TDMS Study 96007-03 Pathology Tables
NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/25/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Time: 11:49:34
14 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1746-01-6
Lock Date: 06/28/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/02/98 - 09/03/98
Treatment Groups: Include 001 0 NG/KG
Include 002 3 NG/KG
Include 003 10 NG/KG
Include 004 22 NG/KG
Include 005 46 NG/KG
Include 006 100 NG/KG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/25/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Time: 11:49:34
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SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98 98
Scheduled Sacrifice 16 16 16 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Fatty Change, Diffuse 2 [1.0]
Inflammation 10 [1.1] 10 [1.0] 8 [1.0] 10 [1.1] 10 [1.2] 10 [1.2]
Mixed Cell Focus 2 1 1 2
Pigmentation 1 [1.0] 1 [1.0]
Hepatocyte, Hypertrophy 1 [1.0] 1 [1.0] 4 [1.3] 7 [1.0] 10 [1.7] 10 [2.3]
Hepatocyte, Multinucleated 3 [1.0]
Pancreas (10) (10) (10) (10) (10) (10)
Inflammation, Chronic Active 2 [1.5]
Acinus, Atrophy 2 [1.5]
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10) (10)
Hypertrophy 1 [1.0] 2 [1.0] 2 [1.5] 1 [2.0] 1 [1.0]
Thyroid Gland (10) (10) (10) (10) (10) (10)
Follicular Cell, Hypertrophy 1 [1.0] 3 [3.0] 4 [2.5] 4 [2.8] 9 [2.1]
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GENERAL BODY SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/25/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Time: 11:49:34
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10)
Atrophy 2 [3.0] 1 [3.0]
Uterus (10) (1) (10)
Metaplasia, Squamous 1 [1.0]
Endometrium, Hyperplasia, Cystic 5 [3.4] 4 [3.8]
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HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Pigmentation 10 [1.2] 10 [1.2]
Thymus (10) (10) (10) (10) (10) (10)
Atrophy 1 [1.0] 4 [1.3] 10 [1.6]
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10) (10)
Inflammation, Chronic 1 [1.0]
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SPECIAL SENSES SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/25/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Time: 11:49:34
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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