0| Inflammation, Chronic Active | | 1 3.0| Inflammation, Suppurative | | 3 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 64 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 2| 7| | | DAY ON TEST | 2| 3| 2| | | | 7| 6| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 100 | 9| 9| 9| | L | NG/KG | 6| 7| 8| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Mineralization | 1 1 | 44 1.0| Necrosis | | 1 2.0| Nephropathy | 1 2 | 38 1.5| Pelvis, Inflammation, Chronic Active | | 2 2.5| Transitional Epithelium, Hyperplasia | | 8 1.9| |__________________________________________________________________________|____________| Ureter | | 1 | Mineralization | | 1 3.0| Transitional Epithelium, Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | Inflammation | | 10 1.4| Transitional Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 65 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6| DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5| | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + M + + + + + + + + + + + + +| Epithelium, Hyperplasia | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X| Basophilic Focus, Multiple | X | Cholangiofibrosis | 2 | Cytoplasmic Alteration | 2 | Eosinophilic Focus | X | Eosinophilic Focus, Multiple | X X X X X X X X X X| Fatty Change, Diffuse | 1 1 1 1 1 1 1 1 1 1 2 1 | Fatty Change, Focal | 1 2 | Hepatocyte, Multinucleate | 1 1 1 1 1 | Hepatodiaphragmatic Nodule | X | Hyperplasia, Nodular | X | Inflammation | 1 2 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X | Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X | Necrosis | 3 1 1 2 2 | Pigmentation | 2 1 2 1 1 1 1 2 2 2 2 2 2 2 2 1 1 2 1 1 1| __________________________________________|__________________________________________________________________________| Page 66 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6| DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5| | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Toxic Hepatopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Artery, Inflammation, Chronic Active | | Bile Duct, Cyst | 2 | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 2 2 2 1 1 1 1 1 | Hepatocyte, Hypertrophy | 1 2 1 3 1 1 1 1 1 2 1 2 1 1 1 1 1 2 1| Oval Cell, Hyperplasia | 1 1 1 1 | |__________________________________________________________________________| Mesentery | + + | Artery, Inflammation, Chronic Active | 4 3 | |__________________________________________________________________________| Oral Mucosa | + + | Gingival, Hyperplasia, Squamous | 2 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Inflammation, Chronic Active | 1 1 1 | Acinus, Atrophy | 1 1 1 2 1 2 | Acinus, Hyperplasia | | Acinus, Vacuolization Cytoplasmic | 2 1 1 | Artery, Inflammation, Chronic Active | 3 1 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 1 | Hyperplasia, Squamous | 2 2 | Inflammation, Chronic Active | 2 | Mineralization | | Ulcer | 2| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | Mineralization | | |__________________________________________________________________________| Tooth | + + + + + + | Peridontal Tissue, Inflammation, | | __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6| DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5| | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Suppurative | 1 2 2 2 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 2 1 1 1| Artery, Inflammation, Chronic Active | 2 | Epicardium, Inflammation, Suppurative| | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 2 2 2 2 2 1 2| Atrophy | 1 | Degeneration, Cystic | 3 4 3 3 4 4 | Hyperplasia | 1 2 1 1 3 4 2 2 1 2 1 1| Hypertrophy | 2 2 2 3 2 2 3 3 3 2 4 2 1 3 1 2 2 1 1 1 1| Necrosis | 3 | Vacuolization Cytoplasmic | 2 2| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hyperplasia | 2 2 3 2 1 | Necrosis | 3 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | |__________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + M + + + + M| Hyperplasia | 1 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 3 1 3 3 3 | Cyst | 1 | Cytoplasmic Alteration | 2 | Pars Distalis, Hyperplasia | 3 3 2 2 2 2 2 1 1 | __________________________________________|__________________________________________________________________________| Page 68 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6| DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5| | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | C-Cell, Hyperplasia | 1 2 2 1 2 2 2 1| Follicular Cell, Hyperplasia | 1 | Follicular Cell, Hypertrophy | 2 1 1 1 1 2 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 2 1 2 2 2 2 2 1 1 2 3 3 | Duct, Cyst | 2 2 1 1 2 2 2 3 2 3 2 2 2 1 1 2 2 2 2 1 2| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4| Cyst | 2 2 3 2 3 2 | Inflammation, Chronic Active | 2 | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenomyosis | 4 | Hemorrhage | 2 | Inflammation, Chronic Active | 3 3 | Inflammation, Suppurative | 3 2 2 2 3 2 1 2 2 1| Metaplasia, Squamous | 3 3 1 1 4 4 2 4 1 1 1 1 2 4 3 | Thrombosis | 2 | Endometrium, Hyperplasia, Cystic | 3 4 2 3 3 3 3 2 1 2 3| Epithelium, Hyperplasia | 3 | Epithelium, Necrosis | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 4 4 4 4 2 4 3 3 2 4 2 3 4 2 3 4 4 3 4 3 3 4| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 69 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6| DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5| | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Lymph Node | + + + + | Ectasia | 2 | Lumbar, Hyperplasia, Plasma Cell | 2 | Mediastinal, Hemorrhage | 2 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 2 2 | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 2 2 2 3 2 2 2 2 2| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +| Hemorrhage | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 2 2 3 3 1 2 1 2 1 2 1 1 1 1 2 2 1 1 1 1 1 1| Pigmentation | 2 2 1 1 1 2 1 1 1 1 1 2 2 2 1 1 1 1 1 1 1 2 1| Lymphoid Follicle, Atrophy | 1 | Red Pulp, Atrophy | | |__________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + + + + + M + + +| Atrophy | 3 3 4 2 2 3 3 2 3 4 3 4 4 2 4 2 2 2 4 3 3 2 2| Inflammation | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 3 | Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1 2| Inflammation, Chronic Active | 3 | Inflammation, Granulomatous | 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Inflammation, | | Suppurative | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 70 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6| DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5| | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2 2 1 2 1 1 2 1 2 2 1 1 2 2 1 2 2 1 1 1 2 2 2| Inflammation, Chronic Active | 2 | Metaplasia, Squamous | | Alveolar Epithelium, Hyperplasia | 3 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 2 2 1 1 1 3 1 2 1 2 1 3 2 1 2 2 1 1 1 2 3 2| Serosa, Inflammation, Suppurative | | Vein, Thrombosis | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Inflammation | | Respiratory Epithelium, Hyperplasia | 2 | Turbinate, Inflammation, Suppurative | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Retina, Atrophy | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | | Casts Protein | 1 1 1 2 1 | Cyst | | Inflammation, Chronic Active | 3 | __________________________________________|__________________________________________________________________________| Page 71 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6| DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5| | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Nephropathy | 1 1 1 1 2 2 1 2 1 2 1 1 1 1 3 1 | Pelvis, Inflammation, Chronic Active | 2 3| Renal Tubule, Dilatation | | Transitional Epithelium, Hyperplasia | 3 3| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Hemorrhage | | Inflammation | 1 3 3| Transitional Epithelium, Hyperplasia | 3 2| __________________________________________|__________________________________________________________________________ Page 72 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7| DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2| | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 1 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + + +| Inflammation, Chronic Active | | Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +| Epithelium, Hyperplasia | 2 | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X | Basophilic Focus, Multiple | X X X X X| Cholangiofibrosis | | Cytoplasmic Alteration | | Eosinophilic Focus | X X| Eosinophilic Focus, Multiple | X X X X X X | Fatty Change, Diffuse | 1 1 1 1 1 1 1 1 2 1 | Fatty Change, Focal | 1 2 1 | Hepatocyte, Multinucleate | 1 1 1 1 1 1 1 1 1 | Hepatodiaphragmatic Nodule | | Hyperplasia, Nodular | | Inflammation | 1 2 1 3 1 2 1 1 1 1 1 2 1 1 2 1 1 1 1 2 1 1 1 1| Mixed Cell Focus | | Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X| Necrosis | 3 2 3 | Pigmentation | 1 2 3 2 1 2 2 1 2 2 1 2 1 2 1 2 2| __________________________________________|__________________________________________________________________________| Page 73 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7| DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2| | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Toxic Hepatopathy | 1 1 1 1 1 1 1 2 1 1 1| Artery, Inflammation, Chronic Active | 2 | Bile Duct, Cyst | 2 | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 1 2 2 1 1| Hepatocyte, Hypertrophy | 1 2 2 1 1 2 1 1 1 1 1 1 1 1 1| Oval Cell, Hyperplasia | 2 1 1| |__________________________________________________________________________| Mesentery | | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Oral Mucosa | + + | Gingival, Hyperplasia, Squamous | 2 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Inflammation, Chronic Active | 2 | Acinus, Atrophy | 3 | Acinus, Hyperplasia | 2 | Acinus, Vacuolization Cytoplasmic | 2 | Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + M + + + + + + + + M + + + + + +| Atrophy | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Hyperplasia, Squamous | | Inflammation, Chronic Active | | Mineralization | 2 | Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Mineralization | 1 | |__________________________________________________________________________| Tooth | + + | Peridontal Tissue, Inflammation, | | __________________________________________|__________________________________________________________________________| Page 74 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7| DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2| | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Suppurative | 1 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 2| Artery, Inflammation, Chronic Active | | Epicardium, Inflammation, Suppurative| 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 2 2 1 2 1 2| Atrophy | 1 1 | Degeneration, Cystic | 3 2 2 2 2 3 2 | Hyperplasia | 2 2 2 2 2 2 3 2 1 1 2 4| Hypertrophy | 2 3 2 2 3 1 2 2 3 3 3 3 2 1 2 2 2 1| Necrosis | | Vacuolization Cytoplasmic | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hyperplasia | 2 2 2 2 2 2| Necrosis | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | |__________________________________________________________________________| Parathyroid Gland | + M + + + + + + + M + + + + + + + + M + + + + + M| Hyperplasia | 2 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 3 2 1 3| Cyst | | Cytoplasmic Alteration | | Pars Distalis, Hyperplasia | 3 1 3 3 2 2 2 | __________________________________________|__________________________________________________________________________| Page 75 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7| DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2| | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + M + + + + + + + + M + + + + + +| Cyst | 2 | C-Cell, Hyperplasia | 1 2 2 2 3 1 2 2 2 2| Follicular Cell, Hyperplasia | | Follicular Cell, Hypertrophy | 1 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + M M + + + + + + + + M + + + + + + + + +| Inflammation | 1 1 1 1 2 2 1 2 1 2 2 1 2 2 | Duct, Cyst | 2 2 2 2 1 2 3 1 1 2 3 3 1 3| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| Cyst | 2 2 2 2 2 2 3 3 2 | Inflammation, Chronic Active | | Artery, Inflammation, Chronic Active | 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + M + + + + + + + + +| Adenomyosis | | Hemorrhage | | Inflammation, Chronic Active | | Inflammation, Suppurative | 2 1 3 2 2 2 | Metaplasia, Squamous | 2 2 1 2 3 3 2 4 2 2 2 | Thrombosis | | Endometrium, Hyperplasia, Cystic | 3 2 1 1 2 2 3 4 3 4 1 4 | Epithelium, Hyperplasia | | Epithelium, Necrosis | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 4 4 2 4 2 3 4 4 3 2 4 3 4 4 2| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 76 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7| DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2| | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Lymph Node | + + | Ectasia | | Lumbar, Hyperplasia, Plasma Cell | 3 | Mediastinal, Hemorrhage | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + M + + + + + +| Ectasia | 3 | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | 3 2 2 2 4 2 3 2 2 2 2 3| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 1 2 3 2 1 1 1 1 3 2 1 2 1 3 1 1| Pigmentation | 1 1 2 2 1 1 1 3 1 2 1 2 2 1 2 1 1 2 2 1 1 1 2 2 2| Lymphoid Follicle, Atrophy | 2 | Red Pulp, Atrophy | 2 | |__________________________________________________________________________| Thymus | M + + + + + + + + + + + + + + M + + + + + + + + +| Atrophy | 3 4 3 2 2 2 3 2 2 3 2 4 2 3 3 4 3 2 2 3| Inflammation | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 | Hyperplasia | 1 2 1 2 2 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Chronic Active | 3 | Inflammation, Granulomatous | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Inflammation, | | Suppurative | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 77 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7| DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2| | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 2 2 3 1 2 3 2 2 1 1 3 2 1 3 2 2| Inflammation, Chronic Active | | Metaplasia, Squamous | 2 1 | Alveolar Epithelium, Hyperplasia | | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 2 1 1 1 1 2 3 2 3 2 2 2 3 1 1 2 3 1| Serosa, Inflammation, Suppurative | 3 | Vein, Thrombosis | 3 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Inflammation | 2 | Respiratory Epithelium, Hyperplasia | | Turbinate, Inflammation, Suppurative | 1 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Retina, Atrophy | 3 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | X | Casts Protein | 1 | Cyst | 1 2 | Inflammation, Chronic Active | | __________________________________________|__________________________________________________________________________| Page 78 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7| DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2| | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 1 2 1 1 2 1 1 1 1 1 1 1 3 1 2 1| Pelvis, Inflammation, Chronic Active | | Renal Tubule, Dilatation | 2 | Transitional Epithelium, Hyperplasia | 2 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +| Edema | 3 | Hemorrhage | 2 | Inflammation | 1 3 2 | Transitional Epithelium, Hyperplasia | | __________________________________________|__________________________________________________________________________ Page 79 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | Muscularis, Inflammation | | 1 1.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | Parasite Metazoan | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 52 | Inflammation, Chronic Active | | 1 2.0| Artery, Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 51 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 51 | Epithelium, Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Liver | + + + | 53 | Angiectasis | | 1 2.0| Basophilic Focus | X | 7 | Basophilic Focus, Multiple | | 6 | Cholangiofibrosis | | 1 2.0| Cytoplasmic Alteration | | 1 2.0| Eosinophilic Focus | X | 4 | Eosinophilic Focus, Multiple | X | 17 | Fatty Change, Diffuse | | 22 1.1| Fatty Change, Focal | 2 | 6 1.5| Hepatocyte, Multinucleate | | 14 1.0| Hepatodiaphragmatic Nodule | | 1 | Hyperplasia, Nodular | | 1 | Inflammation | 1 1 | 50 1.2| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 80 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Mixed Cell Focus | X X | 3 | Mixed Cell Focus, Multiple | X | 29 | Necrosis | | 8 2.1| Pigmentation | 1 | 39 1.6| Toxic Hepatopathy | 1 | 27 1.0| Artery, Inflammation, Chronic Active | | 1 2.0| Bile Duct, Cyst | | 2 2.0| Bile Duct, Fibrosis | | 2 1.0| Bile Duct, Hyperplasia | | 13 1.4| Hepatocyte, Hypertrophy | 1 2 | 36 1.3| Oval Cell, Hyperplasia | | 7 1.1| |__________________________________________________________________________|____________| Mesentery | | 2 | Artery, Inflammation, Chronic Active | | 2 3.5| |__________________________________________________________________________|____________| Oral Mucosa | | 4 | Gingival, Hyperplasia, Squamous | | 2 2.0| |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Basophilic Focus | | 1 | Inflammation, Chronic Active | | 4 1.3| Acinus, Atrophy | | 7 1.6| Acinus, Hyperplasia | | 1 2.0| Acinus, Vacuolization Cytoplasmic | | 4 1.5| Artery, Inflammation, Chronic Active | | 4 2.5| |__________________________________________________________________________|____________| Salivary Glands | + + + | 51 | Atrophy | | 1 1.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | Hyperkeratosis | | 1 1.0| Hyperplasia, Squamous | | 2 2.0| Inflammation, Chronic Active | | 1 2.0| Mineralization | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 81 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Ulcer | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | Erosion | | 1 2.0| Mineralization | | 1 1.0| |__________________________________________________________________________|____________| Tooth | + | 9 | Peridontal Tissue, Inflammation, | | | Suppurative | 1 | 9 1.4| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | Cardiomyopathy | | 16 1.2| Artery, Inflammation, Chronic Active | | 1 2.0| Epicardium, Inflammation, Suppurative| | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Angiectasis | 1 | 19 1.7| Atrophy | | 3 1.0| Degeneration, Cystic | 2 | 14 2.8| Hyperplasia | 3 | 25 2.0| Hypertrophy | 2 2 | 41 2.1| Necrosis | | 1 3.0| Vacuolization Cytoplasmic | | 2 2.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Angiectasis | | 1 2.0| Hyperplasia | | 11 2.0| Necrosis | | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 82 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | Hyperplasia | | 1 1.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 46 | Hyperplasia | | 2 1.5| |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Angiectasis | | 12 2.3| Cyst | | 1 1.0| Cytoplasmic Alteration | | 1 2.0| Pars Distalis, Hyperplasia | 1 | 17 2.1| |__________________________________________________________________________|____________| Thyroid Gland | + + + | 51 | Cyst | | 1 2.0| C-Cell, Hyperplasia | 2 | 19 1.8| Follicular Cell, Hyperplasia | | 1 1.0| Follicular Cell, Hypertrophy | | 17 1.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 50 | Inflammation | 1 | 28 1.6| Duct, Cyst | 2 2 | 37 1.9| |__________________________________________________________________________|____________| Ovary | + + + | 52 | Atrophy | 4 4 4 | 45 4.0| Cyst | | 15 2.3| Inflammation, Chronic Active | | 1 2.0| Artery, Inflammation, Chronic Active | | 1 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 83 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Uterus | + + + | 52 | Adenomyosis | | 1 4.0| Hemorrhage | | 1 2.0| Inflammation, Chronic Active | | 2 3.0| Inflammation, Suppurative | | 16 2.0| Metaplasia, Squamous | 2 2 | 28 2.3| Thrombosis | | 1 2.0| Endometrium, Hyperplasia, Cystic | 2 | 24 2.5| Epithelium, Hyperplasia | | 1 3.0| Epithelium, Necrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Hyperplasia | 4 3 3 | 44 3.3| |__________________________________________________________________________|____________| Lymph Node | | 6 | Ectasia | | 1 2.0| Lumbar, Hyperplasia, Plasma Cell | | 2 2.5| Mediastinal, Hemorrhage | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 51 | Ectasia | | 4 2.5| Hyperplasia, Lymphoid | | 1 2.0| Hyperplasia, Plasma Cell | | 21 2.3| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | Hemorrhage | | 1 2.0| |__________________________________________________________________________|____________| Spleen | + + + | 53 | Hematopoietic Cell Proliferation | 2 1 1 | 45 1.5| Pigmentation | 1 1 1 | 51 1.4| Lymphoid Follicle, Atrophy | | 2 1.5| Red Pulp, Atrophy | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 84 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Thymus | + M + | 48 | Atrophy | 3 2 | 45 2.8| Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Cyst | | 4 3.3| Hyperplasia | | 29 1.2| Inflammation, Chronic Active | | 2 3.0| Inflammation, Granulomatous | | 1 2.0| |__________________________________________________________________________|____________| Skin | + + + | 53 | Subcutaneous Tissue, Inflammation, | | | Suppurative | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Infiltration Cellular, Histiocyte | 1 2 1 | 48 1.6| Inflammation, Chronic Active | | 1 2.0| Metaplasia, Squamous | | 2 1.5| Alveolar Epithelium, Hyperplasia | | 1 3.0| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 2 | 41 1.8| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 85 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Serosa, Inflammation, Suppurative | | 1 3.0| Vein, Thrombosis | | 1 3.0| |__________________________________________________________________________|____________| Nose | + + + | 53 | Nasolacrimal Duct, Inflammation | | 1 2.0| Respiratory Epithelium, Hyperplasia | | 1 2.0| Turbinate, Inflammation, Suppurative | | 1 1.0| |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | Atrophy | | 1 3.0| Retina, Atrophy | | 1 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | Inflammation | | 6 1.2| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Calculus Micro Observation Only | | 1 | Casts Protein | | 6 1.2| Cyst | | 2 1.5| Inflammation, Chronic Active | | 1 3.0| Mineralization | 1 1 1 | 44 1.0| Nephropathy | 1 2 | 35 1.3| Pelvis, Inflammation, Chronic Active | | 2 2.5| Renal Tubule, Dilatation | | 1 2.0| Transitional Epithelium, Hyperplasia | | 4 2.5| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 52 | Edema | | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 86 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 3| 7| 4| | | DAY ON TEST | 8| 2| 3| | | | 5| 7| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 175 | 9| 9| 9| | L | NG/KG | 3| 6| 7| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Hemorrhage | | 1 2.0| Inflammation | | 6 2.2| Transitional Epithelium, Hyperplasia | | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 87 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7| DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2| | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Degeneration | 2 | Muscularis, Inflammation | | Periesophageal Tissue, Inflammation, | | Suppurative | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X | Basophilic Focus, Multiple | X X | Cholangiofibrosis | 1 2 | Cytoplasmic Alteration | | Degeneration, Cystic | 1 | Eosinophilic Focus | X | Eosinophilic Focus, Multiple | X X X X X X X X X X | Fatty Change, Diffuse | 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 | Fatty Change, Focal | 2 1 | Hepatocyte, Multinucleate | 2 2 1 2 1 1 1 1 1 1 1| Hyperplasia, Nodular | X X X| Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X X X X | Necrosis | 1 2 2 | __________________________________________|__________________________________________________________________________| Page 88 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7| DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2| | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Pigmentation | 1 3 1 1 2 2 2 2 1 3 1 2 2 2 2 3 2 3 1 2 2 2 2| Toxic Hepatopathy | 1 2 1 1 1 2 1 2 2 1 2 1 2 1 1 2 1 1 1 1 1| Artery, Inflammation, Chronic Active | | Bile Duct, Cyst | 2 | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 1 1 1 1 1 1| Hepatocyte, Degeneration | 1 | Hepatocyte, Hypertrophy | 2 1 2 1 3 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1| Oval Cell, Hyperplasia | 2 1 1 1 1 2| Portal, Fibrosis | 2 | |__________________________________________________________________________| Mesentery | + + + | Artery, Inflammation, Chronic Active | 3 3 3 | Fat, Necrosis | | |__________________________________________________________________________| Oral Mucosa | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Acinus, Atrophy | | Acinus, Hyperplasia | | Acinus, Vacuolization Cytoplasmic | 1 1 1 1 1 1| Artery, Inflammation, Chronic Active | 2 3 2 1 4| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +| Atrophy | | Cyst | 2 | Inflammation, Acute | | Inflammation, Chronic Active | 2 | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Hyperkeratosis | | Hyperplasia, Squamous | 1 | Inflammation, Chronic Active | | Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 89 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7| DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2| | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Tooth | + + + | Peridontal Tissue, Inflammation, | | Suppurative | 2 2 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 2 1 1 1| Epicardium, Inflammation, Chronic | | Active | | Myocardium, Inflammation | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 1 2 2 2 1 2| Atrophy | 3 1 1| Degeneration, Cystic | 3 1 2 2 3 1 2 | Hyperplasia | 2 2 2 3 3 2 2 2 2 3 3 2 | Hypertrophy | 2 2 3 2 2 2 2 1 2 2 2 2 2 3 2 2 3 1 1 1| Necrosis | | Vacuolization Cytoplasmic | 2 2 2 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Hyperplasia | 2 2 2 2 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + M + + M + + + + + + + M| Hyperplasia | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 3 2 1 2 3 3 2 | Cytoplasmic Alteration | 2 2| __________________________________________|__________________________________________________________________________| Page 90 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7| DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2| | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Necrosis | | Pigmentation | | Pars Distalis, Hyperplasia | 1 1 1 3 2 1 3 1 2 3| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 2 1 2 2 3 2 3 | Follicular Cell, Hypertrophy | 2 2 1 1 1 1 1 2 1 1 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 2 3 1 2 1 1 1 1 1 2 2 1 1 2 1 2 1| Duct, Cyst | 2 3 2 1 1 2 2 2 2 2 1 2 2 2 2 3 2 1 3 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + M + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| Cyst | 2 2 3 1 2 3| Inflammation, Chronic Active | 3 | Necrosis | 4 | |__________________________________________________________________________| Oviduct | | Inflammation, Chronic Active | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Inflammation, Chronic Active | 4 | Inflammation, Suppurative | 1 1 2 2 | Metaplasia, Squamous | 3 2 1 2 1 1 1 1 3 1 2 2 | Cervix, Cyst | | Endometrium, Hyperplasia, Cystic | 2 3 2 1 1 1 3 1 2 2 4 3 4 1 2| |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 91 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7| DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2| | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 4 3 3 3 3 3 4 2 4 3 3 2 2 3 4 4 4 4 3 3 2 3| |__________________________________________________________________________| Lymph Node | + + | Lumbar, Hyperplasia, Plasma Cell | | Mediastinal, Hemorrhage | | Mediastinal, Hyperplasia, Lymphoid | 3 | Mediastinal, Hyperplasia, Plasma Cell| | Mediastinal, Inflammation, | | Suppurative | 2 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| Ectasia | 2 | Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 2 2 2 2 3 2 1 2 2 2 2 2 2 2 2 2| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Plasma Cell | 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 3 1 2 1 3 1 2 2 1 1 2 3 3 2 2 1 1 1| Hyperplasia, Lymphoid | | Pigmentation | 2 2 1 2 1 2 1 1 1 2 1 1 2 2 2 1 1 1 1 1 2 1 1 2 2| Lymphoid Follicle, Atrophy | 2 2 | Red Pulp, Atrophy | | |__________________________________________________________________________| Thymus | + + + + + + M + + + + + + M M + + + M + M + + + +| Atrophy | 4 2 3 3 3 2 4 3 4 3 3 2 3 4 3 4 4 4 4| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 2 2 | Fibrosis, Focal | 2 | Hyperplasia | 1 1 1 1 1 2 2 1 2 1 1 1| Inflammation, Chronic Active | 2 | __________________________________________|__________________________________________________________________________| Page 92 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7| DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2| | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Infiltration Cellular, Histiocyte | 2 2 1 2 1 1 1 2 2 2 1 2 1 2 2 2 1 2 2 1 2 2| Inflammation, Chronic Active | | Metaplasia, Squamous | 2| Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 1 1 3 1 2 2 3 2 2 1 2 3 2 1 2 1 2 2| Serosa, Inflammation, Suppurative | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Inflammation | 2 | Nasolacrimal Duct, Respiratory | | Epithelium, Hyperplasia | 2 | Respiratory Epithelium, Hyperplasia | 2 2 | Respiratory Epithelium, Inflammation,| | Suppurative | 2 | Respiratory Epithelium, Metaplasia | 2 | Turbinate, Inflammation, Suppurative | 2 3 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 93 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7| DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2| | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Ear | + | Inflammation | 1 | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | | Edema | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 | |__________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Necrosis | | Nephropathy | 3 1 1 1 1 1 1 2 2 1 1 1 3 1 2 1 2 1 2 2| Papilla, Angiectasis | | Pelvis, Inflammation, Suppurative | 2 | Transitional Epithelium, Hyperplasia | 2 2 2 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +| Inflammation | 1 2 3 1 1| Transitional Epithelium, Hyperplasia | 3 | __________________________________________|__________________________________________________________________________ Page 94 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6| DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4| | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Degeneration | | Muscularis, Inflammation | 1 | Periesophageal Tissue, Inflammation, | | Suppurative | 3 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | | Basophilic Focus, Multiple | | Cholangiofibrosis | 2 | Cytoplasmic Alteration | 2 | Degeneration, Cystic | | Eosinophilic Focus | X | Eosinophilic Focus, Multiple | X X X X | Fatty Change, Diffuse | 1 1 1 1 2 1 1 1 1 1 2 1 | Fatty Change, Focal | 2 | Hepatocyte, Multinucleate | 1 1 2 1 1 1 2 1 | Hyperplasia, Nodular | | Inflammation | 1 1 1 1 2 1 1 1 1 1 1 1 2 1 2 3 2 2 1 1 2 1 1| Mixed Cell Focus, Multiple | X X X X X X X X X X | Necrosis | 2 2 1 2 2 3 1 3| __________________________________________|__________________________________________________________________________| Page 95 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6| DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4| | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Pigmentation | 2 2 2 1 2 1 2 1 2 2 2 2 2 2 2 2 3 2 3 1 1 2| Toxic Hepatopathy | 1 1 1 1 1 1 1 1 2 1 1 2 2 1 1 | Artery, Inflammation, Chronic Active | 2 | Bile Duct, Cyst | 2 4 | Bile Duct, Fibrosis | | Bile Duct, Hyperplasia | 1 1 1 1 3 2 1 | Hepatocyte, Degeneration | | Hepatocyte, Hypertrophy | 1 3 1 2 2 1 1 2 2 1 1 2 1 1 2 1 1 2 1 | Oval Cell, Hyperplasia | 1 1 1 | Portal, Fibrosis | 2 | |__________________________________________________________________________| Mesentery | + + + | Artery, Inflammation, Chronic Active | 3 4 | Fat, Necrosis | 3 | |__________________________________________________________________________| Oral Mucosa | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 | Acinus, Atrophy | 3 2 | Acinus, Hyperplasia | 2 | Acinus, Vacuolization Cytoplasmic | 1 1 | Artery, Inflammation, Chronic Active | 2 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Cyst | | Inflammation, Acute | 1 | Inflammation, Chronic Active | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Hyperkeratosis | 2 2 1 | Hyperplasia, Squamous | 2 2 2 2 | Inflammation, Chronic Active | 2 | Ulcer | 3 2 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 96 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6| DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4| | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Tooth | + + + + + + | Peridontal Tissue, Inflammation, | | Suppurative | 1 1 1 1 2 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 1| Epicardium, Inflammation, Chronic | | Active | 3 | Myocardium, Inflammation | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 1 1 1 2 1 1 2 | Atrophy | 2 1 | Degeneration, Cystic | 2 3 1 3 3 3 | Hyperplasia | 3 2 4 1 2 2 3 2 3 2 | Hypertrophy | 2 1 1 1 2 2 2 1 2 1 2 1 3 2 1 3 4 2| Necrosis | 2| Vacuolization Cytoplasmic | 2 2 2 1| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hyperplasia | 1 2 2 2 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 3 2 2 1 3| Cytoplasmic Alteration | 2 | __________________________________________|__________________________________________________________________________| Page 97 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6| DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4| | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Necrosis | 2| Pigmentation | 2 | Pars Distalis, Hyperplasia | 2 2 1 1 2 2 1 2 3 3| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 1 3 2 3 1 1 | Follicular Cell, Hypertrophy | 2 2 1 1 3 1 1 3 1 2 2 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 2 2 1 1 1 2 1 1| Duct, Cyst | 1 2 3 2 1 1 2 2 2 2 3 2 2 3 1 2 1 2 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| Cyst | 3 2 2 1 2 2 3 2 2 2| Inflammation, Chronic Active | | Necrosis | | |__________________________________________________________________________| Oviduct | + | Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Inflammation, Chronic Active | | Inflammation, Suppurative | 2 3 1 2 1 | Metaplasia, Squamous | 1 1 4 1 2 2 1 2 2 3 3 1 2 1 3 2| Cervix, Cyst | 2 | Endometrium, Hyperplasia, Cystic | 2 1 2 2 3 3 1 1 1 2| |__________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 98 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6| DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4| | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 4 3 4 3 3 4 4 2 3 3 4 4 4 4 4 4 3 3| |__________________________________________________________________________| Lymph Node | + + | Lumbar, Hyperplasia, Plasma Cell | 3 | Mediastinal, Hemorrhage | 2 | Mediastinal, Hyperplasia, Lymphoid | | Mediastinal, Hyperplasia, Plasma Cell| 2 | Mediastinal, Inflammation, | | Suppurative | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 2 | Hemorrhage | | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 3 2 2 1 3 2 2 2 2 2 1 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Plasma Cell | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 2 1 1 2 2 1 1 1 1 2 2 3 1 1 3 2 2 3| Hyperplasia, Lymphoid | 2 | Pigmentation | 2 1 2 2 1 1 1 2 1 1 2 2 2 2 2 2 1 1 2 1 1 1 2 1| Lymphoid Follicle, Atrophy | 2 2 2 | Red Pulp, Atrophy | 2 | |__________________________________________________________________________| Thymus | + + + + + + M + M + + M + + + + + M M + + + M + +| Atrophy | 3 3 4 4 3 3 2 4 4 2 4 4 4 3 4| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 2 | Fibrosis, Focal | | Hyperplasia | 1 1 1 2 1 1 1| Inflammation, Chronic Active | 2 | __________________________________________|__________________________________________________________________________| Page 99 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6| DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4| | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteopetrosis | 2 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Infiltration Cellular, Histiocyte | 2 1 2 2 1 1 1 2 1 2 1 2 2 1 1 1 2 2 2 2| Inflammation, Chronic Active | 2 | Metaplasia, Squamous | 2 3 | Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 3 1 2 2 2 1 1 3 1 2 1 1 1 2 3 2 2| Serosa, Inflammation, Suppurative | 3 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Inflammation | | Nasolacrimal Duct, Respiratory | | Epithelium, Hyperplasia | | Respiratory Epithelium, Hyperplasia | | Respiratory Epithelium, Inflammation,| | Suppurative | | Respiratory Epithelium, Metaplasia | | Turbinate, Inflammation, Suppurative | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 100 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6| DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4| | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Ear | | Inflammation | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | | Edema | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | |__________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Mineralization | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Necrosis | 3 | Nephropathy | 2 2 1 1 1 1 2 1 2 2 2 3 1 2 1 1| Papilla, Angiectasis | | Pelvis, Inflammation, Suppurative | 2 2 | Transitional Epithelium, Hyperplasia | 2 1 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 1 | Transitional Epithelium, Hyperplasia | | __________________________________________|__________________________________________________________________________ Page 101 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | Muscularis, Degeneration | | 1 2.0| Muscularis, Inflammation | | 1 1.0| Periesophageal Tissue, Inflammation, | | | Suppurative | | 1 3.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | Parasite Metazoan | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | Hyperplasia, Lymphoid | | 1 2.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | Hyperplasia, Lymphoid | | 1 2.0| |__________________________________________________________________________|____________| Liver | + + + | 53 | Angiectasis | | 1 2.0| Basophilic Focus | | 2 | Basophilic Focus, Multiple | | 2 | Cholangiofibrosis | | 3 1.7| Cytoplasmic Alteration | | 1 2.0| Degeneration, Cystic | | 1 1.0| Eosinophilic Focus | | 2 | Eosinophilic Focus, Multiple | X | 15 | Fatty Change, Diffuse | 1 1 | 30 1.1| Fatty Change, Focal | | 3 1.7| Hepatocyte, Multinucleate | | 19 1.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 102 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Hyperplasia, Nodular | | 3 | Inflammation | 1 1 1 | 51 1.2| Mixed Cell Focus, Multiple | X X X | 30 | Necrosis | | 11 1.9| Pigmentation | 2 1 2 | 48 1.9| Toxic Hepatopathy | 1 1 1 | 39 1.3| Artery, Inflammation, Chronic Active | | 1 2.0| Bile Duct, Cyst | | 3 2.7| Bile Duct, Fibrosis | | 1 1.0| Bile Duct, Hyperplasia | 1 | 14 1.2| Hepatocyte, Degeneration | | 1 1.0| Hepatocyte, Hypertrophy | 1 1 1 | 42 1.4| Oval Cell, Hyperplasia | 1 | 10 1.2| Portal, Fibrosis | | 2 2.0| |__________________________________________________________________________|____________| Mesentery | + | 7 | Artery, Inflammation, Chronic Active | 3 | 6 3.2| Fat, Necrosis | | 1 3.0| |__________________________________________________________________________|____________| Oral Mucosa | | 2 | |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Inflammation, Chronic Active | 1 | 4 1.8| Acinus, Atrophy | | 2 2.5| Acinus, Hyperplasia | | 1 2.0| Acinus, Vacuolization Cytoplasmic | 1 | 9 1.0| Artery, Inflammation, Chronic Active | 3 | 8 2.5| |__________________________________________________________________________|____________| Salivary Glands | + + + | 52 | Atrophy | | 1 2.0| Cyst | | 1 2.0| Inflammation, Acute | | 1 1.0| Inflammation, Chronic Active | | 1 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 103 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Stomach, Forestomach | + + + | 53 | Edema | | 1 2.0| Hyperkeratosis | | 3 1.7| Hyperplasia, Squamous | | 5 1.8| Inflammation, Chronic Active | | 1 2.0| Ulcer | | 3 2.3| |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | |__________________________________________________________________________|____________| Tooth | + | 10 | Peridontal Tissue, Inflammation, | | | Suppurative | 1 | 10 1.4| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | Cardiomyopathy | 1 1 | 24 1.1| Epicardium, Inflammation, Chronic | | | Active | | 1 3.0| Myocardium, Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Angiectasis | 1 2 2 | 20 1.5| Atrophy | | 5 1.6| Degeneration, Cystic | 1 | 14 2.1| Hyperplasia | 3 3 2 | 25 2.4| Hypertrophy | 2 1 | 40 1.9| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | 2 | 9 1.9| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 104 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Adrenal Medulla | + + + | 53 | Angiectasis | | 2 2.5| Hyperplasia | 2 1 | 12 1.8| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 49 | Hyperplasia | | 1 3.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Angiectasis | 2 | 16 2.3| Cytoplasmic Alteration | | 3 2.0| Necrosis | | 1 2.0| Pigmentation | | 1 2.0| Pars Distalis, Hyperplasia | 2 | 21 1.9| |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | C-Cell, Hyperplasia | 2 | 18 1.9| Follicular Cell, Hypertrophy | 1 2 | 28 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | Inflammation | 1 2 | 30 1.4| Duct, Cyst | 3 3 | 39 2.0| |__________________________________________________________________________|____________| Ovary | + + + | 52 | Atrophy | 4 4 4 | 47 4.0| Cyst | | 16 2.1| Inflammation, Chronic Active | | 1 3.0| Necrosis | | 1 4.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 105 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Oviduct | | 1 | Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Uterus | + + + | 53 | Hemorrhage | | 2 3.0| Inflammation, Chronic Active | | 1 4.0| Inflammation, Suppurative | 1 | 10 1.6| Metaplasia, Squamous | 1 | 29 1.8| Cervix, Cyst | | 1 2.0| Endometrium, Hyperplasia, Cystic | 2 | 26 2.0| |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Hyperplasia | 4 3 2 | 45 3.2| |__________________________________________________________________________|____________| Lymph Node | | 4 | Lumbar, Hyperplasia, Plasma Cell | | 1 3.0| Mediastinal, Hemorrhage | | 1 2.0| Mediastinal, Hyperplasia, Lymphoid | | 1 3.0| Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0| Mediastinal, Inflammation, | | | Suppurative | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 52 | Ectasia | | 4 2.0| Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | | 2 2.0| Hyperplasia, Plasma Cell | 2 2 | 29 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 106 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Hemorrhage | | 1 2.0| Hyperplasia, Plasma Cell | | 1 2.0| |__________________________________________________________________________|____________| Spleen | + + + | 53 | Hematopoietic Cell Proliferation | 3 1 1 | 41 1.7| Hyperplasia, Lymphoid | | 1 2.0| Pigmentation | 1 1 2 | 52 1.5| Lymphoid Follicle, Atrophy | | 5 2.0| Red Pulp, Atrophy | | 1 2.0| |__________________________________________________________________________|____________| Thymus | M + + | 41 | Atrophy | 3 2 | 36 3.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Cyst | | 5 2.6| Fibrosis, Focal | | 1 2.0| Hyperplasia | 1 1 | 21 1.2| Inflammation, Chronic Active | | 2 2.0| |__________________________________________________________________________|____________| Skin | + + + | 53 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | Osteopetrosis | | 2 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 107 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Lung | + + + | 53 | Congestion | | 1 2.0| Infiltration Cellular, Histiocyte | 2 1 1 | 45 1.6| Inflammation, Chronic Active | | 1 2.0| Metaplasia, Squamous | | 3 2.3| Alveolar Epithelium, Hyperplasia | | 2 1.0| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 2 1 1 | 39 1.7| Serosa, Inflammation, Suppurative | | 1 3.0| |__________________________________________________________________________|____________| Nose | + + + | 52 | Nasolacrimal Duct, Inflammation | | 1 2.0| Nasolacrimal Duct, Respiratory | | | Epithelium, Hyperplasia | | 1 2.0| Respiratory Epithelium, Hyperplasia | | 2 2.0| Respiratory Epithelium, Inflammation,| | | Suppurative | | 1 2.0| Respiratory Epithelium, Metaplasia | | 1 2.0| Turbinate, Inflammation, Suppurative | | 2 2.5| |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | Inflammation | | 1 1.0| |__________________________________________________________________________|____________| Eye | + + + | 53 | Cataract | 3 | 1 3.0| Edema | 3 | 1 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | Inflammation | | 3 1.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 108 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 5| 7| | | DAY ON TEST | 2| 5| 2| | | | 2| 4| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| | A | 300 | 9| 9| 9| | L | NG/KG | 0| 7| 8| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Inflammation, Chronic Active | | 1 1.0| Mineralization | 1 1 1 | 44 1.0| Necrosis | | 1 3.0| Nephropathy | 1 2 | 38 1.5| Papilla, Angiectasis | 2 | 1 2.0| Pelvis, Inflammation, Suppurative | | 3 2.0| Transitional Epithelium, Hyperplasia | 1 | 8 1.6| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 52 | Inflammation | | 7 1.6| Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 109 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2| | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Muscularis, Inflammation | 1 2 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + M + + + + + + + +| Angiectasis | 1 | Basophilic Focus | | Basophilic Focus, Multiple | | Cholangiofibrosis | 1 3 1 3 3 1 1 | Cytoplasmic Alteration | | Degeneration, Cystic | | Eosinophilic Focus | X | Eosinophilic Focus, Multiple | X X X X X X X X | Fatty Change, Diffuse | 1 2 1 1 2 2 2 1 2 2 2 1 1 1 2 1 1 1 1 1| Fatty Change, Focal | | Hematopoietic Cell Proliferation | 2 | Hepatocyte, Multinucleate | 2 2 1 1 1 1 2 1 1 2 2 2 3 1 1 1 1 2 1 3 2| Hyperplasia, Nodular | X X X X X X X X X X X X X X| Inflammation | 2 2 1 1 2 2 1 1 1 1 1 1 2 1 2 2 1 1 2 2 1 2 2 1| Mixed Cell Focus | | Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X | Necrosis | 2 1 3 2 2 3 2 2 1 | Pigmentation | 3 2 2 3 3 2 1 3 2 1 3 2 3 2 3 2 2 2 3 2 3 1 3 4| Toxic Hepatopathy | 3 3 2 2 4 3 1 3 2 1 3 4 3 3 2 2 2 1 2 2 2 2 3 3| Artery, Inflammation, Chronic Active | | __________________________________________|__________________________________________________________________________| Page 110 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2| | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Cyst | 2 2 1 1 2 | Bile Duct, Fibrosis | 1 1 | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 1 2 3 2 2 2 1 1 2 1 2 2 2 3| Hepatocyte, Degeneration | | Hepatocyte, Hypertrophy | 3 2 3 3 2 2 2 2 2 2 2 2 3 3 3 2 1 2 2 2 2 1 3| Oval Cell, Hyperplasia | 2 2 2 2 2 2 2 2 1 3 1 2 1 2 2 2 2| Portal, Fibrosis | | |__________________________________________________________________________| Mesentery | + + + + + + +| Artery, Inflammation, Chronic Active | 3 3 2 3 3| Fat, Necrosis | 3 | |__________________________________________________________________________| Oral Mucosa | + + + + +| Gingival, Hyperplasia, Squamous | 3 1 1 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + M + + + + + + + +| Cyst | | Inflammation, Chronic Active | 2 3 2 | Acinus, Atrophy | 3 3 2 2 2| Acinus, Vacuolization Cytoplasmic | 1 2 1 1 2 1 1 1 1 1 1| Artery, Inflammation, Chronic Active | 1 2 3 2 3 4 4| Artery, Mineralization | 2 | Duct, Hyperplasia | | Duct, Inflammation, Chronic Active | | |__________________________________________________________________________| Salivary Glands | + + M + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + M + + + + + + + +| Hyperkeratosis | | Hyperplasia, Squamous | 2 1 2| Mineralization | 2 | Ulcer | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + | Peridontal Tissue, Inflammation, | | Chronic Active | 4 | __________________________________________|__________________________________________________________________________| Page 111 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2| | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Peridontal Tissue, Inflammation, | | Suppurative | 2 2 2 2 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | 1 | |__________________________________________________________________________| Heart | + + + + M + + + + + + + + + + + M + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 | Degeneration | 3 | Mineralization | 2 | Thrombosis | | Myocardium, Inflammation | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + M + + + + + + + +| Angiectasis | 2 3 1 | Atrophy | 1 2 1 1 3 1 1 1 1 2| Degeneration, Cystic | 2 3 2 | Hyperplasia | 3 2 2 3 2 3 3 3 2 3 2 3 3 3 2| Hypertrophy | 2 1 2 3 2 2 2 2 2 2 2 1 2 4 3 3 2 2 2 2| Mineralization | | Necrosis | | Thrombosis | | Vacuolization Cytoplasmic | 1 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +| Angiectasis | 2 | Hyperplasia | 2 2 1 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + M + + + + + + + +| Hyperplasia | 1 | |__________________________________________________________________________| Parathyroid Gland | + + M + M + + + + + + M + M + + + + + + + + + + +| Hyperplasia | 1 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 112 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2| | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 3 2 1 2 3 1 2 2 3| Cyst | 2 | Cytoplasmic Alteration | | Inflammation, Focal, Granulomatous | | Pars Distalis, Hyperplasia | 1 3 2 3 3 3 2 2 2 3 2 2 | |__________________________________________________________________________| Thyroid Gland | + + M + M + + + + + + + + + + + + + + + + + + + +| Cyst | | C-Cell, Hyperplasia | 1 3 2 2 1 2 2 2 | Follicular Cell, Hypertrophy | 1 1 2 1 1 1 2 2 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Inflammation | 1 2 1 1 1 1 1 2 2 | Duct, Cyst | 1 3 2 2 2 3 1 4 2 2 1 3 3 3 2 3 2 2| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + M + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 | Cyst | 2 2 2 3 2 2 2| Inflammation, Suppurative | 2 | |__________________________________________________________________________| Oviduct | + + | Cyst | 4 | Inflammation, Suppurative | 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + M + + + + + + + +| Adenomyosis | 3 2 | Hemorrhage | 3 | Inflammation, Chronic Active | | Inflammation, Suppurative | 1 3 2 2 | Metaplasia, Squamous | 2 3 3 2 1 3 3 1 2 4 2 | Thrombosis | | __________________________________________|__________________________________________________________________________| Page 113 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2| | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Artery, Inflammation, Chronic Active | 3 | Cervix, Hyperplasia, Stromal | 3 | Endometrium, Hyperplasia, Cystic | 2 3 3 3 3 3 2 1 2 2 3 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hyperplasia | 3 4 4 4 3 3 3 2 4 4 3 2 3 3 3 3 2 3 4 3 3| |__________________________________________________________________________| Lymph Node | + + + + | Lumbar, Ectasia | 2 | Lumbar, Hyperplasia | 2 | Mediastinal, Hyperplasia, Plasma Cell| | Pancreatic, Hyperplasia, Plasma Cell | | |__________________________________________________________________________| Lymph Node, Mandibular | + + M + M + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 2 | Hyperplasia, Plasma Cell | 2 2 2 2| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| Ectasia | 2 | Hyperplasia, Histiocytic | 2| Pigmentation | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + M + + + + + + + +| Hematopoietic Cell Proliferation | 1 2 1 2 1 2 1 1 1 2 1 1 1 1 1 2 2 | Hyperplasia, Lymphoid | | Pigmentation | 2 1 2 2 2 2 1 2 1 1 2 1 2 2 2 2 2 1 1 1 1 1 2 1| Lymphoid Follicle, Atrophy | 2 | |__________________________________________________________________________| Thymus | + + + + M + M + + + + + + + + + M + + + + + + + +| Atrophy | 4 4 3 4 4 4 3 3 4 4 3 2 4 4 3 3 4 3 4 3 4 2| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Cyst | 2 | __________________________________________|__________________________________________________________________________| Page 114 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2| | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Hyperplasia | 2 1 1 1 2 1 2 1 1 1 1 1 1| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cartilage, Hypertrophy, Focal | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hydrocephalus | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + M + + + + + + + + + + + M + + + + + + + +| Infiltration Cellular, Histiocyte | 2 2 1 1 2 1 2 1 2 2 2 2 2 2 1 2 2 2 1 2 2 1| Inflammation, Suppurative | | Metaplasia, Squamous | 1 2 2 2 | Mineralization | 2 | Thrombosis | 2 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 3 2 1 2 2 1 3 2 3 2 3 2 3 3 1 2 2 2 2 3 3 2| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Glands, | | Hyperplasia | | Respiratory Epithelium, Hyperplasia | 3| Respiratory Epithelium, Inflammation,| | Suppurative | | Turbinate, Cyst | 1 | |__________________________________________________________________________| Trachea | + + + + M + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 115 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2| | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Eye | + + M + + + + + + + + + + + + + + + + + + + + + +| Cataract | 3 | Anterior Chamber, Inflammation, | | Suppurative | 3| Cornea, Inflammation, Suppurative | 3| Retina, Atrophy | 3 | Retina, Degeneration | 2 | |__________________________________________________________________________| Harderian Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + M + + + + + + + +| Calculus Micro Observation Only | X | Inflammation, Chronic Active | | Inflammation, Suppurative | 3 | Mineralization | 1 1 3 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 2 | Necrosis | 3 | Nephropathy | 3 2 3 3 2 2 2 3 2 2 3 1 2 2 2 1 2 2 3| Pelvis, Dilatation | 2 | Transitional Epithelium, Hyperplasia | 2 2 2 2 3 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +| Inflammation | 1 1 1 | Transitional Epithelium, Hyperplasia | 3 | __________________________________________|__________________________________________________________________________ Page 116 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2| | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Muscularis, Inflammation | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + M + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X | Basophilic Focus, Multiple | X | Cholangiofibrosis | 2 1 1 2 2 2 | Cytoplasmic Alteration | 2 | Degeneration, Cystic | 2 | Eosinophilic Focus | X X | Eosinophilic Focus, Multiple | X X X X X X X X X X X X| Fatty Change, Diffuse | 1 2 2 2 1 1 1 1 1 2 2 2 1 2 2 2 1 1 1 1 2 1 2| Fatty Change, Focal | 1 | Hematopoietic Cell Proliferation | | Hepatocyte, Multinucleate | 2 2 1 1 2 1 1 1 1 1 2 2 1 1 1 2 2 2 2 1 1 2| Hyperplasia, Nodular | X X X X X X X X X X X| Inflammation | 1 1 1 1 1 2 1 1 1 2 1 1 2 2 2 1 2 1 1 1 1 2 2 1| Mixed Cell Focus | X X | Mixed Cell Focus, Multiple | X X X X X X X X X X X| Necrosis | 2 3 2 1 2 | Pigmentation | 2 2 3 2 2 2 2 2 3 2 2 2 2 3 2 2 3 2 2 1 3 2 2 2| Toxic Hepatopathy | 1 3 3 1 2 2 2 2 2 3 3 3 2 3 3 3 2 2 2 1 3 2 3 2| Artery, Inflammation, Chronic Active | 2 | __________________________________________|__________________________________________________________________________| Page 117 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2| | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Cyst | 4 2 | Bile Duct, Fibrosis | 1 1 | Bile Duct, Hyperplasia | 2 3 1 1 1 1 2 1 2 2 2 2 2 2 1 2 1 1 1 2 4 1| Hepatocyte, Degeneration | 1 | Hepatocyte, Hypertrophy | 2 2 4 1 2 1 2 2 3 2 2 2 2 3 4 1 2 2 3 2 3 3 3 3| Oval Cell, Hyperplasia | 2 2 1 2 2 1 1 2 2 1 3 2 2 2 1 2 1 1 1| Portal, Fibrosis | 1 | |__________________________________________________________________________| Mesentery | + + + + + | Artery, Inflammation, Chronic Active | 2 2 3 3 | Fat, Necrosis | | |__________________________________________________________________________| Oral Mucosa | + | Gingival, Hyperplasia, Squamous | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 3 2 | Acinus, Atrophy | 3 2 3 1 1 | Acinus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1| Artery, Inflammation, Chronic Active | 2 2 3 2 2 3 3 | Artery, Mineralization | | Duct, Hyperplasia | 4 | Duct, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +| Hyperkeratosis | 2 | Hyperplasia, Squamous | 2 2 | Mineralization | | Ulcer | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Tooth | | Peridontal Tissue, Inflammation, | | Chronic Active | | __________________________________________|__________________________________________________________________________| Page 118 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2| | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Peridontal Tissue, Inflammation, | | Suppurative | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | 1 | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 | Degeneration | | Mineralization | | Thrombosis | 2 | Myocardium, Inflammation | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 1 1 1| Atrophy | 3 2 1 1 3 3 3 3 1 | Degeneration, Cystic | 2 2 3 2 1 3 1 2 3 3 2 | Hyperplasia | 3 1 2 2 2 2 3 4 3 4 3 4 3 3| Hypertrophy | 2 2 1 1 2 2 2 3 2 1 2 4 1 3 2 1 1 1| Mineralization | | Necrosis | 2 | Thrombosis | 2 | Vacuolization Cytoplasmic | 1 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Hyperplasia | 2 4 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + M| Hyperplasia | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 119 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2| | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 3 2 3 3| Cyst | | Cytoplasmic Alteration | | Inflammation, Focal, Granulomatous | 2 | Pars Distalis, Hyperplasia | 3 1 2 2 3 2 2 3 2 2 2 2 2| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| Cyst | 2 | C-Cell, Hyperplasia | 2 2 2 2 1 3 | Follicular Cell, Hypertrophy | 1 2 3 1 1 1 1 1 2 2 1 2 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 2 1 1 1 1 2 2 1 1 1 1 2 2 | Duct, Cyst | 2 3 3 2 1 3 3 2 1 3 1 3 3 3 3 2 2 1 2 3 2 2| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| Cyst | 2 2 2 1 2 3 2 2 2| Inflammation, Suppurative | 3 | |__________________________________________________________________________| Oviduct | + | Cyst | | Inflammation, Suppurative | 3 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenomyosis | | Hemorrhage | | Inflammation, Chronic Active | 2 | Inflammation, Suppurative | 3 | Metaplasia, Squamous | 1 3 2 1 2 3 2 2 1 3 3 3 1 1| Thrombosis | 3 | __________________________________________|__________________________________________________________________________| Page 120 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2| | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Artery, Inflammation, Chronic Active | | Cervix, Hyperplasia, Stromal | | Endometrium, Hyperplasia, Cystic | 2 1 3 2 1 2 1 2 3 4 4 2 4 1 2 1 3| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hyperplasia | 3 3 3 3 4 2 4 2 3 2 3 4 4 3 4 4 4 4 3 3 2 2| |__________________________________________________________________________| Lymph Node | + + | Lumbar, Ectasia | 2 | Lumbar, Hyperplasia | | Mediastinal, Hyperplasia, Plasma Cell| 3 | Pancreatic, Hyperplasia, Plasma Cell | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | Hyperplasia, Plasma Cell | 2 2 3 2 2 3| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +| Ectasia | | Hyperplasia, Histiocytic | | Pigmentation | 1 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 1 1 1 1 2 1 2 1 1 3 1 2 3 2 3 1 1 1 2 1| Hyperplasia, Lymphoid | 3 | Pigmentation | 2 1 2 2 2 1 2 1 1 1 2 2 2 1 1 2 2 1 1 1 1 2 2 1 1| Lymphoid Follicle, Atrophy | 2 3 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| Atrophy | 3 3 4 3 4 3 4 3 3 3 4 4 3 3 3 4 3 4 4 3 4 4| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | __________________________________________|__________________________________________________________________________| Page 121 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2| | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Hyperplasia | 1 1 1 1 1 1 1 1 1| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cartilage, Hypertrophy, Focal | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Hydrocephalus | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 2 1 3 2 1 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 1| Inflammation, Suppurative | 2 | Metaplasia, Squamous | 2 2 1 1 2| Mineralization | | Thrombosis | | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 3 2 3 1 2 1 3 3 2 2 2 2 2 3 3 1 1 1 2 2 3 1| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Glands, | | Hyperplasia | 4 | Respiratory Epithelium, Hyperplasia | 2 | Respiratory Epithelium, Inflammation,| | Suppurative | 3 | Turbinate, Cyst | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 122 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2| | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | | Anterior Chamber, Inflammation, | | Suppurative | | Cornea, Inflammation, Suppurative | | Retina, Atrophy | | Retina, Degeneration | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | | Inflammation, Chronic Active | 2 | Inflammation, Suppurative | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| Necrosis | | Nephropathy | 3 3 1 1 1 1 3 2 1 2 2 2 2 3 3 3 2 3 2 1| Pelvis, Dilatation | | Transitional Epithelium, Hyperplasia | 1 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | Transitional Epithelium, Hyperplasia | 2 | __________________________________________|__________________________________________________________________________ Page 123 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 52 | Hemorrhage | | 1 3.0| Muscularis, Inflammation | | 2 1.5| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 51 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 51 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 51 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | |__________________________________________________________________________|____________| Liver | + + + | 51 | Angiectasis | | 2 1.5| Basophilic Focus | | 3 | Basophilic Focus, Multiple | X | 2 | Cholangiofibrosis | | 13 1.8| Cytoplasmic Alteration | | 1 2.0| Degeneration, Cystic | | 1 2.0| Eosinophilic Focus | | 3 | Eosinophilic Focus, Multiple | X | 21 | Fatty Change, Diffuse | 1 1 | 45 1.4| Fatty Change, Focal | 1 | 2 1.0| Hematopoietic Cell Proliferation | | 1 2.0| Hepatocyte, Multinucleate | 1 1 1 | 46 1.5| Hyperplasia, Nodular | X | 26 | Inflammation | 1 1 1 | 51 1.4| Mixed Cell Focus | X | 3 | Mixed Cell Focus, Multiple | X | 26 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 124 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Necrosis | 2 | 15 2.0| Pigmentation | 2 2 2 | 51 2.3| Toxic Hepatopathy | 3 2 3 | 51 2.4| Artery, Inflammation, Chronic Active | | 1 2.0| Bile Duct, Cyst | 2 | 8 2.0| Bile Duct, Fibrosis | | 4 1.0| Bile Duct, Hyperplasia | 2 4 | 45 1.8| Hepatocyte, Degeneration | | 1 1.0| Hepatocyte, Hypertrophy | 3 2 3 | 50 2.3| Oval Cell, Hyperplasia | 3 1 | 38 1.8| Portal, Fibrosis | | 1 1.0| |__________________________________________________________________________|____________| Mesentery | + | 13 | Artery, Inflammation, Chronic Active | 2 | 10 2.6| Fat, Necrosis | | 1 3.0| |__________________________________________________________________________|____________| Oral Mucosa | | 6 | Gingival, Hyperplasia, Squamous | | 4 1.5| |__________________________________________________________________________|____________| Pancreas | + + + | 52 | Cyst | 2 | 1 2.0| Inflammation, Chronic Active | 2 | 6 2.3| Acinus, Atrophy | 2 | 11 2.2| Acinus, Vacuolization Cytoplasmic | | 20 1.1| Artery, Inflammation, Chronic Active | 2 | 15 2.5| Artery, Mineralization | | 1 2.0| Duct, Hyperplasia | | 1 4.0| Duct, Inflammation, Chronic Active | 3 | 2 3.0| |__________________________________________________________________________|____________| Salivary Glands | + + + | 51 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 51 | Hyperkeratosis | | 1 2.0| Hyperplasia, Squamous | 1 | 6 1.7| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 125 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Mineralization | | 1 2.0| Ulcer | | 2 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 51 | |__________________________________________________________________________|____________| Tooth | + + | 9 | Peridontal Tissue, Inflammation, | | | Chronic Active | | 1 4.0| Peridontal Tissue, Inflammation, | | | Suppurative | 2 2 | 8 1.8| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | Aorta, Mineralization | | 2 1.0| |__________________________________________________________________________|____________| Heart | + + + | 51 | Cardiomyopathy | 1 | 28 1.1| Degeneration | | 1 3.0| Mineralization | | 1 2.0| Thrombosis | | 1 2.0| Myocardium, Inflammation | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 52 | Angiectasis | | 8 1.4| Atrophy | | 19 1.8| Degeneration, Cystic | 3 2 | 16 2.3| Hyperplasia | 3 3 | 31 2.7| Hypertrophy | 2 3 2 | 41 2.0| Mineralization | 1 | 1 1.0| Necrosis | | 1 2.0| Thrombosis | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 126 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Vacuolization Cytoplasmic | | 4 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 52 | Angiectasis | | 2 2.5| Hyperplasia | | 6 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 52 | Hyperplasia | | 1 1.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 47 | Hyperplasia | | 1 1.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Angiectasis | 2 2 | 19 2.3| Cyst | 3 | 2 2.5| Cytoplasmic Alteration | 2 | 1 2.0| Inflammation, Focal, Granulomatous | | 1 2.0| Pars Distalis, Hyperplasia | 2 | 26 2.2| |__________________________________________________________________________|____________| Thyroid Gland | + + + | 50 | Cyst | | 1 2.0| C-Cell, Hyperplasia | 1 2 | 16 1.9| Follicular Cell, Hypertrophy | 1 | 26 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 52 | Inflammation | 1 1 | 27 1.3| Duct, Cyst | 2 1 | 42 2.2| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 127 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Ovary | + + + | 52 | Atrophy | 4 4 4 | 46 4.0| Cyst | 2 3 | 18 2.1| Inflammation, Suppurative | | 2 2.5| |__________________________________________________________________________|____________| Oviduct | | 3 | Cyst | | 1 4.0| Inflammation, Suppurative | | 2 2.5| |__________________________________________________________________________|____________| Uterus | + + + | 52 | Adenomyosis | | 2 2.5| Hemorrhage | | 1 3.0| Inflammation, Chronic Active | | 1 2.0| Inflammation, Suppurative | 2 | 6 2.2| Metaplasia, Squamous | 3 2 | 27 2.2| Thrombosis | | 1 3.0| Artery, Inflammation, Chronic Active | | 1 3.0| Cervix, Hyperplasia, Stromal | | 1 3.0| Endometrium, Hyperplasia, Cystic | 2 2 1 | 32 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Angiectasis | | 1 2.0| Hyperplasia | 4 3 4 | 46 3.2| |__________________________________________________________________________|____________| Lymph Node | + | 7 | Lumbar, Ectasia | | 2 2.0| Lumbar, Hyperplasia | | 1 2.0| Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0| Pancreatic, Hyperplasia, Plasma Cell | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 51 | Ectasia | 2 | 4 2.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 128 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Hyperplasia, Plasma Cell | 2 | 11 2.2| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 51 | Ectasia | | 1 2.0| Hyperplasia, Histiocytic | | 1 2.0| Pigmentation | | 1 1.0| |__________________________________________________________________________|____________| Spleen | + + + | 52 | Hematopoietic Cell Proliferation | 2 1 1 | 42 1.4| Hyperplasia, Lymphoid | | 1 3.0| Pigmentation | 1 2 2 | 52 1.5| Lymphoid Follicle, Atrophy | | 3 2.3| |__________________________________________________________________________|____________| Thymus | + + + | 49 | Atrophy | 4 4 3 | 47 3.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 52 | Cyst | | 1 2.0| Hyperplasia | 1 | 23 1.1| |__________________________________________________________________________|____________| Skin | + + + | 53 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | Cartilage, Hypertrophy, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Hemorrhage | | 1 3.0| Hydrocephalus | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 129 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 51 | Infiltration Cellular, Histiocyte | 1 2 2 | 49 1.7| Inflammation, Suppurative | | 1 2.0| Metaplasia, Squamous | | 9 1.7| Mineralization | | 1 2.0| Thrombosis | | 1 2.0| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 2 3 | 47 2.1| |__________________________________________________________________________|____________| Nose | + + + | 53 | Nasolacrimal Duct, Glands, | | | Hyperplasia | | 1 4.0| Respiratory Epithelium, Hyperplasia | | 2 2.5| Respiratory Epithelium, Inflammation,| | | Suppurative | | 1 3.0| Turbinate, Cyst | | 1 1.0| |__________________________________________________________________________|____________| Trachea | + + + | 52 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 52 | Cataract | | 1 3.0| Anterior Chamber, Inflammation, | | | Suppurative | | 1 3.0| Cornea, Inflammation, Suppurative | | 1 3.0| Retina, Atrophy | | 1 3.0| Retina, Degeneration | | 1 2.0| |__________________________________________________________________________|____________| Harderian Gland | + + + | 52 | Inflammation | | 3 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 130 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 __________________________________________________________________________________________________________________________________ | 7| 7| 5| | | DAY ON TEST | 2| 2| 8| | | | 7| 9| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| | A | 550 | 8| 9| 9| | L | NG/KG | 9| 6| 7| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Kidney | + + + | 52 | Calculus Micro Observation Only | | 1 | Inflammation, Chronic Active | | 1 2.0| Inflammation, Suppurative | | 1 3.0| Mineralization | 1 1 1 | 39 1.1| Necrosis | | 1 3.0| Nephropathy | 3 2 2 | 42 2.1| Pelvis, Dilatation | | 1 2.0| Transitional Epithelium, Hyperplasia | 4 | 8 2.3| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 52 | Inflammation | | 4 1.0| Transitional Epithelium, Hyperplasia | | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 131 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Ulcer | | Epithelium, Hyperplasia | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 | Basophilic Focus | X | Basophilic Focus, Multiple | | Cholangiofibrosis | 2 2 2 3 3 3 3 1 2 | Cytoplasmic Alteration | 3 | Degeneration, Cystic | 2 2 | Eosinophilic Focus | X X X | Eosinophilic Focus, Multiple | X X X | Fatty Change, Diffuse | 2 2 2 1 3 2 1 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2| Hepatocyte, Multinucleate | 2 2 2 2 1 2 2 2 2 2 2 2 1 2 1 2 2 3 2 3 1 1 2| Hepatodiaphragmatic Nodule | X | Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X| Inflammation | 1 1 1 3 1 1 2 2 1 2 1 1 2 1 1 1 1 2 1 1 1 1 1| Mixed Cell Focus | X | Mixed Cell Focus, Multiple | X X X X | __________________________________________|__________________________________________________________________________| Page 132 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Necrosis | 3 4 3 2 2 2 | Pigmentation | 3 3 3 3 3 3 2 2 2 3 1 2 2 3 2 2 3 3 3 2 2 2| Toxic Hepatopathy | 4 4 4 4 1 4 4 1 4 3 4 4 4 4 4 3 4 4 3 4 2 3 2| Bile Duct, Cyst | 2 1 2 2 | Bile Duct, Fibrosis | 2 1 1 | Bile Duct, Hyperplasia | 2 2 2 3 3 2 2 2 4 3 3 3 2 2 2 3 3 3 2 3 2| Bile Duct, Inflammation | | Hepatocyte, Degeneration | 2 | Hepatocyte, Hypertrophy | 4 4 3 4 3 4 4 1 4 4 3 4 3 3 4 4 3 4 3 4 3 4 4| Oval Cell, Hyperplasia | 2 3 1 2 2 2 3 2 2 4 1 1 2 3 2 2 2 2| Portal, Fibrosis | 2 2 1 3 3 2 | Serosa, Inflammation | | |__________________________________________________________________________| Mesentery | + + + + + + + + + | Inflammation, Chronic Active | 3 3 2 | Artery, Inflammation, Chronic Active | 3 3 1 3 3 | Fat, Necrosis | 2 | |__________________________________________________________________________| Oral Mucosa | + + | Gingival, Cyst, Squamous | | Gingival, Hyperplasia, Squamous | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 2 3 1 2 | Necrosis | | Acinus, Atrophy | 3 2 3 1 2 2 3 2 | Acinus, Vacuolization Cytoplasmic | 2 2 2 1 2 2 1 2 2 1 1| Artery, Inflammation, Chronic Active | 3 4 4 3 2 | Duct, Dilatation | | Duct, Hyperplasia | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +| Inflammation, Acute | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 1 | Hyperplasia, Squamous | 1 2 | __________________________________________|__________________________________________________________________________| Page 133 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Mineralization | 2 | Ulcer | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Mineralization | | Artery, Inflammation, Chronic Active | | Glands, Ectasia | | Glands, Hyperplasia | | |__________________________________________________________________________| Tooth | + + + + + + + +| Peridontal Tissue, Fibrosis | | Peridontal Tissue, Inflammation, | | Suppurative | 3 1 2 2 3 1 1 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + M + + + + + + + + + + +| Cardiomyopathy | 1 1 1 2 2 1 1 1 2 1 1 1 1 1 | Thrombosis | | Endocardium, Myocardium, | | Inflammation, Acute | | Epicardium, Inflammation, Chronic | | Active | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Atrophy | 2 3 2 1 1 2 3 2 3 3 2 2 4 1| Degeneration, Cystic | 1 2 2 3 2 3 | Hyperplasia | 2 3 2 3 2 2 3 3 4 3 1| Hypertrophy | 2 2 2 2 2 2 2 3 1 1 2 3 1 1 2 1 2 2 1 1| Mineralization | 2 | Necrosis | | Vacuolization Cytoplasmic | 2 2 3 3 2 3 2 1 | __________________________________________|__________________________________________________________________________| Page 134 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + M + + M + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M M M + + + M + + + M + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 1| Cyst | 1 | Pars Distalis, Hyperplasia | 2 1 2 3 2 2| |__________________________________________________________________________| Thyroid Gland | + + + + A + + + + + + + + M + + + + + + A + + + +| Atrophy | | Infiltration Cellular, Lymphocyte | 2 | C-Cell, Hyperplasia | 1 2 2 1 1 2 2 2 3| Follicular Cell, Hyperplasia | 4 | Follicular Cell, Hypertrophy | 1 1 1 1 1 2 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Inflammation | 1 1 1 1 2 1 1 2 1 1| Duct, Cyst | 2 3 2 1 2 2 3 3 3 2 4 2 3 1 3 2 3 2 2 2 1 1| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 4 4 4 4 3 4 4 4 3| Cyst | 3 2 3 2 2 | |__________________________________________________________________________| Oviduct | | Inflammation, Suppurative | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | __________________________________________|__________________________________________________________________________| Page 135 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Inflammation, Suppurative | 4 | Metaplasia, Squamous | 1 3 1 2 | Endometrium, Hyperplasia, Cystic | 1 1 2 1 | |__________________________________________________________________________| Vagina | | Cyst | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Hyperplasia | 3 4 3 4 4 4 3 3 4 3 3 3 4 4 3 3 3 3 3 4 | |__________________________________________________________________________| Lymph Node | + + + + | Mediastinal, Angiectasis | | Mediastinal, Ectasia | 2 2 | Mediastinal, Hemorrhage | 2 | Mediastinal, Hyperplasia, Lymphoid | 2 | Mediastinal, Pigmentation | | Pancreatic, Hemorrhage | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| Atrophy | | Ectasia | 2 3 | Hemorrhage | 2 | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | 3 2 2 1 3 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Ectasia | 2 | Hemorrhage | | Hyperplasia, Histiocytic | 2 | Hyperplasia, Lymphoid | | |__________________________________________________________________________| Spleen | + M + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 2 2 2 1 1 2 1 2 1 1 2 2 2 1 1| Hyperplasia, Lymphoid | 2 | __________________________________________|__________________________________________________________________________| Page 136 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Pigmentation | 2 2 1 2 1 2 2 1 1 1 1 2 1 1 1 2 2 1 1 1 1 2| Lymphoid Follicle, Atrophy | 2 2 | Red Pulp, Atrophy | 2 | |__________________________________________________________________________| Thymus | + + + + M + + M + + + + + M + + + M + + + + + M +| Atrophy | 4 4 4 4 4 3 4 3 3 3 1 3 4 3 3 4 3 4| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Hyperplasia | 3 2 1 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst, Squamous | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Inflammation, Focal, Suppurative | 3 | Necrosis, Focal | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + M + + + + + + + + + + +| Hemorrhage | 2 | Infiltration Cellular, Histiocyte | 2 2 1 2 1 2 2 2 2 1 1 1 1 2 1 1 2 1 2 2| Inflammation, Chronic Active | 3 | Metaplasia, Squamous | 2 2 | Mineralization | 2 | __________________________________________|__________________________________________________________________________| Page 137 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 2 2 2 2 3 2 2 2 2 1 2 3 2 2 3 3 1 1| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Goblet Cell, Respiratory Epithelium, | | Hyperplasia | | Nasolacrimal Duct, Inflammation | 3 | Nasolacrimal Duct, Respiratory | | Epithelium, Hyperplasia | 3 | Nasopharyngeal Duct, Respiratory | | Epithelium, Hyperplasia | 3 | Respiratory Epithelium, Hyperplasia | | Turbinate, Cyst | | Turbinate, Inflammation, Suppurative | 2 2 | Vomeronasal Organ, Vacuolization | | Cytoplasmic | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + M + + + + + + + + + + +| Anterior Chamber, Inflammation, | | Suppurative | 3 | Cornea, Inflammation, Suppurative | 2 3 | Optic Nerve, Degeneration | | Retina, Atrophy | 2 3 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Inflammation | 2 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Casts Protein | 1 | Inflammation, Suppurative | 2 | __________________________________________|__________________________________________________________________________| Page 138 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5| DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8| | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Necrosis | 3 | Nephropathy | 3 3 2 2 1 1 3 3 2 1 3 1 1 2 2 3 2 2 2 2 2 2| Papilla, Necrosis | 2 | Pelvis, Dilatation | 4 3 | Pelvis, Hemorrhage | 3 | Pelvis, Inflammation, Chronic Active | 3 | Pelvis, Metaplasia, Squamous | 2 | Transitional Epithelium, Hyperplasia | 2 1 3 2 3 2 2 1| |__________________________________________________________________________| Ureter | + + + | Inflammation | 2 | Metaplasia, Squamous | 2 3 | Mineralization | 4 3 | Transitional Epithelium, Hyperplasia | 3 4 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 1 1 3 1 | Metaplasia, Squamous | 2 | Transitional Epithelium, Hyperplasia | 2 4 | __________________________________________|__________________________________________________________________________ Page 139 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6| DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1| | 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| Cyst | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 1 | Ulcer | 3 | Epithelium, Hyperplasia | 2 | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X | Basophilic Focus, Multiple | X X X | Cholangiofibrosis | 3 3 3 2 3 2 1 3 1 3 2| Cytoplasmic Alteration | | Degeneration, Cystic | | Eosinophilic Focus | X X | Eosinophilic Focus, Multiple | X X X X X X X| Fatty Change, Diffuse | 2 2 3 2 1 1 2 2 2 2 1 1 1 1 2 2 2 1 1 1 2 2 2| Hepatocyte, Multinucleate | 1 2 1 2 2 1 1 3 2 2 1 1 1 1 2 3 3 2 1 2 1 1 2| Hepatodiaphragmatic Nodule | | Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X| Inflammation | 1 1 1 1 1 2 1 1 1 2 1 2 2 1 1 1 1 1 2 1 1 1 1 1 1| Mixed Cell Focus | X X X | Mixed Cell Focus, Multiple | | __________________________________________|__________________________________________________________________________| Page 140 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6| DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1| | 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Necrosis | 2 2 3 2 2 2 2 2 2 | Pigmentation | 2 3 2 2 3 2 3 3 3 3 3 3 2 3 3 3 2 2 2 2 2 3 3| Toxic Hepatopathy | 4 3 4 1 4 4 1 4 4 4 4 3 4 3 3 4 4 4 2 2 3 4 4 3| Bile Duct, Cyst | 2 3 2 2 2 2 2| Bile Duct, Fibrosis | 1 1 | Bile Duct, Hyperplasia | 3 1 2 3 2 3 2 3 3 2 3 2 3 3 3 3 1 2 2 2 2 2| Bile Duct, Inflammation | 2 | Hepatocyte, Degeneration | 2 2 2 3 | Hepatocyte, Hypertrophy | 4 3 4 4 4 2 3 2 4 4 3 4 4 3 3 4 3 3 3 4 3 4 3| Oval Cell, Hyperplasia | 3 2 2 2 3 2 3 3 2 3 3 2 2 2 2 1 2 1 3 2| Portal, Fibrosis | 2 2 | Serosa, Inflammation | 1 | |__________________________________________________________________________| Mesentery | + +| Inflammation, Chronic Active | | Artery, Inflammation, Chronic Active | 3 3| Fat, Necrosis | | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + +| Gingival, Cyst, Squamous | 2 | Gingival, Hyperplasia, Squamous | 4 2 2 | |__________________________________________________________________________| Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Inflammation, Chronic Active | 2 3 3 2 3 2 1| Necrosis | 2 | Acinus, Atrophy | 2 1 3 3 2 2 1 1| Acinus, Vacuolization Cytoplasmic | 3 2 1 1 1 1 1 1 1 1 1| Artery, Inflammation, Chronic Active | 3 2 3 3 2 3| Duct, Dilatation | 4 4 | Duct, Hyperplasia | 2 | |__________________________________________________________________________| Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 2 | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 2 | Hyperplasia, Squamous | 2 2 3 2 | __________________________________________|__________________________________________________________________________| Page 141 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6| DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1| | 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Mineralization | | Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Mineralization | | Artery, Inflammation, Chronic Active | 2 | Glands, Ectasia | 2 | Glands, Hyperplasia | 2 | |__________________________________________________________________________| Tooth | + + + + + + + + + + | Peridontal Tissue, Fibrosis | 3 | Peridontal Tissue, Inflammation, | | Suppurative | 2 1 1 1 1 2 2 1 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + M + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1| Thrombosis | 3 | Endocardium, Myocardium, | | Inflammation, Acute | 3 | Epicardium, Inflammation, Chronic | | Active | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Atrophy | 2 2 3 1 2 1 3 1 3 1 3 2 3 3 | Degeneration, Cystic | 2 3 2 | Hyperplasia | 3 3 1 3 2 2 2 3 3 3 3 3 2| Hypertrophy | 2 1 1 2 1 2 1 2 1 2 2 2 2 1 3 1 2 1 2| Mineralization | | Necrosis | 1 | Vacuolization Cytoplasmic | 2 2 1 1 2 1 2 2 1 | __________________________________________|__________________________________________________________________________| Page 142 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6| DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1| | 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + M + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 2 2 2 2 2 | Cyst | | Pars Distalis, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 | |__________________________________________________________________________| Thyroid Gland | + + + M + + A + + + + + + + + + + + + + + + + + +| Atrophy | 4 | Infiltration Cellular, Lymphocyte | | C-Cell, Hyperplasia | 1 1 1 2 2 1 2 3 2 | Follicular Cell, Hyperplasia | | Follicular Cell, Hypertrophy | 2 2 2 1 1 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Inflammation | 1 1 1 1 1 1 3 3 1 1| Duct, Cyst | 3 1 3 2 2 3 2 2 3 3 2 3 1 2 3 2 2 1 3 3 3| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4| Cyst | 3 4 3 2 2 1 | |__________________________________________________________________________| Oviduct | + | Inflammation, Suppurative | 3 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | __________________________________________|__________________________________________________________________________| Page 143 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6| DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1| | 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Inflammation, Suppurative | 2 3 | Metaplasia, Squamous | 2 1 3 4 2 3 | Endometrium, Hyperplasia, Cystic | 1 1 3 | |__________________________________________________________________________| Vagina | + | Cyst | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 3 2 3 4 4 3 4 3 4 3 4 4 4 4 4 2 3 3 3 3 3 3 3 4| |__________________________________________________________________________| Lymph Node | + + + + + + + +| Mediastinal, Angiectasis | 2 | Mediastinal, Ectasia | 2 2 1| Mediastinal, Hemorrhage | 2 1 2 2 3 | Mediastinal, Hyperplasia, Lymphoid | | Mediastinal, Pigmentation | 2 2 | Pancreatic, Hemorrhage | 1 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Ectasia | 2 | Hemorrhage | | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 2 2 2 2 2 2 1 3| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Ectasia | | Hemorrhage | 2 1 | Hyperplasia, Histiocytic | | Hyperplasia, Lymphoid | 2 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 2 2 2 2 3 1 2 1 1 1 1 2 1 3 1 1 2| Hyperplasia, Lymphoid | 2 2 | __________________________________________|__________________________________________________________________________| Page 144 NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03 Route: GAVAGE Time: 11:43:51 _____________________________________________________________________________________________________________________ | 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6| DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1| | 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Pigmentation | 2 1 1 1 1 1 1 1 2 1 2 1 1 1 1 2 2 2 1 1 1 2 1 1 1| Lymphoid Follicle, Atrophy | 2 3 3 2 | Red Pulp, Atrophy | 3 | |__________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + M + + + + + + + +| Atrophy | 3 4 4 4 4 4 4 4 4 3 4 3 4 3 3 4 4 4 4 4 3 3| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | 1 1 2 1 1 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst, Squamous | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Focal, Suppurative | | Necrosis, Focal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + M + + + + + + + + +