TDMS Study 96007-03 Pathology Tables
NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/25/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Time: 12:05:37
31 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1746-01-6
Lock Date: 06/28/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 12/30/98 - 12/31/98
Treatment Groups: Include 001 0 NG/KG
Include 002 3 NG/KG
Include 003 10 NG/KG
Include 004 22 NG/KG
Include 005 46 NG/KG
Include 006 100 NG/KG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/25/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Time: 12:05:37
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SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98 98
Scheduled Sacrifice 16 16 16 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Angiectasis 1 [2.0] 1 [2.0]
Fatty Change, Diffuse 6 [1.0]
Hepatodiaphragmatic Nodule 1
Inflammation 9 [1.0] 9 [1.3] 10 [1.3] 10 [1.5] 10 [1.5] 10 [1.8]
Mitotic Alteration 1 [2.0]
Mixed Cell Focus 1 3 3 2 3 3
Mixed Cell Focus, Multiple 2 4 1 1 7
Necrosis 1 [1.0]
Pigmentation 1 [1.0] 8 [1.0] 9 [1.0] 10 [1.0] 10 [2.1]
Toxic Hepatopathy 10 [2.0]
Bile Duct, Hyperplasia 1 [2.0]
Hepatocyte, Hypertrophy 2 [1.0] 3 [1.0] 6 [1.2] 9 [1.3] 10 [2.7]
Hepatocyte, Multinucleated 5 [1.0] 9 [2.0]
Oval Cell, Hyperplasia 1 [1.0]
Pancreas (10) (10) (10) (10) (10) (10)
Acinus, Atrophy 2 [1.0] 1 [1.0] 1 [1.0]
Acinus, Vacuolization Cytoplasmic 5 [1.0]
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10) (10)
Degeneration, Cystic 1 [2.0] 1 [2.0]
Hyperplasia 1 [2.0]
Hypertrophy 2 [1.5] 3 [1.3] 3 [1.3] 3 [1.3] 3 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/25/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Time: 12:05:37
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
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ENDOCRINE SYSTEM - CONT
Necrosis 1 [1.0]
Thyroid Gland (10) (10) (10) (10) (10) (10)
Follicular Cell, Hypertrophy 3 [1.7] 3 [1.7] 3 [1.3] 4 [1.3] 6 [1.8]
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (10)
Atrophy 9 [3.9] 7 [4.0]
Uterus (10) (1) (10)
Inflammation, Suppurative 1 [2.0]
Metaplasia, Squamous 8 [1.5] 4 [1.0]
Endometrium, Hyperplasia, Cystic 1 [3.0] 1 [4.0] 2 [4.0]
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HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Pigmentation 10 [1.2] 10 [1.2]
Thymus (10) (10) (10) (10) (10) (10)
Atrophy 2 [2.0] 1 [1.0] 5 [1.6] 6 [1.8] 7 [2.0] 10 [3.1]
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/25/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Time: 12:05:37
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10) (10)
Infiltration Cellular, Histiocyte 2 [1.0] 3 [1.0] 1 [1.0] 1 [1.0] 1 [1.0]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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