TDMS Study 96007-03 Pathology Tables
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
31 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1746-01-6
Lock Date: 06/28/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 12/30/98 - 12/31/98
Treatment Groups: Include 001 0 NG/KG
Include 002 3 NG/KG
Include 003 10 NG/KG
Include 004 22 NG/KG
Include 005 46 NG/KG
Include 006 100 NG/KG
Page 1
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG/KG | 1| 2| 2| 2| 2| 3| 4| 4| 6| 6| 6| 6| 7| 7| 8| 9| | L |
| 5| 6| 7| 8| 9| 0| 5| 6| 6| 7| 8| 9| 0| 4| 5| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Mitotic Alteration | 2 | 1 2.0|
Mixed Cell Focus | X | 1 |
Mixed Cell Focus, Multiple | X X | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Acinus, Atrophy | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG/KG | 1| 2| 2| 2| 2| 3| 4| 4| 6| 6| 6| 6| 7| 7| 8| 9| | L |
| 5| 6| 7| 8| 9| 0| 5| 6| 6| 7| 8| 9| 0| 4| 5| 4| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Ovary | + + + + + + + + + + | 10 |
Atrophy | 4 4 4 4 3 4 4 4 4 | 9 3.9|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Metaplasia, Squamous | 2 1 2 1 1 1 2 2 | 8 1.5|
Endometrium, Hyperplasia, Cystic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Pigmentation | 1 2 1 1 1 1 1 2 1 1 | 10 1.2|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG/KG | 1| 2| 2| 2| 2| 3| 4| 4| 6| 6| 6| 6| 7| 7| 8| 9| | L |
| 5| 6| 7| 8| 9| 0| 5| 6| 6| 7| 8| 9| 0| 4| 5| 4| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
3 NG/KG | 0| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 7| 8| 9| 9| | L |
| 1| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 6| 0| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Angiectasis | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation | 2 1 1 1 1 1 2 2 1 | 9 1.3|
Mixed Cell Focus | X X X | 3 |
Mixed Cell Focus, Multiple | X X X X | 4 |
Pigmentation | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Hypertrophy | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Follicular Cell, Hypertrophy | 2 2 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Uterus | + | 1 |
Inflammation, Suppurative | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
3 NG/KG | 0| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 7| 8| 9| 9| | L |
| 1| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 6| 0| 6| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | + + + + + + + + + + | 10 |
Atrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Pleura | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 3| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10 NG/KG | 1| 3| 3| 3| 3| 4| 4| 5| 6| 8| 9| 9| 9| 9| 9| 9| | L |
| 9| 6| 7| 8| 9| 0| 8| 1| 5| 1| 1| 2| 3| 4| 5| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation | 1 1 2 2 2 1 1 1 1 1 | 10 1.3|
Mixed Cell Focus | X X X | 3 |
Mixed Cell Focus, Multiple | X | 1 |
Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0|
Hepatocyte, Hypertrophy | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Acinus, Atrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Hypertrophy | 1 2 1 | 3 1.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Follicular Cell, Hypertrophy | 1 1 3 | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 2 2 2 1 1 | 5 1.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 3| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
10 NG/KG | 1| 3| 3| 3| 3| 4| 4| 5| 6| 8| 9| 9| 9| 9| 9| 9| | L |
| 9| 6| 7| 8| 9| 0| 8| 1| 5| 1| 1| 2| 3| 4| 5| 8| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 4| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
22 NG/KG | 0| 1| 2| 2| 2| 2| 2| 6| 6| 7| 7| 7| 7| 7| 7| 9| | L |
| 8| 3| 1| 2| 3| 4| 5| 6| 9| 1| 2| 3| 4| 5| 8| 1| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation | 2 1 2 2 1 1 1 2 1 2 | 10 1.5|
Mixed Cell Focus | X X | 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Hepatocyte, Hypertrophy | 1 1 1 1 1 2 | 6 1.2|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 1 1 2 | 3 1.3|
Necrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Follicular Cell, Hypertrophy | 1 1 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 2 2 2 2 2 1 | 6 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 4| 3| 3| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
22 NG/KG | 0| 1| 2| 2| 2| 2| 2| 6| 6| 7| 7| 7| 7| 7| 7| 9| | L |
| 8| 3| 1| 2| 3| 4| 5| 6| 9| 1| 2| 3| 4| 5| 8| 1| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pleura | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 4| 3| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 3| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
46 NG/KG | 2| 2| 3| 3| 3| 3| 4| 4| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 0| 9| 6| 7| 8| 9| 0| 3| 0| 6| 1| 2| 3| 4| 5| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Angiectasis | 2 | 1 2.0|
Inflammation | 2 1 2 1 2 2 1 1 1 2 | 10 1.5|
Mixed Cell Focus | X X X | 3 |
Mixed Cell Focus, Multiple | X | 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Hepatocyte, Hypertrophy | 2 1 1 1 2 1 1 1 2 | 9 1.3|
Hepatocyte, Multinucleated | 1 1 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Acinus, Atrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Degeneration, Cystic | 2 | 1 2.0|
Hypertrophy | 1 1 2 | 3 1.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Follicular Cell, Hypertrophy | 2 1 1 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 4| 3| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 3| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
46 NG/KG | 2| 2| 3| 3| 3| 3| 4| 4| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 0| 9| 6| 7| 8| 9| 0| 3| 0| 6| 1| 2| 3| 4| 5| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Atrophy | 1 2 2 2 2 3 2 | 7 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pleura | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 3| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 3| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100 | 0| 7| 7| 7| 7| 8| 8| 0| 1| 2| 2| 2| 2| 3| 3| 4| | L |
NG/KG | 8| 6| 7| 8| 9| 0| 8| 0| 9| 6| 7| 8| 9| 0| 4| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Fatty Change, Diffuse | 1 1 1 1 1 1 | 6 1.0|
Inflammation | 2 2 1 2 1 2 2 2 2 2 | 10 1.8|
Mixed Cell Focus | X X X | 3 |
Mixed Cell Focus, Multiple | X X X X X X X | 7 |
Necrosis | 1 | 1 1.0|
Pigmentation | 2 2 2 2 2 2 3 2 2 2 | 10 2.1|
Toxic Hepatopathy | 2 2 1 2 2 2 2 2 2 3 | 10 2.0|
Bile Duct, Hyperplasia | 2 | 1 2.0|
Hepatocyte, Hypertrophy | 3 3 2 2 3 2 3 2 3 4 | 10 2.7|
Hepatocyte, Multinucleated | 2 1 2 2 2 2 3 2 2 | 9 2.0|
Oval Cell, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Acinus, Vacuolization Cytoplasmic | 1 1 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Hypertrophy | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 3| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 3| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100 | 0| 7| 7| 7| 7| 8| 8| 0| 1| 2| 2| 2| 2| 3| 3| 4| | L |
NG/KG | 8| 6| 7| 8| 9| 0| 8| 0| 9| 6| 7| 8| 9| 0| 4| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Follicular Cell, Hypertrophy | 1 2 3 1 1 3 | 6 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 4 4 4 4 4 4 4 | 7 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Metaplasia, Squamous | 1 1 1 1 | 4 1.0|
Endometrium, Hyperplasia, Cystic | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Pigmentation | 1 1 1 1 1 2 1 1 2 1 | 10 1.2|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 3 3 3 3 4 3 3 3 3 3 | 10 3.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:01:07
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 4| 3| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 3| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
100 | 0| 7| 7| 7| 7| 8| 8| 0| 1| 2| 2| 2| 2| 3| 3| 4| | L |
NG/KG | 8| 6| 7| 8| 9| 0| 8| 0| 9| 6| 7| 8| 9| 0| 4| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
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