TDMS Study 96007-03 Pathology Tables
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
FINAL # 3 RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 1746-01-6
Lock Date: 06/28/01
Cage Range: All
Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|
| 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + M + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X |
Basophilic Focus, Multiple | X X|
Cholangiofibrosis | 1 |
Clear Cell Focus | X |
Clear Cell Focus, Multiple | X |
Congestion | 1|
Eosinophilic Focus | X X X X |
Eosinophilic Focus, Multiple | X X |
Fatty Change, Focal | 2 1 |
Hematopoietic Cell Proliferation | |
Inflammation | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X X X |
Mixed Cell Focus, Multiple | X X X X X X X X X X X |
Necrosis | |
Pigmentation | 1 |
Bile Duct, Cyst | 4|
Bile Duct, Hyperplasia | 2 1 2 2 |
Centrilobular, Degeneration | 2|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|
| 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Mesentery | +|
Metaplasia, Osseous | 2|
Vein, Thrombosis | 3|
|__________________________________________________________________________|
Oral Mucosa | |
Gingival, Hyperplasia, Squamous | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + M + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | 2 |
Acinus, Vacuolization Cytoplasmic | 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Hyperplasia, Squamous | |
Inflammation | |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | 1 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + +|
Peridontal Tissue, Fibrosis | |
Peridontal Tissue, Inflammation | 1 2 1 2 1 2 1 3 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 |
Mineralization | |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|
| 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 1 2 1 1|
Atrophy | |
Degeneration, Cystic | 3 3 3 3|
Hyperplasia | 2 1 1 2 2 2 2 |
Hypertrophy | 2 2 3 2 3 2 1 2 2 1 3 3 4 3 1 3 2 2 2|
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Vacuolization Cytoplasmic | 1 2 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 2 1 1 2 2 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + M + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 3 3 1 2 3 3 3 |
Atypia Cellular | 2 |
Cyst | |
Cytoplasmic Alteration | |
Developmental Malformation | |
Pars Distalis, Hyperplasia | 1 3 2 2 2 1 2 2 2 2 3 3 |
Pars Intermedia, Hyperplasia | 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
C-Cell, Hyperplasia | 1 1 2 1 3 1 3 3 |
Follicular Cell, Hyperplasia | 2 |
Follicular Cell, Hypertrophy | 3 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|
| 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 |
Inflammation | 1 1 2 1 1 1 1 2 2 3 2 1 2 1 2 2 2 1 1 1|
Duct, Cyst | 2 2 3 2 2 3 2 4 2 2 2 1 1 4 3 2 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 2 3 2 3 3 3 2 3 3 3 |
|__________________________________________________________________________|
Oviduct | + |
Inflammation | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Suppurative | 2 1 2 |
Metaplasia, Squamous | 2 2 3 1 2 3 1 4 2 1 2 1 3 2 1|
Endometrium, Hyperplasia, Cystic | 3 1 2 1 3 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 4 3 4 3 3 3 3 2 3 3 3 3 3 4 3|
|__________________________________________________________________________|
Lymph Node | |
Lumbar, Ectasia | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Histiocytic | |
|__________________________________________________________________________|
Spleen | + + + + + + M + + + + + + M + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 1 2 1 3 3 2 1 1 1 2 2 1 1 2 1 3 2 1 2|
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 2 1 1 1 1 1 1 1 3 2 1 2 1 2 2 1 1 2 2 1|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|
| 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymphoid Follicle, Atrophy | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 3 2 3 4 2 3 3 2 2 2 2 3 3 1 3|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 1 1 1 1 1 1 1 3 2 1 1 1 |
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Developmental | |
Malformation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 2 2 1 2 2 1 2 1 1 2 3 1 2 1 2 2 |
Inflammation, Granulomatous | 1 1 |
Inflammation, Suppurative | 3 |
Metaplasia, Squamous | |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|
| 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Nasolacrimal Duct, Inflammation | 2 |
Squamous Epithelium, Inflammation, | |
Suppurative | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Hemorrhage | |
Retina, Atrophy | 2 2 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Inflammation | 2 1 |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 2 |
Casts Protein | 2 |
Cyst | 2 |
Inflammation, Chronic Active | 1 2 1 1 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy | 1 3 1 2 1 1 1 1 1 1 1 1 1 1 1 |
Pelvis, Dilatation | 3 3 |
Pelvis, Inflammation | 3 3 |
Transitional Epithelium, Hyperplasia | 3 2 |
|__________________________________________________________________________|
Ureter | + |
Inflammation | 2 |
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|
| 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Transitional Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 3 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________
Page 8
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|
| 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +|
Parasite Metazoan | X X X X|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X |
Basophilic Focus, Multiple | X X |
Cholangiofibrosis | |
Clear Cell Focus | X X X |
Clear Cell Focus, Multiple | |
Congestion | 1 |
Eosinophilic Focus | X X X X |
Eosinophilic Focus, Multiple | X |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | 2 |
Inflammation | 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1|
Mixed Cell Focus | X |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X X|
Necrosis | 2 |
Pigmentation | 1 1 1 |
Bile Duct, Cyst | 3 3 |
Bile Duct, Hyperplasia | 1 |
Centrilobular, Degeneration | 3 |
__________________________________________|__________________________________________________________________________|
Page 9
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|
| 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Mesentery | + |
Metaplasia, Osseous | |
Vein, Thrombosis | |
|__________________________________________________________________________|
Oral Mucosa | + +|
Gingival, Hyperplasia, Squamous | 4|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + M + + + + + + + + + + +|
Acinus, Atrophy | 1 |
Acinus, Hyperplasia | 3 |
Acinus, Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + M + + + + + + + + + + + + + +|
Mineralization | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 1 1 2 |
Inflammation | 3 |
Ulcer | 2 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Mineralization | 2 |
|__________________________________________________________________________|
Tooth | + + + + + +|
Peridontal Tissue, Fibrosis | 2 |
Peridontal Tissue, Inflammation | 2 3 2 2 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 3 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 2 |
Mineralization | 2 |
__________________________________________|__________________________________________________________________________|
Page 10
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|
| 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 1 |
Atrophy | 2 |
Degeneration, Cystic | 2 2 2 3 1 2 |
Hyperplasia | 2 2 3 1 3 3 2|
Hypertrophy | 2 2 2 2 2 2 1 1 2 2 3 3 1 2 2 1 3 3 2|
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 1 |
Vacuolization Cytoplasmic | 2 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 2 2 2 3 2 2|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M M + + + + + M + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 1 2 2 3 3 1 2 2 2 3|
Atypia Cellular | |
Cyst | 2 |
Cytoplasmic Alteration | 1 |
Developmental Malformation | X |
Pars Distalis, Hyperplasia | 3 2 2 2 1 3 2 |
Pars Intermedia, Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | |
C-Cell, Hyperplasia | 3 2 2 2 1 1 2 1 2 2 |
Follicular Cell, Hyperplasia | 3 |
Follicular Cell, Hypertrophy | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 11
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|
| 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M M + + + M + + + + + + +|
Hyperplasia, Basal Cell | |
Inflammation | 1 2 1 2 2 3 2 2 3 1 1 1 2 1 2 3 2 1|
Duct, Cyst | 2 3 1 3 2 1 1 3 2 1 3 3 3 3 3|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 2 2 2 2 |
|__________________________________________________________________________|
Oviduct | + |
Inflammation | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 2 1 1 4 |
Metaplasia, Squamous | 1 3 1 3 1 1 2 2 1 3 2 4 2 |
Endometrium, Hyperplasia, Cystic | 2 1 3 3 3 2 1 2 3 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 3 2 3 2 3 4 3 3 4 3 3 2 2 3 3|
|__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Ectasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + M + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 3 1 1 1 1 1 1 1 3 3 2 1 1 2 1 1 1 1 1|
Hyperplasia, Lymphoid | |
Pigmentation | 1 1 2 1 1 2 2 2 2 2 1 1 1 2 1 1 2 2 2 2 1 |
__________________________________________|__________________________________________________________________________|
Page 12
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|
| 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymphoid Follicle, Atrophy | 3 2 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + M + + + + + + + + +|
Atrophy | 2 2 4 2 3 2 2 2 2 4 2 3 3 3 3 3|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 3 2 |
Hyperplasia | 2 1 2 1 1 2 1 1 1 2 1|
Inflammation, Granulomatous | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Developmental | |
Malformation | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 2 2 3 3 2 1 2 2 3 2 1 1 1 2 1 2 2 2 3 2|
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
Metaplasia, Squamous | 1 |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 2 1 1 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|
| 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Nasolacrimal Duct, Inflammation | 2 |
Squamous Epithelium, Inflammation, | |
Suppurative | |
|__________________________________________________________________________|
Trachea | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 4 |
Hemorrhage | 2 |
Retina, Atrophy | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Inflammation | 1 1 2 1 1 2 1 1 1 |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Casts Protein | 1 1 |
Cyst | 3 |
Inflammation, Chronic Active | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1|
Nephropathy | 2 1 1 1 1 2 1 1 1 1 3 1 1 1 1 1|
Pelvis, Dilatation | |
Pelvis, Inflammation | |
Transitional Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Ureter | |
Inflammation | |
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|
| 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Transitional Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation | 1 1 1 |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 15
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 52 |
Muscularis, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 52 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
Parasite Metazoan | | 6 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 51 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | 2 | 2 1.5|
Basophilic Focus | | 8 |
Basophilic Focus, Multiple | | 4 |
Cholangiofibrosis | | 1 1.0|
Clear Cell Focus | | 4 |
Clear Cell Focus, Multiple | | 1 |
Congestion | | 2 1.0|
Eosinophilic Focus | | 8 |
Eosinophilic Focus, Multiple | | 3 |
Fatty Change, Focal | | 2 1.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation | 1 1 | 33 1.1|
Mixed Cell Focus | | 4 |
Mixed Cell Focus, Multiple | X X | 26 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Pigmentation | | 4 1.0|
Bile Duct, Cyst | | 3 3.3|
Bile Duct, Hyperplasia | | 5 1.6|
Centrilobular, Degeneration | | 2 2.5|
|__________________________________________________________________________|____________|
Mesentery | | 2 |
Metaplasia, Osseous | | 1 2.0|
Vein, Thrombosis | | 1 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
Gingival, Hyperplasia, Squamous | | 1 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + | 51 |
Acinus, Atrophy | | 1 1.0|
Acinus, Hyperplasia | | 2 2.5|
Acinus, Vacuolization Cytoplasmic | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 51 |
Mineralization | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Hyperkeratosis | | 1 1.0|
Hyperplasia, Squamous | | 3 1.3|
Inflammation | | 1 3.0|
Ulcer | | 2 2.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Erosion | | 1 3.0|
Mineralization | | 3 1.3|
|__________________________________________________________________________|____________|
Tooth | | 16 |
Peridontal Tissue, Fibrosis | | 1 2.0|
Peridontal Tissue, Inflammation | | 15 1.7|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
Aorta, Mineralization | | 1 3.0|
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Cardiomyopathy | | 10 1.2|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | 2 | 11 1.5|
Atrophy | 3 | 2 2.5|
Degeneration, Cystic | 3 | 11 2.5|
Hyperplasia | 2 2 | 16 2.0|
Hypertrophy | 2 1 4 | 41 2.1|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
Vacuolization Cytoplasmic | 3 1 1 | 11 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Hyperplasia | | 19 1.8|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 51 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + | 46 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Angiectasis | 1 3 3 | 25 2.3|
Atypia Cellular | | 1 2.0|
Cyst | | 1 2.0|
Cytoplasmic Alteration | | 1 1.0|
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pars Distalis, Hyperplasia | | 19 2.1|
Pars Intermedia, Hyperplasia | | 2 2.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
Cyst | | 1 3.0|
C-Cell, Hyperplasia | 2 | 19 1.8|
Follicular Cell, Hyperplasia | | 2 2.5|
Follicular Cell, Hypertrophy | | 3 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 50 |
Hyperplasia, Basal Cell | | 1 2.0|
Inflammation | 1 1 1 | 41 1.6|
Duct, Cyst | 1 2 | 34 2.2|
|__________________________________________________________________________|____________|
Ovary | + + + | 51 |
Atrophy | 4 4 4 | 49 4.0|
Cyst | | 14 2.5|
|__________________________________________________________________________|____________|
Oviduct | | 2 |
Inflammation | | 2 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + | 52 |
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | | 7 1.9|
Metaplasia, Squamous | 3 | 29 2.0|
Endometrium, Hyperplasia, Cystic | 2 1 3 | 30 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Bone Marrow | + + + | 53 |
Hyperplasia | 2 | 36 3.0|
|__________________________________________________________________________|____________|
Lymph Node | | 2 |
Lumbar, Ectasia | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
Congestion | | 1 2.0|
Hyperplasia, Plasma Cell | 2 3 3 | 25 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 52 |
Hyperplasia, Histiocytic | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + | 51 |
Hematopoietic Cell Proliferation | 1 1 1 | 46 1.5|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | 1 2 1 | 45 1.5|
Lymphoid Follicle, Atrophy | | 4 2.3|
|__________________________________________________________________________|____________|
Thymus | + + + | 51 |
Atrophy | 3 2 | 36 2.6|
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Cyst | | 4 2.5|
Hyperplasia | 3 | 25 1.4|
Inflammation, Granulomatous | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Cerebellum, Developmental | | |
Malformation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Infiltration Cellular, Histiocyte | 2 2 2 | 41 1.9|
Inflammation, Granulomatous | | 2 1.0|
Inflammation, Suppurative | | 1 3.0|
Metaplasia, Squamous | | 1 1.0|
Mineralization | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 | 12 1.1|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation | | 2 2.5|
Nasolacrimal Duct, Inflammation | | 2 2.0|
Squamous Epithelium, Inflammation, | | |
Suppurative | | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 2 |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Degeneration | | 1 4.0|
Hemorrhage | | 1 2.0|
Retina, Atrophy | 1 | 5 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Atrophy, Focal | | 1 2.0|
Inflammation | 1 | 12 1.3|
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Calculus Micro Observation Only | | 1 2.0|
Casts Protein | | 3 1.3|
Cyst | | 2 2.5|
Inflammation, Chronic Active | | 5 1.2|
Mineralization | 1 1 1 | 40 1.1|
Nephropathy | 1 1 1 | 34 1.2|
Pelvis, Dilatation | | 2 3.0|
Pelvis, Inflammation | | 2 3.0|
Transitional Epithelium, Hyperplasia | | 3 2.3|
|__________________________________________________________________________|____________|
Ureter | | 1 |
Inflammation | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
Inflammation | 1 | 6 1.5|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|
| 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X |
Basophilic Focus, Multiple | |
Cholangiofibrosis | 1 |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X |
Eosinophilic Focus, Multiple | X X X X |
Fatty Change, Diffuse | 1 |
Fatty Change, Focal | 2 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Inflammation | 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1|
Mixed Cell Focus | X X X X X |
Mixed Cell Focus, Multiple | X X X X |
Necrosis | 2 1 |
Pigmentation | 1 1 1 1 |
Toxic Hepatopathy | 1 1 |
Bile Duct, Cyst | |
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|
| 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Fibrosis | |
Bile Duct, Hyperplasia | 1 1 1 |
Centrilobular, Degeneration | 2 |
Hepatocyte, Hypertrophy | 2 1 1 1 1 1 1 1 1 2 |
Oval Cell, Hyperplasia | 1 1 1 |
|__________________________________________________________________________|
Mesentery | |
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + |
Gingival, Hyperplasia, Squamous | 1 1 1 2 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 |
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 1 2 |
Inflammation | 2 |
Ulcer | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + |
Peridontal Tissue, Inflammation | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 |
Artery, Mineralization | |
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|
| 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 2 2 2 |
Degeneration, Cystic | 2 1 2 2 2 1 2 3 |
Hyperplasia | 3 1 2 1 2 3 |
Hypertrophy | 3 3 3 1 3 1 2 1 2 3 3 2 2 1 2 1 2 3 3 3 2 |
Necrosis | |
Vacuolization Cytoplasmic | 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 3 2 3 2 1 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + M + M + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 3 3 3 2 |
Cyst | 3 |
Vacuolization Cytoplasmic | 2 1 |
Pars Distalis, Hyperplasia | 2 2 2 1 1 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
C-Cell, Hyperplasia | 3 2 3 3 3 2 1 2 3 2 |
Follicular Cell, Hyperplasia | 3 |
Follicular Cell, Hypertrophy | 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 1 2 1 1 1 2 2 1 1 2 2 1 3 2 2 2 1 1 2 |
Duct, Cyst | 1 2 2 2 3 1 2 3 1 2 1 2 2 3 1 3 2 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|
| 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 2 2 3 2 2 |
Corpus Luteum, Cyst | |
|__________________________________________________________________________|
Oviduct | + |
Inflammation | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 1 1 2 3 |
Metaplasia, Squamous | 1 2 2 1 3 3 2 4 1 2 2 1 3 3 |
Cervix, Hyperplasia, Stromal | 4 |
Endometrium, Hyperplasia, Cystic | 1 2 3 1 2 2 2 4 2 1 2 3 2 2 1 |
|__________________________________________________________________________|
Vagina | |
Hyperplasia, Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 2 4 3 4 4 3 3 4 3 3 2 4 4 2 2 4 3|
|__________________________________________________________________________|
Lymph Node | + + + +|
Lumbar, Ectasia | 2 |
Lumbar, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Hemorrhage | 3|
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Ectasia | 3|
Renal, Hyperplasia, Histiocytic | 2|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 2 2 2 3 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|
| 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 2 1 2 1 2 1 1 2 1 2 3 2 1 3 1 1 1 1 1 3|
Pigmentation | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 2 1 1 3 1|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 4 2 3 3 2 2 4 3 2 4 2 4 3 3 4 2 3 2 4 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 3 4 |
Hyperplasia | 1 1 1 1 3 2 2 1 |
Inflammation, Granulomatous | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Inflammation, Focal, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Mineralization | 2 |
Glial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 2 3 2 2 2 2 2 1 3 1 1 1 1 1 2 1 1 2 2 2 1 3 |
Inflammation, Granulomatous | |
Pigmentation | 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 1 1 1 2 2 1 2 2 1 |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|
| 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Retina, Atrophy | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Casts Protein | 1 2 1 2 |
Fibrosis | 2 |
Inflammation, Chronic Active | 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 |
Pelvis, Dilatation | 2 |
Pelvis, Inflammation | 2 |
Transitional Epithelium, Hyperplasia | 2 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Hemorrhage | 3 |
Inflammation | 1 2 1 1 1 2 1 |
Transitional Epithelium, Hyperplasia | 3 1 |
__________________________________________|__________________________________________________________________________
Page 28
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|
| 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 3 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X|
Basophilic Focus, Multiple | X X |
Cholangiofibrosis | |
Clear Cell Focus | |
Eosinophilic Focus | X X |
Eosinophilic Focus, Multiple | X X X X |
Fatty Change, Diffuse | 1 |
Fatty Change, Focal | 1 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation | 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1|
Mixed Cell Focus | X X |
Mixed Cell Focus, Multiple | X X X X X X |
Necrosis | 3 |
Pigmentation | 2 1 1 |
Toxic Hepatopathy | |
Bile Duct, Cyst | 3 |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|
| 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Fibrosis | 2 2 |
Bile Duct, Hyperplasia | 3 |
Centrilobular, Degeneration | 2 |
Hepatocyte, Hypertrophy | 1 2 1 1 1 1 1 1|
Oval Cell, Hyperplasia | 1 |
|__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic Active | 3 |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + |
Gingival, Hyperplasia, Squamous | 2 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Hyperplasia, Squamous | 1 2 |
Inflammation | |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + |
Peridontal Tissue, Inflammation | 1 1 1 1 1 1 2 1 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 |
Artery, Mineralization | 2 |
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|
| 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 2 1 2 2 2 3 2 2 2 2 2|
Degeneration, Cystic | 2 2 3 3 2 3 |
Hyperplasia | 3 3 2 3 2 2 2 2 2|
Hypertrophy | 1 2 1 1 1 2 2 2 1 3 1 2 2 1 2 3 2 2 2|
Necrosis | 3 |
Vacuolization Cytoplasmic | 1 1 1 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 1 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 3 3 2 2 3 2 3 3|
Cyst | |
Vacuolization Cytoplasmic | 2 |
Pars Distalis, Hyperplasia | 2 1 2 1 3 3 2 3 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
C-Cell, Hyperplasia | 3 2 2 3 1 1 2 |
Follicular Cell, Hyperplasia | 1 |
Follicular Cell, Hypertrophy | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Inflammation | 1 3 1 1 2 3 2 2 2 2 1 2 1 2 3 2 |
Duct, Cyst | 3 2 2 1 2 2 3 2 1 1 3 2 3 3 3 2|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|
| 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 2 2 1 3 2 2 1 1 2 2 2|
Corpus Luteum, Cyst | 3 |
|__________________________________________________________________________|
Oviduct | |
Inflammation | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 1 |
Metaplasia, Squamous | 2 2 1 2 2 2 1 1 4 1 2 2 2 1 2 2|
Cervix, Hyperplasia, Stromal | |
Endometrium, Hyperplasia, Cystic | 1 2 2 3 2 3 1 1 2 3 1 1 3 1 2|
|__________________________________________________________________________|
Vagina | + |
Hyperplasia, Stromal | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 4 3 2 3 3 3 3 3 4 3 4 3 4 2 2 4 4 |
|__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Ectasia | 2 |
Lumbar, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Renal, Ectasia | |
Renal, Hyperplasia, Histiocytic | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | 2 2 3 2 2 2 2 2 3 2 2 2 3 2|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|
| 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 1 1 1 2 2 2 2 1 1 2 1 1 3 1 1 3 2 3 1 2 1 2 1|
Pigmentation | 1 1 2 1 1 1 1 1 1 2 2 1 1 1 1 1 2 2 3 2 1 4 2|
|__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + M|
Atrophy | 3 3 3 2 2 2 2 2 3 2 2 2 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 3 2 1 1 1 3 1 1 1 1 |
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Inflammation, Focal, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
Mineralization | |
Glial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 1 1 2 3 2 1 2 3 1 2 2 2 2 2 2 2 2 2 3 1|
Inflammation, Granulomatous | |
Pigmentation | |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 2 1 2 2 3 1 2 1 2 |
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|
DAY ON TEST | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|
| 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 NG/KG | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Retina, Atrophy | 2 3 2 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Casts Protein | 1 |
Fibrosis | |
Inflammation, Chronic Active | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1|
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Pelvis, Dilatation | |
Pelvis, Inflammation | |
Transitional Epithelium, Hyperplasia | 1 2 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Hemorrhage | |
Inflammation | 1 1 2 |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 34
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| | |
DAY ON TEST | 0| 5| 3| 3| | |
| 4| 6| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
3 NG/KG | 8| 8| 9| 9| | L |
| 3| 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
Muscularis, Inflammation | | 2 2.5|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + M + + | 53 |
Parasite Metazoan | | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 54 |
Parasite Metazoan | | 4 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 54 |
Ulcer | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Angiectasis | | 1 1.0|
Basophilic Focus | | 6 |
Basophilic Focus, Multiple | X | 3 |
Cholangiofibrosis | | 1 1.0|
Clear Cell Focus | | 1 |
Eosinophilic Focus | | 6 |
Eosinophilic Focus, Multiple | | 8 |
Fatty Change, Diffuse | | 2 1.0|
Fatty Change, Focal | 1 1 | 6 1.5|
Hematopoietic Cell Proliferation | 1 | 2 1.0|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation | 1 1 1 1 | 46 1.2|
Mixed Cell Focus | X | 8 |
Mixed Cell Focus, Multiple | X | 11 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| | |
DAY ON TEST | 0| 5| 3| 3| | |
| 4| 6| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
3 NG/KG | 8| 8| 9| 9| | L |
| 3| 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Necrosis | 3 | 4 2.3|
Pigmentation | 1 2 | 9 1.2|
Toxic Hepatopathy | | 2 1.0|
Bile Duct, Cyst | | 1 3.0|
Bile Duct, Fibrosis | | 2 2.0|
Bile Duct, Hyperplasia | | 4 1.5|
Centrilobular, Degeneration | | 2 2.0|
Hepatocyte, Hypertrophy | 1 | 19 1.2|
Oval Cell, Hyperplasia | | 4 1.0|
|__________________________________________________________________________|____________|
Mesentery | | 2 |
Artery, Inflammation, Chronic Active | | 1 3.0|
Fat, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | | 9 |
Gingival, Hyperplasia, Squamous | | 7 1.4|
|__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
Acinus, Atrophy | 2 | 2 1.5|
Artery, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + | 54 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
Hyperkeratosis | | 1 1.0|
Hyperplasia, Squamous | | 4 1.5|
Inflammation | | 1 2.0|
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
|__________________________________________________________________________|____________|
Tooth | | 16 |
Peridontal Tissue, Inflammation | | 16 1.2|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| | |
DAY ON TEST | 0| 5| 3| 3| | |
| 4| 6| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
3 NG/KG | 8| 8| 9| 9| | L |
| 3| 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + | 54 |
Aorta, Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + | 54 |
Cardiomyopathy | 1 | 12 1.0|
Artery, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 54 |
Angiectasis | 1 | 21 1.9|
Degeneration, Cystic | 1 | 15 2.1|
Hyperplasia | 2 | 16 2.2|
Hypertrophy | 1 4 2 | 43 2.0|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic | | 7 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 54 |
Angiectasis | | 1 2.0|
Hyperplasia | 2 | 10 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + M + | 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 54 |
Angiectasis | 3 1 | 18 2.6|
Cyst | | 1 3.0|
Vacuolization Cytoplasmic | | 3 1.7|
Pars Distalis, Hyperplasia | 2 2 | 19 2.1|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 54 |
Angiectasis | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| | |
DAY ON TEST | 0| 5| 3| 3| | |
| 4| 6| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
3 NG/KG | 8| 8| 9| 9| | L |
| 3| 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
C-Cell, Hyperplasia | | 17 2.2|
Follicular Cell, Hyperplasia | | 2 2.0|
Follicular Cell, Hypertrophy | | 4 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + M + + | 52 |
Inflammation | 2 2 1 | 40 1.7|
Duct, Cyst | 3 2 2 | 37 2.1|
|__________________________________________________________________________|____________|
Ovary | + M + + | 53 |
Atrophy | 4 4 4 | 46 4.0|
Cyst | | 16 1.9|
Corpus Luteum, Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Oviduct | | 1 |
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + M + + | 53 |
Inflammation, Chronic Active | | 2 3.0|
Inflammation, Suppurative | 3 | 6 1.8|
Metaplasia, Squamous | 2 | 31 2.0|
Cervix, Hyperplasia, Stromal | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 | 33 1.9|
|__________________________________________________________________________|____________|
Vagina | | 1 |
Hyperplasia, Stromal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| | |
DAY ON TEST | 0| 5| 3| 3| | |
| 4| 6| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
3 NG/KG | 8| 8| 9| 9| | L |
| 3| 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia | 4 3 3 | 41 3.2|
|__________________________________________________________________________|____________|
Lymph Node | | 6 |
Lumbar, Ectasia | | 2 2.0|
Lumbar, Hyperplasia, Plasma Cell | | 2 3.0|
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Ectasia | | 1 3.0|
Renal, Hyperplasia, Histiocytic | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 54 |
Hyperplasia, Lymphoid | | 3 2.0|
Hyperplasia, Plasma Cell | 2 2 2 2 | 31 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + | 53 |
Atrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + | 54 |
Hematopoietic Cell Proliferation | 2 2 1 | 50 1.6|
Pigmentation | 2 2 1 | 49 1.4|
|__________________________________________________________________________|____________|
Thymus | + + + + | 52 |
Atrophy | 2 3 2 3 | 41 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + | 54 |
Cyst | | 3 2.7|
Hyperplasia | 1 1 | 21 1.4|
Inflammation, Granulomatous | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| | |
DAY ON TEST | 0| 5| 3| 3| | |
| 4| 6| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
3 NG/KG | 8| 8| 9| 9| | L |
| 3| 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone | + + + + | 54 |
Maxilla, Inflammation, Focal, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + | 54 |
Hydrocephalus | | 1 2.0|
Mineralization | | 1 2.0|
Glial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 | 46 1.8|
Inflammation, Granulomatous | 2 | 1 2.0|
Pigmentation | | 1 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | | 19 1.6|
|__________________________________________________________________________|____________|
Nose | + + + + | 54 |
|__________________________________________________________________________|____________|
Trachea | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + | 54 |
Retina, Atrophy | | 5 2.2|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + | 54 |
Inflammation | | 3 1.3|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| | |
DAY ON TEST | 0| 5| 3| 3| | |
| 4| 6| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| | A |
3 NG/KG | 8| 8| 9| 9| | L |
| 3| 4| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + | 54 |
Calculus Micro Observation Only | | 1 |
Casts Protein | | 5 1.4|
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Mineralization | 1 1 1 | 39 1.1|
Nephropathy | 2 1 | 26 1.1|
Pelvis, Dilatation | | 1 2.0|
Pelvis, Inflammation | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 6 1.7|
|__________________________________________________________________________|____________|
Urinary Bladder | + M + + | 53 |
Calculus Micro Observation Only | | 1 |
Hemorrhage | | 1 3.0|
Inflammation | | 10 1.3|
Transitional Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|
DAY ON TEST | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|
| 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Perforation | X |
Muscularis, Inflammation | |
Periesophageal Tissue, Inflammation | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X |
Basophilic Focus, Multiple | X X X X |
Cholangiofibrosis | 2 |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X |
Eosinophilic Focus, Multiple | X X X X X X X X|
Fatty Change, Diffuse | 1 1 1 1 1 |
Fatty Change, Focal | 1 3 |
Hematopoietic Cell Proliferation | 1 |
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X X|
Mixed Cell Focus, Multiple | X X X X X X X X X X |
Necrosis | 2 1 3 |
Pigmentation | 1 1 2 2 1 1 1 1 1 1 1 1 2 2 3 2 1 1|
Toxic Hepatopathy | 1 1 1 1 1 2 |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|
DAY ON TEST | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|
| 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Cyst | 2 |
Bile Duct, Hyperplasia | 1 1 1 |
Hepatocyte, Hypertrophy | 1 1 1 2 1 1 1 1 1 1|
Hepatocyte, Multinucleated | 1 1 2 1 2 1 1 1|
Oval Cell, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 2 2 1 2 1 2 1|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | |
Artery, Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | |
Erosion | |
Hyperkeratosis | |
Hyperplasia, Squamous | 2 |
Inflammation | |
Mineralization | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
|__________________________________________________________________________|
Tooth | + + + + + + +|
Peridontal Tissue, Inflammation | 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 4 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|
DAY ON TEST | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|
| 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 1 2 2 2 2 |
Atrophy | 1 |
Degeneration, Cystic | 3 3 3 1 1 2 3 3 2 |
Hyperplasia | 2 2 3 3 2 3 3 2 2 2 2 2 |
Hypertrophy | 2 2 3 3 2 2 3 2 2 2 3 1 2 2 3 2 2 2 2 2 1|
Necrosis | 1 2 |
Vacuolization Cytoplasmic | 1 1 1 3 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 1 2 1 2 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M M M + + M + + + +|
Fibrosis | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 3 3 2 3 3 2 1 2 3 1 1 |
Cytoplasmic Alteration | |
Vacuolization Cytoplasmic | |
Pars Distalis, Hyperplasia | 1 3 2 2 3 3 1 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
C-Cell, Hyperplasia | 3 1 2 2 2 3 2 2 2 3 2 |
Follicular Cell, Hypertrophy | 3 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|
DAY ON TEST | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|
| 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | |
Inflammation | 1 2 2 2 1 1 1 1 1 3 2 1 3 1 1 2 1|
Duct, Cyst | 2 2 3 2 2 3 1 1 2 2 2 1 3 1 3 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 3 2 2 2 3 |
Fibrosis | |
|__________________________________________________________________________|
Oviduct | + |
Inflammation | 2 |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2|
Inflammation, Suppurative | 3 4 2 4 1 4 3 |
Metaplasia, Squamous | 4 2 2 2 2 2 3 1 2 3 3 4 3 2 1 4|
Ulcer | |
Cervix, Hyperplasia, Stromal | 4 |
Endometrium, Adenomyosis | |
Endometrium, Hyperplasia, Cystic | 2 1 2 2 2 3 2 2 3 3 2 1 4|
Serosa, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Vagina | |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 2 4 3 2 3 3 3 4 3 4 2 3 3 4 4|
|__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Ectasia | 3 |
Mediastinal, Hyperplasia, Histiocytic| 2 |
Mediastinal, Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|
DAY ON TEST | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|
| 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 2 2 2 2 2 3 3 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 2 1 1 1 1 1 1 3 1 1 1 2 1 1 2 2 1|
Necrosis | |
Pigmentation | 1 1 1 1 2 2 2 1 1 2 2 1 2 2 2 2 1 1 2 2 1 1 1 1 1|
Lymphoid Follicle, Atrophy | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 3 2 2 3 2 3 2 3 3 3 3 4 4 3 4 3 3|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 1 3 2 2 1 1 |
Inflammation, Granulomatous | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Squamous | |
Inflammation, Chronic Active | |
Necrosis | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|
DAY ON TEST | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|
| 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Hydrocephalus | |
Mineralization | |
Vacuolization Cytoplasmic, Focal | |
Cerebellum, Necrosis | |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
Gliosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Edema | 2 2 |
Infiltration Cellular, Histiocyte | 1 2 2 2 2 1 1 2 3 1 3 1 2 2 1 1 1 2|
Inflammation, Granulomatous | 3 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 2 1 2 1 1 1 2 2 1 1 2|
Bronchiole, Dilatation | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Turbinate, Septum, Inflammation | 2 |
Turbinate, Respiratory Epithelium, | |
Hyperplasia | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cornea, Inflammation, Suppurative | |
Retina, Atrophy | 2 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|
DAY ON TEST | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|
| 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Casts Protein | |
Infarct | 3 |
Inflammation, Suppurative | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 3 1 |
Papilla, Necrosis | |
Pelvis, Dilatation | 3 |
Pelvis, Inflammation | 2 |
Transitional Epithelium, Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 1 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________
Page 48
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|
| 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Perforation | X |
Muscularis, Inflammation | 2 |
Periesophageal Tissue, Inflammation | 3 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X |
Basophilic Focus, Multiple | X |
Cholangiofibrosis | 1 |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | X X X X X|
Fatty Change, Diffuse | 1 2 1 1 1 1 |
Fatty Change, Focal | 1 1|
Hematopoietic Cell Proliferation | 1 |
Inflammation | 1 1 2 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 |
Mixed Cell Focus | X X X|
Mixed Cell Focus, Multiple | X X X X X X X X X X X |
Necrosis | 2 |
Pigmentation | 2 2 1 1 2 2 1 1 1 1 2 1 1 2 |
Toxic Hepatopathy | 1 2 |
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|
| 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Cyst | 2 |
Bile Duct, Hyperplasia | 2 1 1 1 |
Hepatocyte, Hypertrophy | 2 2 1 1 1 1 2 1|
Hepatocyte, Multinucleated | 1 1 1 2 1 1 |
Oval Cell, Hyperplasia | 2 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + |
Gingival, Hyperplasia, Squamous | 2 2 1 3 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 |
Acinus, Atrophy | 1 2 2 |
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 1 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | 2 |
Erosion | 2 |
Hyperkeratosis | 1 |
Hyperplasia, Squamous | 1 1 3|
Inflammation | 1 2|
Mineralization | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
|__________________________________________________________________________|
Tooth | + + + + |
Peridontal Tissue, Inflammation | 1 1 3 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1|
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|
| 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 1 2 1 2 2 1 1|
Atrophy | 2 1 2 |
Degeneration, Cystic | 1 1 2 3 2 2 2 1 2 2 3 3|
Hyperplasia | 2 2 3 2 3 3 |
Hypertrophy | 2 1 2 1 1 2 3 2 1 2 3 4 2 2 2 3 1 1 1 2 3 4|
Necrosis | |
Vacuolization Cytoplasmic | 1 1 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 1 2 3 2 2 2 2 1 3 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + M + + + + + + + +|
Fibrosis | 3 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 2 3 2 1 3 3 2 2 3|
Cytoplasmic Alteration | 1 |
Vacuolization Cytoplasmic | 2 |
Pars Distalis, Hyperplasia | 3 2 3 3 1 2 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
C-Cell, Hyperplasia | 3 2 1 2 3 1 2 2 2 3 |
Follicular Cell, Hypertrophy | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|
| 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 |
Inflammation | 1 2 3 3 1 1 2 3 1 3 2 2 1 1 1|
Duct, Cyst | 3 3 4 3 3 2 1 3 1 3 2 1 3 2 3 3 2 2 2 2 1 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 3 2 3 2 3 2 2 |
Fibrosis | 3 |
|__________________________________________________________________________|
Oviduct | + |
Inflammation | |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 |
Inflammation, Suppurative | 1 2 1 2 2 |
Metaplasia, Squamous | 1 3 3 2 4 1 3 3 3 2 3 |
Ulcer | 2 |
Cervix, Hyperplasia, Stromal | |
Endometrium, Adenomyosis | 3 |
Endometrium, Hyperplasia, Cystic | 1 1 3 3 3 1 2 1 3 1 2 2 2 1 2 2 4 2 3 1|
Serosa, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Vagina | + |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 4 3 4 3 3 2 3 3 3|
|__________________________________________________________________________|
Lymph Node | + |
Lumbar, Ectasia | |
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|
| 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 4 2 2 3 3 2 2 2 3 2|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 1 1 2 1 1 2 2 1 1 1 1 1 2 1 1|
Necrosis | 3 |
Pigmentation | 1 2 1 1 1 2 1 2 1 2 1 2 1 2 2 2 2 1 2 1 1 1|
Lymphoid Follicle, Atrophy | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Atrophy | 4 4 4 4 3 4 3 3 3 4 2 3 3 3 4 2 2 2 2 4 3 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 1 1 2 1 2 2 1 1|
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Squamous | 2 |
Inflammation, Chronic Active | 3 3 |
Necrosis | 3 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|
| 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Hydrocephalus | |
Mineralization | 2 |
Vacuolization Cytoplasmic, Focal | |
Cerebellum, Necrosis | 3 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
Gliosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Edema | |
Infiltration Cellular, Histiocyte | 1 1 1 2 2 2 1 2 2 2 1 2 2 2 3 2 2 2 2 3 2 2 3|
Inflammation, Granulomatous | 2 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 1 2 2 2 1 1 2 1 1 2 2 2 1 1 3 1 2 2|
Bronchiole, Dilatation | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Turbinate, Septum, Inflammation | |
Turbinate, Respiratory Epithelium, | |
Hyperplasia | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cornea, Inflammation, Suppurative | 1 |
Retina, Atrophy | 2 3 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 |
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|
DAY ON TEST | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|
| 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 NG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Casts Protein | 1 1 |
Infarct | |
Inflammation, Suppurative | 3 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 2 1 1 1 1 1 1 3 1 1 1 1 2 2 1 |
Papilla, Necrosis | 3 |
Pelvis, Dilatation | |
Pelvis, Inflammation | |
Transitional Epithelium, Hyperplasia | 2 1 2 2 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 55
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
Hemorrhage | | 1 4.0|
Perforation | | 2 |
Muscularis, Inflammation | | 1 2.0|
Periesophageal Tissue, Inflammation | 3 | 3 2.7|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
Parasite Metazoan | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | | 1 1.0|
Basophilic Focus | | 8 |
Basophilic Focus, Multiple | | 5 |
Cholangiofibrosis | | 2 1.5|
Clear Cell Focus | | 1 |
Eosinophilic Focus | | 7 |
Eosinophilic Focus, Multiple | X | 14 |
Fatty Change, Diffuse | 1 | 12 1.1|
Fatty Change, Focal | | 4 1.5|
Hematopoietic Cell Proliferation | | 2 1.0|
Inflammation | 1 1 | 47 1.1|
Mixed Cell Focus | | 8 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mixed Cell Focus, Multiple | | 21 |
Necrosis | | 4 2.0|
Pigmentation | 2 2 | 34 1.4|
Toxic Hepatopathy | | 8 1.3|
Bile Duct, Cyst | | 2 2.0|
Bile Duct, Hyperplasia | | 7 1.1|
Hepatocyte, Hypertrophy | 1 | 19 1.2|
Hepatocyte, Multinucleated | 1 1 | 16 1.2|
Oval Cell, Hyperplasia | | 3 1.3|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 16 |
Gingival, Hyperplasia, Squamous | 2 | 14 1.6|
|__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
Inflammation, Chronic Active | | 2 1.5|
Acinus, Atrophy | 1 | 4 1.5|
Artery, Inflammation, Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
Inflammation | | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Cyst, Squamous | | 1 2.0|
Erosion | | 1 2.0|
Hyperkeratosis | | 1 1.0|
Hyperplasia, Squamous | | 4 1.8|
Inflammation | | 2 1.5|
Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Diverticulum | | 1 |
|__________________________________________________________________________|____________|
Tooth | + | 12 |
Peridontal Tissue, Inflammation | 3 | 12 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
Thrombosis | | 1 4.0|
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Cardiomyopathy | 1 | 22 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | | 18 1.6|
Atrophy | | 4 1.5|
Degeneration, Cystic | | 21 2.1|
Hyperplasia | | 18 2.4|
Hypertrophy | 1 2 1 | 46 2.0|
Necrosis | | 2 1.5|
Vacuolization Cytoplasmic | 1 1 | 12 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Angiectasis | | 2 2.0|
Hyperplasia | 3 3 | 18 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 47 |
Fibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + M | 52 |
Angiectasis | 3 | 25 2.3|
Cytoplasmic Alteration | | 1 1.0|
Vacuolization Cytoplasmic | | 1 2.0|
Pars Distalis, Hyperplasia | | 16 2.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Thyroid Gland | + + + | 53 |
Angiectasis | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
C-Cell, Hyperplasia | 2 | 22 2.1|
Follicular Cell, Hypertrophy | | 4 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
Hyperplasia, Basal Cell | | 1 2.0|
Inflammation | 1 3 1 | 35 1.7|
Duct, Cyst | 1 3 2 | 41 2.2|
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Atrophy | 4 4 4 | 50 4.0|
Cyst | 2 | 13 2.4|
Fibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Oviduct | | 2 |
Inflammation | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Inflammation, Chronic Active | | 3 2.7|
Inflammation, Suppurative | | 12 2.4|
Metaplasia, Squamous | 3 | 28 2.5|
Ulcer | | 1 2.0|
Cervix, Hyperplasia, Stromal | | 1 4.0|
Endometrium, Adenomyosis | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 1 1 | 35 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Serosa, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Vagina | | 1 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Hyperplasia | 2 4 | 32 3.2|
|__________________________________________________________________________|____________|
Lymph Node | | 3 |
Lumbar, Ectasia | | 1 3.0|
Mediastinal, Hyperplasia, Histiocytic| | 1 2.0|
Mediastinal, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 52 |
Hyperplasia, Lymphoid | 2 | 3 2.0|
Hyperplasia, Plasma Cell | 2 3 | 23 2.4|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Hematopoietic Cell Proliferation | 3 | 38 1.3|
Necrosis | | 1 3.0|
Pigmentation | 1 3 | 49 1.5|
Lymphoid Follicle, Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + | 52 |
Atrophy | 3 2 2 | 44 3.0|
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Hyperplasia | 2 | 24 1.5|
Inflammation, Granulomatous | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Chronic Active | | 2 3.0|
Necrosis | | 1 3.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Hemorrhage | | 1 3.0|
Hydrocephalus | 2 | 1 2.0|
Mineralization | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 | 1 1.0|
Cerebellum, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Gliosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Congestion | | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Edema | | 2 2.0|
Infiltration Cellular, Histiocyte | 2 2 | 43 1.8|
Inflammation, Granulomatous | | 2 2.5|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 2 1 | 33 1.5|
Bronchiole, Dilatation | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Turbinate, Septum, Inflammation | | 1 2.0|
Turbinate, Respiratory Epithelium, | | |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 2 |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
Cornea, Inflammation, Suppurative | | 1 1.0|
Retina, Atrophy | | 5 2.2|
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Inflammation | | 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Calculus Micro Observation Only | | 1 |
Casts Protein | | 2 1.0|
Infarct | | 1 3.0|
Inflammation, Suppurative | | 2 2.0|
Mineralization | 1 | 30 1.0|
Nephropathy | 1 1 | 32 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 2| 6| 6| | |
DAY ON TEST | 3| 3| 5| | |
| 6| 5| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
10 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Papilla, Necrosis | | 1 3.0|
Pelvis, Dilatation | | 1 3.0|
Pelvis, Inflammation | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 8 1.8|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Inflammation | | 4 1.5|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|
| 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X|
Basophilic Focus, Multiple | |
Cholangiofibrosis | |
Clear Cell Focus | |
Clear Cell Focus, Multiple | X |
Degeneration, Cystic | |
Eosinophilic Focus | X X X X X X |
Eosinophilic Focus, Multiple | X X X X X X X X X|
Fatty Change, Diffuse | 2 1 2 1 2 1 2 1 1 |
Fatty Change, Focal | 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Nodular | X |
Inflammation | 2 2 1 2 2 1 2 1 1 1 1 1 1 1 1 1 3 1 2 1 3 2 1 1|
Mitotic Alteration | |
Mixed Cell Focus, Multiple | X X X X X X X X X X X |
Necrosis | 2 2 2 2 2 |
Pigmentation | 2 2 1 1 2 1 1 2 1 2 1 2 1 1 2 1 2 2 2 2 2 2 1 2|
Toxic Hepatopathy | 1 1 1 1 1 2 1 1 1 2 1|
Bile Duct, Cyst | 1 2 |
Bile Duct, Fibrosis | |
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|
| 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 1|
Centrilobular, Degeneration | 2 |
Hepatocyte, Hypertrophy | 1 1 2 1 3 1 1 1 1 1 1 1 1 3 2 3 1 2 1 3 1 2|
Hepatocyte, Multinucleated | 1 1 1 1 1 1 1 2 1 1 1 1|
Oval Cell, Hyperplasia | 1 1 1 2 1 1 1 1|
|__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + |
Gingival, Hyperplasia, Squamous | 2 3 1 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 1 |
Necrosis | |
Acinus, Atrophy | 2 1 |
Acinus, Hyperplasia | 2 |
Acinus, Vacuolization Cytoplasmic | |
Artery, Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + M + + + + + +|
Atrophy | 3 2 |
Inflammation | 2 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperkeratosis | 3 |
Hyperplasia, Squamous | 2 |
Ulcer | 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
|__________________________________________________________________________|
Tooth | + + + + |
Peridontal Tissue, Inflammation | 2 3 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|
| 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 2 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 1 2 2|
Atrophy | 3 4 |
Degeneration, Cystic | 2 3 2 2 1 1 4 2 2|
Hyperplasia | 3 1 1 2 2 3 2 2 2 3 3 2 2|
Hypertrophy | 2 2 1 2 1 1 2 4 1 1 2 3 1 2 2 2 2 3 4|
Necrosis | 3 |
Thrombosis | 2 |
Vacuolization Cytoplasmic | 1 2 2 2 3 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 2 1 2 |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + + + M + M M + + M + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 3 2 2 2|
Cytoplasmic Alteration | 2 |
Vacuolization Cytoplasmic | |
Pars Distalis, Hyperplasia | 1 2 3 2 3 2 3 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 |
C-Cell, Hyperplasia | 2 2 1 2 3 2 2 3|
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|
| 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Follicular Cell, Hypertrophy | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 3 1 2 1 1 1 1 1 2 1 2 1 1 1 2 1|
Duct, Cyst | 1 3 1 1 2 1 2 1 1 3 2 3 1 2 2 1 2 2 2 3|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Congestion | |
Cyst | 2 3 2 2 2 2 2 2 2 3 2|
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 4 |
Periovarian Tissue, Inflammation, | |
Suppurative | 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 3 |
Metaplasia, Squamous | 3 2 2 2 1 1 3 2 2 3 4 3 |
Necrosis | |
Cervix, Hyperplasia, Stromal | |
Endometrium, Hyperplasia, Cystic | 3 1 2 1 1 2 3 2 4 1 3 3 3|
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Vagina | + |
Inflammation | |
Necrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 3 3 3 3 3 3 3 3 4 3 3 4 3 3 |
|__________________________________________________________________________|
Lymph Node | + |
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|
| 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Deep Cervical, Hemorrhage | 3 |
Lumbar, Ectasia | |
Lumbar, Hemorrhage | |
Lumbar, Hyperplasia, Plasma Cell | |
Lumbar, Pigmentation | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Plasma Cell| |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + M + + + + + +|
Hyperplasia, Plasma Cell | 2 2 2 2 2 3 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 3 1 3 2 1 1 2 1 1 2 1 1 3 1 3 1 2 1|
Pigmentation | 2 2 1 1 2 1 2 2 2 2 1 1 1 1 2 1 2 1 2 1 1 2 1 2|
|__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + M|
Atrophy | 3 2 3 4 2 3 4 2 2 3 2 3 3 4 4 2 2 4 3 4 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperplasia | 1 1 2 1 1 1 2 1 1|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|
| 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 2 2 2 1 2 1 2 2 2 1 1 2 1 3 1 1 2 1|
Inflammation, Granulomatous | 1 1 |
Inflammation, Suppurative | 1 |
Necrosis | |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 2 2 1 1 1 1 1 2 1 2 1 2 1 2 1 1 1|
Serosa, Inflammation, Focal, | |
Suppurative | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Nasopharyngeal Duct, Inflammation | |
Nasopharyngeal Duct, Necrosis | |
Respiratory Epithelium, Hyperplasia | 3 |
Turbinate, Septum, Inflammation | 2 |
Turbinate, Respiratory Epithelium, | |
Hyperplasia | 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Retina, Atrophy | 2 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|
| 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis | 3 |
Nephropathy | 2 1 1 1 2 1 1 1 2 1 2 1 1 1 2 2 2|
Pelvis, Inflammation | 1 |
Transitional Epithelium, Hyperplasia | 1 1 1 2 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 70
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|
| 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|
| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Muscularis, Inflammation | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Basophilic Focus, Multiple | X |
Cholangiofibrosis | 1 |
Clear Cell Focus | X X |
Clear Cell Focus, Multiple | X|
Degeneration, Cystic | 1 1|
Eosinophilic Focus | X X X |
Eosinophilic Focus, Multiple | X X X X X X X |
Fatty Change, Diffuse | 1 1 2 1 1 1 1 1 |
Fatty Change, Focal | 1 2 2|
Hematopoietic Cell Proliferation | 2 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Nodular | X X |
Inflammation | 1 1 2 1 1 1 1 1 1 1 1 2 1 2 2 1 2 1 1 1 2 1 1 2|
Mitotic Alteration | 2 |
Mixed Cell Focus, Multiple | X X X X X X X X X X|
Necrosis | 3 3 2 |
Pigmentation | 3 2 1 2 3 2 1 1 2 2 3 2 2 1 1 1 2 2 2 2 2|
Toxic Hepatopathy | 2 2 1 1 3 1 1 2 1 1 1 1 1 1 1 1 1|
Bile Duct, Cyst | |
Bile Duct, Fibrosis | 2 |
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|
| 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|
| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Bile Duct, Hyperplasia | 1 1 3 1 2 2 2 1 1 2 1 |
Centrilobular, Degeneration | 3 1 3 |
Hepatocyte, Hypertrophy | 3 1 2 1 3 1 2 1 1 2 1 1 2 1 1 1 1|
Hepatocyte, Multinucleated | 1 2 1 1 2 2 1 1 1 1 1 1|
Oval Cell, Hyperplasia | 1 1 1 3 2 1 1 1 2 1 |
|__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + |
Gingival, Hyperplasia, Squamous | 1 2 1 2 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 |
Inflammation, Chronic Active | 1 |
Necrosis | 3 |
Acinus, Atrophy | 2 1 |
Acinus, Hyperplasia | |
Acinus, Vacuolization Cytoplasmic | 1 |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +|
Atrophy | |
Inflammation | 3 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperkeratosis | |
Hyperplasia, Squamous | 2 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
|__________________________________________________________________________|
Tooth | + + + + + + + + |
Peridontal Tissue, Inflammation | 2 1 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|
| 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|
| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + M + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 1 2 1 1 2|
Atrophy | 3 2 |
Degeneration, Cystic | 3 3 3 3 2 3 2 1 |
Hyperplasia | 3 2 2 3 2 3 2 3 3 2|
Hypertrophy | 2 2 4 4 4 3 2 2 1 2 2 2 1 4 2 2 2 2|
Necrosis | |
Thrombosis | |
Vacuolization Cytoplasmic | 1 1 3 2 1 1 2 1 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 1 2|
Inflammation, Suppurative | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + M + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 3 1 1 3 2 1 2 3|
Cytoplasmic Alteration | 1 2 1 |
Vacuolization Cytoplasmic | 2 1 |
Pars Distalis, Hyperplasia | 2 2 2 3 2 1 1 3 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 |
Cyst | |
C-Cell, Hyperplasia | 3 2 2 2 1 3 3 2|
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|
| 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|
| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Follicular Cell, Hypertrophy | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Inflammation | 1 3 1 3 2 3 2 2 2 2 1 1 1 1 2|
Duct, Cyst | 3 2 1 4 3 3 3 1 2 2 3 2 2 2 3 1 2 1 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Congestion | 2 |
Cyst | 2 2 3 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Periovarian Tissue, Inflammation, | |
Suppurative | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 4 3 1 2 |
Metaplasia, Squamous | 3 2 2 4 2 3 1 4 3 4|
Necrosis | 4 |
Cervix, Hyperplasia, Stromal | 4 |
Endometrium, Hyperplasia, Cystic | 3 2 2 4 2 1 3 2 4 1 3 |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Vagina | + + |
Inflammation | 4 4 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 3 3 3 3 3 3 3 4 2 2 4 3 3 4 |
|__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|
| 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|
| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Deep Cervical, Hemorrhage | |
Lumbar, Ectasia | 2 2 |
Lumbar, Hemorrhage | 2 |
Lumbar, Hyperplasia, Plasma Cell | 3 |
Lumbar, Pigmentation | 3 |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Plasma Cell | 2 2 3 3 2 2 2 2 4 3 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 2 2 3 1 1 2 2 1 1 1 2 3 1 1 3 1 1|
Pigmentation | 2 2 1 1 1 1 1 2 2 2 1 1 3 1 2 1 1 1 2 1 1 2 2 2|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + M + + + +|
Atrophy | 4 4 4 4 4 3 4 2 4 2 3 4 4 2 4 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 3 1 1 2 1 1 1 2 1 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
Hemorrhage | 3 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|
| 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|
| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + M + + + +|
Infiltration Cellular, Histiocyte | 3 2 1 1 1 2 2 2 1 1 2 2 1 3 2 2 2 2 1 2 1|
Inflammation, Granulomatous | |
Inflammation, Suppurative | 2 |
Necrosis | 2 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 2 1 1 2 1 2 2 1 2 1 1 2 1 3 1|
Serosa, Inflammation, Focal, | |
Suppurative | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Nasopharyngeal Duct, Inflammation | 3 |
Nasopharyngeal Duct, Necrosis | 3 |
Respiratory Epithelium, Hyperplasia | |
Turbinate, Septum, Inflammation | |
Turbinate, Respiratory Epithelium, | |
Hyperplasia | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + M + + + +|
Retina, Atrophy | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation | 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X |
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|
DAY ON TEST | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|
| 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
22 NG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|
| 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Necrosis | |
Nephropathy | 1 3 1 1 2 2 2 1 2 1 1 1 1 1 1 2|
Pelvis, Inflammation | |
Transitional Epithelium, Hyperplasia | 1 1 1|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________|__________________________________________________________________________
Page 77
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 5| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 1| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
22 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 52 |
Muscularis, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 52 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Basophilic Focus | | 7 |
Basophilic Focus, Multiple | | 1 |
Cholangiofibrosis | | 1 1.0|
Clear Cell Focus | | 2 |
Clear Cell Focus, Multiple | | 2 |
Degeneration, Cystic | | 2 1.0|
Eosinophilic Focus | X | 10 |
Eosinophilic Focus, Multiple | X | 17 |
Fatty Change, Diffuse | | 17 1.3|
Fatty Change, Focal | | 4 1.8|
Hematopoietic Cell Proliferation | 1 1 | 4 1.5|
Hepatodiaphragmatic Nodule | | 1 |
Hyperplasia, Nodular | | 3 |
Inflammation | 1 3 | 50 1.4|
Mitotic Alteration | | 1 2.0|
Mixed Cell Focus, Multiple | X X | 23 |
Necrosis | | 8 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 5| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 1| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
22 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Pigmentation | 2 1 3 | 48 1.7|
Toxic Hepatopathy | 1 1 | 30 1.2|
Bile Duct, Cyst | | 2 1.5|
Bile Duct, Fibrosis | | 1 2.0|
Bile Duct, Hyperplasia | 1 1 | 22 1.3|
Centrilobular, Degeneration | | 4 2.3|
Hepatocyte, Hypertrophy | 1 2 1 | 42 1.5|
Hepatocyte, Multinucleated | 1 1 | 26 1.2|
Oval Cell, Hyperplasia | 1 1 | 20 1.3|
|__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + | 16 |
Gingival, Hyperplasia, Squamous | 1 1 | 13 1.6|
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic Active | | 2 1.0|
Necrosis | | 1 3.0|
Acinus, Atrophy | | 4 1.5|
Acinus, Hyperplasia | | 1 2.0|
Acinus, Vacuolization Cytoplasmic | | 1 1.0|
Artery, Inflammation, Chronic Active | | 2 2.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 50 |
Atrophy | | 2 2.5|
Inflammation | | 3 2.3|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Edema | 2 | 1 2.0|
Hyperkeratosis | | 1 3.0|
Hyperplasia, Squamous | | 2 2.0|
Ulcer | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 5| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 1| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
22 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 13 |
Peridontal Tissue, Inflammation | 1 | 13 1.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 52 |
Cardiomyopathy | 1 | 25 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | 2 | 17 1.8|
Atrophy | 1 | 5 2.6|
Degeneration, Cystic | 2 | 18 2.3|
Hyperplasia | 3 2 | 25 2.3|
Hypertrophy | 3 2 3 | 40 2.2|
Necrosis | | 1 3.0|
Thrombosis | | 1 2.0|
Vacuolization Cytoplasmic | 1 1 2 | 21 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Angiectasis | | 1 2.0|
Hyperplasia | 1 | 7 1.6|
Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 5| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 1| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
22 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Parathyroid Gland | + + + | 44 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Angiectasis | 2 | 20 2.1|
Cytoplasmic Alteration | | 4 1.5|
Vacuolization Cytoplasmic | | 2 1.5|
Pars Distalis, Hyperplasia | 2 1 | 21 2.1|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 51 |
Angiectasis | | 1 2.0|
Cyst | | 1 2.0|
C-Cell, Hyperplasia | 3 3 3 | 19 2.3|
Follicular Cell, Hypertrophy | | 7 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 52 |
Inflammation | 1 2 | 34 1.6|
Duct, Cyst | 2 1 1 | 42 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Atrophy | 4 4 4 | 44 4.0|
Congestion | | 1 2.0|
Cyst | | 15 2.2|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Periovarian Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Inflammation, Suppurative | 1 | 9 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 5| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 1| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
22 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Metaplasia, Squamous | 2 | 23 2.5|
Necrosis | | 1 4.0|
Cervix, Hyperplasia, Stromal | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3 2 3 | 27 2.4|
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Vagina | | 3 |
Inflammation | | 2 4.0|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Hyperplasia | 3 3 | 35 3.1|
|__________________________________________________________________________|____________|
Lymph Node | | 5 |
Deep Cervical, Hemorrhage | | 1 3.0|
Lumbar, Ectasia | | 2 2.0|
Lumbar, Hemorrhage | | 1 2.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Lumbar, Pigmentation | | 1 3.0|
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 50 |
Hyperplasia, Plasma Cell | 3 2 | 22 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Hematopoietic Cell Proliferation | 2 1 | 42 1.6|
Pigmentation | 1 1 2 | 51 1.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 5| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 1| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
22 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | + + + | 49 |
Atrophy | 2 4 | 41 3.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Cyst | | 1 3.0|
Hyperplasia | 2 1 | 22 1.4|
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 52 |
Infiltration Cellular, Histiocyte | 1 1 1 | 43 1.6|
Inflammation, Granulomatous | | 2 1.0|
Inflammation, Suppurative | | 2 1.5|
Necrosis | | 1 2.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 1 | 35 1.4|
Serosa, Inflammation, Focal, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 5| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 1| 3| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
22 NG/KG | 9| 9| 9| | L |
| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation | 2 | 3 1.7|
Nasopharyngeal Duct, Inflammation | | 1 3.0|
Nasopharyngeal Duct, Necrosis | | 1 3.0|
Respiratory Epithelium, Hyperplasia | | 1 3.0|
Turbinate, Septum, Inflammation | | 1 2.0|
Turbinate, Respiratory Epithelium, | | |
Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 52 |
Retina, Atrophy | | 3 2.3|
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 52 |
Inflammation | | 2 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Calculus Micro Observation Only | | 3 |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | 1 1 | 32 1.0|
Necrosis | | 1 3.0|
Nephropathy | 2 1 1 | 36 1.4|
Pelvis, Inflammation | | 1 1.0|
Transitional Epithelium, Hyperplasia | | 8 1.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|
| 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | 1 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Basophilic Focus, Multiple | X |
Cholangiofibrosis | 2 2 2 1 3 4 |
Clear Cell Focus | |
Clear Cell Focus, Multiple | |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | X X X X X X X X X|
Fatty Change, Diffuse | 1 1 1 1 1 2 3 1 1 1 3 1 2|
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | X X|
Hyperplasia, Nodular | X X X X |
Inflammation | 1 1 1 1 1 1 1 2 2 1 1 1 1 1 2 1 1 2 2 1 1 1 1 1|
Mitotic Alteration | 2 |
Mixed Cell Focus | |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X X|
Necrosis | 2 1 1 2 2 3 |
Pigmentation | 2 3 2 2 2 2 2 2 2 2 2 1 2 3 2 2 2 2 2 2 1 1 2 2|
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|
| 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Toxic Hepatopathy | 3 3 3 2 3 2 2 2 2 1 1 2 3 1 2 2 1 1 2 2 2|
Bile Duct, Fibrosis | 1 2 |
Bile Duct, Hyperplasia | 2 1 2 1 2 1 2 2 2 1 2 2 1 1 1 1 1 1 2|
Centrilobular, Degeneration | 2 |
Hepatocyte, Hypertrophy | 1 2 2 2 3 1 1 1 1 3 1 1 3 4 1 3 1 |
Hepatocyte, Multinucleated | 2 2 1 1 1 2 1 2 1 3 1 2 1 2 1 1 1 |
Hepatocyte, Centrilobular, Atrophy | 2 |
Oval Cell, Hyperplasia | 2 1 2 1 1 1 3 2 2 3 1 1 1 1 2 1 2|
Portal, Fibrosis | 2 1 2 |
|__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + |
Gingival, Hyperplasia, Squamous | 3 2 2 2 2 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 |
Acinus, Hyperplasia | 2 3 |
Acinus, Vacuolization Cytoplasmic | 1 1 1 2 2 1 1 1 |
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +|
Atrophy | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperkeratosis | 2 2 |
Hyperplasia, Squamous | 3 3 3 |
Inflammation | |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | 2 |
Mineralization | 2 2 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|
| 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Tooth | + + + + + + + |
Peridontal Tissue, Inflammation | 3 3 1 2 4 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 2 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 1 2 2 2|
Atrophy | 3 1 |
Degeneration, Cystic | 2 2 2 2 2 2 |
Hyperplasia | 3 3 2 3 3 2 2 3 2 2 2 2 1 |
Hypertrophy | 3 2 1 3 3 1 2 2 2 2 2 1 1 3 3 1 4 2 2|
Necrosis | 3 |
Vacuolization Cytoplasmic | 1 2 2 2 1 1 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M + + M + + M + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 2 1 2 2 2 3 |
Cytoplasmic Alteration | |
Vacuolization Cytoplasmic | 2 |
Pars Distalis, Hyperplasia | 3 3 4 1 2 3 3 2 3 3|
Pars Intermedia, Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|
| 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Angiectasis | 2 |
C-Cell, Hyperplasia | 2 1 2 1 3 |
Follicular Cell, Hypertrophy | 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation | 2 1 1 3 3 2 2 2 1 4 |
Duct, Cyst | 3 3 3 4 1 3 3 3 2 3 3 2 3 1 2 2 1 1 3 3|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 2 2 2 2 2 2 3|
Fibrosis | 2 |
Inflammation, Suppurative | 2|
|__________________________________________________________________________|
Oviduct | |
Necrosis | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 1 3 3 3 1 2 2 |
Metaplasia, Squamous | 2 4 1 3 2 2 2 4 4 3 1 3 2 3 |
Cervix, Hyperplasia, Stromal | |
Cervix, Inflammation, Suppurative | 3 |
Endometrium, Hyperplasia, Cystic | 2 1 2 2 2 2 3 2 2 1 3 4 1 3 1 2|
|__________________________________________________________________________|
Vagina | + |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 3 3 3 3 3 3 4 3 4 4 4 2 2 2|
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|
| 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Ectasia | 2 |
Mediastinal, Congestion | |
Mediastinal, Ectasia | 2 |
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia, Plasma Cell | 2 3 2 2 2 3 2 2 2|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Histiocytic | |
Hyperplasia, Plasma Cell | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 1 2 2 1 1 1 2 1 1 2 2 3 2 1 1 1 1 1|
Pigmentation | 2 3 1 1 2 2 1 2 1 2 2 1 2 1 1 1 1 1 2 1 2 2 2 2|
Lymphoid Follicle, Atrophy | |
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | 4 4 4 4 3 4 4 2 2 4 3 3 3 4 4 4 4 4 4 4 4|
Cyst | 3 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 2 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Ulcer | 2 |
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|
| 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Mineralization | 1 |
Artery, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Infiltration Cellular, Histiocyte | 2 1 2 2 2 2 1 2 1 2 2 2 2 2 1 2 2 2 2 2 3 2|
Metaplasia, Squamous | |
Mineralization | 1 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 1 2 2 2 1 1 2 1 3 2 2 3 2 1 2 1 1 2 2 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | |
Inflammation | 2 3 2 2 1 |
Goblet Cell, Septum, Hyperplasia | |
Nasolacrimal Duct, Respiratory | |
Epithelium, Hyperplasia | 2 |
Olfactory Epithelium, Degeneration | 2 |
Olfactory Epithelium, Inflammation | 3 |
Respiratory Epithelium, Cyst | 2 |
Respiratory Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Degeneration | |
Retina, Atrophy | 2 3 |
__________________________________________|__________________________________________________________________________|
Page 90
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|
| 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|
| 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Retina, Degeneration | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Casts Protein | |
Cyst | 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 3 |
Mineralization | 1 1 2 1 1 1 1 1 1 1 3 1 1 1 3 1 1 1|
Necrosis | |
Nephropathy | 1 2 1 1 1 2 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Dilatation | 3 |
Pelvis, Inflammation | 2 2 |
Transitional Epithelium, Hyperplasia | 2 3 2 2 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 2 2 3 1|
Transitional Epithelium, Hyperplasia | 2 2 2 2 |
__________________________________________|__________________________________________________________________________
Page 91
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|
DAY ON TEST | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|
| 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X |
Cholangiofibrosis | 4 1 2 4 2 |
Clear Cell Focus | X |
Clear Cell Focus, Multiple | |
Eosinophilic Focus | X X X |
Eosinophilic Focus, Multiple | X X X X X X X X X X X X|
Fatty Change, Diffuse | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
Fatty Change, Focal | 1 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Nodular | X X X|
Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 2 1 1 1 2 1 1 1 1|
Mitotic Alteration | |
Mixed Cell Focus | X X |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X X|
Necrosis | 2 3 2 1 |
Pigmentation | 2 2 2 2 2 2 2 2 1 2 3 2 2 2 3 2 2 3 3 2 2 1 2 2 1|
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|
DAY ON TEST | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|
| 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Toxic Hepatopathy | 2 2 2 2 2 1 2 1 1 2 1 1 1 3 3 2 1 2 1 1 1|
Bile Duct, Fibrosis | 1 |
Bile Duct, Hyperplasia | 2 1 1 1 2 1 1 2 1 1 2 1 2 1 2 1 1 1 1 |
Centrilobular, Degeneration | 2 2 |
Hepatocyte, Hypertrophy | 3 2 2 3 2 2 3 3 2 1 1 2 2 3 2 3 1 3 1 2 2|
Hepatocyte, Multinucleated | 1 1 1 1 1 1 2 1 1 1 2 2 2 1 1 1|
Hepatocyte, Centrilobular, Atrophy | |
Oval Cell, Hyperplasia | 2 2 2 1 2 1 1 1 1 1 1 1 1 2 1 2 1 2 1 1 |
Portal, Fibrosis | 1 3 |
|__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic Active | 2 3 |
Fat, Necrosis | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 3 2 2 3 2 4 1 2|
|__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 |
Acinus, Atrophy | 2 2 |
Acinus, Hyperplasia | |
Acinus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 |
Artery, Inflammation, Chronic Active | 3 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +|
Atrophy | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperkeratosis | |
Hyperplasia, Squamous | 1 2 2 |
Inflammation | 1 2 |
Ulcer | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | |
Mineralization | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 93
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|
DAY ON TEST | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|
| 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Tooth | + + + + + + +|
Peridontal Tissue, Inflammation | 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 2 1 1 1 2 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 2 |
Atrophy | 1 1 1|
Degeneration, Cystic | 1 3 2 3 3 2 1 3 2|
Hyperplasia | 3 3 2 1 2 3 2 3 2 2 3 2 3 2 |
Hypertrophy | 2 1 2 2 2 2 2 2 3 2 1 2 3 3 1 3 2 2 2 1 2 2 3|
Necrosis | 2 3 |
Vacuolization Cytoplasmic | 2 3 1 2 2 1 1 2 1 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 3 |
|__________________________________________________________________________|
Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + M + + + + M + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 2 2 2 1 1 1 2|
Cytoplasmic Alteration | 2 2 2 |
Vacuolization Cytoplasmic | 3 |
Pars Distalis, Hyperplasia | 2 4 2 2 3 2 2 2 1 3 1 2 3 3 2|
Pars Intermedia, Hyperplasia | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 94
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|
DAY ON TEST | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|
| 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Angiectasis | 2 2 2 |
C-Cell, Hyperplasia | 2 1 1 1 2 2 3 2 1|
Follicular Cell, Hypertrophy | 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Inflammation | 3 2 2 2 1 2 1 2 2 1 1 1 1 1 1|
Duct, Cyst | 1 1 3 2 2 2 2 1 1 3 2 2 2 3 3 2 3 2 2 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 3 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | 2 4 2 2 2 2 |
Fibrosis | |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Oviduct | + |
Necrosis | 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | 2 |
Inflammation, Chronic Active | 3 4 3 |
Inflammation, Suppurative | 3 3 1 3 |
Metaplasia, Squamous | 4 3 2 4 3 2 2 2 3 1 3 4 2 3 2 2|
Cervix, Hyperplasia, Stromal | 4 |
Cervix, Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 2 1 2 1 3 3 2 1|
|__________________________________________________________________________|
Vagina | + + |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 3 3 3 3 3 4 2 4 3 4 3 3 2 2|
__________________________________________|__________________________________________________________________________|
Page 95
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|
DAY ON TEST | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|
| 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Ectasia | |
Mediastinal, Congestion | 2 |
Mediastinal, Ectasia | |
Mediastinal, Hyperplasia, Histiocytic| 2 |
Mediastinal, Hyperplasia | 4 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Plasma Cell | 3 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Plasma Cell | |
|__________________________________________________________________________|
Spleen | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 1 2 2 1 1 1 2 1 1 2 3 1 3 1 3 1 1 1|
Pigmentation | 2 2 1 1 2 1 1 2 1 2 1 2 3 2 2 1 1 1 2 2 2 2|
Lymphoid Follicle, Atrophy | 2 |
|__________________________________________________________________________|
Thymus | + + + M + + + M + + M + + + + + + M + + + + + + +|
Atrophy | 4 4 4 3 3 4 2 4 2 3 4 4 4 4 4 4 4 2 4 4 4|
Cyst | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 1 1 1 1 1 1 2 |
Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Ulcer | |
__________________________________________|__________________________________________________________________________|
Page 96
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|
DAY ON TEST | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|
| 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mineralization | 1 |
Artery, Thrombosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Infiltration Cellular, Histiocyte | 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 1 1 1 1 2 1 1|
Metaplasia, Squamous | 1 1 4 2 3 |
Mineralization | |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 2 1 3 2 1 2 1 1 2 3 2 2 2 2 1 2 1 1 1 3 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | 3 |
Inflammation | |
Goblet Cell, Septum, Hyperplasia | 2 |
Nasolacrimal Duct, Respiratory | |
Epithelium, Hyperplasia | |
Olfactory Epithelium, Degeneration | |
Olfactory Epithelium, Inflammation | |
Respiratory Epithelium, Cyst | |
Respiratory Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Degeneration | 4 |
Retina, Atrophy | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 97
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|
DAY ON TEST | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|
| 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
46 NG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Retina, Degeneration | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 2 |
Casts Protein | 1 |
Cyst | |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Necrosis | 2 |
Nephropathy | 1 1 2 1 1 2 1 2 2 2 2 3 2 1 1|
Pelvis, Dilatation | 3 |
Pelvis, Inflammation | 3 2 |
Transitional Epithelium, Hyperplasia | 3 1 3 1 3 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 3 |
Transitional Epithelium, Hyperplasia | 2 3 |
__________________________________________|__________________________________________________________________________
Page 98
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
Muscularis, Inflammation | | 2 1.5|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
Parasite Metazoan | X | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | 2 | 3 1.7|
Basophilic Focus | X | 3 |
Basophilic Focus, Multiple | | 2 |
Cholangiofibrosis | | 11 2.5|
Clear Cell Focus | | 1 |
Clear Cell Focus, Multiple | X | 1 |
Eosinophilic Focus | X | 5 |
Eosinophilic Focus, Multiple | X | 22 |
Fatty Change, Diffuse | 1 1 | 30 1.2|
Fatty Change, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | | 2 |
Hyperplasia, Nodular | | 7 |
Inflammation | 1 1 1 | 52 1.2|
Mitotic Alteration | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mixed Cell Focus | | 2 |
Mixed Cell Focus, Multiple | X X | 28 |
Necrosis | | 10 1.9|
Pigmentation | 2 2 2 | 52 2.0|
Toxic Hepatopathy | 1 1 1 | 45 1.8|
Bile Duct, Fibrosis | | 3 1.3|
Bile Duct, Hyperplasia | 2 2 | 40 1.4|
Centrilobular, Degeneration | | 3 2.0|
Hepatocyte, Hypertrophy | 1 2 3 | 41 2.0|
Hepatocyte, Multinucleated | 1 1 2 | 36 1.4|
Hepatocyte, Centrilobular, Atrophy | | 1 2.0|
Oval Cell, Hyperplasia | 2 | 38 1.5|
Portal, Fibrosis | | 5 1.8|
|__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Artery, Inflammation, Chronic Active | 2 2 | 4 2.3|
Fat, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + | 22 |
Gingival, Hyperplasia, Squamous | 2 | 15 2.2|
|__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
Inflammation, Chronic Active | | 3 1.3|
Acinus, Atrophy | 1 | 4 1.5|
Acinus, Hyperplasia | | 2 2.5|
Acinus, Vacuolization Cytoplasmic | | 15 1.1|
Artery, Inflammation, Chronic Active | | 2 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 51 |
Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Erosion | | 1 2.0|
Hyperkeratosis | | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hyperplasia, Squamous | 1 | 7 2.1|
Inflammation | | 2 1.5|
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Metaplasia | | 1 2.0|
Mineralization | | 3 1.7|
|__________________________________________________________________________|____________|
Tooth | | 14 |
Peridontal Tissue, Inflammation | | 14 1.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
Aorta, Mineralization | | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Cardiomyopathy | 1 1 1 | 32 1.1|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | 2 1 | 17 1.6|
Atrophy | | 5 1.4|
Degeneration, Cystic | 3 3 | 17 2.2|
Hyperplasia | 2 3 | 29 2.3|
Hypertrophy | 2 4 3 | 45 2.1|
Necrosis | | 3 2.7|
Vacuolization Cytoplasmic | | 18 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Hyperplasia | 3 3 | 10 2.4|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Islets, Pancreatic | + + + | 52 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Angiectasis | 3 3 | 21 1.9|
Cytoplasmic Alteration | | 3 2.0|
Vacuolization Cytoplasmic | | 2 2.5|
Pars Distalis, Hyperplasia | 2 | 26 2.4|
Pars Intermedia, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
Angiectasis | | 4 2.0|
C-Cell, Hyperplasia | 3 3 | 16 1.9|
Follicular Cell, Hypertrophy | | 10 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 51 |
Inflammation | 1 1 1 | 28 1.7|
Duct, Cyst | 2 | 41 2.2|
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Atrophy | 4 4 4 | 50 4.0|
Cyst | 2 | 14 2.2|
Fibrosis | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Oviduct | | 1 |
Necrosis | | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Uterus | + + + | 53 |
Adenomyosis | | 1 2.0|
Inflammation, Chronic Active | | 3 3.3|
Inflammation, Suppurative | | 11 2.3|
Metaplasia, Squamous | 1 2 | 32 2.5|
Cervix, Hyperplasia, Stromal | | 1 4.0|
Cervix, Inflammation, Suppurative | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 3 | 31 2.0|
|__________________________________________________________________________|____________|
Vagina | | 3 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Hyperplasia | 2 2 | 37 2.9|
|__________________________________________________________________________|____________|
Lymph Node | | 6 |
Inguinal, Ectasia | | 1 2.0|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Ectasia | | 1 2.0|
Mediastinal, Hyperplasia, Histiocytic| | 1 2.0|
Mediastinal, Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
Ectasia | | 1 2.0|
Hyperplasia, Plasma Cell | 3 | 15 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Hemorrhage | | 1 3.0|
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + | 52 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hematopoietic Cell Proliferation | 1 1 | 44 1.5|
Pigmentation | 2 2 2 | 49 1.6|
Lymphoid Follicle, Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + M + | 46 |
Atrophy | 2 4 | 44 3.6|
Cyst | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Cyst | | 1 2.0|
Hyperplasia | 2 | 18 1.2|
Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Hyperplasia, Squamous | | 1 2.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Inflammation, Suppurative | | 1 3.0|
Mineralization | | 2 1.0|
Artery, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Edema | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 2 | 49 1.8|
Metaplasia, Squamous | | 5 2.2|
Mineralization | | 1 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 3 1 2 | 45 1.7|
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Cyst, Squamous | | 1 3.0|
Inflammation | | 5 2.0|
Goblet Cell, Septum, Hyperplasia | | 1 2.0|
Nasolacrimal Duct, Respiratory | | |
Epithelium, Hyperplasia | | 1 2.0|
Olfactory Epithelium, Degeneration | | 1 2.0|
Olfactory Epithelium, Inflammation | | 1 3.0|
Respiratory Epithelium, Cyst | 2 | 2 2.0|
Respiratory Epithelium, Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
Lens, Degeneration | | 1 4.0|
Retina, Atrophy | | 4 2.3|
Retina, Degeneration | | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Inflammation | | 8 1.1|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Calculus Micro Observation Only | | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| | |
DAY ON TEST | 3| 3| 4| | |
| 3| 3| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
46 NG/KG | 9| 9| 9| | L |
| 0| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Casts Protein | | 1 1.0|
Cyst | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | 1 1 1 | 42 1.1|
Necrosis | | 1 2.0|
Nephropathy | 1 2 2 | 39 1.4|
Pelvis, Dilatation | | 2 3.0|
Pelvis, Inflammation | | 4 2.3|
Transitional Epithelium, Hyperplasia | | 11 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Inflammation | | 8 2.0|
Transitional Epithelium, Hyperplasia | | 6 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|
DAY ON TEST | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|
| 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + M + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Basophilic Focus, Multiple | X X X X |
Cholangiofibrosis | 2 3 3 1 2 2 2 2 2 2 2 2 1 2 3|
Clear Cell Focus | |
Clear Cell Focus, Multiple | X |
Congestion | 2 2 |
Cytoplasmic Alteration | 2 |
Degeneration, Cystic | 2 |
Eosinophilic Focus | X|
Eosinophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X |
Fatty Change, Diffuse | 2 2 1 2 2 2 2 2 1 2 1 3 2 2 2 2 2 2 2 2 2 2|
Fatty Change, Focal | 1 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X|
Inflammation | 1 1 2 1 1 1 1 1 1 2 3 1 1 1 1 1 2 1 1 1 1 2 1 1|
Mixed Cell Focus | X|
Mixed Cell Focus, Multiple | X X X X X X X X X |
Necrosis | 2 3 2 3 2 2 3 2|
__________________________________________|__________________________________________________________________________|
Page 107
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|
DAY ON TEST | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|
| 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pigmentation | 2 3 2 3 2 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Thrombosis | |
Toxic Hepatopathy | 3 4 4 4 3 3 4 4 4 3 4 4 4 3 3 3 3 3 3 4 3 4 3 4 4|
Artery, Inflammation, Chronic Active | 2 |
Bile Duct, Cyst | 3 4 2 2 3 2 4 3 |
Bile Duct, Fibrosis | 1 |
Bile Duct, Hyperplasia | 2 2 2 3 2 3 2 2 2 2 2 2 2 3 2 2 2 1 1 2 2 3 2 2 2|
Centrilobular, Degeneration | 2 2 3|
Hepatocyte, Hypertrophy | 2 3 3 4 3 4 3 3 3 3 4 3 3 3 3 3 4 3 3 4 3 3 3 3|
Hepatocyte, Multinucleated | 1 1 2 2 2 1 2 2 3 2 2 1 3 1 1 1 1 2 2 1 2 2 2|
Oval Cell, Hyperplasia | 2 2 2 2 2 3 3 3 3 2 3 2 2 2 3 2 1 1 2 3 2 3 3 2 3|
Portal, Fibrosis | 2 2 2 3 2 2 2 1 2 3 2|
|__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic Active | 2 2 3 2 |
Fat, Necrosis | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 3 2 4 2 1 4 3|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic Active | 3 2 |
Necrosis | 2 |
Acinus, Atrophy | 2 2 2 2 1 |
Acinus, Vacuolization Cytoplasmic | 2 1 1 2 3 3 2 2 3 1 1 2 3 2 2 2 3 |
Artery, Inflammation, Chronic Active | 3 2 3 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +|
Inflammation | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 2 1 2 3 2 2 |
Inflammation | 3 |
Necrosis | |
Ulcer | 3 3 1 |
__________________________________________|__________________________________________________________________________|
Page 108
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|
DAY ON TEST | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|
| 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 2 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + +|
Peridontal Tissue, Inflammation | 2 2 2 2 1 1 1 1 1 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + M + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 3 1 1 1 2 1 1 1 2 1 2 1 2|
Artery, Inflammation | 1 |
Artery, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 2 1 2 |
Atrophy | 3 3 1 3 2 4 2 4 1 2 2 4 2|
Degeneration, Cystic | 2 2 2 2 2 3 2|
Hyperplasia | 3 3 3 4 3 2 2 2 2 2 4 2 2 2 2|
Hypertrophy | 3 2 2 4 2 3 2 4 4 3 4 2 1 2 2 2 2 1 4 4|
Mineralization | |
Necrosis | 3 |
Vacuolization Cytoplasmic | 1 2 3 1 3 2 3 3 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 2 1 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Angiectasis | 2 1 2 |
Cyst | 2 |
__________________________________________|__________________________________________________________________________|
Page 109
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|
DAY ON TEST | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|
| 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Inflammation, Chronic | |
Pars Distalis, Hyperplasia | 2 3 1 1 3 1 1 1 1 2 2 2 1|
Pars Intermedia, Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
C-Cell, Hyperplasia | 2 1 2 1 3 2 2 2 2 1 2 3 |
Follicular Cell, Hypertrophy | 1 1 1 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 1 2 2 2 1 1 1 1|
Duct, Cyst | 3 2 2 2 2 2 2 2 2 3 3 3 1 3 2 3 3 2 3 2 2 1|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 3 4 4 4 |
Cyst | 2 3 2 2 2 |
Inflammation, Chronic Active | 3 |
Artery, Inflammation, Chronic Active | |
|__________________________________________________________________________|
Oviduct | |
Inflammation | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3|
Hemorrhage | 3 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 1 |
Metaplasia, Squamous | 1 1 2 1 1 2 1 |
Endometrium, Hyperplasia, Cystic | 2 1 1 2 1 1 3 |
|__________________________________________________________________________|
Vagina | + |
__________________________________________|__________________________________________________________________________|
Page 110
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|
DAY ON TEST | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|
| 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia | 2 2 3 3 4 2 2 2 2 3 3 3 3 3 3 3 3 4 3 3 3|
|__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Ectasia | 2 |
Mediastinal, Hemorrhage | 3 2 |
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
Ectasia | 3 3 |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | 2 3 2 2 3 2 3 |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Ectasia | |
Hyperplasia, Histiocytic | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 1 2 2 1 1 1 1 1 3 2 2 2 1 1 2 1 1 1|
Hyperplasia, Lymphoid | 2 |
Pigmentation | 1 1 1 1 1 2 2 2 1 1 2 2 3 1 1 1 1 1 1 2 2 |
Lymphoid Follicle, Atrophy | 2|
|__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + M M + M + + + + + + M M|
Atrophy | 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 1 2 1 1 1 2 2 2 2 1|
Inflammation, Granulomatous | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 111
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|
DAY ON TEST | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|
| 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 3 |
Inflammation, Chronic Active | 3 |
Epidermis, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Glial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2 2|
Inflammation, Chronic Active | 3 |
Metaplasia, Squamous | 1 2 3 3 2|
Mineralization | |
Necrosis | 4 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 2 2 1 1 1 2 3 2 3 2 2 2 1 2 3 1 2 2 2 3 2 2 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Nasopharyngeal Duct, Inflammation | |
Olfactory Epithelium, Inflammation | |
Septum, Hyperplasia, Squamous | |
Septum, Inflammation | |
Turbinate, Hyperplasia, Squamous | |
Turbinate, Septum, Inflammation | 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 112
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|
DAY ON TEST | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|
| 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anterior Chamber, Inflammation, | |
Suppurative | |
Cornea, Inflammation, Suppurative | |
Retina, Atrophy | 2 2 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | 4 |
Casts Protein | |
Cyst | |
Inflammation, Suppurative | 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 3 3 1 2 3 3 3 2 2 2 2 3 2 2 2 2 1 1 2 3 1 3 1 3 2|
Pelvis, Inflammation | 3 |
Renal Tubule, Degeneration | 2 |
Transitional Epithelium, Hyperplasia | 4 2 2 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Metaplasia, Squamous | 3 |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________
Page 113
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|
| 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 1 |
Basophilic Focus | X |
Basophilic Focus, Multiple | X |
Cholangiofibrosis | 3 2 2 3 3 3 3 2 2 3 3 3 3 3|
Clear Cell Focus | X |
Clear Cell Focus, Multiple | |
Congestion | |
Cytoplasmic Alteration | |
Degeneration, Cystic | 2 3 2 |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X X X X|
Fatty Change, Diffuse | 3 1 2 2 1 2 2 2 2 1 2 2 1 2 3 2 2 2 2 2 2 2 1|
Fatty Change, Focal | 3 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Nodular | X X X X X X X X X X X X X X X X|
Inflammation | 1 1 1 1 1 1 1 1 1 2 2 1 1 3 2 1 2 1 1 2 1 2|
Mixed Cell Focus | X X X |
Mixed Cell Focus, Multiple | X X X X X X X |
Necrosis | 2 3 4 3 3 2 2 3 |
__________________________________________|__________________________________________________________________________|
Page 114
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|
| 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pigmentation | 2 2 2 2 2 2 2 2 3 2 2 3 2 3 2 2 3 3 2 3 3 2 3 2 2|
Thrombosis | 3 |
Toxic Hepatopathy | 3 3 4 3 3 3 4 3 3 3 4 4 3 3 3 4 4 4 4 4 3 4 4 4 3|
Artery, Inflammation, Chronic Active | 2 |
Bile Duct, Cyst | 3 2 3 4 3 3 2 2 3 3 3 2|
Bile Duct, Fibrosis | 2 2 2 |
Bile Duct, Hyperplasia | 2 2 3 2 2 2 3 2 2 1 3 2 2 2 2 2 2 2 2 2 2 3 3 2 2|
Centrilobular, Degeneration | 1 |
Hepatocyte, Hypertrophy | 3 4 4 4 3 3 3 3 3 2 4 3 3 3 3 3 3 3 3 3 4 1 4 4 3|
Hepatocyte, Multinucleated | 2 2 2 2 2 1 2 2 2 2 3 1 1 2 2 1 2 2 2 2 2 2 2 2 2|
Oval Cell, Hyperplasia | 3 2 3 2 2 2 3 2 2 1 3 2 2 1 3 3 3 2 2 3 2 3 2 3 2|
Portal, Fibrosis | 3 3 2 1 2 1 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic Active | 3 4 3 |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + +|
Gingival, Hyperplasia, Squamous | 1 2 2 2 2 2 1 4 1|
|__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 1 2 2 2|
Necrosis | |
Acinus, Atrophy | 3 3 2 3|
Acinus, Vacuolization Cytoplasmic | 2 3 1 2 2 2 2 1 2 1 2 2 3 1 1 1 1 3 2 2 2 1 |
Artery, Inflammation, Chronic Active | 1 3 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 |
Hyperkeratosis | 2 2|
Hyperplasia, Squamous | 1 1 1 2 2|
Inflammation | 1 1 2 2 |
Necrosis | 1 |
Ulcer | 3 |
__________________________________________|__________________________________________________________________________|
Page 115
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|
| 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
|__________________________________________________________________________|
Tooth | + + + + + + + +|
Peridontal Tissue, Inflammation | 1 1 2 2 3 1 2 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Artery, Inflammation | |
Artery, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 3 2 |
Atrophy | 1 2 2 3 2 4 3 1 3 2 2|
Degeneration, Cystic | 2 2 2 2 3 3 3 2|
Hyperplasia | 2 3 2 2 3 2 3 3 2 4 2 3 2 2|
Hypertrophy | 2 2 2 2 2 3 3 2 2 3 2 2 2 2 4 2 2 2 2 2 3 1 2 2|
Mineralization | 2 |
Necrosis | |
Vacuolization Cytoplasmic | 2 2 2 2 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M M M + + + + + + + + + + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 3 2 |
Cyst | |
__________________________________________|__________________________________________________________________________|
Page 116
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|
| 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Inflammation, Chronic | 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 |
Pars Intermedia, Hyperplasia | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Cyst | 2 |
C-Cell, Hyperplasia | 2 1 1 2 2 2 3 2 3 2 |
Follicular Cell, Hypertrophy | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 2 1 1 1 1 1 1 1 2|
Duct, Cyst | 2 2 3 2 1 3 2 2 2 1 2 1 3 2 2 2 2 3 3 4 3 2 3|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4|
Cyst | 2 2 3 3 3 2 3 3 |
Inflammation, Chronic Active | |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Oviduct | + |
Inflammation | 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | |
Inflammation, Chronic Active | 4 |
Inflammation, Suppurative | 2 3 2 3 |
Metaplasia, Squamous | 2 2 3 3 2 2 2 1 2 1|
Endometrium, Hyperplasia, Cystic | 1 1 2 3 3 4 3 3 2 2 2 2|
|__________________________________________________________________________|
Vagina | |
__________________________________________|__________________________________________________________________________|
Page 117
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|
| 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 3 2 3 3 3 2 2 3 3 4 3 3 2 2 3 3 2 3 3|
|__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Ectasia | 2 |
Mediastinal, Hemorrhage | 2 2 |
Mediastinal, Hyperplasia, Histiocytic| 2 |
Mediastinal, Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 3 3 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 2 2 3 2 2 2 2|
Inflammation, Suppurative | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia, Histiocytic | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 1 2 1 2 2 2 3 2 2 1 1 2 1 1 2 1 1 2|
Hyperplasia, Lymphoid | 2 2 2|
Pigmentation | 1 2 1 1 2 1 2 1 1 2 1 1 1 2 2 2 1 2 1 1 2 1 2|
Lymphoid Follicle, Atrophy | |
|__________________________________________________________________________|
Thymus | + + + M + + + M M + + + + + + + + + M + + + + + +|
Atrophy | 4 3 4 4 3 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 3 1 1 |
Inflammation, Granulomatous | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 118
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|
| 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic Active | |
Epidermis, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Glial Cell, Hyperplasia | 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 1 2 2 2 2 2|
Inflammation, Chronic Active | |
Metaplasia, Squamous | 2 |
Mineralization | 2 |
Necrosis | |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 3 2 2 2 2 3 1 1 3 3 1 2 1 2 3 1 2 2 3 2 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 4 2 1 |
Nasopharyngeal Duct, Inflammation | 4 |
Olfactory Epithelium, Inflammation | 2 |
Septum, Hyperplasia, Squamous | 2 |
Septum, Inflammation | 3 4 |
Turbinate, Hyperplasia, Squamous | 2 |
Turbinate, Septum, Inflammation | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 119
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|
DAY ON TEST | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|
| 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anterior Chamber, Inflammation, | |
Suppurative | 4 |
Cornea, Inflammation, Suppurative | 4 |
Retina, Atrophy | 3 3 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Casts Protein | 1 |
Cyst | 2 |
Inflammation, Suppurative | 3 |
Mineralization | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 2 2 2 1 3 2 3 2 2 1 3 2 3 3 2 3 2 2 2 2 2 2 3 2|
Pelvis, Inflammation | 3 |
Renal Tubule, Degeneration | |
Transitional Epithelium, Hyperplasia | 1 1 1 1 4 1 1|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 |
Metaplasia, Squamous | |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________
Page 120
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + M + | 51 |
Parasite Metazoan | X | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
Parasite Metazoan | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M + | 52 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + | 51 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Angiectasis | | 5 2.0|
Basophilic Focus | X | 3 |
Basophilic Focus, Multiple | | 5 |
Cholangiofibrosis | 3 3 | 31 2.4|
Clear Cell Focus | | 1 |
Clear Cell Focus, Multiple | | 1 |
Congestion | | 2 2.0|
Cytoplasmic Alteration | 2 | 2 2.0|
Degeneration, Cystic | | 4 2.3|
Eosinophilic Focus | | 2 |
Eosinophilic Focus, Multiple | X X | 42 |
Fatty Change, Diffuse | 3 1 3 | 48 1.9|
Fatty Change, Focal | | 2 2.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Nodular | X X | 36 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 121
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation | 1 1 2 | 49 1.3|
Mixed Cell Focus | | 4 |
Mixed Cell Focus, Multiple | X | 17 |
Necrosis | 2 | 17 2.5|
Pigmentation | 2 2 2 | 53 2.2|
Thrombosis | | 1 3.0|
Toxic Hepatopathy | 4 3 4 | 53 3.5|
Artery, Inflammation, Chronic Active | | 2 2.0|
Bile Duct, Cyst | 4 | 21 2.9|
Bile Duct, Fibrosis | | 4 1.8|
Bile Duct, Hyperplasia | 2 2 2 | 53 2.1|
Centrilobular, Degeneration | 2 | 5 2.0|
Hepatocyte, Hypertrophy | 3 4 4 | 52 3.2|
Hepatocyte, Multinucleated | 2 2 1 | 51 1.8|
Oval Cell, Hyperplasia | 2 2 3 | 53 2.3|
Portal, Fibrosis | 1 2 2 | 27 2.0|
|__________________________________________________________________________|____________|
Mesentery | | 8 |
Artery, Inflammation, Chronic Active | | 7 2.7|
Fat, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 29 |
Gingival, Hyperplasia, Squamous | | 16 2.3|
|__________________________________________________________________________|____________|
Pancreas | + + + | 51 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | | 6 2.0|
Necrosis | | 1 2.0|
Acinus, Atrophy | | 9 2.2|
Acinus, Vacuolization Cytoplasmic | 1 1 1 | 42 1.8|
Artery, Inflammation, Chronic Active | | 7 2.3|
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 122
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Edema | | 1 1.0|
Hyperkeratosis | | 3 2.0|
Hyperplasia, Squamous | | 11 1.7|
Inflammation | | 5 1.8|
Necrosis | | 1 1.0|
Ulcer | | 4 2.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Ulcer | | 2 2.5|
|__________________________________________________________________________|____________|
Tooth | | 18 |
Peridontal Tissue, Inflammation | | 18 1.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 52 |
Cardiomyopathy | 1 | 36 1.3|
Artery, Inflammation | | 1 1.0|
Artery, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Angiectasis | | 11 1.7|
Atrophy | 2 2 3 | 27 2.4|
Degeneration, Cystic | 2 3 | 17 2.3|
Hyperplasia | 2 | 30 2.5|
Hypertrophy | 2 2 1 | 47 2.4|
Mineralization | | 1 2.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 123
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Vacuolization Cytoplasmic | | 15 2.1|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Hyperplasia | | 9 1.9|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 52 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Angiectasis | 2 | 9 2.1|
Cyst | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Pars Distalis, Hyperplasia | | 19 1.7|
Pars Intermedia, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
Angiectasis | | 1 1.0|
Cyst | | 1 2.0|
C-Cell, Hyperplasia | 1 | 23 1.9|
Follicular Cell, Hypertrophy | 1 | 17 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
Inflammation | 2 1 1 | 26 1.3|
Duct, Cyst | 3 2 2 | 48 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Atrophy | 4 | 31 3.9|
Cyst | | 13 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 124
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Chronic Active | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Oviduct | | 1 |
Inflammation | | 1 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Cyst | | 1 3.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
Inflammation, Suppurative | | 5 2.2|
Metaplasia, Squamous | | 17 1.7|
Endometrium, Hyperplasia, Cystic | | 19 2.1|
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Atrophy | | 1 4.0|
Hyperplasia | 3 3 2 | 43 2.8|
|__________________________________________________________________________|____________|
Lymph Node | + | 9 |
Mediastinal, Ectasia | 2 | 3 2.0|
Mediastinal, Hemorrhage | 2 | 5 2.2|
Mediastinal, Hyperplasia, Histiocytic| | 1 2.0|
Mediastinal, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 52 |
Ectasia | | 6 2.7|
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia, Plasma Cell | 2 | 16 2.3|
Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 125
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mesenteric | + M + | 51 |
Ectasia | | 1 2.0|
Hyperplasia, Histiocytic | | 2 2.5|
|__________________________________________________________________________|____________|
Spleen | + + + | 52 |
Hematopoietic Cell Proliferation | 1 1 | 43 1.5|
Hyperplasia, Lymphoid | | 4 2.0|
Pigmentation | 2 1 1 | 47 1.4|
Lymphoid Follicle, Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + M | 42 |
Atrophy | 4 4 | 42 3.9|
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Cyst | | 1 2.0|
Hyperplasia | 1 1 | 16 1.5|
Inflammation, Granulomatous | | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Cyst Epithelial Inclusion | | 2 3.0|
Inflammation, Chronic Active | | 1 3.0|
Epidermis, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
Fracture | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 126
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Mineralization | | 2 2.0|
Glial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 52 |
Hemorrhage | | 2 2.5|
Infiltration Cellular, Histiocyte | 2 2 1 | 50 2.0|
Inflammation, Chronic Active | | 1 3.0|
Metaplasia, Squamous | | 6 2.2|
Mineralization | | 1 2.0|
Necrosis | | 1 4.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 | 46 2.0|
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Inflammation | | 4 2.5|
Nasopharyngeal Duct, Inflammation | | 1 4.0|
Olfactory Epithelium, Inflammation | | 1 2.0|
Septum, Hyperplasia, Squamous | | 1 2.0|
Septum, Inflammation | | 2 3.5|
Turbinate, Hyperplasia, Squamous | | 1 2.0|
Turbinate, Septum, Inflammation | | 2 2.5|
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
Anterior Chamber, Inflammation, | | |
Suppurative | | 1 4.0|
Cornea, Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 127
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 6| 6| | |
DAY ON TEST | 3| 8| 4| | |
| 3| 0| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
100 | 4| 4| 4| | L |
NG/KG | 1| 2| 4| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Retina, Atrophy | | 6 2.3|
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Inflammation | 2 | 6 1.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Calculus Gross Observation | | 1 4.0|
Casts Protein | | 1 1.0|
Cyst | | 1 2.0|
Inflammation, Suppurative | | 2 3.0|
Mineralization | 1 1 1 | 42 1.1|
Nephropathy | 2 3 2 | 52 2.2|
Pelvis, Inflammation | | 2 3.0|
Renal Tubule, Degeneration | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 11 1.8|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Inflammation | | 3 1.7|
Metaplasia, Squamous | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 128
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atypia Cellular | 1 |
Basophilic Focus | X X X X |
Basophilic Focus, Multiple | X X X X X X |
Cholangiofibrosis | |
Clear Cell Focus | X X X |
Clear Cell Focus, Multiple | X |
Cytoplasmic Alteration | 1 |
Eosinophilic Focus | X X X X|
Eosinophilic Focus, Multiple | X X X X X X X X X X X |
Fatty Change, Diffuse | 1 1 1 2 |
Fatty Change, Focal | 1 1 1 1 2 1 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | |
Inflammation | 1 1 2 1 3 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1|
Mixed Cell Focus | |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X |
Necrosis | 3 1 1 1 2 |
Pigmentation | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1 1 1 2 2 3 2 2 2|
__________________________________________|__________________________________________________________________________|
Page 129
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Toxic Hepatopathy | 1 2 1 2 1 1 1 2 1 1 2 1 2 1 |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Cyst | 3 2 2 2 3 |
Bile Duct, Fibrosis | 1 1 1 2 1 |
Bile Duct, Hyperplasia | 1 1 1 1 |
Hepatocyte, Hypertrophy | 2 3 2 1 2 1 2 1 1 2 1 1 3 3 |
Hepatocyte, Multinucleated | 1 1 1 2 1 1 1 1 1 1 2 2 1 1 1 1 1 3 2 1 1|
Oval Cell, Hyperplasia | 1 |
Portal, Fibrosis | 2 |
Serosa, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Mesentery | + |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + |
Gingival, Hyperplasia, Squamous | 2 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 |
Inflammation, Chronic Active | 1 1 |
Acinus, Atrophy | 1 2 |
Artery, Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | 2 |
Fibrosis | |
Inflammation | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 2 |
Inflammation | 2 |
Ulcer | 2 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 130
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Tongue | + |
Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Tooth | + + + + + |
Peridontal Tissue, Inflammation | 1 1 3 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 3 1 1 2 1 1|
Inflammation | 2 |
Atrium, Thrombosis | 3 |
Epicardium, Inflammation, Chronic | |
Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 1 1 2 |
Atrophy | 3 |
Degeneration, Cystic | 3 1 2 2 1 3 2 2 1 |
Hyperplasia | 3 2 3 3 2 2 |
Hypertrophy | 2 3 1 1 2 2 2 3 3 3 2 2 2 2 3 2 2 2 3 1 1 3 2 1|
Necrosis | 3 3 |
Vacuolization Cytoplasmic | 1 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + M + + + + M + M + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 1 1 2 3|
__________________________________________|__________________________________________________________________________|
Page 131
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Cytoplasmic Alteration | 2 |
Vacuolization Cytoplasmic | 1 2 |
Pars Distalis, Hyperplasia | 2 2 2 1 1 1 2 2 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Angiectasis | 2 |
C-Cell, Hyperplasia | 3 2 2 1 1 |
Follicular Cell, Hypertrophy | 1 3 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia, Basal Cell | 1 |
Hyperplasia, Squamous | |
Inflammation | 2 1 1 1 1 2 2 2 1 1 2 2 2 1 1 2 |
Duct, Cyst | 3 3 3 3 1 3 2 3 1 1 2 1 2 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 4 4 4|
Cyst | 2 2 2 2 2 2 2 3 |
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Oviduct | + + |
Inflammation | 3 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 3 3 4 2 1 3 2|
Metaplasia, Squamous | 2 1 1 2 2 3 2 4 3 2 2 2 2 2 1 3 3 2|
Cervix, Inflammation, Chronic Active | 3 |
Endometrium, Hyperplasia, Cystic | 2 1 2 2 2 1 2 2 3 1 1 4 2 2 2 2 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 132
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 3 2 3 3 3 4 2 3 3 3 3 3 4 4 2 4 3 4 3|
Myelofibrosis | |
|__________________________________________________________________________|
Lymph Node | + |
Lumbar, Ectasia | |
Lumbar, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Plasma Cell| |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 3 2 2 2 2 3 3 2 1 2 2 2 2 3 3 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 1 2 1 1 1 2 1 1 2 2 3 2 1 1 1 3 1 3 3|
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 3 2 1 1 1 1 1 2 2 1 2 2 2 1 1 2 2 1 2 1 |
Lymphoid Follicle, Atrophy | |
Red Pulp, Atrophy | |
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 4 3 4 3 4 4 4 2 4 3 3 4 2 4 2 2 3 3 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 2 |
Hyperplasia | 1 1 2 1 1 2 1 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________|__________________________________________________________________________|
Page 133
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 3 1 2 2 2 2 2 2 1 2 3 1 2 2 2 1 3 3 2|
Inflammation, Suppurative | 3 |
Metaplasia, Squamous | 2 |
Alveolar Epithelium, Metaplasia, | |
Bronchiolar | 2 1 1 1 1 1 1 1 1 1 2 1 2 2 1|
Serosa, Inflammation, Suppurative | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | |
Nasolacrimal Duct, Inflammation | |
Olfactory Epithelium, Degeneration | |
Olfactory Epithelium, Inflammation | |
Olfactory Epithelium, Glands, | |
Hyperplasia | |
Respiratory Epithelium, Cyst | 2 |
Respiratory Epithelium, Inflammation,| |
Suppurative | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 134
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|
| 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 NG/ | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Retinal Detachment | |
Bilateral, Cataract | |
Retina, Atrophy | 2 2 2 1 |
Retina, Degeneration | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 1 4 |
Casts Protein | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1|
Nephropathy | 1 2 2 1 1 1 1 2 2 1 1 1 1 2 1 1 2 2 2 1 1 1|
Papilla, Transitional Epithelium, | |
Hyperplasia | |
Pelvis, Dilatation | 2 |
Transitional Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________|__________________________________________________________________________
Page 135
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 5 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + M +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 2 | 4 1.5|
Atypia Cellular | | 1 1.0|
Basophilic Focus | X X X | 7 |
Basophilic Focus, Multiple | X X X | 9 |
Cholangiofibrosis | 2 | 1 2.0|
Clear Cell Focus | X X X | 6 |
Clear Cell Focus, Multiple | X | 2 |
Cytoplasmic Alteration | | 1 1.0|
Eosinophilic Focus | X X | 6 |
Eosinophilic Focus, Multiple | X X X X X X X X X X | 21 |
Fatty Change, Diffuse | 1 3 2 1 1 1 | 10 1.4|
Fatty Change, Focal | 2 1| 8 1.3|
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation | 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1| 43 1.2|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 136
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mixed Cell Focus | X | 1 |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X X X| 28 |
Necrosis | 1 3 2 | 8 1.8|
Pigmentation | 2 1 2 2 1 1 2 2 2 2 1 2 2 2 2 1 1 2 2 3 2 | 45 1.8|
Toxic Hepatopathy | 1 1 | 16 1.3|
Vacuolization Cytoplasmic | | 1 1.0|
Bile Duct, Cyst | 2 | 6 2.3|
Bile Duct, Fibrosis | | 5 1.2|
Bile Duct, Hyperplasia | 1 2 2 | 7 1.3|
Hepatocyte, Hypertrophy | 2 1 1 2 1 1 2 2 | 22 1.7|
Hepatocyte, Multinucleated | 2 2 1 1 1 3 1 2 1 1 1 | 32 1.3|
Oval Cell, Hyperplasia | | 1 1.0|
Portal, Fibrosis | | 1 2.0|
Serosa, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | | 1 |
Artery, Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + + + | 11 |
Gingival, Hyperplasia, Squamous | 1 2 2 3 2 1 | 8 1.9|
|__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | | 1 1.0|
Inflammation, Chronic Active | 2 2| 4 1.5|
Acinus, Atrophy | 1 3| 4 1.8|
Artery, Inflammation, Chronic Active | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 2 2.0|
Fibrosis | 2 | 1 2.0|
Inflammation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 137
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia, Squamous | 2 2 2 1 | 5 1.8|
Inflammation | 3 2 1 | 4 2.0|
Ulcer | 3 1 | 4 2.3|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
Inflammation, Chronic Active | | 1 3.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + | 12 |
Peridontal Tissue, Inflammation | 1 1 2 1 1 1 2 | 12 1.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 1 1 1 1 2 1 1 1 2 1| 22 1.4|
Inflammation | | 1 2.0|
Atrium, Thrombosis | 3 | 2 3.0|
Epicardium, Inflammation, Chronic | | |
Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 2 3 2 2 2 3 2 | 15 1.9|
Atrophy | 2 1 1 | 4 1.8|
Degeneration, Cystic | 1 3 3 2 3 3 3 3| 17 2.2|
Hyperplasia | 2 3 3 3 2 3 2 3 3 3 3 2 3 2 | 20 2.6|
Hypertrophy | 1 2 2 3 3 3 2 2 1 3 2 2 2 1 2 1 3 2 3 3 2 3| 46 2.1|
Necrosis | 3 | 3 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 138
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Vacuolization Cytoplasmic | 1 3 1 1 1 2 1 1 1 2| 13 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 3 3 2 3 2 | 15 2.1|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + M +| 44 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 2 3 1 4 3 3 1| 15 2.1|
Cytoplasmic Alteration | | 1 2.0|
Vacuolization Cytoplasmic | 2 | 3 1.7|
Pars Distalis, Hyperplasia | 2 3 2 2 1 2 2 1 | 18 1.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
C-Cell, Hyperplasia | 2 2 2 1 2 2 2 2 2 3 | 15 1.9|
Follicular Cell, Hypertrophy | 1 2 | 6 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 2.0|
Hyperplasia, Basal Cell | | 1 1.0|
Hyperplasia, Squamous | 3 | 1 3.0|
Inflammation | 1 1 2 1 2 2 1 1 1 2 1 2 1 1 3 2 2 1 3 | 35 1.5|
Duct, Cyst | 2 3 2 1 2 1 1 3 2 2 1 1 1 1 2 3 3 2 2 3 1| 35 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 139
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4| 45 4.0|
Cyst | 2 2 4 3 3 2 2 2 | 16 2.3|
Inflammation, Granulomatous | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Oviduct | | 2 |
Inflammation | | 2 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3| 1 3.0|
Inflammation, Suppurative | 4 | 9 2.7|
Metaplasia, Squamous | 2 2 2 1 2 2 3 2 2 2 1 1 2 2 3| 33 2.1|
Cervix, Inflammation, Chronic Active | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 1 2 2 1 3 2 1 4 3 4 2 2 1 2 | 32 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Hyperplasia | 3 3 2 2 3 2 2 3 4 3 3 3 2 3 2 3 | 36 2.9|
Myelofibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 5 |
Lumbar, Ectasia | 2 3 | 2 2.5|
Lumbar, Hyperplasia, Plasma Cell | 3 | 2 2.5|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 1 | 2 2.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
Hyperplasia, Plasma Cell | 2 2 3 1 2 2 2 2 2 2 2 2 2 | 30 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Histiocytic | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 140
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spleen | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 1 1 1 2 2 1 2 2 1 2 1 1 2 1 1 1 2 1 1 3| 42 1.5|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | 1 2 2 2 1 2 2 1 2 2 1 2 2 2 1 2 1 2 1 2 1 | 42 1.6|
Lymphoid Follicle, Atrophy | 2 | 1 2.0|
Red Pulp, Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 2 4 4 3 3 4 4 4 2 4 4 2 4 3 3 4 2 2 4 4 4 3 4| 45 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 4 2.3|
Hyperplasia | 1 1 2 1 1 1 1 1 2 1 1| 19 1.2|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 141
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 2 2 2 2 3 2 2 2 2 1 2 2 2 2 1 2 2 3 2 1 2| 41 2.0|
Inflammation, Suppurative | | 1 3.0|
Metaplasia, Squamous | 1 1 | 3 1.3|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 1 2 2 1 1 1 1 1 1 1 2 2 1 1| 31 1.3|
Serosa, Inflammation, Suppurative | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation | 3 | 1 3.0|
Olfactory Epithelium, Degeneration | 3 | 1 3.0|
Olfactory Epithelium, Inflammation | 3 | 1 3.0|
Olfactory Epithelium, Glands, | | |
Hyperplasia | 2 | 1 2.0|
Respiratory Epithelium, Cyst | | 1 2.0|
Respiratory Epithelium, Inflammation,| | |
Suppurative | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Retinal Detachment | 3 | 1 3.0|
Bilateral, Cataract | 3 | 1 3.0|
Retina, Atrophy | 2 2 | 6 1.8|
Retina, Degeneration | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation | 1 1 1 | 9 1.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 142
NTP Experiment-Test: 96007-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD) Date: 09/30/03
Route: GAVAGE Time: 08:37:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 3| 7| 6| 7| 5| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 2| 2| 2| 3| 4| 8| 3| 4| 3| 0| 3| 7| 3| 4| 5| 7| 3| |
| 3| 8| 1| 1| 7| 1| 2| 2| 9| 4| 0| 1| 5| 4| 1| 5| 3| 4| 1| 8| 3| 1| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
100 NG/ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 2 2.5|
Casts Protein | 1 | 1 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0|
Nephropathy | 1 1 2 2 2 1 2 1 1 2 1 2 2 1 1 1 1 1 2 | 41 1.4|
Papilla, Transitional Epithelium, | | |
Hyperplasia | 1 | 1 1.0|
Pelvis, Dilatation | | 1 2.0|
Transitional Epithelium, Hyperplasia | 1 2 1 1 | 5 1.4|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 143
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---------- END OF REPORT ----------
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