TDMS Study 96007-03 Pathology Tables
NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:07:58
53 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1746-01-6
Lock Date: 06/28/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 06/03/99 - 06/04/99
Treatment Groups: Include 001 0 NG/KG
Include 002 3 NG/KG
Include 003 10 NG/KG
Include 004 22 NG/KG
Include 005 46 NG/KG
Include 006 100 NG/KG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:07:58
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SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
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DISPOSITION SUMMARY
Animals Initially in Study 98 98 98 98 98 98
Scheduled Sacrifice 13 12 13 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8 8
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ALIMENTARY SYSTEM
None
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Medulla (8) (1) (8)
Pheochromocytoma Benign 1 (100%)
Pituitary Gland (8) (1) (7)
Adenoma 1 (100%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Uterus (8) (1) (8)
Polyp Stromal 1 (13%) 1 (13%)
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:07:58
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (2) (2) (8)
Fibroadenoma 2 (100%) 1 (50%)
Fibroadenoma, Multiple 1 (50%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
None
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 11/25/02
Route: GAVAGE Time: 12:07:58
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 2 3 1
Total Primary Neoplasms 1 2 4 1
Total Animals with Benign Neoplasms 1 2 3 1
Total Benign Neoplasms 1 2 4 1
Total Animals with Malignant Neoplasms
Total Malignant Neoplasms
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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