TDMS Study 96007-04 Pathology Tables
NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/22/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Time: 10:28:55
14 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFDIOXINMIX
Lock Date: 09/12/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/17/98 - 09/18/98
Treatment Groups: Include 001 TERT.MIXCONTROL
Include 002 TERT.MIXTEQ=10
Include 003 TERT.MIXTEQ=22
Include 004 TERT.MIXTEQ=46
Include 005 TERT.MIXTEQ=100
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/22/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Time: 10:28:55
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SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98
Scheduled Sacrifice 16 16 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10)
Clear Cell Focus 1
Fatty Change, Diffuse 1 [1.0]
Inflammation 10 [1.0] 10 [1.0] 10 [1.0] 10 [1.0] 8 [1.0]
Mixed Cell Focus, Multiple 1
Hepatocyte, Hypertrophy 1 [1.0] 3 [1.0] 5 [1.2] 8 [1.4]
Pancreas (10) (10) (10) (10) (10)
Basophilic Focus 1
Inflammation, Chronic Active 2 [1.0]
Acinus, Atrophy 1 [1.0]
Stomach, Forestomach (10) (10)
Hyperkeratosis 1 [2.0]
Hyperplasia, Squamous 1 [3.0]
Inflammation 1 [2.0]
Stomach, Glandular (10) (10)
Cyst 1 [1.0]
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10)
Hyperplasia 1 [1.0]
Hypertrophy 1 [2.0]
Thyroid Gland (10) (10) (10) (10) (10)
Follicular Cell, Hypertrophy 3 [1.0] 7 [1.0] 10 [1.4] 7 [1.4]
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/22/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Time: 10:28:55
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (10) (10) (10) (10)
Atrophy 1 [3.0] 2 [3.0] 3 [2.7] 4 [3.5]
Uterus (10) (10) (10) (10) (10)
Metaplasia, Squamous 1 [1.0] 1 [1.0] 2 [1.5]
Endometrium, Hyperplasia, Cystic 2 [3.0] 2 [3.0]
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HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Pigmentation 10 [1.2] 10 [1.0]
Thymus (10) (10) (10) (10) (10)
Atrophy 2 [1.0] 3 [1.0] 4 [1.0] 7 [1.1]
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10)
Hemorrhage 1 [1.0] 1 [1.0]
Infiltration Cellular, Histiocyte 1 [1.0]
Inflammation, Chronic Active 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/22/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Time: 10:28:55
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 1 [3.0]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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