TDMS Study 96007-04 Pathology Tables
NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:22:30
14 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFDIOXINMIX
Lock Date: 09/12/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/17/98 - 09/18/98
Treatment Groups: Include 001 TERT.MIXCONTROL
Include 002 TERT.MIXTEQ=10
Include 003 TERT.MIXTEQ=22
Include 004 TERT.MIXTEQ=46
Include 005 TERT.MIXTEQ=100
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:22:30
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SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98
Scheduled Sacrifice 16 16 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10)
Clear Cell Focus 1 (10%)
Fatty Change, Diffuse 1 (10%)
Inflammation 10 (100%) 10 (100%) 10 (100%) 10 (100%) 8 (80%)
Mixed Cell Focus, Multiple 1 (10%)
Hepatocyte, Hypertrophy 1 (10%) 3 (30%) 5 (50%) 8 (80%)
Pancreas (10) (10) (10) (10) (10)
Basophilic Focus 1 (10%)
Inflammation, Chronic Active 2 (20%)
Acinus, Atrophy 1 (10%)
Stomach, Forestomach (10) (10)
Hyperkeratosis 1 (10%)
Hyperplasia, Squamous 1 (10%)
Inflammation 1 (10%)
Stomach, Glandular (10) (10)
Cyst 1 (10%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10)
Hyperplasia 1 (10%)
Hypertrophy 1 (10%)
Thyroid Gland (10) (10) (10) (10) (10)
Follicular Cell, Hypertrophy 3 (30%) 7 (70%) 10 (100%) 7 (70%)
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:22:30
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (10) (10) (10) (10)
Atrophy 1 (10%) 2 (20%) 3 (30%) 4 (40%)
Uterus (10) (10) (10) (10) (10)
Metaplasia, Squamous 1 (10%) 1 (10%) 2 (20%)
Endometrium, Hyperplasia, Cystic 2 (20%) 2 (20%)
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HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Pigmentation 10 (100%) 10 (100%)
Thymus (10) (10) (10) (10) (10)
Atrophy 2 (20%) 3 (30%) 4 (40%) 7 (70%)
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10)
Hemorrhage 1 (10%) 1 (10%)
Infiltration Cellular, Histiocyte 1 (10%)
Inflammation, Chronic Active 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:22:30
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 1 (10%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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