TDMS Study 96007-03 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Battelle Columbus TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) DATE: 11/25/02
EXPERIMENT: 96007 TEST: 03 TIME: 11:36:08
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP: C96007G
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BATTELLE COLUMBUS TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) DATE: 11/25/02
EXPERIMENT: 96007 TEST: 03 TIME: 11:45:37
SPECIES: RATS, SPRAGUE-DAWLEY
TEST TYPE: TWO YEAR ROUTE: ORAL GAVAGE NTP: 96007G
CONT: NO1-ES-75411 CAS: 1746-01-6
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
TWO YEAR ORAL GAVAGE STUDY OF TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)
==========================================================================================================================
WEEK 0 NG/KG 3 NG/KG 10 NG/KG 22 NG/KG 46 NG/KG
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
B 176.5 98 175.2 99.3 98 175.1 99.2 98 174.8 99.0 98 174.8 99.0 98
1 176.5 98 175.2 99.3 98 175.1 99.2 98 174.8 99.0 98 174.8 99.0 98
2 198.4 98 196.0 98.8 98 198.1 99.8 98 196.2 98.9 98 196.9 99.2 98
3 216.4 98 213.5 98.7 98 215.7 99.7 98 213.8 98.8 98 216.1 99.9 98
4 231.3 98 228.9 99.0 98 230.6 99.7 98 228.9 99.0 98 228.9 99.0 98
5 236.9 98 236.5 99.8 98 240.6 101.6 98 241.2 101.8 98 236.7 99.9 98
6 246.9 98 244.7 99.1 98 248.3 100.6 98 245.9 99.6 98 243.7 98.7 98
7 255.0 98 249.1 97.7 98 252.4 99.0 98 252.3 98.9 98 250.0 98.0 98
8 260.3 98 257.5 98.9 98 259.8 99.8 97 257.5 98.9 98 256.1 98.4 98
9 264.6 98 262.3 99.1 98 262.3 99.1 96 259.5 98.1 97 259.6 98.1 98
10 270.1 98 266.5 98.7 98 268.3 99.3 96 265.2 98.2 97 262.9 97.3 98
11 274.2 98 270.9 98.8 98 273.3 99.7 96 268.4 97.9 97 265.1 96.7 98
12 277.6 98 273.2 98.4 98 275.4 99.2 96 272.5 98.2 97 267.6 96.4 98
13 278.9 98 275.0 98.6 98 278.0 99.7 96 274.5 98.4 97 270.0 96.8 98
17 290.0 82 (I) 284.2 98.0 82 (I) 284.2 98.0 80 (I) 279.9 96.5 81 (I) 275.5 95.0 82 (I)
21 295.8 82 292.3 98.8 82 292.2 98.8 80 288.2 97.4 81 283.7 95.9 82
25 299.7 81 298.3 99.5 82 297.9 99.4 80 290.3 96.9 81 286.4 95.6 81
29 301.9 80 302.3 100.1 82 300.4 99.5 79 294.8 97.6 80 288.3 95.5 80
33 306.0 64 (I) 307.9 100.6 65 (I) 304.2 99.4 63 (I) 298.0 97.4 64 (I) 293.4 95.9 64 (I)
37 311.1 64 314.0 100.9 64 308.7 99.2 61 304.4 97.8 64 296.5 95.3 64
41 314.7 64 317.9 101.0 62 313.7 99.7 61 309.4 98.3 64 299.9 95.3 64
45 320.7 64 321.9 100.4 62 318.6 99.3 61 313.7 97.8 64 306.1 95.4 64
49 327.6 64 329.8 100.7 62 327.8 100.1 61 316.5 96.6 64 308.7 94.2 63
52 329.3 62 334.3 101.5 60 330.4 100.3 59 320.1 97.2 63 309.5 94.0 62
57 336.7 48 (I) 338.1 100.4 48 (I) 332.1 98.6 46 (I) 327.8 97.4 47 (I) 319.8 95.0 49 (I)
61 344.5 48 349.2 101.4 47 340.6 98.9 46 336.8 97.8 44 321.7 93.4 48
65 352.6 48 355.9 100.9 45 350.2 99.3 45 342.0 97.0 44 325.7 92.4 47
69 359.3 46 364.9 101.6 44 360.2 100.3 45 351.6 97.9 42 330.4 92.0 46
73 360.0 44 368.4 102.3 41 361.3 100.4 45 352.5 97.9 41 324.2 90.1 44
77 364.3 41 376.8 103.4 40 366.9 100.7 45 355.2 97.5 39 326.7 89.7 43
81 367.6 40 373.0 101.5 33 371.6 101.1 44 359.3 97.7 36 326.9 88.9 42
85 370.7 40 374.9 101.1 31 367.5 99.1 39 363.1 97.9 33 334.6 90.3 40
89 374.6 39 375.1 100.1 27 368.0 98.2 36 358.9 95.8 29 335.0 89.4 38
93 382.0 37 374.9 98.1 26 372.1 97.4 33 358.8 93.9 25 340.1 89.0 35
97 380.8 31 376.3 98.8 24 376.8 98.9 30 356.3 93.6 24 344.0 90.3 31
101 382.6 27 373.0 97.5 23 377.3 98.6 28 359.9 94.1 21 336.7 88.0 25
TERM. SAC. 25 21 23 19 22
==========================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
TWO YEAR ORAL GAVAGE STUDY OF TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)
========================================================
100 NG/KG 100 NG/ KG/STOP
WEEK ---------------- ----------------
AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=======================================================
B 176.0 99.7 98 173.9 98.5 50
1 176.0 99.7 98 173.9 98.5 50
2 197.7 99.6 98 195.3 98.4 50
3 214.6 99.2 98 213.9 98.8 50
4 227.6 98.4 98 225.8 97.6 50
5 234.2 98.9 98 232.2 98.0 50
6 240.2 97.3 98 236.6 95.8 50
7 246.6 96.7 98 244.3 95.8 50
8 251.6 96.7 98 250.9 96.4 50
9 253.7 95.9 98 252.5 95.4 50
10 257.1 95.2 98 255.3 94.5 50
11 259.8 94.7 98 255.9 93.3 50
12 263.7 95.0 98 259.5 93.5 50
13 263.8 94.6 98 262.4 94.1 50
17 271.6 93.7 82 (I) 267.0 92.1 50
21 279.4 94.5 82 273.1 92.3 50
25 281.6 94.0 82 273.8 91.4 50
29 281.0 93.1 82 276.7 91.7 50
33 282.2 92.2 66 (I) 278.8 91.1 49
37 286.0 91.9 66 283.8 91.2 49
41 288.2 91.6 66 291.1 92.5 49
45 289.3 90.2 66 296.4 92.4 49
49 292.5 89.3 66 300.2 91.6 49
52 293.5 89.1 66 302.0 91.7 48
57 300.3 89.2 53 (I) 305.6 90.8 48
61 301.8 87.6 52 311.9 90.5 46
65 304.6 86.4 52 319.1 90.5 46
69 310.4 86.4 51 320.2 89.1 45
73 307.2 85.3 51 321.1 89.2 44
77 306.9 84.2 51 328.7 90.2 43
81 306.7 83.4 49 334.6 91.0 42
85 310.7 83.8 48 342.5 92.4 38
89 299.4 79.9 41 347.1 92.7 36
93 302.9 79.3 36 344.6 90.2 31
97 303.5 79.7 29 355.7 93.4 29
101 308.7 80.7 26 351.2 91.8 28
TERM. SAC. 21 21
========================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.