TDMS Study 96007-03 Pathology Tables
NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:07:47
53 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1746-01-6
Lock Date: 06/28/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 06/03/99 - 06/04/99
Treatment Groups: Include 001 0 NG/KG
Include 002 3 NG/KG
Include 003 10 NG/KG
Include 004 22 NG/KG
Include 005 46 NG/KG
Include 006 100 NG/KG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:07:47
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SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98 98
Scheduled Sacrifice 13 12 13 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8 8
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ALIMENTARY SYSTEM
Liver (8) (8) (8) (8) (8) (8)
Basophilic Focus 1 (13%) 2 (25%)
Basophilic Focus, Multiple 1 (13%) 1 (13%)
Cholangiofibrosis 1 (13%) 1 (13%)
Clear Cell Focus 2 (25%)
Fatty Change, Diffuse 2 (25%) 6 (75%)
Hepatodiaphragmatic Nodule 1 (13%)
Inflammation 8 (100%) 8 (100%) 8 (100%) 8 (100%) 8 (100%) 8 (100%)
Mixed Cell Focus 2 (25%) 1 (13%) 2 (25%) 1 (13%)
Mixed Cell Focus, Multiple 4 (50%) 4 (50%) 6 (75%) 8 (100%)
Pigmentation 5 (63%) 8 (100%) 8 (100%) 8 (100%)
Toxic Hepatopathy 1 (13%) 6 (75%) 8 (100%)
Bile Duct, Cyst 1 (13%)
Bile Duct, Fibrosis 1 (13%) 2 (25%)
Bile Duct, Hyperplasia 1 (13%) 2 (25%) 3 (38%) 8 (100%)
Hepatocyte, Hypertrophy 4 (50%) 7 (88%) 8 (100%) 8 (100%) 8 (100%)
Hepatocyte, Multinucleated 2 (25%) 8 (100%)
Pancreas (8) (8) (8) (8) (8) (8)
Inflammation, Chronic Active 2 (25%)
Acinus, Atrophy 2 (25%)
Acinus, Vacuolization Cytoplasmic 7 (88%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (8) (8) (8) (8) (8) (8)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:07:47
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Degeneration, Cystic 1 (13%) 1 (13%) 1 (13%) 2 (25%) 1 (13%)
Hyperplasia 1 (13%) 3 (38%) 2 (25%)
Hypertrophy 5 (63%) 3 (38%) 4 (50%) 4 (50%) 5 (63%) 7 (88%)
Vacuolization Cytoplasmic 1 (13%)
Pituitary Gland (8) (1) (7)
Cyst 1 (13%)
Thyroid Gland (8) (8) (8) (8) (8) (8)
Follicular Cell, Hypertrophy 1 (13%) 2 (25%) 2 (25%) 3 (38%) 5 (63%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (7)
Atrophy 8 (100%) 5 (71%)
Uterus (8) (1) (8)
Metaplasia, Squamous 7 (88%) 4 (50%)
Cervix, Cyst, Squamous 1 (13%)
Endometrium, Hyperplasia, Cystic 5 (63%) 1 (100%) 2 (25%)
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HEMATOPOIETIC SYSTEM
Spleen (8) (8)
Hyperplasia, Focal, Lymphoid 1 (13%)
Pigmentation 8 (100%) 8 (100%)
Thymus (8) (8) (7) (8) (8) (8)
Atrophy 4 (50%) 2 (25%) 3 (43%) 7 (88%) 8 (100%) 8 (100%)
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (2) (2) (8)
Cyst 3 (38%)
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MUSCULOSKELETAL SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:07:47
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (8) (8) (8) (8) (8)
Infiltration Cellular, Histiocyte 3 (38%) 1 (13%) 2 (25%) 1 (13%) 4 (50%) 3 (38%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (2) (1)
Cyst 1 (50%)
Inflammation, Chronic Active 1 (50%)
Nephropathy 1 (100%)
Pelvis, Dilatation 1 (50%) 1 (100%)
Ureter (1) (1)
Mineralization 1 (100%)
Transitional Epithelium, Hyperplasia 1 (100%) 1 (100%)
Urinary Bladder (1)
Inflammation 1 (100%)
Transitional Epithelium, Hyperplasia 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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