TDMS Study 96007-04 Pathology Tables
NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:29:25
31 WEEK SSAC/FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFDIOXINMIX
Lock Date: 09/12/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 01/13/99 - 01/14/99
Treatment Groups: Include 001 TERT.MIXCONTROL
Include 002 TERT.MIXTEQ=10
Include 003 TERT.MIXTEQ=22
Include 004 TERT.MIXTEQ=46
Include 005 TERT.MIXTEQ=100
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:29:25
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SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98
Scheduled Sacrifice 16 16 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10)
Clear Cell Focus 1 (10%)
Eosinophilic Focus 1 (10%)
Fatty Change, Diffuse 1 (10%)
Inflammation 8 (80%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Mixed Cell Focus 3 (30%) 2 (20%) 1 (10%) 4 (40%) 2 (20%)
Mixed Cell Focus, Multiple 3 (30%) 2 (20%) 4 (40%) 4 (40%) 6 (60%)
Pigmentation 4 (40%) 9 (90%) 10 (100%) 10 (100%)
Hepatocyte, Hypertrophy 3 (30%) 5 (50%) 9 (90%) 10 (100%)
Hepatocyte, Multinucleated 1 (10%) 8 (80%)
Pancreas (10) (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%) 1 (10%)
Acinus, Atrophy 1 (10%) 1 (10%) 2 (20%)
Acinus, Vacuolization Cytoplasmic 5 (50%)
Stomach, Glandular (10) (10)
Glands, Ectasia 2 (20%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10)
Degeneration, Cystic 1 (10%)
Hyperplasia 1 (10%) 2 (20%)
Hypertrophy 5 (50%) 1 (10%) 1 (10%) 1 (10%) 3 (30%)
Vacuolization Cytoplasmic 1 (10%)
Pituitary Gland (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:29:25
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (10%)
Hypertrophy 1 (10%)
Thyroid Gland (10) (10) (10) (10) (10)
C-Cell, Hyperplasia 1 (10%)
Follicular Cell, Hypertrophy 1 (10%) 5 (50%) 1 (10%) 4 (40%) 3 (30%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (10) (10) (10) (10)
Atrophy 10 (100%) 9 (90%) 9 (90%) 8 (80%) 9 (90%)
Uterus (10) (10) (10) (10) (10)
Inflammation, Suppurative 4 (40%) 1 (10%) 2 (20%)
Metaplasia, Squamous 8 (80%) 9 (90%) 8 (80%) 8 (80%) 8 (80%)
Endometrium, Hyperplasia, Cystic 2 (20%) 1 (10%) 2 (20%)
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HEMATOPOIETIC SYSTEM
Lymph Node (1)
Metaplasia, Squamous 1 (100%)
Spleen (10) (10)
Pigmentation 10 (100%) 10 (100%)
Thymus (10) (10) (10) (10) (9)
Atrophy 3 (30%) 7 (70%) 7 (78%)
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:29:25
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10)
Hemorrhage 1 (10%)
Infiltration Cellular, Histiocyte 1 (10%) 1 (10%) 1 (10%) 1 (10%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (1)
Inflammation, Chronic Active 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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