TDMS Study 96007-04 Pathology Tables
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
FINAL#4/RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFDIOXINMIX
Lock Date: 09/12/01
Cage Range: All
Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 6| 5| 6| 4| 5| 5| 6| 2| 6| 7| 7| 1| 6| 6| 7| 6| 6| 4| 7| 5| 7| 3| 7| 2| 4|
DAY ON TEST | 6| 4| 9| 5| 2| 0| 2| 7| 6| 3| 2| 7| 6| 2| 3| 4| 2| 4| 2| 7| 2| 8| 3| 1| 1|
| 8| 0| 3| 6| 6| 0| 6| 6| 6| 0| 3| 6| 8| 5| 0| 5| 7| 4| 9| 5| 9| 7| 0| 8| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TERT.MIX | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 3| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | X |
|__________________________________________________________________________|
Tooth | + + + + + + + +|
Peridontal Tissue, Fibrosarcoma | |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 6| 5| 6| 4| 5| 5| 6| 2| 6| 7| 7| 1| 6| 6| 7| 6| 6| 4| 7| 5| 7| 3| 7| 2| 4|
DAY ON TEST | 6| 4| 9| 5| 2| 0| 2| 7| 6| 3| 2| 7| 6| 2| 3| 4| 2| 4| 2| 7| 2| 8| 3| 1| 1|
| 8| 0| 3| 6| 6| 0| 6| 6| 6| 0| 3| 6| 8| 5| 0| 5| 7| 4| 9| 5| 9| 7| 0| 8| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TERT.MIX | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 3| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Adventitia, Carcinoma, | |
Metastatic, Mammary Gland | X |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Pars Distalis, Adenoma | X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 6| 5| 6| 4| 5| 5| 6| 2| 6| 7| 7| 1| 6| 6| 7| 6| 6| 4| 7| 5| 7| 3| 7| 2| 4|
DAY ON TEST | 6| 4| 9| 5| 2| 0| 2| 7| 6| 3| 2| 7| 6| 2| 3| 4| 2| 4| 2| 7| 2| 8| 3| 1| 1|
| 8| 0| 3| 6| 6| 0| 6| 6| 6| 0| 3| 6| 8| 5| 0| 5| 7| 4| 9| 5| 9| 7| 0| 8| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TERT.MIX | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 3| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
Polyp Stromal | X X |
Polyp Stromal, Multiple | X |
Schwannoma Malignant | X |
Squamous Cell Papilloma | |
Cervix, Carcinoma | |
Serosa, Carcinoma, Metastatic, Uterus| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | |
Lumbar, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 6| 5| 6| 4| 5| 5| 6| 2| 6| 7| 7| 1| 6| 6| 7| 6| 6| 4| 7| 5| 7| 3| 7| 2| 4|
DAY ON TEST | 6| 4| 9| 5| 2| 0| 2| 7| 6| 3| 2| 7| 6| 2| 3| 4| 2| 4| 2| 7| 2| 8| 3| 1| 1|
| 8| 0| 3| 6| 6| 0| 6| 6| 6| 0| 3| 6| 8| 5| 0| 5| 7| 4| 9| 5| 9| 7| 0| 8| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TERT.MIX | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 3| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X X X |
Carcinoma, Multiple | |
Fibroadenoma | X X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
Meninges, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | X X X |
Carcinoma, Metastatic, Uterus | |
Fibrosarcoma, Metastatic, Skin | X |
Lymphoma Malignant | |
Mediastinum, Carcinoma, Metastatic, | |
Mammary Gland | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 6| 5| 6| 4| 5| 5| 6| 2| 6| 7| 7| 1| 6| 6| 7| 6| 6| 4| 7| 5| 7| 3| 7| 2| 4|
DAY ON TEST | 6| 4| 9| 5| 2| 0| 2| 7| 6| 3| 2| 7| 6| 2| 3| 4| 2| 4| 2| 7| 2| 8| 3| 1| 1|
| 8| 0| 3| 6| 6| 0| 6| 6| 6| 0| 3| 6| 8| 5| 0| 5| 7| 4| 9| 5| 9| 7| 0| 8| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TERT.MIX | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 3| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephroblastoma | X |
Bilateral, Renal Tubule, Carcinoma | X |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 7| 7| 6| 7| 5| 6| 7| 5| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 3| 5| 8| 2| 2| 8| 2| 6| 3| 2| 8| 2| 5| 0| 2| 0| 3| 3| 2| 2| 3| 2| 1|
| 1| 5| 5| 8| 2| 9| 9| 2| 9| 8| 1| 9| 7| 9| 4| 8| 9| 2| 0| 0| 9| 7| 0| 9| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TERT.MIX | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
CONTROL | 6| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 0| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Oral Mucosa | + + + |
Gingival, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + |
Peridontal Tissue, Fibrosarcoma | X |
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 7| 7| 6| 7| 5| 6| 7| 5| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 3| 5| 8| 2| 2| 8| 2| 6| 3| 2| 8| 2| 5| 0| 2| 0| 3| 3| 2| 2| 3| 2| 1|
| 1| 5| 5| 8| 2| 9| 9| 2| 9| 8| 1| 9| 7| 9| 4| 8| 9| 2| 0| 0| 9| 7| 0| 9| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TERT.MIX | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
CONTROL | 6| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 0| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Adventitia, Carcinoma, | |
Metastatic, Mammary Gland | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X|
Bilateral, Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + M + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X X X X X X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 8
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 7| 7| 6| 7| 5| 6| 7| 5| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 3| 5| 8| 2| 2| 8| 2| 6| 3| 2| 8| 2| 5| 0| 2| 0| 3| 3| 2| 2| 3| 2| 1|
| 1| 5| 5| 8| 2| 9| 9| 2| 9| 8| 1| 9| 7| 9| 4| 8| 9| 2| 0| 0| 9| 7| 0| 9| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TERT.MIX | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
CONTROL | 6| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 0| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
Polyp Stromal | X |
Polyp Stromal, Multiple | |
Schwannoma Malignant | |
Squamous Cell Papilloma | X |
Cervix, Carcinoma | X |
Serosa, Carcinoma, Metastatic, Uterus| X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Lymphoma Malignant | X |
Mediastinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 7| 7| 6| 7| 5| 6| 7| 5| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 3| 5| 8| 2| 2| 8| 2| 6| 3| 2| 8| 2| 5| 0| 2| 0| 3| 3| 2| 2| 3| 2| 1|
| 1| 5| 5| 8| 2| 9| 9| 2| 9| 8| 1| 9| 7| 9| 4| 8| 9| 2| 0| 0| 9| 7| 0| 9| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TERT.MIX | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
CONTROL | 6| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 0| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Carcinoma, Multiple | X |
Fibroadenoma | X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
Meninges, Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | |
Carcinoma, Metastatic, Uterus | X |
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant | X |
Mediastinum, Carcinoma, Metastatic, | |
Mammary Gland | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 10
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 7| 7| 6| 7| 5| 6| 7| 5| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 3| 5| 8| 2| 2| 8| 2| 6| 3| 2| 8| 2| 5| 0| 2| 0| 3| 3| 2| 2| 3| 2| 1|
| 1| 5| 5| 8| 2| 9| 9| 2| 9| 8| 1| 9| 7| 9| 4| 8| 9| 2| 0| 0| 9| 7| 0| 9| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
TERT.MIX | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
CONTROL | 6| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 0| 2| 3| 4| 6| 7| 8| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + M + + + + + + + + + + + + + + +|
Nephroblastoma | |
Bilateral, Renal Tubule, Carcinoma | |
|__________________________________________________________________________|
Ureter | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
Page 11
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 4| 6| 6| | |
DAY ON TEST | 8| 6| 2| | |
| 4| 9| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
TERT.MIX | 8| 8| 9| | L |
CONTROL | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 52 |
Leiomyosarcoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 52 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | + | 10 |
Gingival, Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
|__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 4| 6| 6| | |
DAY ON TEST | 8| 6| 2| | |
| 4| 9| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
TERT.MIX | 8| 8| 9| | L |
CONTROL | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Tooth | + + | 24 |
Peridontal Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
Aorta, Adventitia, Carcinoma, | | |
Metastatic, Mammary Gland | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Schwannoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 52 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 52 |
Pheochromocytoma Benign | | 4 |
Bilateral, Pheochromocytoma Benign | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 52 |
Adenoma | | 1 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 50 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Lymphoma Malignant | | 1 |
Pars Distalis, Adenoma | X | 28 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 4| 6| 6| | |
DAY ON TEST | 8| 6| 2| | |
| 4| 9| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
TERT.MIX | 8| 8| 9| | L |
CONTROL | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
Bilateral, C-Cell, Adenoma | | 2 |
C-Cell, Adenoma | | 15 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + M | 51 |
|__________________________________________________________________________|____________|
Ovary | + + + | 52 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + | 52 |
Leiomyosarcoma | | 1 |
Polyp Stromal | | 3 |
Polyp Stromal, Multiple | | 1 |
Schwannoma Malignant | | 1 |
Squamous Cell Papilloma | | 1 |
Cervix, Carcinoma | | 1 |
Serosa, Carcinoma, Metastatic, Uterus| | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | + | 4 |
Lumbar, Lymphoma Malignant | | 1 |
Mediastinal, Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 4| 6| 6| | |
DAY ON TEST | 8| 6| 2| | |
| 4| 9| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
TERT.MIX | 8| 8| 9| | L |
CONTROL | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 52 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + | 52 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + | 52 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Carcinoma | | 5 |
Carcinoma, Multiple | | 1 |
Fibroadenoma | X | 21 |
Fibroadenoma, Multiple | X | 13 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Fibroma | | 1 |
Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 4| 6| 6| | |
DAY ON TEST | 8| 6| 2| | |
| 4| 9| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
TERT.MIX | 8| 8| 9| | L |
CONTROL | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Carcinoma, Metastatic, Kidney | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Meninges, Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Carcinoma, Metastatic, Mammary Gland | | 3 |
Carcinoma, Metastatic, Uterus | | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant | | 1 |
Mediastinum, Carcinoma, Metastatic, | | |
Mammary Gland | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 4| 6| 6| | |
DAY ON TEST | 8| 6| 2| | |
| 4| 9| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
TERT.MIX | 8| 8| 9| | L |
CONTROL | 4| 5| 6| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 52 |
Nephroblastoma | | 1 |
Bilateral, Renal Tubule, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Ureter | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 2| 4| 8| 6| 5| 3| 3| 3| 3| 6| 3| 2| 3| 4| 8| 1| 6| 2| 2| 3| 6| 6| 5| 6| 2|
| 9| 0| 3| 9| 6| 0| 0| 0| 1| 2| 0| 9| 0| 8| 9| 8| 2| 1| 7| 0| 3| 8| 2| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
TERT.MIX | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
TEQ=10 | 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Carcinoma | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 2| 4| 8| 6| 5| 3| 3| 3| 3| 6| 3| 2| 3| 4| 8| 1| 6| 2| 2| 3| 6| 6| 5| 6| 2|
| 9| 0| 3| 9| 6| 0| 0| 0| 1| 2| 0| 9| 0| 8| 9| 8| 2| 1| 7| 0| 3| 8| 2| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
TERT.MIX | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
TEQ=10 | 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skeletal Muscle | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X X |
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 2| 4| 8| 6| 5| 3| 3| 3| 3| 6| 3| 2| 3| 4| 8| 1| 6| 2| 2| 3| 6| 6| 5| 6| 2|
| 9| 0| 3| 9| 6| 0| 0| 0| 1| 2| 0| 9| 0| 8| 9| 8| 2| 1| 7| 0| 3| 8| 2| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
TERT.MIX | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
TEQ=10 | 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skeletal Muscle | X |
|__________________________________________________________________________|
Oviduct | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Polyp Stromal | |
Cervix, Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X |
Fibroadenoma | X X X X X X X X |
Fibroadenoma, Multiple | X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 2| 4| 8| 6| 5| 3| 3| 3| 3| 6| 3| 2| 3| 4| 8| 1| 6| 2| 2| 3| 6| 6| 5| 6| 2|
| 9| 0| 3| 9| 6| 0| 0| 0| 1| 2| 0| 9| 0| 8| 9| 8| 2| 1| 7| 0| 3| 8| 2| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
TERT.MIX | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
TEQ=10 | 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Fibrous Histiocytoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Medulloblastoma Mal | X |
Meninges, Meningioma Malignant | |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | |
Fibrous Histiocytoma, Metastatic, | |
Skeletal Muscle | X |
Mediastinum, Fibrous Histiocytoma, | |
Metastatic, Skeletal Muscle | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 2| 4| 8| 6| 5| 3| 3| 3| 3| 6| 3| 2| 3| 4| 8| 1| 6| 2| 2| 3| 6| 6| 5| 6| 2|
| 9| 0| 3| 9| 6| 0| 0| 0| 1| 2| 0| 9| 0| 8| 9| 8| 2| 1| 7| 0| 3| 8| 2| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
TERT.MIX | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
TEQ=10 | 1| 2| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal Tubule, Carcinoma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 3| 6| 4| 7| 7| 7| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 6| 5| 5| 1| 2| 2| 3| 2| 2| 2| 3| 6| 3| 3| 2| 3| 2| 5| 0| 0| 2|
| 0| 9| 8| 0| 8| 0| 9| 6| 9| 9| 0| 7| 7| 7| 0| 3| 0| 0| 6| 0| 9| 5| 2| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
TERT.MIX | 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
TEQ=10 | 6| 9| 0| 3| 5| 6| 8| 9| 0| 1| 2| 3| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
|__________________________________________________________________________|
Mesentery | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + |
Gingival, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Carcinoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 3| 6| 4| 7| 7| 7| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 6| 5| 5| 1| 2| 2| 3| 2| 2| 2| 3| 6| 3| 3| 2| 3| 2| 5| 0| 0| 2|
| 0| 9| 8| 0| 8| 0| 9| 6| 9| 9| 0| 7| 7| 7| 0| 3| 0| 0| 6| 0| 9| 5| 2| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
TERT.MIX | 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
TEQ=10 | 6| 9| 0| 3| 5| 6| 8| 9| 0| 1| 2| 3| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + M + + + + + + + + + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 3| 6| 4| 7| 7| 7| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 6| 5| 5| 1| 2| 2| 3| 2| 2| 2| 3| 6| 3| 3| 2| 3| 2| 5| 0| 0| 2|
| 0| 9| 8| 0| 8| 0| 9| 6| 9| 9| 0| 7| 7| 7| 0| 3| 0| 0| 6| 0| 9| 5| 2| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
TERT.MIX | 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
TEQ=10 | 6| 9| 0| 3| 5| 6| 8| 9| 0| 1| 2| 3| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Ovary | + + + + + + + + + + + + + + + + + + + + + M + + +|
Fibrous Histiocytoma, Metastatic, | |
Skeletal Muscle | |
|__________________________________________________________________________|
Oviduct | + + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Polyp Stromal | X |
Cervix, Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X X X|
Fibroadenoma | X X X X X X X X |
Fibroadenoma, Multiple | X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 3| 6| 4| 7| 7| 7| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 6| 5| 5| 1| 2| 2| 3| 2| 2| 2| 3| 6| 3| 3| 2| 3| 2| 5| 0| 0| 2|
| 0| 9| 8| 0| 8| 0| 9| 6| 9| 9| 0| 7| 7| 7| 0| 3| 0| 0| 6| 0| 9| 5| 2| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
TERT.MIX | 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
TEQ=10 | 6| 9| 0| 3| 5| 6| 8| 9| 0| 1| 2| 3| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
Fibrous Histiocytoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Medulloblastoma Mal | |
Meninges, Meningioma Malignant | X |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | X |
Fibrous Histiocytoma, Metastatic, | |
Skeletal Muscle | |
Mediastinum, Fibrous Histiocytoma, | |
Metastatic, Skeletal Muscle | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 3| 6| 4| 7| 7| 7| 6| 2| 6| 7| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 6| 5| 5| 1| 2| 2| 3| 2| 2| 2| 3| 6| 3| 3| 2| 3| 2| 5| 0| 0| 2|
| 0| 9| 8| 0| 8| 0| 9| 6| 9| 9| 0| 7| 7| 7| 0| 3| 0| 0| 6| 0| 9| 5| 2| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
TERT.MIX | 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
TEQ=10 | 6| 9| 0| 3| 5| 6| 8| 9| 0| 1| 2| 3| 8| 1| 2| 3| 5| 6| 7| 8| 9| 0| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal Tubule, Carcinoma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 4| 2| 2| | |
| 6| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
TERT.MIX | 8| 9| 9| | L |
TEQ=10 | 9| 0| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hepatocellular Adenoma | | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | + + | 18 |
Gingival, Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Acinus, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 4| 2| 2| | |
| 6| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
TERT.MIX | 8| 9| 9| | L |
TEQ=10 | 9| 0| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Tooth | + + | 23 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Fibrous Histiocytoma, Metastatic, | | |
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Adenoma | | 1 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Benign | | 3 |
Bilateral, Pheochromocytoma Benign | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Adenoma | X | 29 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
Bilateral, C-Cell, Adenoma | | 2 |
C-Cell, Adenoma | | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 4| 2| 2| | |
| 6| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
TERT.MIX | 8| 9| 9| | L |
TEQ=10 | 9| 0| 6| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
|__________________________________________________________________________|____________|
Ovary | + + + | 52 |
Fibrous Histiocytoma, Metastatic, | | |
Skeletal Muscle | | 1 |
|__________________________________________________________________________|____________|
Oviduct | | 2 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Carcinoma | | 1 |
Polyp Stromal | | 1 |
Cervix, Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
|__________________________________________________________________________|____________|
Thymus | + + M | 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoma | | 1 |
Carcinoma | | 6 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 4| 2| 2| | |
| 6| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
TERT.MIX | 8| 9| 9| | L |
TEQ=10 | 9| 0| 6| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Fibroadenoma | X | 17 |
Fibroadenoma, Multiple | X | 10 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Fibroma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Fibrous Histiocytoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Medulloblastoma Mal | | 1 |
Meninges, Meningioma Malignant | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skeletal Muscle | | 1 |
Mediastinum, Fibrous Histiocytoma, | | |
Metastatic, Skeletal Muscle | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 4| 2| 2| | |
| 6| 9| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
TERT.MIX | 8| 9| 9| | L |
TEQ=10 | 9| 0| 6| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Renal Tubule, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 6| 5| 7| 7| 0| 2| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 6| 3| 2| 2| 3| 0| 5| 0| 6| 1| 2| 6| 2| 2| 3| 4| 6| 4| 0| 3| 2| 3| 2| 3|
| 9| 9| 0| 9| 9| 9| 2| 6| 9| 9| 6| 3| 6| 9| 9| 0| 6| 3| 8| 3| 0| 9| 0| 6| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
TERT.MIX | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
TEQ=22 | 1| 2| 3| 4| 5| 2| 4| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Adenomatous | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X X |
Hepatocellular Adenoma | |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Adenoma | X|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 6| 5| 7| 7| 0| 2| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 6| 3| 2| 2| 3| 0| 5| 0| 6| 1| 2| 6| 2| 2| 3| 4| 6| 4| 0| 3| 2| 3| 2| 3|
| 9| 9| 0| 9| 9| 9| 2| 6| 9| 9| 6| 3| 6| 9| 9| 0| 6| 3| 8| 3| 0| 9| 0| 6| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
TERT.MIX | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
TEQ=22 | 1| 2| 3| 4| 5| 2| 4| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 4|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Pars Distalis, Adenoma | X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + A + + A + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X X |
Bilateral, Follicular Cell, Carcinoma| |
C-Cell, Adenoma | X X X X X X|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 6| 5| 7| 7| 0| 2| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 6| 3| 2| 2| 3| 0| 5| 0| 6| 1| 2| 6| 2| 2| 3| 4| 6| 4| 0| 3| 2| 3| 2| 3|
| 9| 9| 0| 9| 9| 9| 2| 6| 9| 9| 6| 3| 6| 9| 9| 0| 6| 3| 8| 3| 0| 9| 0| 6| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
TERT.MIX | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
TEQ=22 | 1| 2| 3| 4| 5| 2| 4| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Granulosa Cell Tumor Malignant | X |
Granulosa Cell Tumor Benign | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Leiomyoma | |
Polyp Stromal | |
Polyp Stromal, Multiple | |
Schwannoma Malignant | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma | X |
Adenolipoma | X |
Carcinoma | X X |
Fibroadenoma | X X X X X X X X X|
Fibroadenoma, Multiple | X X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 6| 5| 7| 7| 0| 2| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 6| 3| 2| 2| 3| 0| 5| 0| 6| 1| 2| 6| 2| 2| 3| 4| 6| 4| 0| 3| 2| 3| 2| 3|
| 9| 9| 0| 9| 9| 9| 2| 6| 9| 9| 6| 3| 6| 9| 9| 0| 6| 3| 8| 3| 0| 9| 0| 6| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
TERT.MIX | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
TEQ=22 | 1| 2| 3| 4| 5| 2| 4| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 4|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Granular Cell Tumor Malignant | X |
Medulloblastoma Mal | X |
Oligodendroglioma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Adrenal Cortex| |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 6| 5| 7| 7| 0| 2| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 6| 3| 2| 2| 3| 0| 5| 0| 6| 1| 2| 6| 2| 2| 3| 4| 6| 4| 0| 3| 2| 3| 2| 3|
| 9| 9| 0| 9| 9| 9| 2| 6| 9| 9| 6| 3| 6| 9| 9| 0| 6| 3| 8| 3| 0| 9| 0| 6| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
TERT.MIX | 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
TEQ=22 | 1| 2| 3| 4| 5| 2| 4| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 4|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenolipoma | X |
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 2| 6|
DAY ON TEST | 3| 2| 9| 2| 3| 9| 0| 3| 2| 0| 3| 3| 3| 2| 3| 1| 3| 2| 8| 2| 0| 4| 5| 0| 5|
| 0| 1| 9| 9| 0| 2| 9| 0| 9| 2| 0| 0| 0| 9| 0| 7| 0| 9| 3| 9| 2| 0| 9| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
TERT.MIX | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
TEQ=22 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Adenomatous | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | |
Hepatocellular Adenoma | |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Adenoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 2| 6|
DAY ON TEST | 3| 2| 9| 2| 3| 9| 0| 3| 2| 0| 3| 3| 3| 2| 3| 1| 3| 2| 8| 2| 0| 4| 5| 0| 5|
| 0| 1| 9| 9| 0| 2| 9| 0| 9| 2| 0| 0| 0| 9| 0| 7| 0| 9| 3| 9| 2| 0| 9| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
TERT.MIX | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
TEQ=22 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Pars Distalis, Adenoma | X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
Bilateral, Follicular Cell, Carcinoma| X |
C-Cell, Adenoma | X X X X X X X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 2| 6|
DAY ON TEST | 3| 2| 9| 2| 3| 9| 0| 3| 2| 0| 3| 3| 3| 2| 3| 1| 3| 2| 8| 2| 0| 4| 5| 0| 5|
| 0| 1| 9| 9| 0| 2| 9| 0| 9| 2| 0| 0| 0| 9| 0| 7| 0| 9| 3| 9| 2| 0| 9| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
TERT.MIX | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
TEQ=22 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Granulosa Cell Tumor Malignant | |
Granulosa Cell Tumor Benign | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Leiomyoma | X |
Polyp Stromal | X X |
Polyp Stromal, Multiple | X |
Schwannoma Malignant | X |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma | |
Adenolipoma | |
Carcinoma | X |
Fibroadenoma | X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 2| 6|
DAY ON TEST | 3| 2| 9| 2| 3| 9| 0| 3| 2| 0| 3| 3| 3| 2| 3| 1| 3| 2| 8| 2| 0| 4| 5| 0| 5|
| 0| 1| 9| 9| 0| 2| 9| 0| 9| 2| 0| 0| 0| 9| 0| 7| 0| 9| 3| 9| 2| 0| 9| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
TERT.MIX | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
TEQ=22 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
Granular Cell Tumor Malignant | |
Medulloblastoma Mal | |
Oligodendroglioma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Adrenal Cortex| X|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 5| 6| 2| 6|
DAY ON TEST | 3| 2| 9| 2| 3| 9| 0| 3| 2| 0| 3| 3| 3| 2| 3| 1| 3| 2| 8| 2| 0| 4| 5| 0| 5|
| 0| 1| 9| 9| 0| 2| 9| 0| 9| 2| 0| 0| 0| 9| 0| 7| 0| 9| 3| 9| 2| 0| 9| 3| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
TERT.MIX | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
TEQ=22 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 6| 8| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 4|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
|__________________________________________________________________________|
Ureter | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenolipoma | |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 6| 7| 3| | |
DAY ON TEST | 5| 3| 2| | |
| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
TERT.MIX | 9| 9| 9| | L |
TEQ=22 | 5| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
Polyp Adenomatous | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
Leiomyosarcoma | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Cholangiocarcinoma | | 2 |
Hepatocellular Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 2 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 19 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Acinus, Adenoma | | 2 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 6| 7| 3| | |
DAY ON TEST | 5| 3| 2| | |
| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
TERT.MIX | 9| 9| 9| | L |
TEQ=22 | 5| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Glandular | + + + | 53 |
|__________________________________________________________________________|____________|
Tooth | | 27 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Adenoma | | 1 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Benign | | 4 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Carcinoma | | 1 |
Pars Distalis, Adenoma | X X | 22 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 51 |
Bilateral, C-Cell, Adenoma | | 3 |
Bilateral, Follicular Cell, Carcinoma| | 1 |
C-Cell, Adenoma | X X | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 6| 7| 3| | |
DAY ON TEST | 5| 3| 2| | |
| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
TERT.MIX | 9| 9| 9| | L |
TEQ=22 | 5| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Granulosa Cell Tumor Malignant | | 1 |
Granulosa Cell Tumor Benign | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Carcinoma | X | 2 |
Leiomyoma | X | 2 |
Polyp Stromal | | 2 |
Polyp Stromal, Multiple | | 1 |
Schwannoma Malignant | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 6| 7| 3| | |
DAY ON TEST | 5| 3| 2| | |
| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
TERT.MIX | 9| 9| 9| | L |
TEQ=22 | 5| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Thymus | + + + | 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoacanthoma | | 1 |
Adenolipoma | | 1 |
Carcinoma | | 3 |
Fibroadenoma | X X | 19 |
Fibroadenoma, Multiple | X | 16 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Fibroma | | 2 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Granular Cell Tumor Malignant | | 1 |
Medulloblastoma Mal | | 1 |
Oligodendroglioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 6| 7| 3| | |
DAY ON TEST | 5| 3| 2| | |
| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
TERT.MIX | 9| 9| 9| | L |
TEQ=22 | 5| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X | 1 |
Carcinoma, Metastatic, Adrenal Cortex| | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Schwannoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 52 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Ureter | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Adenolipoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 4| 7| 5| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 5| 5| 6| 6| 4| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 2| 0| 6| 6| 8| 6| 3| 2| 8| 4| 1| 6| 2| 2| 2| 6| 9| 9| 1| 3| 3| 2| 3| 8|
| 5| 9| 5| 9| 9| 2| 9| 0| 6| 5| 2| 6| 9| 9| 1| 1| 9| 7| 0| 9| 0| 0| 9| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
TERT.MIX | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|
TEQ=46 | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 7| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Schwannoma Malignant, Metastatic, | |
Uterus | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X X X |
Cholangiocarcinoma, Multiple | X |
Hepatocellular Adenoma | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Mesentery | + + + |
Lipoma | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Carcinoma | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 4| 7| 5| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 5| 5| 6| 6| 4| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 2| 0| 6| 6| 8| 6| 3| 2| 8| 4| 1| 6| 2| 2| 2| 6| 9| 9| 1| 3| 3| 2| 3| 8|
| 5| 9| 5| 9| 9| 2| 9| 0| 6| 5| 2| 6| 9| 9| 1| 1| 9| 7| 0| 9| 0| 0| 9| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
TERT.MIX | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|
TEQ=46 | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 7| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X X|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 4| 7| 5| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 5| 5| 6| 6| 4| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 2| 0| 6| 6| 8| 6| 3| 2| 8| 4| 1| 6| 2| 2| 2| 6| 9| 9| 1| 3| 3| 2| 3| 8|
| 5| 9| 5| 9| 9| 2| 9| 0| 6| 5| 2| 6| 9| 9| 1| 1| 9| 7| 0| 9| 0| 0| 9| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
TERT.MIX | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|
TEQ=46 | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 7| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Oviduct | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Polyp Stromal | X |
Schwannoma Malignant | X X |
|__________________________________________________________________________|
Vagina | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + |
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | |
Inguinal, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 4| 7| 5| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 5| 5| 6| 6| 4| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 2| 0| 6| 6| 8| 6| 3| 2| 8| 4| 1| 6| 2| 2| 2| 6| 9| 9| 1| 3| 3| 2| 3| 8|
| 5| 9| 5| 9| 9| 2| 9| 0| 6| 5| 2| 6| 9| 9| 1| 1| 9| 7| 0| 9| 0| 0| 9| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
TERT.MIX | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|
TEQ=46 | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 7| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X X |
Fibroadenoma | X X X X X X X X X X X X|
Fibroadenoma, Multiple | X X X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X X |
Fibrosarcoma | X|
Pilomatrixoma | |
Schwannoma Malignant, Metastatic, | |
Uterus | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Mammary Gland | X |
Cystic Keratinizing Epithelioma | X X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 4| 7| 5| 6| 6| 6| 4| 7| 6| 5| 5| 6| 6| 7| 5| 5| 6| 6| 4| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 2| 0| 6| 6| 8| 6| 3| 2| 8| 4| 1| 6| 2| 2| 2| 6| 9| 9| 1| 3| 3| 2| 3| 8|
| 5| 9| 5| 9| 9| 2| 9| 0| 6| 5| 2| 6| 9| 9| 1| 1| 9| 7| 0| 9| 0| 0| 9| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
TERT.MIX | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4|
TEQ=46 | 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 7| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Transitional Epithelium, Papilloma | |
|__________________________________________________________________________|
Ureter | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 2| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 7|
DAY ON TEST | 3| 6| 2| 3| 2| 6| 2| 2| 6| 3| 7| 6| 0| 2| 2| 3| 3| 2| 2| 3| 3| 1| 2| 8| 3|
| 0| 9| 9| 0| 9| 8| 2| 9| 8| 0| 6| 8| 2| 9| 6| 0| 3| 9| 9| 0| 0| 5| 9| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
TERT.MIX | 4| 4| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
TEQ=46 | 3| 4| 5| 6| 8| 9| 1| 2| 4| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Schwannoma Malignant, Metastatic, | |
Uterus | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X X |
Cholangiocarcinoma, Multiple | X |
Hepatocellular Adenoma | X|
Lymphoma Malignant | |
|__________________________________________________________________________|
Mesentery | + + +|
Lipoma | X |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Carcinoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 2| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 7|
DAY ON TEST | 3| 6| 2| 3| 2| 6| 2| 2| 6| 3| 7| 6| 0| 2| 2| 3| 3| 2| 2| 3| 3| 1| 2| 8| 3|
| 0| 9| 9| 0| 9| 8| 2| 9| 8| 0| 6| 8| 2| 9| 6| 0| 3| 9| 9| 0| 0| 5| 9| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
TERT.MIX | 4| 4| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
TEQ=46 | 3| 4| 5| 6| 8| 9| 1| 2| 4| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M M M + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 2| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 7|
DAY ON TEST | 3| 6| 2| 3| 2| 6| 2| 2| 6| 3| 7| 6| 0| 2| 2| 3| 3| 2| 2| 3| 3| 1| 2| 8| 3|
| 0| 9| 9| 0| 9| 8| 2| 9| 8| 0| 6| 8| 2| 9| 6| 0| 3| 9| 9| 0| 0| 5| 9| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
TERT.MIX | 4| 4| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
TEQ=46 | 3| 4| 5| 6| 8| 9| 1| 2| 4| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Oviduct | + + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Polyp Stromal | X X|
Schwannoma Malignant | |
|__________________________________________________________________________|
Vagina | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + +|
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | X |
Inguinal, Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 2| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 7|
DAY ON TEST | 3| 6| 2| 3| 2| 6| 2| 2| 6| 3| 7| 6| 0| 2| 2| 3| 3| 2| 2| 3| 3| 1| 2| 8| 3|
| 0| 9| 9| 0| 9| 8| 2| 9| 8| 0| 6| 8| 2| 9| 6| 0| 3| 9| 9| 0| 0| 5| 9| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
TERT.MIX | 4| 4| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
TEQ=46 | 3| 4| 5| 6| 8| 9| 1| 2| 4| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | X X X X X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Fibrosarcoma | |
Pilomatrixoma | X|
Schwannoma Malignant, Metastatic, | |
Uterus | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Mammary Gland | X |
Cystic Keratinizing Epithelioma | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 2| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 7|
DAY ON TEST | 3| 6| 2| 3| 2| 6| 2| 2| 6| 3| 7| 6| 0| 2| 2| 3| 3| 2| 2| 3| 3| 1| 2| 8| 3|
| 0| 9| 9| 0| 9| 8| 2| 9| 8| 0| 6| 8| 2| 9| 6| 0| 3| 9| 9| 0| 0| 5| 9| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
TERT.MIX | 4| 4| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
TEQ=46 | 3| 4| 5| 6| 8| 9| 1| 2| 4| 2| 3| 4| 5| 7| 9| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Transitional Epithelium, Papilloma | X |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 4| 3| 3| | |
| 8| 0| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
TERT.MIX | 9| 9| 9| | L |
TEQ=46 | 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
Lymphoma Malignant | | 1 |
Schwannoma Malignant, Metastatic, | | |
Uterus | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Cholangiocarcinoma | | 5 |
Cholangiocarcinoma, Multiple | | 2 |
Hepatocellular Adenoma | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 6 |
Lipoma | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | + + | 29 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Acinus, Carcinoma | X | 2 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 4| 3| 3| | |
| 8| 0| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
TERT.MIX | 9| 9| 9| | L |
TEQ=46 | 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Salivary Glands | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Tooth | + + + | 37 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 52 |
|__________________________________________________________________________|____________|
Heart | + + + | 52 |
Lymphoma Malignant | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Benign | | 4 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Adenoma | X X | 20 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 4| 3| 3| | |
| 8| 0| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
TERT.MIX | 9| 9| 9| | L |
TEQ=46 | 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | X X | 8 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 51 |
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Granulosa Cell Tumor Benign | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Oviduct | | 2 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Carcinoma | | 2 |
Polyp Stromal | | 3 |
Schwannoma Malignant | | 2 |
|__________________________________________________________________________|____________|
Vagina | + | 1 |
Schwannoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | + | 9 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 4| 3| 3| | |
| 8| 0| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
TERT.MIX | 9| 9| 9| | L |
TEQ=46 | 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Deep Cervical, Carcinoma, Metastatic,| | |
Thyroid Gland | | 1 |
Inguinal, Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + | 53 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Carcinoma | | 5 |
Fibroadenoma | X | 20 |
Fibroadenoma, Multiple | | 8 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Fibroma | X | 3 |
Fibrosarcoma | | 1 |
Pilomatrixoma | | 1 |
Schwannoma Malignant, Metastatic, | | |
Uterus | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 4| 3| 3| | |
| 8| 0| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
TERT.MIX | 9| 9| 9| | L |
TEQ=46 | 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 1 |
Carcinoma, Metastatic, Mammary Gland | | 2 |
Cystic Keratinizing Epithelioma | | 2 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Lymphoma Malignant | | 1 |
Transitional Epithelium, Papilloma | | 1 |
|__________________________________________________________________________|____________|
Ureter | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 4| 3| 3| | |
| 8| 0| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
TERT.MIX | 9| 9| 9| | L |
TEQ=46 | 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|
DAY ON TEST | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|
| 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
TERT.MIX | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
TEQ=100 | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X X |
Cholangiocarcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Mesentery | + + + + + |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + + +|
Gingival, Squamous Cell Carcinoma | X X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Skin | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|
DAY ON TEST | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|
| 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
TERT.MIX | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
TEQ=100 | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | +|
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|
DAY ON TEST | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|
| 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
TERT.MIX | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
TEQ=100 | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Carcinoma | X |
Hemangiosarcoma | X |
Polyp Stromal | X |
Schwannoma Malignant | X |
Cervix, Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | |
Renal, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Spleen | + + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Thymus | + + + + + + + M + + + + M + + + + + + + + + + M +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|
DAY ON TEST | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|
| 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
TERT.MIX | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
TEQ=100 | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Fibroadenoma | X X X X X X X X X |
Fibroadenoma, Multiple | X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystic Keratinizing Epithelioma | X X X X |
Cystic Keratinizing Epithelioma, | |
Multiple | X X X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Schwannoma Malignant, Metastatic, | |
Skin | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 5| 5| 5| 7| 7| 7| 3| 6| 0| 5| 7| 4| 7| 5| 4| 5| 7| 6| 7| 5| 5| 7| 4| 6| 3|
DAY ON TEST | 2| 9| 7| 2| 2| 2| 8| 8| 0| 6| 2| 0| 2| 9| 3| 4| 2| 8| 2| 4| 6| 2| 9| 3| 9|
| 6| 8| 5| 9| 9| 9| 7| 2| 2| 2| 8| 9| 9| 2| 4| 2| 9| 8| 9| 6| 3| 1| 7| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
TERT.MIX | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
TEQ=100 | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 5| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Ureter | +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|
DAY ON TEST | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|
| 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
TERT.MIX | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
TEQ=100 | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + M + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + M + + + + + + + + + + + + + +|
Cholangiocarcinoma | X X X |
Cholangiocarcinoma, Multiple | X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Mesentery | + + +|
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + + + + + + + |
Gingival, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Skin | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|
DAY ON TEST | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|
| 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
TERT.MIX | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
TEQ=100 | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|
DAY ON TEST | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|
| 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
TERT.MIX | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
TEQ=100 | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + M + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
|__________________________________________________________________________|
Oviduct | + + + + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Carcinoma | |
Hemangiosarcoma | |
Polyp Stromal | X |
Schwannoma Malignant | |
Cervix, Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Inguinal, Lymphoma Malignant | X |
Mediastinal, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + M + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|
DAY ON TEST | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|
| 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
TERT.MIX | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
TEQ=100 | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystic Keratinizing Epithelioma | X X X X X |
Cystic Keratinizing Epithelioma, | |
Multiple | X X X X X X |
Histiocytic Sarcoma | X|
Lymphoma Malignant | X |
Schwannoma Malignant, Metastatic, | |
Skin | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 6| 5| 3| 7| 7| 6| 2| 4| 6| 6| 6| 6| 6| 7| 6| 6| 5| 4| 6| 6| 3|
DAY ON TEST | 2| 2| 4| 4| 3| 8| 3| 1| 2| 8| 8| 3| 7| 1| 3| 8| 7| 2| 3| 7| 9| 9| 5| 8| 1|
| 8| 3| 8| 8| 4| 9| 9| 8| 9| 9| 7| 4| 4| 7| 9| 9| 4| 9| 3| 4| 8| 8| 8| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
TERT.MIX | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
TEQ=100 | 4| 5| 6| 8| 9| 3| 4| 5| 7| 8| 9| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 6| 7| 3| | |
DAY ON TEST | 6| 1| 9| | |
| 6| 5| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
TERT.MIX | 8| 8| 9| | L |
TEQ=100 | 8| 9| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 51 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 50 |
|__________________________________________________________________________|____________|
Liver | + + + | 51 |
Cholangiocarcinoma | | 5 |
Cholangiocarcinoma, Multiple | | 4 |
Hepatocellular Adenoma | X | 9 |
Hepatocellular Adenoma, Multiple | | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 8 |
|__________________________________________________________________________|____________|
Oral Mucosa | + | 31 |
Gingival, Squamous Cell Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 51 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
Schwannoma Malignant, Metastatic, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 6| 7| 3| | |
DAY ON TEST | 6| 1| 9| | |
| 6| 5| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
TERT.MIX | 8| 8| 9| | L |
TEQ=100 | 8| 9| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Skin | | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 52 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 52 |
|__________________________________________________________________________|____________|
Tongue | | 1 |
|__________________________________________________________________________|____________|
Tooth | + + | 30 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Schwannoma Malignant | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 51 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 51 |
Pheochromocytoma Benign | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 51 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 52 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Adenoma | X | 10 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 6| 7| 3| | |
DAY ON TEST | 6| 1| 9| | |
| 6| 5| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
TERT.MIX | 8| 8| 9| | L |
TEQ=100 | 8| 9| 6| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Thyroid Gland | + + + | 51 |
C-Cell, Adenoma | | 5 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 50 |
|__________________________________________________________________________|____________|
Ovary | + + + | 51 |
Granulosa Cell Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Oviduct | | 5 |
|__________________________________________________________________________|____________|
Uterus | + + + | 51 |
Carcinoma | | 1 |
Hemangiosarcoma | | 1 |
Polyp Stromal | | 2 |
Schwannoma Malignant | | 1 |
Cervix, Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | + | 11 |
Inguinal, Lymphoma Malignant | | 1 |
Mediastinal, Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 6| 7| 3| | |
DAY ON TEST | 6| 1| 9| | |
| 6| 5| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
TERT.MIX | 8| 8| 9| | L |
TEQ=100 | 8| 9| 6| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 50 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + | 51 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + | 50 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 52 |
Carcinoma | | 1 |
Fibroadenoma | X | 15 |
Fibroadenoma, Multiple | | 3 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 96007-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Date: 09/29/03
Route: GAVAGE Time: 12:03:26
__________________________________________________________________________________________________________________________________
| 6| 7| 3| | |
DAY ON TEST | 6| 1| 9| | |
| 6| 5| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
TERT.MIX | 8| 8| 9| | L |
TEQ=100 | 8| 9| 6| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Cystic Keratinizing Epithelioma | | 9 |
Cystic Keratinizing Epithelioma, | | |
Multiple | | 11 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
Schwannoma Malignant, Metastatic, | | |
Skin | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 51 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Ureter | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 78
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---------- END OF REPORT ----------
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