TDMS Study 96007-03 Pathology Tables
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
FINAL # 3 RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1746-01-6
Lock Date: 06/28/01
Cage Range: All
Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|
| 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Mesentery | +|
Schwannoma Malignant | |
|__________________________________________________________________________|
Oral Mucosa | |
Gingival, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|
| 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + M + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Adenoma, Multiple | X X |
Pars Intermedia, Adenoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X X X X X X X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|
| 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +|
Periovarian Tissue, Schwannoma | |
Malignant, Metastatic, Uterus | X |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
Polyp Stromal | X X X X X |
Polyp Stromal, Multiple | |
Squamous Cell Papilloma | X |
Cervix, Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | |
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + M + + + + + + M + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Uterus | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|
| 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Carcinoma, Multiple | |
Fibroadenoma | X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Fibroma | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
Pinna, Neural Crest Tumor | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|
| 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Uterus | X |
|__________________________________________________________________________|
Ureter | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Uterus | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|
| 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Mesentery | + |
Schwannoma Malignant | X |
|__________________________________________________________________________|
Oral Mucosa | + +|
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|
| 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M M + + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Pars Distalis, Adenoma | X X X X X X X X|
Pars Distalis, Adenoma, Multiple | X |
Pars Intermedia, Adenoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M M + + + M + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 8
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|
| 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +|
Periovarian Tissue, Schwannoma | |
Malignant, Metastatic, Uterus | |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + M + + + + + + + + + + +|
Leiomyoma | |
Polyp Stromal | X X X X |
Polyp Stromal, Multiple | |
Squamous Cell Papilloma | |
Cervix, Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Uterus | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X |
__________________________________________|__________________________________________________________________________|
Page 9
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|
| 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Carcinoma, Multiple | X |
Fibroadenoma | X X X X X X X X X X X X|
Fibroadenoma, Multiple | X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Fibroma | X |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + + |
Pinna, Neural Crest Tumor | X |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | |
__________________________________________|__________________________________________________________________________|
Page 10
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|
| 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Uterus | |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Uterus | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 11
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 51 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
|__________________________________________________________________________|____________|
Mesentery | | 2 |
Schwannoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
Gingival, Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 51 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 51 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
|__________________________________________________________________________|____________|
Tooth | | 16 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Benign | | 3 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 51 |
Adenoma | | 1 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + | 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Adenoma | | 4 |
Pars Distalis, Adenoma | X X X | 18 |
Pars Distalis, Adenoma, Multiple | | 3 |
Pars Intermedia, Adenoma | | 2 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
Bilateral, C-Cell, Adenoma | X | 3 |
C-Cell, Adenoma | X | 17 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 50 |
|__________________________________________________________________________|____________|
Ovary | + + + | 51 |
Periovarian Tissue, Schwannoma | | |
Malignant, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Oviduct | | 2 |
|__________________________________________________________________________|____________|
Uterus | + + + | 52 |
Leiomyoma | | 1 |
Polyp Stromal | | 9 |
Polyp Stromal, Multiple | X X | 2 |
Squamous Cell Papilloma | | 1 |
Cervix, Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | | 2 |
Deep Cervical, Carcinoma, Metastatic,| | |
Thyroid Gland | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 52 |
|__________________________________________________________________________|____________|
Spleen | + + + | 51 |
Schwannoma Malignant, Metastatic, | | |
Uterus | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + | 51 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoma | | 2 |
Carcinoma | | 3 |
Carcinoma, Multiple | | 1 |
Fibroadenoma | X | 21 |
Fibroadenoma, Multiple | | 12 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Basal Cell Carcinoma | | 1 |
Fibroma | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
Trachea | + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Pinna, Neural Crest Tumor | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Schwannoma Malignant, Metastatic, | | |
Uterus | | 1 |
|__________________________________________________________________________|____________|
Ureter | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
Schwannoma Malignant, Metastatic, | | |
Uterus | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|
| 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Mesentery | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|
| 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + M + M + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|
| 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Carcinoma | |
Polyp Stromal | X X X X |
Cervix, Carcinoma | |
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node | + + + +|
Mediastinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X X X X |
Carcinoma, Multiple | |
Fibroadenoma | X X X X X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lipoma | X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|
| 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Mammary Gland | X |
Lymphoma Malignant | X |
Nephroblastoma, Metastatic, Kidney | X|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephroblastoma | X|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|
| 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Mesentery | + + |
|__________________________________________________________________________|
Oral Mucosa | + + + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|
| 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X X X |
C-Cell, Adenoma | X X X X X X|
C-Cell, Carcinoma | X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|
| 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Carcinoma | |
Polyp Stromal | X X |
Cervix, Carcinoma | X |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + M|
Carcinoma, Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
Carcinoma, Multiple | X |
Fibroadenoma | X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lipoma | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|
| 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Mammary Gland | |
Lymphoma Malignant | |
Nephroblastoma, Metastatic, Kidney | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephroblastoma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| | |
DAY ON TEST | 0| 5| 3| 3| | |
| 4| 6| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
3 NG/KG | 8| 8| 9| 9| | L |
| 3| 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + M + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 54 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 2 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 9 |
Gingival, Squamous Cell Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + | 54 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
|__________________________________________________________________________|____________|
Tooth | | 16 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| | |
DAY ON TEST | 0| 5| 3| 3| | |
| 4| 6| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
3 NG/KG | 8| 8| 9| 9| | L |
| 3| 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + | 54 |
|__________________________________________________________________________|____________|
Heart | + + + + | 54 |
Lymphoma Malignant | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 54 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 54 |
Pheochromocytoma Benign | | 2 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + M + | 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 54 |
Pars Distalis, Adenoma | X X | 20 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 54 |
Bilateral, C-Cell, Adenoma | | 3 |
C-Cell, Adenoma | | 12 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + M + + | 52 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| | |
DAY ON TEST | 0| 5| 3| 3| | |
| 4| 6| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
3 NG/KG | 8| 8| 9| 9| | L |
| 3| 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Ovary | + M + + | 53 |
|__________________________________________________________________________|____________|
Oviduct | | 1 |
|__________________________________________________________________________|____________|
Uterus | + M + + | 53 |
Carcinoma | X | 1 |
Polyp Stromal | X | 7 |
Cervix, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | | 6 |
Mediastinal, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 54 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + | 53 |
|__________________________________________________________________________|____________|
Spleen | + + + + | 54 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + | 52 |
Carcinoma, Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| | |
DAY ON TEST | 0| 5| 3| 3| | |
| 4| 6| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
3 NG/KG | 8| 8| 9| 9| | L |
| 3| 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Mammary Gland | + + + + | 54 |
Carcinoma | | 7 |
Carcinoma, Multiple | | 1 |
Fibroadenoma | X X | 26 |
Fibroadenoma, Multiple | X | 14 |
|__________________________________________________________________________|____________|
Skin | + + + + | 54 |
Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Lymphoma Malignant | | 1 |
Nephroblastoma, Metastatic, Kidney | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + | 54 |
|__________________________________________________________________________|____________|
Trachea | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + | 54 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| | |
DAY ON TEST | 0| 5| 3| 3| | |
| 4| 6| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
3 NG/KG | 8| 8| 9| 9| | L |
| 3| 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + | 54 |
Nephroblastoma | | 2 |
|__________________________________________________________________________|____________|
Urinary Bladder | + M + + | 53 |
Polyp | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 54 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|
DAY ON TEST | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|
| 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + +|
Gingival, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Tooth | + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|
DAY ON TEST | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|
| 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant | |
Capsule, Sarcoma, Metastatic, | |
Skeletal Muscle | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M M M + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|
DAY ON TEST | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|
| 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Polyp Stromal | X |
Squamous Cell Papilloma | |
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node | + + |
Lymphoma Malignant | |
Lumbar, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|
DAY ON TEST | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|
| 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, Lung| X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Fibroadenoma | X X X X X X X X X|
Fibroadenoma, Multiple | X X X X X X X X X X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Fibroma | X |
Myxosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glioma Malignant | X |
Granular Cell Tumor Malignant | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|
DAY ON TEST | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|
| 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | |
Sarcoma, Metastatic, Skeletal Muscle | X |
Mediastinum, Sarcoma | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | |
Nephroblastoma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|
| 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Tooth | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|
| 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant | X |
Capsule, Sarcoma, Metastatic, | |
Skeletal Muscle | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Pars Distalis, Adenoma | X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|
| 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Polyp Stromal | X X X |
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node | + |
Lymphoma Malignant | X |
Lumbar, Lymphoma Malignant | X |
Mediastinal, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|
| 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Histiocytic Sarcoma, Metastatic, Lung| |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X |
Fibroadenoma | X X X X X X X|
Fibroadenoma, Multiple | X X X X X X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Fibroma | X |
Myxosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glioma Malignant | |
Granular Cell Tumor Malignant | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|
| 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skeletal Muscle | |
Mediastinum, Sarcoma | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | X |
Nephroblastoma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | + | 16 |
Gingival, Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Tooth | + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Adenoma | | 2 |
Lymphoma Malignant | | 1 |
Capsule, Sarcoma, Metastatic, | | |
Skeletal Muscle | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Lymphoma Malignant | | 1 |
Pheochromocytoma Benign | | 2 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 2 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + M | 52 |
Lymphoma Malignant | | 1 |
Pars Distalis, Adenoma | X | 26 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Bilateral, C-Cell, Adenoma | | 2 |
C-Cell, Adenoma | | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
|__________________________________________________________________________|____________|
Oviduct | | 2 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Adenoma | | 1 |
Polyp Stromal | | 4 |
Squamous Cell Papilloma | | 1 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | | 3 |
Lymphoma Malignant | | 1 |
Lumbar, Lymphoma Malignant | | 1 |
Mediastinal, Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 52 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + | 52 |
Histiocytic Sarcoma, Metastatic, Lung| | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoma | | 1 |
Carcinoma | X | 4 |
Fibroadenoma | X | 17 |
Fibroadenoma, Multiple | X | 17 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Basal Cell Carcinoma | X | 1 |
Fibroma | | 2 |
Myxosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Glioma Malignant | | 1 |
Granular Cell Tumor Malignant | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 1 |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
Mediastinum, Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 1 |
Nephroblastoma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|
| 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | |
|__________________________________________________________________________|
Mesentery | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + M + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|
| 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + + + M + M M + + M + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meningioma Malignant, Metastatic, | |
Brain | X |
Pars Distalis, Adenoma | X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Multiple | X |
Polyp Stromal | X X X X |
Polyp Stromal, Multiple | X |
|__________________________________________________________________________|
Vagina | + |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|
| 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Schwannoma Malignant, Metastatic, | |
Skin | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + M + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | X |
Keratoacanthoma | |
Schwannoma Malignant | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Schwannoma Malignant, | |
Metastatic, Skin | X |
Periosteum, Fibrosarcoma | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|
| 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Skeletal Muscle | |
Fibrous Histiocytoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Stromal Nephroma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|
| 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|
| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|
| 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|
| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X X|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + M + + + + + M + + + +|
Adenoma | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meningioma Malignant, Metastatic, | |
Brain | |
Pars Distalis, Adenoma | X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X X X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Multiple | |
Polyp Stromal | X X X |
Polyp Stromal, Multiple | X |
|__________________________________________________________________________|
Vagina | + + |
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|
| 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|
| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Schwannoma Malignant, Metastatic, | |
Skin | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Fibroadenoma | X X X X X X X X X X |
Fibroadenoma, Multiple | X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
Keratoacanthoma | X |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Schwannoma Malignant, | |
Metastatic, Skin | |
Periosteum, Fibrosarcoma | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|
| 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|
| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Skeletal Muscle | + + |
Fibrous Histiocytoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Stromal Nephroma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 1| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
22 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 52 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Cholangiocarcinoma | | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | + + | 16 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
|__________________________________________________________________________|____________|
Tooth | + | 13 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 1| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
22 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 52 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Adenoma | | 2 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Benign | | 3 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 44 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Meningioma Malignant, Metastatic, | | |
Brain | | 1 |
Pars Distalis, Adenoma | X | 15 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 51 |
Bilateral, C-Cell, Adenoma | | 2 |
C-Cell, Adenoma | X | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 1| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
22 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 52 |
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Carcinoma, Multiple | | 1 |
Polyp Stromal | X | 8 |
Polyp Stromal, Multiple | X | 3 |
|__________________________________________________________________________|____________|
Vagina | | 3 |
Schwannoma Malignant, Metastatic, | | |
Skin | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
|__________________________________________________________________________|____________|
Thymus | + + + | 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 1| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
22 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Fibroadenoma | X | 17 |
Fibroadenoma, Multiple | X | 12 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Fibrosarcoma | | 1 |
Keratoacanthoma | | 1 |
Schwannoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
Cranium, Schwannoma Malignant, | | |
Metastatic, Skin | | 1 |
Periosteum, Fibrosarcoma | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Fibrous Histiocytoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 52 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
Trachea | + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 1| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
22 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Eye | + + + | 52 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 52 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Stromal Nephroma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|
| 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uterus | X X |
Cholangiocarcinoma | X X|
Cholangiocarcinoma, Multiple | X |
Hepatocellular Adenoma | |
|__________________________________________________________________________|
Mesentery | + + |
Carcinoma, Metastatic, Uterus | X |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + |
Gingival, Squamous Cell Carcinoma | X X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uterus | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|
| 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Pheochromocytoma Benign | X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M + + M + + M + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|
| 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
Lymphoma Malignant | X |
Thecoma Benign | |
|__________________________________________________________________________|
Oviduct | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Hemangiosarcoma | |
Lymphoma Malignant | X |
Polyp Stromal | X X X X|
Polyp Stromal, Multiple | |
Squamous Cell Carcinoma | X X X |
Squamous Cell Carcinoma, Multiple | |
|__________________________________________________________________________|
Vagina | + |
Schwannoma Malignant | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Carcinoma, Metastatic, Uterus| X |
Mediastinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|
| 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X X X X X X X X X X|
Fibroadenoma, Multiple | X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|
| 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Uterus | |
Transitional Epithelium, Carcinoma | X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|
DAY ON TEST | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|
| 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uterus | |
Cholangiocarcinoma | X |
Cholangiocarcinoma, Multiple | |
Hepatocellular Adenoma | X |
|__________________________________________________________________________|
Mesentery | + + |
Carcinoma, Metastatic, Uterus | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + +|
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uterus | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X|
Squamous Cell Papilloma | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|
DAY ON TEST | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|
| 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + M + + + + M + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|
DAY ON TEST | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|
| 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
Lymphoma Malignant | |
Thecoma Benign | X |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Hemangiosarcoma | X |
Lymphoma Malignant | |
Polyp Stromal | X X X X X |
Polyp Stromal, Multiple | |
Squamous Cell Carcinoma | X |
Squamous Cell Carcinoma, Multiple | X |
|__________________________________________________________________________|
Vagina | + + |
Schwannoma Malignant | X |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Carcinoma, Metastatic, Uterus| |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
Renal, Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|
DAY ON TEST | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|
| 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Spleen | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
|__________________________________________________________________________|
Thymus | + + + M + + + M + + M + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|
DAY ON TEST | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|
| 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Uterus | X |
Transitional Epithelium, Carcinoma | |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
Leiomyoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Carcinoma, Metastatic, Uterus | | 2 |
Cholangiocarcinoma | | 3 |
Cholangiocarcinoma, Multiple | | 1 |
Hepatocellular Adenoma | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Carcinoma, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | + + | 22 |
Gingival, Squamous Cell Carcinoma | X | 4 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
Carcinoma, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 51 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Forestomach | + + + | 53 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
|__________________________________________________________________________|____________|
Tooth | | 14 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Adenoma | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Lymphoma Malignant | | 1 |
Pheochromocytoma Benign | | 3 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 52 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Adenoma | X X | 20 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | X | 12 |
C-Cell, Carcinoma | | 2 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 51 |
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Granulosa Cell Tumor Malignant | | 1 |
Lymphoma Malignant | | 1 |
Thecoma Benign | | 1 |
|__________________________________________________________________________|____________|
Oviduct | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Carcinoma | | 2 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant | | 1 |
Polyp Stromal | | 9 |
Polyp Stromal, Multiple | X | 1 |
Squamous Cell Carcinoma | | 4 |
Squamous Cell Carcinoma, Multiple | | 1 |
|__________________________________________________________________________|____________|
Vagina | | 3 |
Schwannoma Malignant | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | | 6 |
Lumbar, Carcinoma, Metastatic, Uterus| | 1 |
Mediastinal, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
Renal, Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
|__________________________________________________________________________|____________|
Spleen | + + + | 52 |
Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Thymus | + M + | 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Carcinoma | | 2 |
Fibroadenoma | X | 24 |
Fibroadenoma, Multiple | X | 12 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Squamous Cell Carcinoma, Metastatic, | | |
Uterus | | 1 |
Transitional Epithelium, Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|
DAY ON TEST | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|
| 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | |
Cholangiocarcinoma | X X X X X X |
Cholangiocarcinoma, Multiple | X X X X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X X |
Hepatocholangioma | |
|__________________________________________________________________________|
Mesentery | + + + + |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + +|
Gingival, Squamous Cell Carcinoma | X X X X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + + + + + + + + + + + +|
Acinus, Adenoma | |
Acinus, Carcinoma | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|
DAY ON TEST | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|
| 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Adenoma | |
Pars Distalis, Adenoma | X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X X |
C-Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|
DAY ON TEST | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|
| 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Polyp Stromal | |
Polyp Stromal, Multiple | |
|__________________________________________________________________________|
Vagina | + |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
Deep Cervical, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + M M + M + + + + + + M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Fibroadenoma | X X X X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|
DAY ON TEST | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|
| 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroadenoma, Multiple | X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + M + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | |
Cystic Keratinizing Epithelioma | X X X |
Cystic Keratinizing Epithelioma, | |
Multiple | X|
Mediastinum, Sarcoma | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|
DAY ON TEST | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|
| 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|
| 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | X X|
Cholangiocarcinoma | X X |
Cholangiocarcinoma, Multiple | X X X X X X X X X X|
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Hepatocholangioma | X X |
|__________________________________________________________________________|
Mesentery | + + + + |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + +|
Gingival, Squamous Cell Carcinoma | X X X X X |
|__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
Acinus, Adenoma | X |
Acinus, Carcinoma | X X|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 79
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|
| 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M M M + + + + + + + + + + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Pars Distalis, Adenoma | X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|
| 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Polyp Stromal | X X X X X X X |
Polyp Stromal, Multiple | X |
|__________________________________________________________________________|
Vagina | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + |
Deep Cervical, Lymphoma Malignant | X |
Inguinal, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + M + + + M M + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Fibroadenoma | X X X X X X X X |
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|
| 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroadenoma, Multiple | X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | X |
Cystic Keratinizing Epithelioma | X X X |
Cystic Keratinizing Epithelioma, | |
Multiple | X |
Mediastinum, Sarcoma | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|
| 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + M + | 51 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M + | 52 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + | 51 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Carcinoma, Metastatic, Pancreas | | 2 |
Cholangiocarcinoma | | 8 |
Cholangiocarcinoma, Multiple | X X | 17 |
Hepatocellular Adenoma | X X | 10 |
Hepatocellular Adenoma, Multiple | | 3 |
Hepatocholangioma | | 2 |
|__________________________________________________________________________|____________|
Mesentery | | 8 |
|__________________________________________________________________________|____________|
Oral Mucosa | + | 29 |
Gingival, Squamous Cell Carcinoma | X | 10 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 51 |
Acinus, Adenoma | | 1 |
Acinus, Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 84
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Squamous Cell Papilloma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
|__________________________________________________________________________|____________|
Tooth | | 18 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 52 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Adenoma | X | 1 |
Pheochromocytoma Benign | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 3 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 52 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Adenoma | | 1 |
Pars Distalis, Adenoma | | 10 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 85
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Thyroid Gland | + + + | 52 |
Bilateral, C-Cell, Adenoma | | 3 |
C-Cell, Adenoma | X X | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
|__________________________________________________________________________|____________|
Oviduct | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Carcinoma | | 1 |
Polyp Stromal | | 7 |
Polyp Stromal, Multiple | | 1 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | + | 9 |
Deep Cervical, Lymphoma Malignant | | 1 |
Inguinal, Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 52 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 86
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + | 51 |
|__________________________________________________________________________|____________|
Spleen | + + + | 52 |
|__________________________________________________________________________|____________|
Thymus | + + M | 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoma | | 1 |
Fibroadenoma | X | 20 |
Fibroadenoma, Multiple | | 4 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Fibroma | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 52 |
Carcinoma, Metastatic, Pancreas | | 1 |
Cystic Keratinizing Epithelioma | X | 7 |
Cystic Keratinizing Epithelioma, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 87
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Multiple | | 2 |
Mediastinum, Sarcoma | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Squamous Cell Carcinoma, Metastatic, | | |
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Squamous Cell Carcinoma, Metastatic, | | |
Oral Mucosa | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 88
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Heart | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | |
Cholangiocarcinoma, Multiple | |
Cholangioma | X |
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Hepatocellular Adenoma | X X |
Lymphoma Malignant | |
Schwannoma Malignant, Metastatic, | |
Heart | |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Oral Mucosa | + + + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Carcinoma | |
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + |
Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Tooth | + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Fibrous Histiocytoma, | |
Metastatic, Skin | X |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | |
Lymphoma Malignant | |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Capsule, Schwannoma Malignant, | |
Metastatic, Heart | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 90
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Parathyroid Gland | M + + + + + + + + M + + + + M + M + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Pars Distalis, Adenoma | X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uterus | X |
|__________________________________________________________________________|
Oviduct | + + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
Polyp Stromal | X |
Polyp Stromal, Multiple | X |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
|__________________________________________________________________________|
Lymph Node | + |
__________________________________________|__________________________________________________________________________|
Page 91
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Hemangiosarcoma | |
Lymphoma Malignant | |
Schwannoma Malignant, Metastatic, | |
Heart | |
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Lymphoma Malignant | |
Thymoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenolipoma | X |
Carcinoma | |
Fibroadenoma | X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Fibrous Histiocytoma | X |
Liposarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Tongue | X |
|__________________________________________________________________________|
Skeletal Muscle | + |
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | |
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Lymphoma Malignant | |
Schwannoma Malignant, Metastatic, | |
Heart | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 93
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenolipoma | X |
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 94
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Schwannoma Malignant, Metastatic, | | |
Heart | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + M +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cholangiocarcinoma | X | 1 |
Cholangiocarcinoma, Multiple | X | 1 |
Cholangioma | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Hepatocellular Adenoma | | 2 |
Lymphoma Malignant | X | 1 |
Schwannoma Malignant, Metastatic, | | |
Heart | X | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 95
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Gingival, Squamous Cell Carcinoma | X X X X | 5 |
|__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Aorta, Fibrous Histiocytoma, | | |
Metastatic, Skin | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Mammary Gland | X | 1 |
Lymphoma Malignant | X | 1 |
Schwannoma Malignant | X X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
Capsule, Schwannoma Malignant, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 96
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Metastatic, Heart | X | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | X | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + M +| 44 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X| 19 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, C-Cell, Adenoma | X | 2 |
C-Cell, Adenoma | X X X X X | 11 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Oviduct | | 2 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 97
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Carcinoma | | 2 |
Polyp Stromal | X X | 3 |
Polyp Stromal, Multiple | | 1 |
Squamous Cell Carcinoma | X| 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant | X | 1 |
Schwannoma Malignant, Metastatic, | | |
Heart | X | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 98
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Thymoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenolipoma | | 1 |
Carcinoma | X | 1 |
Fibroadenoma | X X X X X X X X X | 19 |
Fibroadenoma, Multiple | X X X X X X X| 13 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibroma | X | 1 |
Fibrous Histiocytoma | | 1 |
Liposarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma, Metastatic, | | |
Tongue | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 99
NTP Experiment-Test: 96007-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Carcinoma, Metastatic, Mammary Gland | X | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Lymphoma Malignant | X | 1 |
Schwannoma Malignant, Metastatic, | | |
Heart | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenolipoma | | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 100
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---------- END OF REPORT ----------
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