TDMS Study 96007-04 Pathology Tables
NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/22/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Time: 10:36:36
31 WEEK SSAC/FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFDIOXINMIX
Lock Date: 09/12/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 01/13/99 - 01/14/99
Treatment Groups: Include 001 TERT.MIXCONTROL
Include 002 TERT.MIXTEQ=10
Include 003 TERT.MIXTEQ=22
Include 004 TERT.MIXTEQ=46
Include 005 TERT.MIXTEQ=100
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/22/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Time: 10:36:36
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SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98
Scheduled Sacrifice 16 16 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10)
Clear Cell Focus 1
Eosinophilic Focus 1
Fatty Change, Diffuse 1 [1.0]
Inflammation 8 [1.0] 10 [1.0] 10 [1.1] 10 [1.3] 10 [1.6]
Mixed Cell Focus 3 2 1 4 2
Mixed Cell Focus, Multiple 3 2 4 4 6
Pigmentation 4 [1.0] 9 [1.1] 10 [1.6] 10 [1.6]
Hepatocyte, Hypertrophy 3 [1.0] 5 [1.0] 9 [1.3] 10 [1.4]
Hepatocyte, Multinucleated 1 [1.0] 8 [1.1]
Pancreas (10) (10) (10) (10) (10)
Inflammation, Chronic Active 1 [1.0] 1 [1.0]
Acinus, Atrophy 1 [1.0] 1 [1.0] 2 [1.0]
Acinus, Vacuolization Cytoplasmic 5 [1.0]
Stomach, Glandular (10) (10)
Glands, Ectasia 2 [1.5]
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10)
Degeneration, Cystic 1 [2.0]
Hyperplasia 1 [2.0] 2 [2.0]
Hypertrophy 5 [1.4] 1 [1.0] 1 [1.0] 1 [1.0] 3 [1.0]
Vacuolization Cytoplasmic 1 [1.0]
Pituitary Gland (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/22/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Time: 10:36:36
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
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ENDOCRINE SYSTEM - CONT
Hyperplasia 1 [2.0]
Hypertrophy 1 [1.0]
Thyroid Gland (10) (10) (10) (10) (10)
C-Cell, Hyperplasia 1 [2.0]
Follicular Cell, Hypertrophy 1 [1.0] 5 [1.8] 1 [1.0] 4 [2.0] 3 [1.0]
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (10) (10) (10) (10)
Atrophy 10 [3.8] 9 [3.8] 9 [4.0] 8 [3.8] 9 [3.9]
Uterus (10) (10) (10) (10) (10)
Inflammation, Suppurative 4 [1.3] 1 [2.0] 2 [1.0]
Metaplasia, Squamous 8 [1.9] 9 [1.4] 8 [1.9] 8 [1.9] 8 [1.8]
Endometrium, Hyperplasia, Cystic 2 [3.5] 1 [4.0] 2 [4.0]
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HEMATOPOIETIC SYSTEM
Lymph Node (1)
Metaplasia, Squamous 1 [1.0]
Spleen (10) (10)
Pigmentation 10 [1.4] 10 [1.4]
Thymus (10) (10) (10) (10) (9)
Atrophy 3 [1.3] 7 [1.9] 7 [2.1]
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/22/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Time: 10:36:36
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
____________________________________________________________________________________________________________________________________
None
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RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10)
Hemorrhage 1 [2.0]
Infiltration Cellular, Histiocyte 1 [1.0] 1 [1.0] 1 [1.0] 1 [1.0]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (1)
Inflammation, Chronic Active 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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