TDMS Study 96007-03 Pathology Tables
NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02 Route: GAVAGE Time: 12:07:58 53 WEEK SSAC Facility: Battelle Columbus Laboratory Chemical CAS #: 1746-01-6 Lock Date: 06/28/01 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 06/03/99 - 06/04/99 Treatment Groups: Include 001 0 NG/KG Include 002 3 NG/KG Include 003 10 NG/KG Include 004 22 NG/KG Include 005 46 NG/KG Include 006 100 NG/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02 Route: GAVAGE Time: 12:07:58 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100 NG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 98 98 98 98 98 98 Scheduled Sacrifice 13 12 13 13 13 13 Early Deaths Survivors Animals Examined Microscopically 8 8 8 8 8 8 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Medulla (8) (1) (8) Pheochromocytoma Benign 1 (100%) Pituitary Gland (8) (1) (7) Adenoma 1 (100%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Uterus (8) (1) (8) Polyp Stromal 1 (13%) 1 (13%) ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02 Route: GAVAGE Time: 12:07:58 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100 NG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (8) (2) (2) (8) Fibroadenoma 2 (100%) 1 (50%) Fibroadenoma, Multiple 1 (50%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None Page 3 NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02 Route: GAVAGE Time: 12:07:58 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100 NG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 1 2 3 1 Total Primary Neoplasms 1 2 4 1 Total Animals with Benign Neoplasms 1 2 3 1 Total Benign Neoplasms 1 2 4 1 Total Animals with Malignant Neoplasms Total Malignant Neoplasms Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------