TDMS Study 96007-03 Pathology Tables
NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/25/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Time: 12:18:35
53 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1746-01-6
Lock Date: 06/28/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 06/03/99 - 06/04/99
Treatment Groups: Include 001 0 NG/KG
Include 002 3 NG/KG
Include 003 10 NG/KG
Include 004 22 NG/KG
Include 005 46 NG/KG
Include 006 100 NG/KG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/25/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Time: 12:18:35
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SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98 98
Scheduled Sacrifice 13 12 13 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8 8
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ALIMENTARY SYSTEM
Liver (8) (8) (8) (8) (8) (8)
Basophilic Focus 1 2
Basophilic Focus, Multiple 1 1
Cholangiofibrosis 1 [3.0] 1 [2.0]
Clear Cell Focus 2
Fatty Change, Diffuse 2 [1.0] 6 [1.7]
Hepatodiaphragmatic Nodule 1
Inflammation 8 [1.0] 8 [1.0] 8 [1.0] 8 [1.5] 8 [1.5] 8 [2.0]
Mixed Cell Focus 2 1 2 1
Mixed Cell Focus, Multiple 4 4 6 8
Pigmentation 5 [1.0] 8 [1.0] 8 [1.8] 8 [2.6]
Toxic Hepatopathy 1 [1.0] 6 [1.5] 8 [3.4]
Bile Duct, Cyst 1 [2.0]
Bile Duct, Fibrosis 1 [1.0] 2 [2.0]
Bile Duct, Hyperplasia 1 [1.0] 2 [1.0] 3 [1.3] 8 [1.9]
Hepatocyte, Hypertrophy 4 [1.0] 7 [1.1] 8 [1.3] 8 [2.0] 8 [3.3]
Hepatocyte, Multinucleated 2 [1.0] 8 [1.6]
Pancreas (8) (8) (8) (8) (8) (8)
Inflammation, Chronic Active 2 [2.0]
Acinus, Atrophy 2 [2.0]
Acinus, Vacuolization Cytoplasmic 7 [1.0]
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (8) (8) (8) (8) (8) (8)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/25/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Time: 12:18:35
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
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ENDOCRINE SYSTEM - CONT
Degeneration, Cystic 1 [1.0] 1 [1.0] 1 [2.0] 2 [2.0] 1 [1.0]
Hyperplasia 1 [1.0] 3 [1.7] 2 [1.5]
Hypertrophy 5 [1.6] 3 [2.0] 4 [1.3] 4 [1.5] 5 [1.0] 7 [2.0]
Vacuolization Cytoplasmic 1 [1.0]
Pituitary Gland (8) (1) (7)
Cyst 1 [3.0]
Thyroid Gland (8) (8) (8) (8) (8) (8)
Follicular Cell, Hypertrophy 1 [1.0] 2 [1.0] 2 [1.5] 3 [1.0] 5 [1.6]
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (7)
Atrophy 8 [4.0] 5 [4.0]
Uterus (8) (1) (8)
Metaplasia, Squamous 7 [2.4] 4 [1.5]
Cervix, Cyst, Squamous 1 [3.0]
Endometrium, Hyperplasia, Cystic 5 [2.0] 1 [4.0] 2 [2.5]
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HEMATOPOIETIC SYSTEM
Spleen (8) (8)
Hyperplasia, Focal, Lymphoid 1 [2.0]
Pigmentation 8 [1.8] 8 [1.8]
Thymus (8) (8) (7) (8) (8) (8)
Atrophy 4 [2.0] 2 [2.0] 3 [2.3] 7 [2.3] 8 [3.4] 8 [3.4]
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (2) (2) (8)
Cyst 3 [2.0]
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MUSCULOSKELETAL SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/25/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Time: 12:18:35
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG 100
NG/KG
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (8) (8) (8) (8) (8)
Infiltration Cellular, Histiocyte 3 [1.0] 1 [1.0] 2 [1.0] 1 [1.0] 4 [1.3] 3 [1.0]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (2) (1)
Cyst 1 [2.0]
Inflammation, Chronic Active 1 [2.0]
Nephropathy 1 [3.0]
Pelvis, Dilatation 1 [3.0] 1 [2.0]
Ureter (1) (1)
Mineralization 1 [3.0]
Transitional Epithelium, Hyperplasia 1 [3.0] 1 [2.0]
Urinary Bladder (1)
Inflammation 1 [2.0]
Transitional Epithelium, Hyperplasia 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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