TDMS Study 96007-04 Pathology Tables
NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:39:38
53 WEEK SSAC/FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFDIOXINMIX
Lock Date: 09/12/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 06/16/99 - 06/19/99
Treatment Groups: Include 001 TERT.MIXCONTROL
Include 002 TERT.MIXTEQ=10
Include 003 TERT.MIXTEQ=22
Include 004 TERT.MIXTEQ=46
Include 005 TERT.MIXTEQ=100
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:39:38
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SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98
Scheduled Sacrifice 13 13 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8
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ALIMENTARY SYSTEM
Liver (8) (8) (8) (8) (8)
Basophilic Focus 1 (13%) 1 (13%)
Cholangiofibrosis 2 (25%) 1 (13%)
Clear Cell Focus 1 (13%) 1 (13%) 1 (13%)
Eosinophilic Focus 1 (13%) 1 (13%)
Eosinophilic Focus, Multiple 1 (13%)
Fatty Change, Diffuse 2 (25%)
Fatty Change, Focal 3 (38%) 4 (50%)
Inflammation 8 (100%) 8 (100%) 8 (100%) 8 (100%) 8 (100%)
Mixed Cell Focus 2 (25%) 2 (25%) 4 (50%) 1 (13%)
Mixed Cell Focus, Multiple 1 (13%) 2 (25%) 3 (38%) 5 (63%) 7 (88%)
Pigmentation 4 (50%) 8 (100%) 8 (100%) 8 (100%)
Regeneration 1 (13%)
Toxic Hepatopathy 3 (38%) 8 (100%)
Bile Duct, Fibrosis 1 (13%)
Bile Duct, Hyperplasia 6 (75%)
Bile Duct, Inflammation, Chronic Active 1 (13%) 1 (13%)
Hepatocyte, Hypertrophy 5 (63%) 7 (88%) 8 (100%) 8 (100%)
Hepatocyte, Multinucleated 3 (38%) 8 (100%)
Pancreas (8) (8) (8) (8) (8)
Basophilic Focus 1 (13%)
Inflammation, Chronic Active 1 (13%) 1 (13%)
Acinus, Atrophy 1 (13%) 1 (13%)
Acinus, Vacuolization Cytoplasmic 2 (25%) 7 (88%)
Stomach, Glandular (8) (1) (8)
Cyst, Squamous 1 (13%)
Developmental Malformation 1 (100%)
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CARDIOVASCULAR SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:39:38
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
____________________________________________________________________________________________________________________________________
None
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ENDOCRINE SYSTEM
Adrenal Cortex (8) (8) (8) (8) (8)
Degeneration, Cystic 1 (13%) 2 (25%)
Hyperplasia 2 (25%) 1 (13%) 2 (25%)
Hypertrophy 3 (38%) 7 (88%) 5 (63%) 3 (38%) 5 (63%)
Vacuolization Cytoplasmic 1 (13%)
Thyroid Gland (8) (8) (8) (8) (8)
C-Cell, Hyperplasia 1 (13%)
Follicular Cell, Hypertrophy 2 (25%) 2 (25%) 3 (38%) 3 (38%) 4 (50%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (8) (8) (8) (8)
Atrophy 8 (100%) 8 (100%) 8 (100%) 6 (75%) 8 (100%)
Cyst 1 (13%)
Inflammation, Suppurative 1 (13%)
Uterus (8) (8) (8) (8) (8)
Inflammation, Suppurative 1 (13%)
Metaplasia, Squamous 8 (100%) 8 (100%) 8 (100%) 6 (75%) 7 (88%)
Endometrium, Hyperplasia, Cystic 6 (75%) 2 (25%)
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HEMATOPOIETIC SYSTEM
Spleen (8) (8)
Pigmentation 8 (100%) 8 (100%)
Thymus (8) (8) (8) (8) (6)
Atrophy 3 (38%) 7 (88%) 8 (100%) 8 (100%) 6 (100%)
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (1) (1) (1) (8)
Cyst 3 (38%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:39:38
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Hyperplasia 1 (13%) 1 (13%)
Skin (1)
Ulcer 1 (100%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (8) (8) (8) (8)
Infiltration Cellular, Histiocyte 6 (75%) 5 (63%) 5 (63%) 4 (50%) 6 (75%)
Inflammation 1 (13%)
Inflammation, Chronic Active 1 (13%)
Alveolar Epithelium, Metaplasia, Bronchiolar 1 (13%) 2 (25%) 4 (50%) 6 (75%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (1) (1)
Inflammation, Chronic Active 1 (100%) 1 (100%)
Nephropathy 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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