TDMS Study 96007-04 Pathology Tables
NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:42:39
53 WEEK SSAC/FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFDIOXINMIX
Lock Date: 09/12/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 06/16/99 - 06/19/99
Treatment Groups: Include 001 TERT.MIXCONTROL
Include 002 TERT.MIXTEQ=10
Include 003 TERT.MIXTEQ=22
Include 004 TERT.MIXTEQ=46
Include 005 TERT.MIXTEQ=100
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:42:39
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SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
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DISPOSITION SUMMARY
Animals Initially in Study 98 98 98 98 98
Scheduled Sacrifice 13 13 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8
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ALIMENTARY SYSTEM
None
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Thyroid Gland (8) (8) (8) (8) (8)
C-Cell, Adenoma 2 (25%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
None
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HEMATOPOIETIC SYSTEM
None
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:42:39
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (1) (1) (1) (8)
Fibroadenoma 1 (100%) 1 (100%) 1 (100%) 2 (25%)
Skin (1)
Subcutaneous Tissue, Fibrosarcoma 1 (100%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
None
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:42:39
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 2 1 2 1 2
Total Primary Neoplasms 2 1 2 1 2
Total Animals with Benign Neoplasms 2 1 1 1 2
Total Benign Neoplasms 2 1 1 1 2
Total Animals with Malignant Neoplasms 1
Total Malignant Neoplasms 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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