TDMS Study 96007-04 Pathology Tables
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
53 WEEK SSAC/FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFDIOXINMIX
Lock Date: 09/12/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 06/16/99 - 06/19/99
Treatment Groups: Include 001 TERT.MIXCONTROL
Include 002 TERT.MIXTEQ=10
Include 003 TERT.MIXTEQ=22
Include 004 TERT.MIXTEQ=46
Include 005 TERT.MIXTEQ=100
Page 1
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
TERT.MIX | 1| 1| 3| 3| 3| 3| 4| 4| 5| 5| 5| 7| 7| | L |
CONTROL | 2| 4| 6| 7| 8| 9| 0| 8| 1| 3| 5| 1| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 1 |
Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0|
Mixed Cell Focus | X X | 2 |
Mixed Cell Focus, Multiple | X | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
Cyst, Squamous | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Degeneration, Cystic | 2 | 1 2.0|
Hypertrophy | 2 2 1 | 3 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
Follicular Cell, Hypertrophy | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
TERT.MIX | 1| 1| 3| 3| 3| 3| 4| 4| 5| 5| 5| 7| 7| | L |
CONTROL | 2| 4| 6| 7| 8| 9| 0| 8| 1| 3| 5| 1| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 3 4 4 4 4 | 8 3.9|
Inflammation, Suppurative | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Inflammation, Suppurative | 1 | 1 1.0|
Metaplasia, Squamous | 2 3 2 3 2 2 2 1 | 8 2.1|
Endometrium, Hyperplasia, Cystic | 1 2 3 2 1 1 | 6 1.7|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
Pigmentation | 1 2 1 2 2 2 2 1 | 8 1.6|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
Cyst | 1 1 1 | 3 1.0|
Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
TERT.MIX | 1| 1| 3| 3| 3| 3| 4| 4| 5| 5| 5| 7| 7| | L |
CONTROL | 2| 4| 6| 7| 8| 9| 0| 8| 1| 3| 5| 1| 5| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 | 6 1.2|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 6| 6| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
TERT.MIX | 1| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 9| | L |
TEQ=10 | 8| 1| 2| 3| 4| 5| 8| 2| 4| 6| 7| 9| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus, Multiple | X | 1 |
Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0|
Mixed Cell Focus | X X | 2 |
Mixed Cell Focus, Multiple | X X | 2 |
Pigmentation | 1 1 1 1 | 4 1.0|
Hepatocyte, Hypertrophy | 1 1 2 1 1 | 5 1.2|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Hypertrophy | 1 1 1 1 1 1 1 | 7 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
Follicular Cell, Hypertrophy | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 4 | 8 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 6| 6| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
TERT.MIX | 1| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 9| | L |
TEQ=10 | 8| 1| 2| 3| 4| 5| 8| 2| 4| 6| 7| 9| 7| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Metaplasia, Squamous | 2 3 2 3 2 1 2 2 | 8 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 1 1 2 2 2 2 2 | 7 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 | 5 1.0|
Inflammation | 1 | 1 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
TERT.MIX | 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 5| 7| 9| | L |
TEQ=22 | 6| 8| 0| 1| 5| 1| 2| 3| 4| 5| 3| 7| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Eosinophilic Focus | X | 1 |
Inflammation | 1 2 1 1 1 1 1 1 | 8 1.1|
Mixed Cell Focus | X X X X | 4 |
Mixed Cell Focus, Multiple | X X X | 3 |
Pigmentation | 1 2 1 1 1 1 2 1 | 8 1.3|
Hepatocyte, Hypertrophy | 1 1 2 1 2 2 1 | 7 1.4|
Hepatocyte, Multinucleated | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Hyperplasia | 2 2 | 2 2.0|
Hypertrophy | 1 1 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
C-Cell, Hyperplasia | 1 | 1 1.0|
Follicular Cell, Hypertrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 4 | 8 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
TERT.MIX | 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 5| 7| 9| | L |
TEQ=22 | 6| 8| 0| 1| 5| 1| 2| 3| 4| 5| 3| 7| 6| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Metaplasia, Squamous | 2 2 2 2 2 3 2 2 | 8 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 1 3 2 2 2 2 2 2 | 8 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
|__________________________________________________________________________|____________|
Skin | + | 1 |
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 | 5 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
TERT.MIX | 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 5| 7| 9| | L |
TEQ=22 | 6| 8| 0| 1| 5| 1| 2| 3| 4| 5| 3| 7| 6| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Kidney | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
Nephropathy | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
TERT.MIX | 3| 3| 3| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| | L |
TEQ=46 | 2| 6| 8| 2| 6| 7| 8| 9| 0| 1| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Cholangiofibrosis | 1 1 | 2 1.0|
Fatty Change, Focal | 1 1 1 | 3 1.0|
Inflammation | 2 1 2 1 1 2 1 1 | 8 1.4|
Mixed Cell Focus | X | 1 |
Mixed Cell Focus, Multiple | X X X X X | 5 |
Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0|
Toxic Hepatopathy | 1 2 1 | 3 1.3|
Bile Duct, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 2 2 1 1 2 2 1 1 | 8 1.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
Inflammation, Chronic Active | 3 | 1 3.0|
Acinus, Atrophy | 2 | 1 2.0|
Acinus, Vacuolization Cytoplasmic | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
Developmental Malformation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
Follicular Cell, Hypertrophy | 1 3 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
TERT.MIX | 3| 3| 3| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| | L |
TEQ=46 | 2| 6| 8| 2| 6| 7| 8| 9| 0| 1| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 | 6 4.0|
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Metaplasia, Squamous | 2 3 1 3 4 2 | 6 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 4 3 3 2 3 4 4 4 | 8 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 1 | 4 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
TERT.MIX | 3| 3| 3| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| | L |
TEQ=46 | 2| 6| 8| 2| 6| 7| 8| 9| 0| 1| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
TERT.MIX | 0| 0| 0| 0| 0| 3| 5| 5| 5| 6| 7| 7| 9| | L |
TEQ=100 | 1| 2| 3| 4| 5| 1| 7| 8| 9| 6| 3| 5| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X | 1 |
Cholangiofibrosis | 1 | 1 1.0|
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X | 1 |
Fatty Change, Diffuse | 1 1 | 2 1.0|
Fatty Change, Focal | 1 2 1 1 | 4 1.3|
Inflammation | 2 2 2 2 2 1 2 2 | 8 1.9|
Mixed Cell Focus, Multiple | X X X X X X X | 7 |
Pigmentation | 3 2 2 2 2 2 2 1 | 8 2.0|
Regeneration | X | 1 |
Toxic Hepatopathy | 3 2 1 1 1 2 1 2 | 8 1.6|
Bile Duct, Fibrosis | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 | 6 1.0|
Bile Duct, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 3 3 2 2 3 3 2 2 | 8 2.5|
Hepatocyte, Multinucleated | 1 2 2 2 2 2 2 1 | 8 1.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
Basophilic Focus | X | 1 |
Inflammation, Chronic Active | 1 | 1 1.0|
Acinus, Atrophy | 2 | 1 2.0|
Acinus, Vacuolization Cytoplasmic | 1 1 2 2 2 2 1 | 7 1.6|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
TERT.MIX | 0| 0| 0| 0| 0| 3| 5| 5| 5| 6| 7| 7| 9| | L |
TEQ=100 | 1| 2| 3| 4| 5| 1| 7| 8| 9| 6| 3| 5| 7| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Degeneration, Cystic | 1 2 | 2 1.5|
Hyperplasia | 2 2 | 2 2.0|
Hypertrophy | 1 1 2 3 1 | 5 1.6|
Vacuolization Cytoplasmic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
Follicular Cell, Hypertrophy | 3 2 3 1 | 4 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 3 4 4 4 3 | 8 3.8|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Metaplasia, Squamous | 2 2 1 4 2 2 2 | 7 2.1|
Endometrium, Hyperplasia, Cystic | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
Pigmentation | 2 1 4 2 2 2 2 2 | 8 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 96007-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 04/22/03
Route: GAVAGE Time: 10:45:22
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 7| 6| 6| 6| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
TERT.MIX | 0| 0| 0| 0| 0| 3| 5| 5| 5| 6| 7| 7| 9| | L |
TEQ=100 | 1| 2| 3| 4| 5| 1| 7| 8| 9| 6| 3| 5| 7| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thymus | + I + + + + + M | 6 |
Atrophy | 4 3 3 4 4 4 | 6 3.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 6 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 2 2 1 1 1 | 6 1.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
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